메뉴 건너뛰기




Volumn 2, Issue 11, 2009, Pages 915-918

A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BEXAROTENE; DEGUELIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ESTROGEN RECEPTOR; GEFITINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE KINASE INHIBITOR; RETINOID X RECEPTOR; WNT PROTEIN; DRUG DERIVATIVE; ROTENONE;

EID: 74049148153     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-09-0208     Document Type: Review
Times cited : (5)

References (39)
  • 1
    • 77949749479 scopus 로고    scopus 로고
    • Horner MJ, Ries LAG, Krapcho M, et al. SEER cancer statistics review, 1975-2006. http://seercancergov/csr/1975-2006/ 2009 [cited July 15, 2009].
    • Horner MJ, Ries LAG, Krapcho M, et al. SEER cancer statistics review, 1975-2006. http://seercancergov/csr/1975-2006/ 2009 [cited July 15, 2009].
  • 2
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998;90:1371-88.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 3
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
    • Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006;295:2727-41.
    • (2006) JAMA , vol.295 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 5
    • 33750715421 scopus 로고    scopus 로고
    • Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats
    • Samy RP, Gopalakrishnakone P, Ignacimuthu S. Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem Biol Interact 2006;164:1-14.
    • (2006) Chem Biol Interact , vol.164 , pp. 1-14
    • Samy, R.P.1    Gopalakrishnakone, P.2    Ignacimuthu, S.3
  • 6
    • 38049074972 scopus 로고    scopus 로고
    • Epidemiology of soy exposures and breast cancer risk
    • Wu AH, Yu MC, Tseng CC, Pike MC. Epidemiology of soy exposures and breast cancer risk. Br J Cancer 2008;98:9-14.
    • (2008) Br J Cancer , vol.98 , pp. 9-14
    • Wu, A.H.1    Yu, M.C.2    Tseng, C.C.3    Pike, M.C.4
  • 7
    • 46749111467 scopus 로고    scopus 로고
    • Soy isoflavones, estrogen therapy, and breast cancer risk: Analysis and commentary
    • Messina MJ, Wood CE. Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutr J 2008;7:17.
    • (2008) Nutr J , vol.7 , pp. 17
    • Messina, M.J.1    Wood, C.E.2
  • 9
    • 0033305279 scopus 로고    scopus 로고
    • Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast
    • Hargreaves DF, Potten CS, Harding C, et al. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metab 1999;84:4017-24.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4017-4024
    • Hargreaves, D.F.1    Potten, C.S.2    Harding, C.3
  • 11
    • 4644295057 scopus 로고    scopus 로고
    • A pilot clinical study of short-term isoflavone supplements in breast cancer patients
    • Sartippour MR, Rao JY, Apple S, et al. A pilot clinical study of short-term isoflavone supplements in breast cancer patients. Nutr Cancer 2004;49:59-65.
    • (2004) Nutr Cancer , vol.49 , pp. 59-65
    • Sartippour, M.R.1    Rao, J.Y.2    Apple, S.3
  • 12
    • 0035092599 scopus 로고    scopus 로고
    • Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries
    • Carlton PS, Kresty LA, Siglin JC, et al. Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries. Carcinogenesis 2001;22:441-6.
    • (2001) Carcinogenesis , vol.22 , pp. 441-446
    • Carlton, P.S.1    Kresty, L.A.2    Siglin, J.C.3
  • 13
    • 0035881625 scopus 로고    scopus 로고
    • Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries
    • Kresty LA, Morse MA, Morgan C, et al. Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 2001;61:6112-9.
    • (2001) Cancer Res , vol.61 , pp. 6112-6119
    • Kresty, L.A.1    Morse, M.A.2    Morgan, C.3
  • 14
    • 0033395987 scopus 로고    scopus 로고
    • Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer
    • Stoner GD, Kresty LA, Carlton PS, Siglin JC, Morse MA. Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer. Toxicol Sci 1999;52:95-100.
    • (1999) Toxicol Sci , vol.52 , pp. 95-100
    • Stoner, G.D.1    Kresty, L.A.2    Carlton, P.S.3    Siglin, J.C.4    Morse, M.A.5
  • 15
    • 9344256065 scopus 로고    scopus 로고
    • Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels
    • Olsson ME, Gustavsson KE, Andersson S, Nilsson A, Duan RD. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 2004;52:7264-71.
    • (2004) J Agric Food Chem , vol.52 , pp. 7264-7271
    • Olsson, M.E.1    Gustavsson, K.E.2    Andersson, S.3    Nilsson, A.4    Duan, R.D.5
  • 16
    • 33846131249 scopus 로고    scopus 로고
    • Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro
    • Seeram NP, Adams LS, Zhang Y, et al. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 2006;54:9329-39.
    • (2006) J Agric Food Chem , vol.54 , pp. 9329-9339
    • Seeram, N.P.1    Adams, L.S.2    Zhang, Y.3
  • 17
    • 74049162893 scopus 로고    scopus 로고
    • Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway
    • Murillo G, Peng XH, Torres KEO, Mehta RG. Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Cancer Prev Res 2009;2:942-50.
    • (2009) Cancer Prev Res , vol.2 , pp. 942-950
    • Murillo, G.1    Peng, X.H.2    Torres, K.E.O.3    Mehta, R.G.4
  • 18
    • 84993915009 scopus 로고
    • Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
    • Gerhauser C, Mar W, Lee SK, et al. Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med 1995;1:260-6.
    • (1995) Nat Med , vol.1 , pp. 260-266
    • Gerhauser, C.1    Mar, W.2    Lee, S.K.3
  • 19
    • 0030878978 scopus 로고    scopus 로고
    • Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
    • Udeani GO, Gerhauser C, Thomas CF, et al. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res 1997;57:3424-8.
    • (1997) Cancer Res , vol.57 , pp. 3424-3428
    • Udeani, G.O.1    Gerhauser, C.2    Thomas, C.F.3
  • 20
    • 0037453909 scopus 로고    scopus 로고
    • Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
    • Chun KH, Kosmeder JW II, Sun S, et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 2003;95:291-302.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 291-302
    • Chun, K.H.1    Kosmeder II, J.W.2    Sun, S.3
  • 21
    • 27944452718 scopus 로고    scopus 로고
    • Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
    • Lee HY, Oh SH, Woo JK, et al. Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst 2005;97:1695-9.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1695-1699
    • Lee, H.Y.1    Oh, S.H.2    Woo, J.K.3
  • 22
    • 37549005069 scopus 로고    scopus 로고
    • Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin
    • Jin Q, Feng L, Behrens C, et al. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res 2007;67:11630-9.
    • (2007) Cancer Res , vol.67 , pp. 11630-11639
    • Jin, Q.1    Feng, L.2    Behrens, C.3
  • 23
    • 49649102136 scopus 로고    scopus 로고
    • Survivin expression in normal human bronchial epithelial cells: An early and critical step in tumorigenesis induced by tobacco exposure
    • Jin Q, Menter DG, Mao L, Hong WK, Lee HY. Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure. Carcinogenesis 2008;29:1614-22.
    • (2008) Carcinogenesis , vol.29 , pp. 1614-1622
    • Jin, Q.1    Menter, D.G.2    Mao, L.3    Hong, W.K.4    Lee, H.Y.5
  • 24
    • 60549083336 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1α
    • Kim WY, Oh SH, Woo JK, Hong WK, Lee HY. Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1α. Cancer Res 2009;69:1624-32.
    • (2009) Cancer Res , vol.69 , pp. 1624-1632
    • Kim, W.Y.1    Oh, S.H.2    Woo, J.K.3    Hong, W.K.4    Lee, H.Y.5
  • 25
    • 1042278720 scopus 로고    scopus 로고
    • Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells
    • Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK, Kurie JM. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res 2004;10:1074-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 1074-1079
    • Lee, H.Y.1    Suh, Y.A.2    Kosmeder, J.W.3    Pezzuto, J.M.4    Hong, W.K.5    Kurie, J.M.6
  • 26
    • 33749524818 scopus 로고    scopus 로고
    • Deguelin, an Akt inhibitor, suppresses IκBα kinase activation leading to suppression of NF-κB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion
    • Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB. Deguelin, an Akt inhibitor, suppresses IκBα kinase activation leading to suppression of NF-κB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. J Immunol 2006;177:5612-22.
    • (2006) J Immunol , vol.177 , pp. 5612-5622
    • Nair, A.S.1    Shishodia, S.2    Ahn, K.S.3    Kunnumakkara, A.B.4    Sethi, G.5    Aggarwal, B.B.6
  • 27
    • 36749072578 scopus 로고    scopus 로고
    • Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1α
    • Oh SH, Woo JK, Jin Q, et al. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1α. Int J Cancer 2008;122:5-14.
    • (2008) Int J Cancer , vol.122 , pp. 5-14
    • Oh, S.H.1    Woo, J.K.2    Jin, Q.3
  • 28
    • 34347256360 scopus 로고    scopus 로고
    • Structural basis for depletion of heat shock protein 90 client proteins by deguelin
    • Oh SH, Woo JK, Yazici YD, et al. Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst 2007;99:949-61.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 949-961
    • Oh, S.H.1    Woo, J.K.2    Yazici, Y.D.3
  • 29
    • 33845885778 scopus 로고    scopus 로고
    • Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells
    • Peng XH, Karna P, O'Regan RM, et al. Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Mol Pharmacol 2007;71:101-11.
    • (2007) Mol Pharmacol , vol.71 , pp. 101-111
    • Peng, X.H.1    Karna, P.2    O'Regan, R.M.3
  • 30
    • 46449121785 scopus 로고    scopus 로고
    • Enhancement radiosensitization of breast cancer cells by deguelin
    • Yi T, Li H, Wang X, Wu Z. Enhancement radiosensitization of breast cancer cells by deguelin. Cancer Biother Radiopharm 2008;23:355-62.
    • (2008) Cancer Biother Radiopharm , vol.23 , pp. 355-362
    • Yi, T.1    Li, H.2    Wang, X.3    Wu, Z.4
  • 31
    • 59049104410 scopus 로고    scopus 로고
    • Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice
    • Strecker TE, Shen Q, Zhang Y, et al. Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. J Natl Cancer Inst 2009;101:107-13.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 107-113
    • Strecker, T.E.1    Shen, Q.2    Zhang, Y.3
  • 32
    • 0037112520 scopus 로고    scopus 로고
    • The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
    • Wu K, Zhang Y, Xu XC, et al. The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice. Cancer Res 2002;62:6376-80.
    • (2002) Cancer Res , vol.62 , pp. 6376-6380
    • Wu, K.1    Zhang, Y.2    Xu, X.C.3
  • 33
    • 22844438305 scopus 로고    scopus 로고
    • β-Catenin is associated with breast cancer progression in vitro
    • Calaf GM, Alvarado ME, Hei TK. β-Catenin is associated with breast cancer progression in vitro. Int J Oncol 2005;26:913-21.
    • (2005) Int J Oncol , vol.26 , pp. 913-921
    • Calaf, G.M.1    Alvarado, M.E.2    Hei, T.K.3
  • 34
    • 34548066245 scopus 로고    scopus 로고
    • Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    • Huang S, Li Y, Chen Y, et al. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biol 2005;6:R84.
    • (2005) Genome Biol , vol.6
    • Huang, S.1    Li, Y.2    Chen, Y.3
  • 35
    • 8844252230 scopus 로고    scopus 로고
    • Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease
    • Caboni P, Sherer TB, Zhang N, et al. Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease. Chem Res Toxicol 2004;17:1540-8.
    • (2004) Chem Res Toxicol , vol.17 , pp. 1540-1548
    • Caboni, P.1    Sherer, T.B.2    Zhang, N.3
  • 36
    • 67549093924 scopus 로고    scopus 로고
    • Liposomal encapsulation of deguelin: Evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis
    • Woo JK, Choi DS, Tran HT, Gilbert BE, Hong WK, Lee HY. Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res 2009;2:361-9.
    • (2009) Cancer Prev Res , vol.2 , pp. 361-369
    • Woo, J.K.1    Choi, D.S.2    Tran, H.T.3    Gilbert, B.E.4    Hong, W.K.5    Lee, H.Y.6
  • 37
    • 62349092784 scopus 로고    scopus 로고
    • A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy
    • Kim WY, Chang DJ, Hennessy B, et al. A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res (Phila Pa) 2008;1:577-87.
    • (2008) Cancer Prev Res (Phila Pa) , vol.1 , pp. 577-587
    • Kim, W.Y.1    Chang, D.J.2    Hennessy, B.3
  • 38
    • 4143078350 scopus 로고    scopus 로고
    • Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells
    • Lee HY. Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol 2004;68:1119-24.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1119-1124
    • Lee, H.Y.1
  • 39
    • 0036892114 scopus 로고    scopus 로고
    • Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest
    • Murillo G, Salti GI, Kosmeder JW II, Pezzuto JM, Mehta RG. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 2002;38:2446-54.
    • (2002) Eur J Cancer , vol.38 , pp. 2446-2454
    • Murillo, G.1    Salti, G.I.2    Kosmeder II, J.W.3    Pezzuto, J.M.4    Mehta, R.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.