-
1
-
-
0141450537
-
Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity
-
Tao Y-X, Segaloff DL. Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. Endocrinology 2003;144:4544-51.
-
(2003)
Endocrinology
, vol.144
, pp. 4544-4551
-
-
Tao, Y.-X.1
Segaloff, D.L.2
-
2
-
-
31544447196
-
Obesity-associated mutations in the human melanocortin-4 receptor gene
-
MacKenzie RG. Obesity-associated mutations in the human melanocortin-4 receptor gene. Peptides 2006;27:395-403.
-
(2006)
Peptides
, vol.27
, pp. 395-403
-
-
MacKenzie, R.G.1
-
3
-
-
34748892295
-
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor
-
Staubert C, Tarnow P, Brumm H, et al. Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 2007;148:4642-8.
-
(2007)
Endocrinology
, vol.148
, pp. 4642-4648
-
-
Staubert, C.1
Tarnow, P.2
Brumm, H.3
-
4
-
-
12244281827
-
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity
-
Larsen LH, Echwald SM, Sorensen TI, Andersen T, Wulff BS, Pedersen O. Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab 2005;90:219-24.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 219-224
-
-
Larsen, L.H.1
Echwald, S.M.2
Sorensen, T.I.3
Andersen, T.4
Wulff, B.S.5
Pedersen, O.6
-
5
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
Chambers JC, Elliott P, Zabaneh D, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008;40:716-8.
-
(2008)
Nat Genet
, vol.40
, pp. 716-718
-
-
Chambers, J.C.1
Elliott, P.2
Zabaneh, D.3
-
6
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-75.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
-
7
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
-
8
-
-
33846818764
-
-
Cai G, Cole SA, Butte NF, et al. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity (Silver Spring) 2006;14:1596-604.
-
Cai G, Cole SA, Butte NF, et al. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity (Silver Spring) 2006;14:1596-604.
-
-
-
-
9
-
-
33750123701
-
Viva la Familia Study: Genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population
-
Butte NF, Cai G, Cole SA, Comuzzie AG. Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population. Am J Clin Nutr 2006;84:646-54.
-
(2006)
Am J Clin Nutr
, vol.84
, pp. 646-654
-
-
Butte, N.F.1
Cai, G.2
Cole, S.A.3
Comuzzie, A.G.4
-
11
-
-
0030819243
-
Body composition of a young, multiethnic, male population
-
Ellis KJ. Body composition of a young, multiethnic, male population. Am J Clin Nutr 1997;66:1323-31.
-
(1997)
Am J Clin Nutr
, vol.66
, pp. 1323-1331
-
-
Ellis, K.J.1
-
12
-
-
0031047627
-
Body composition of a young, multiethnic female population
-
Ellis KJ, Abrams SA, Wong WW. Body composition of a young, multiethnic female population. Am J Clin Nutr 1997;65:724-31.
-
(1997)
Am J Clin Nutr
, vol.65
, pp. 724-731
-
-
Ellis, K.J.1
Abrams, S.A.2
Wong, W.W.3
-
13
-
-
37149038936
-
Body size, body composition, and metabolic profile explain higher energy expenditure in overweight children
-
Butte NF, Puyau MR, Vohra FA, Adolph AL, Mehta NR, Zakeri I. Body size, body composition, and metabolic profile explain higher energy expenditure in overweight children. J Nutr 2007;137:2660-7.
-
(2007)
J Nutr
, vol.137
, pp. 2660-2667
-
-
Butte, N.F.1
Puyau, M.R.2
Vohra, F.A.3
Adolph, A.L.4
Mehta, N.R.5
Zakeri, I.6
-
14
-
-
0028802042
-
Closed-loop control of carbon dioxide concentration and pressure improves response of room respiration calorimeters
-
Moon JK, Vohra FA, Valerio Jimenez OS, Puyau MR, Butte NF. Closed-loop control of carbon dioxide concentration and pressure improves response of room respiration calorimeters. J Nutr 1995;125:220-8.
-
(1995)
J Nutr
, vol.125
, pp. 220-228
-
-
Moon, J.K.1
Vohra, F.A.2
Valerio Jimenez, O.S.3
Puyau, M.R.4
Butte, N.F.5
-
15
-
-
0034979880
-
Glucose production, gluconeogenesis, and insulin sensitivity in children and adolescents: An evaluation of their reproducibility
-
Sunehag AL, Treuth MS, Toffolo G, et al. Glucose production, gluconeogenesis, and insulin sensitivity in children and adolescents: an evaluation of their reproducibility. Pediatr Res 2001;50:115-23.
-
(2001)
Pediatr Res
, vol.50
, pp. 115-123
-
-
Sunehag, A.L.1
Treuth, M.S.2
Toffolo, G.3
-
16
-
-
0023878876
-
Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: Evaluation of errors with special reference to the detailed composition of fuels
-
Livesey G, Elia M. Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 1988;47:608-28.
-
(1988)
Am J Clin Nutr
, vol.47
, pp. 608-628
-
-
Livesey, G.1
Elia, M.2
-
17
-
-
0001857573
-
Basal metabolic rate-review and prediction, together with annotated bibliography of source material
-
Schofield WN, Schofield C, James WPT. Basal metabolic rate-review and prediction, together with annotated bibliography of source material. Hum Nutr Clin Nutr 1985;39C:1-96.
-
(1985)
Hum Nutr Clin Nutr
, vol.39 C
, pp. 1-96
-
-
Schofield, W.N.1
Schofield, C.2
James, W.P.T.3
-
18
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta cell function from fasting glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudensky AS, Naylor A, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudensky, A.S.3
Naylor, A.4
Treacher, D.F.5
Turner, R.C.6
-
19
-
-
34548348644
-
Physical activity in nonoverweight and overweight Hispanic children and adolescents
-
Butte NF, Puyau MR, Adolph AL, Vohra FA, Zakeri I. Physical activity in nonoverweight and overweight Hispanic children and adolescents. Med Sci Sports Exerc 2007;39:1257-66.
-
(2007)
Med Sci Sports Exerc
, vol.39
, pp. 1257-1266
-
-
Butte, N.F.1
Puyau, M.R.2
Adolph, A.L.3
Vohra, F.A.4
Zakeri, I.5
-
20
-
-
4444382491
-
Prediction of activity energy expenditure using accelerometers in children
-
Puyau MR, Adolph AL, Vohra FA, Zakeri I, Butte NF. Prediction of activity energy expenditure using accelerometers in children. Med Sci Sports Exerc 2004;36:1625-31.
-
(2004)
Med Sci Sports Exerc
, vol.36
, pp. 1625-1631
-
-
Puyau, M.R.1
Adolph, A.L.2
Vohra, F.A.3
Zakeri, I.4
Butte, N.F.5
-
22
-
-
0031966959
-
Multipoint quantitative-trait linkage analysis in general pedigrees
-
Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-211.
-
(1998)
Am J Hum Genet
, vol.62
, pp. 1198-1211
-
-
Almasy, L.1
Blangero, J.2
-
23
-
-
0032727359
-
Oligogenic model selection using the Bayesian Information Criterion: Linkage analysis of the P300 Cz event-related brain potential
-
Blangero J, Williams JT, Iturria SJ, Almasy L. Oligogenic model selection using the Bayesian Information Criterion: linkage analysis of the P300 Cz event-related brain potential. Genet Epidemiol 1999;17:S67-72.
-
(1999)
Genet Epidemiol
, vol.17
-
-
Blangero, J.1
Williams, J.T.2
Iturria, S.J.3
Almasy, L.4
-
24
-
-
33644849257
-
Quantitative trait nucleotide analysis using bayesian model selection
-
Blangero J, Goring HH, Kent JW, et al. Quantitative trait nucleotide analysis using bayesian model selection. Hum Biol 2005;77:541-59.
-
(2005)
Hum Biol
, vol.77
, pp. 541-559
-
-
Blangero, J.1
Goring, H.H.2
Kent, J.W.3
-
25
-
-
0022649864
-
The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods
-
Boerwinkle E, Chakraborty R, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet 1986;50:181-94.
-
(1986)
Ann Hum Genet
, vol.50
, pp. 181-194
-
-
Boerwinkle, E.1
Chakraborty, R.2
Sing, C.F.3
-
27
-
-
27644490692
-
Genetic variation in selenoprotein S influences inflammatory response
-
Curran JE, Jowett JBM, Elliott KS, et al. Genetic variation in selenoprotein S influences inflammatory response. Nat Genet 2005;37:1234-41.
-
(2005)
Nat Genet
, vol.37
, pp. 1234-1241
-
-
Curran, J.E.1
Jowett, J.B.M.2
Elliott, K.S.3
-
28
-
-
33644872131
-
The F7 gene and clotting factor VII levels: Dissection of a human quantitative trait locus
-
Soria JM, Almasy L, Souto JC, Sabater-Lleal M, Pontcuberta J, Blangero J. The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus. Hum Biol 2005;77:561-75.
-
(2005)
Hum Biol
, vol.77
, pp. 561-575
-
-
Soria, J.M.1
Almasy, L.2
Souto, J.C.3
Sabater-Lleal, M.4
Pontcuberta, J.5
Blangero, J.6
-
29
-
-
1442308234
-
Exploring positional candidate genes: Linkage conditional on measured genotype
-
Almasy L, Blangero J. Exploring positional candidate genes: linkage conditional on measured genotype. Behav Genet 2004;34:173-7.
-
(2004)
Behav Genet
, vol.34
, pp. 173-177
-
-
Almasy, L.1
Blangero, J.2
-
30
-
-
0036152533
-
A statistical method for identification of polymorphisms that explain a linkage result
-
Sun L, Cox NJ, McPeek MS. A statistical method for identification of polymorphisms that explain a linkage result. Am J Hum Genet 2002;70:399-411.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 399-411
-
-
Sun, L.1
Cox, N.J.2
McPeek, M.S.3
-
31
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GSH, Lank EJ, Cheetham T, O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348:1085-95.
-
(2003)
N Engl J Med
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.H.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
32
-
-
26244440175
-
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects
-
Tao YX, Segaloff DL. Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects. J Clin Endocrinol Metab 2005;90:5632-8.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 5632-5638
-
-
Tao, Y.X.1
Segaloff, D.L.2
-
33
-
-
18644363563
-
Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: The Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
-
Jacobson P, Ukkola O, Rankinen T, et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab 2002;87:4442-6.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4442-4446
-
-
Jacobson, P.1
Ukkola, O.2
Rankinen, T.3
-
34
-
-
34547839796
-
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: The two facets of a Janus obesity gene
-
Stutzmann F, Vatin V, Cauchi S, et al. Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007;16:1837-44.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1837-1844
-
-
Stutzmann, F.1
Vatin, V.2
Cauchi, S.3
-
35
-
-
33847091706
-
A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity
-
Rettenbacher E, Tarnow P, Brumm H, et al. A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity. Exp Clin Endocrinol Diabetes 2007;115:7-12.
-
(2007)
Exp Clin Endocrinol Diabetes
, vol.115
, pp. 7-12
-
-
Rettenbacher, E.1
Tarnow, P.2
Brumm, H.3
-
36
-
-
33847186636
-
Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE
-
Alharbi KK, Spanakis E, Tan K, et al. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat 2007;28:294-302.
-
(2007)
Hum Mutat
, vol.28
, pp. 294-302
-
-
Alharbi, K.K.1
Spanakis, E.2
Tan, K.3
-
37
-
-
33746040561
-
Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
-
Rong R, Tao YX, Cheung BM, Xu A, Cheung GC, Lam KS. Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population. Clin Endocrinol (Oxf) 2006;65:198-205.
-
(2006)
Clin Endocrinol (Oxf)
, vol.65
, pp. 198-205
-
-
Rong, R.1
Tao, Y.X.2
Cheung, B.M.3
Xu, A.4
Cheung, G.C.5
Lam, K.S.6
-
38
-
-
32544455518
-
Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children
-
Beckers S, Mertens I, Peeters A, Van GL, Van HW. Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children. Int J Obes (Lond) 2006;30:221-5.
-
(2006)
Int J Obes (Lond)
, vol.30
, pp. 221-225
-
-
Beckers, S.1
Mertens, I.2
Peeters, A.3
Van GL, V.H.4
-
39
-
-
22244479316
-
Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population.]
-
in German
-
Zakel UA, Wudy SA, Heinzel-Gutenbrunner M, et al. [Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population.] Klin Padiatr 2005;217:244-9 (in German).
-
(2005)
Klin Padiatr
, vol.217
, pp. 244-249
-
-
Zakel, U.A.1
Wudy, S.A.2
Heinzel-Gutenbrunner, M.3
-
40
-
-
12144289073
-
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
-
Geller F, Reichwald K, Dempfle A, et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004;74:572-81.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
Reichwald, K.2
Dempfle, A.3
-
41
-
-
34547831224
-
The V103I polymorphism of the MC4R gene and obesity: Population based studies and meta-analysis of 29 563 individuals
-
Young EH, Wareham NJ, Farooqi S, et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int J Obes (Lond) 2007;31:1437-41.
-
(2007)
Int J Obes (Lond)
, vol.31
, pp. 1437-1441
-
-
Young, E.H.1
Wareham, N.J.2
Farooqi, S.3
-
42
-
-
39449108661
-
-
Heid IM, Vollmert C, Kronenberg F, et al. Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring) 2008;16:369-76.
-
Heid IM, Vollmert C, Kronenberg F, et al. Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring) 2008;16:369-76.
-
-
-
-
43
-
-
0344412890
-
The human MC4R promoter: Characterization and role in obesity
-
Lubrano-Berthelier C, Cavazos M, Le SC, et al. The human MC4R promoter: characterization and role in obesity. Diabetes 2003;52:2996-3000.
-
(2003)
Diabetes
, vol.52
, pp. 2996-3000
-
-
Lubrano-Berthelier, C.1
Cavazos, M.2
Le, S.C.3
-
44
-
-
37549003312
-
Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice
-
Trevaskis JL, Meyer EA, Galgani JE, Butler AA. Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology 2008;149:174-84.
-
(2008)
Endocrinology
, vol.149
, pp. 174-184
-
-
Trevaskis, J.L.1
Meyer, E.A.2
Galgani, J.E.3
Butler, A.A.4
-
45
-
-
36048955043
-
The central melanocortin system directly controls peripheral lipid metabolism
-
Nogueiras R, Wiedmer P, Perez-Tilve D, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 2007;117:3475-88.
-
(2007)
J Clin Invest
, vol.117
, pp. 3475-3488
-
-
Nogueiras, R.1
Wiedmer, P.2
Perez-Tilve, D.3
-
46
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GS, Keogh JM, et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 2000;106:271-9.
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.2
Keogh, J.M.3
-
48
-
-
27544450765
-
Divergence of melanocortin pathways in the control of food intake and energy expenditure
-
Balthasar N, Dalgaard LT, Lee CE, et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005;123:493-505.
-
(2005)
Cell
, vol.123
, pp. 493-505
-
-
Balthasar, N.1
Dalgaard, L.T.2
Lee, C.E.3
-
49
-
-
12944331892
-
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
-
Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, Palmiter RD. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci USA 2000;97:12339-44.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12339-12344
-
-
Ste Marie, L.1
Miura, G.I.2
Marsh, D.J.3
Yagaloff, K.4
Palmiter, R.D.5
-
50
-
-
6344260352
-
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
-
Rutanen J, Pihlajamaki J, Karhapaa P, et al. The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain. Obes Res 2004;12:1060-6.
-
(2004)
Obes Res
, vol.12
, pp. 1060-1066
-
-
Rutanen, J.1
Pihlajamaki, J.2
Karhapaa, P.3
-
51
-
-
0033694150
-
Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24
-
Ohman M, Oksanen L, Kaprio J, et al. Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24. J Clin Endocrinol Metab 2000;85:3183-90.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 3183-3190
-
-
Ohman, M.1
Oksanen, L.2
Kaprio, J.3
-
52
-
-
0031455342
-
Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study
-
Chagnon YC, Chen WJ, Perusse L, et al. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Mol Med 1997;3:663-73.
-
(1997)
Mol Med
, vol.3
, pp. 663-673
-
-
Chagnon, Y.C.1
Chen, W.J.2
Perusse, L.3
-
53
-
-
17344373951
-
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians
-
Norman RA, Tataranni PA, Pratley R, et al. Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 1998;62:659-68.
-
(1998)
Am J Hum Genet
, vol.62
, pp. 659-668
-
-
Norman, R.A.1
Tataranni, P.A.2
Pratley, R.3
|