Motor rehabilitation after stroke, traumatic brain, and spinal cord injury: Common denominators within recent clinical trials

Current Opinion in Neurology

Volumn 22, Issue 6, 2009, Pages 563-569

  Dobkin, Bruce H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Functional electrical stimulation; Gait training; Robotics; Spinal cord injury; Stroke rehabilitation

Indexed keywords

ARM EXERCISE; BRAIN DEPTH STIMULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; GAIT; HUMAN; LEARNING; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MUSCLE STRENGTH; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; REVIEW; ROBOTICS; SPINAL CORD INJURY; STROKE; TRAUMATIC BRAIN INJURY; TREADMILL EXERCISE;

BRAIN INJURIES; EXERCISE TEST; EXERCISE THERAPY; HUMANS; LOCOMOTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SPINAL CORD INJURIES; STROKE;

EID: 74049144029     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/WCO.0b013e3283314b11     Document Type: Review

References (74)

1. Saatman K, Duhaime A-C, Bullock R, et al. Classification of traumatic brain injury for targeted therapies. J Neurotrauma 2008; 25:719-738.
2. Hoffman A, Malena R, Westergom B, et al. Environmental enrichment-mediated functional improvements after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience. Neurosci Lett 2008; 431:226-230.
3. Blesch A, Tuszynski MH. Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci 2008; 32:41-47.
4. Verma P, Garcia-Alias G, Fawcett JW. Spinal cord repair: bridging the divide. Neurorehabil Neural Repair 2008; 22:429-437.
5. Carmichael ST. Themes and strategies for studying the biology of stroke recovery in the poststroke epoch. Stroke 2008; 39:1380-1388.
6. Cramer SC. Repairing the human brain after stroke. I: Mechanisms of spontaneous recovery. Ann Neurol 2008; 63:272-287.
7. Dobkin BH. Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation. Dev Neurobiol 2007; 67:1133-1147.
8. Snaphaan L, Rijpkema M, van Uden I, et al. Reduced medial temporal lobe functionality in stroke patients: a functional magnetic resonance imaging study. Brain 2009; 132:1882-1888.
9. Dobkin BH. Confounders in rehabilitation trials of task-oriented training: lessons from the designs of the EXCITE and SCILT multicenter trials. Neurorehabil Neural Repair 2007; 21:3-13.
10. Dobkin BH. Training and exercise to drive poststroke recovery. Nat Clin Pract Neurol 2008; 4:76-85.
11. Dobkin BH. Collaborative models for translational neuroscience research. Neurorehabil Neural Repair 2009; [Epub ahead of print]. doi: 10.1177/ 1545968309338290.
12. Morris ME, Perry A, Bilney B, et al. Outcomes of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease: a systematic review. Neurorehabil Neural Repair 2006; 20:424-434.
13. Snook E, Motl R. Effect of exercise training on walking mobility in multiple sclerosis: a meta-analysis. Neurorehabil Neural Repair 2009; 23:108-116.
14. Ridgel A, Vitek J, Alberts J. Forced, not voluntary exercise improves motor function in Parkinson's disease patients. Neurorehabil Neural Repair 2009; 23:600-608.
15. Byl NN, Pitsch EA, Abrams GM. Functional outcomes can vary by dose: learning-based sensorimotor training for patients stable poststroke. Neurorehabil Neural Repair 2008; 22:494-504.
16. Levin MF, Kleim JA, Wolf SL. What do motor 'recovery' and 'compensation' mean in patients following stroke? Neurorehabil Neural Repair 2009; 23:313-319.
17. Dobkin B, Apple D, Barbeau H, et al. Methods for a randomized trial of weight-supported treadmill training versus conventional training for walking during inpatient rehabilitation after incomplete traumatic spinal cord injury. Neuro-rehabil Neural Repair 2003; 17:153-167.
18. Winstein C, Miller J, Blanton S, et al. Methods for a multisite randomized trial to investigate the effect of constraint-induced movement therapy in improving upper extremity function among adults recovering from a cerebrovascular stroke. Neurorehabil Neural Repair 2003; 17:137-152.
19. Duncan PW, Sullivan KJ, Behrman AL, et al. Protocol for the Locomotor Experience Applied Poststroke (LEAPS) trial: a randomized controlled trial. BMC Neurol 2007; 7:39.
20. Harvey R, Winstein C. Design for the Everest randomized trial of cortical stimulation and rehabilitation for arm function following stroke. Neurorehabil Neural Repair 2009; 23:32-44.
21. Lo A, Guarino P, Krebs H, et al. Multicenter randomized trial of robot-assisted rehabilitation for chronic stroke: methods and entry characteristics for VA ROBOTICS. Neurorehabil Neural Repair 2009; 23. doi: 10.1177/ 1545968309338195.
22. Swayne OB, Rothwell JC, Ward NS, Greenwood RJ. Stages of motor output reorganization after hemispheric stroke suggested by longitudinal studies of cortical physiology. Cereb Cortex 2008; 18:1281-1291.
23. Enzinger C, Dawes H, Johansen-Berg H, et al. Brain activity changes associated with treadmill training after stroke. Stroke 2009; 40:435-441.
24. Luft AR, Macko RF, Forrester LW, et al. Treadmill exercise activates sub-cortical neural networks and improves walking after stroke. A randomized controlled trial. Stroke 2008; 39:3341-3350.
25. Sawaki L, Butler AJ, Xiaoyan L, et al. Constraint-induced movement therapy results in increased motor map area in subjects 3 to 9 months after stroke. Neurorehabil Neural Repair 2008; 22:505-513.
26. Askim T, Indredavik B, Vangberg T, Haberg A. Motor network changes associated with successful motor skill relearning after acute ischemic stroke: a longitudinal fMRI study. Neurorehabil Neural Repair 2009; 23: 295-304.
27. Scheibel RS, Newsome MR, Steinberg JL, et al. Altered brain activation during cognitive control in patients with moderate to severe traumatic brain injury. Neurorehabil Neural Repair 2007; 21:36-45.
28. Jurkiewicz MT, Mikulis DJ, McIlroy WE, et al. Sensorimotor cortical plasticity during recovery following spinal cord injury: a longitudinal fMRI study. Neu-rorehabil Neural Repair 2007; 21:527-538.
29. Criscimagna-Hemminger SE, Shadmehr R. Consolidation patterns of human motor memory. J Neurosci 2008; 28:9610-9618.
30. Fawcett J. Recovery from spinal cord injury: regeneration, plasticity and rehabilitation. Brain 2009; 132:1417-1418.
31. Alaverdashvili M, Foroud A, Lim D, Whishaw I. 'Learned baduse' limits recovery of skilled reaching for food after forelimb motor cortex stroke in rats: a new analysis of the effect of gestures on success. Behav Brain Res 2008; 188:281-290.
32. Dobkin BH. Fatigue versus activity-dependent fatigability in patients with central or peripheral motor impairments. Neurorehabil Neural Repair 2008; 22:105-110.
33. Pollock A, Baer G, Langhorne P, Pomeroy V. Physiotherapy treatment approaches for stroke (Cochrane Database). Stroke 2008; 39:519-520.
34. Tang A, Sibley KM, Thomas SG, et al. Effects of an aerobic exercise program on aerobic capacity, spatiotemporal gait parameters, and functional capacity in subacute stroke. Neurorehabil Neural Repair 2008; 23:398-406.
35. Kloosterman M, Snoek G, Jannink M. Systematic review of the effects of exercise therapy on the upper extremity of patients with spinal cord injury. Spinal Cord 2009; 47:196-203.
36. Pang M, Eng J, Dawson A, Gylfadottir S. The use of aerobic exercise training in improving aerobic capacity in individuals with stroke: a meta-analysis. Clin Rehabil 2006; 20:97-111.
37. Hassett LM, Moseley A, Tate R, et al. Efficacy of a fitness centre-based exercise programme compared with a home-based exercise programme in traumatic brain injury: a randomized controlled trial. J Rehabil Med 2009; 41:247-255.
38. Quaney BM, Boyd LA, McDowd J, et al. Exercise improves cognition and motor function poststroke. Neurorehabil Neural Repair 2009; [Epub ahead of print]. doi:10.1177/1545968309338193.
39. Angevaren M, Aufdemkampe G, Verhaar H, et al. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Review 2008:CD005381.
40. van Praag H. Exercise and the brain: something to chew on. Trends Neurosci 2009; 32:283-289.
41. Sullivan KJ, Brown DA, Klassen T, et al. Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial. Phys Ther 2007; 87:1580-1602.
42. Donaldson C, Tallis R, Miller S, et al. Effects of conventional physical therapy and functional strength training on upper limb motor recovery after stroke: a randomized Phase II study. Neurorehabil Neural Repair 2009; 23:389-397.
43. French B, Thomas L, Leathley M, et al. Repetitive task training for improving functional ability after stroke. Cochrane Database Syst Rev 2007:CD006073.
44. Wolf SL, Winstein CJ, Miller JP, et al. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA 2006; 296:2095-2104.
45. Boake C, Noser EA, RoT, et al. Constraint-induced movement therapy during early stroke rehabilitation. Neurorehabil Neural Repair 2007; 21:14-24.
46. Lin K-C, Wu C-Y, Liu J-S, et al. Constraint-induced therapy versus dose-matched control intervention to improve motor ability, basic/extended daily functions, and quality of life in stroke. Neurorehabil Neural Repair 2009; 23:160-165.
47. Dromerick A, Lang C, Birkenmeier R, et al. Very early constraint-induced movement during stroke rehabilitation (VECTORS). A single-center RCT. Neurology 2009; 73:195-201.
48. Kerkovich D. Transformational technologies in single-event neurological conditions: applying lessons learned in stroke to cerebral palsy. Neurorehabil Neural Repair 2009; [Epub ahead of print].
49. Kwakkel G, Kollen BJ, Krebs HI. Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review. Neurorehabil Neural Repair 2008; 22:111-121.
50. Mehrolz J, PlatzT, Kugler J, Pohl M. Electromechanical and robot-assisted arm training for improving arm function and activities of daily living after stroke. Cochrane Database Syst Rev 2008:CD006876d.
51. Housman S, Scott K, Reinkensmeyer D. A randomized controlled trial of gravity-supported, computer-enhanced arm exercise for individuals with severe hemiparesis. Neurorehabil Neural Repair 2009; 23:505-514.
52. Volpe BT, Lynch D, Rykman-Berland A, et al. Intensive sensorimotor arm training mediated by therapist or robot improves hemiparesis in patients with chronic stroke. Neurorehabil Neural Repair 2008; 22:305-310.
53. Hesse S, Werner C, Pohl M, et al. Mechanical arm trainer for the treatment of the severely affected arm after a stroke. Am J Phys Med Rehabil 2008; 87:779-788.
54. Alon G, Levitt A, McCarthey P. Functional electrical stimulation of upper extremity functional recovery during stroke rehabilitation. Neurorehabil Neural Repair 2007; 21:207-215.
55. Thrasher TA, Zivanovic V, McIlroy W, Popovic MR. Rehabilitation of reaching and grasping function in severe hemiplegic patients using functional electrical stimulation therapy. Neurorehabil Neural Repair 2008; 22:706-714.
56. Fujiwara T, Kasashima Y, Honaga K, et al. Motor improvement and corticospinal modulation induced by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy in patients with chronic stroke. Neurorehabil Neural Repair 2009; 23:125-132.
57. Hiscock A, Miller S, Rothwell J, et al. Informing dose-finding studies of repetitive transcranial magnetic stimulation to enhance motor function: a qualitative systematic review. Neurorehabil Neural Repair 2008; 22:228-249.
58. Pomeroy VM, Cloud G, Tallis RC, et al. Transcranial magnetic stimulation and muscle contraction to enhance stroke recovery: a randomized proof-of-principle and feasibility investigation. Neurorehabil Neural Repair 2007; 21:509-517.
59. Plow E, Carey J, Nudo R, Pascual-Leone A. Invasive cortical stimulation to promote recovery of function after stroke. Stroke 2009; 40:1926-1931.
60. Cheeran B, Cohen L, Dobkin B, et al. The restorative neurosciences in stroke: driving the translational research pipeline from basic science to the rehabilitation of people after stroke. Cumberland Consensus Group. Neurorehabil Neural Repair 2009; 23:97-107.
61. Simmons L, Sharma N, Baron JC, Pomeroy VM. Motor imagery to enhance recovery after subcortical stroke: who might benefit, daily dose, and potential effects. Neurorehabil Neural Repair 2008; 22:458-467.
62. Gueugneau N, Mauvieux B, Papaxanthis C. Circadian modulation of mentally simulated motor actions: implications for the potential use of motor imagery in rehabilitation. Neurorehabil Neural Repair 2009; 23:237-245.
63. Franceschini M, Carda S, Agosti M, et al. Walking after stroke: what does treadmill training with body weight support add to overground gait training in patients early after stroke-a single-blind, randomized, controlled trial. Stroke 2009. [Epub ahead of print]. doi: 10.1161/STROKEAHA.109.555540.
64. Dobkin BH, Apple D, Barbeau H, et al. Weight-supported treadmill vs overground training for walking after acute incomplete SCI. Neurology 2006; 66:484-493.
65. Mehrholz J, Kugler J, Pohl M. Locomotor training for walking after spinal cord injury. Cochrane Database Syst Rev 2008:CD006676.
66. Mehrholz J, Werner C, Kugler J, Pohl M. Electromechanical-assisted training for walking after stroke. Cochrane Database Syst Rev 2007:CD006185.
67. Hidler J, Nichols D, Pelliccino M, et al. Multicenter randomized clinical trial evaluating the effectiveness of the Lokomat in sub-acute stroke. Neurorehabil Neural Repair 2009; 23:5-13.
68. Hornby TG, Campbell DD, Kahn JH, et al. Enhanced gait-related improvements after therapist-versus robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Stroke 2008; 39:1786-1792.
69. Westlake K, Patten C. Pilot study of Lokomat versus manual-assisted treadmill training for locomotor recovery poststroke. J Neuroeng Rehabil 2009; 6:18.
70. Winchester P, McColl R, Querry R, et al. Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury. Neurorehabil Neural Repair 2005; 19:313-324.
71. Beer S, Aschbacher B, Manoglou D, et al. Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Multiple Sclerosis 2008; 14:231-236.
72. Lo A, Triche E. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair 2008; 22:661-671.
73. Goodman A, Brown T, Krupp L, et al. Sustained-release oral fampridine in multiple sclerosis. Lancet 2009; 373:732-738.
74. Ward N. Getting lost in translation. Curr Opin Neurol 2008; 21:625-627.