Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138

World Journal of Gastroenterology

Volumn 15, Issue 44, 2009, Pages 5533-5540

  Tsujimoto, Tatsuhiro ^a   Kawaratani, Hideto ^a   Kitazawa, Toshiyuki ^a   Yoshiji, Hitoshi ^a   Fujimoto, Masao ^a   Uemura, Masahito ^a   Fukui, Hiroshi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Innate immunity; Interferon ; Interleukin 10; Kupffer cell; Nonalcoholic steatohepatitis; Tumor necrosis factor ; Y 40138

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINO ACID; CHOLINE; IMMUNOMODULATING AGENT; INTERLEUKIN 10; N [1 [4 [4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]METHYLPHENYL]CYCLOPROPYL]ACETAMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Y 40138;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; KUPFFER CELL; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; RAT;

EID: 74049134998     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.5533     Document Type: Article

References (28)

1. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845
2. Tsujimoto T, Kuriyama S, Yamazaki M, Nakatani Y, Okuda H, Yoshiji H, Fukui H. Augmented hepatocellular carcinoma progression and depressed Kupffer cell activity in rat cirrhotic livers. Int J Oncol 2001; 18: 41-47
3. Kawaratani H, Tsujimoto T, Kitazawa T, Kitade M, Yoshiji H, Uemura M, Fukui H. Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. World J Gastroenterol 2008; 14: 6655-6661
4. Tsujimoto T, Kawaratani H, Kitazawa T, Hirai T, Ohishi H, Kitade M, Yoshiji H, Uemura M, Fukui H. Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. World J Gastroenterol 2008; 14: 6036-6043
5. Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A, Kitamura N, Toda K, Kaneko T, Horie Y, Han JY, Kato S, Shimoda M, Oike Y, Tomizawa M, Makino S, Ohkura T, Saito H, Kumagai N, Nagata H, Ishii H, Hibi T. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 2006; 55: 415-424
6. Sakaida I, Kubota M, Kayano K, Takenaka K, Mori K, Okita K. Prevention of fibrosis reduces enzyme-altered lesions in the rat liver. Carcinogenesis 1994; 15: 2201-2206
7. Koteish A, Diehl AM. Animal models of steatosis. Semin Liver Dis 2001; 21: 89-104
8. Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC. The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-kappa B targeting in the alveolar epithelium. Br J Pharmacol 2001; 133: 49-60
9. Hisadome M, Fukuda T, Adachi K, Komatsu H. Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats. Eur J Pharmacol 2004; 497: 351-359
10. Nakae D, Mizumoto Y, Yoshiji H, Andoh N, Horiguchi K, Shiraiwa K, Kobayashi E, Endoh T, Shimoji N, Tamura K. Different roles of 8-hydroxyguanine formation and 2-thiobarbituric acid-reacting substance generation in the early phase of liver carcinogenesis induced by a choline-deficient, L-amino acid-defined diet in rats. Jpn J Cancer Res 1994; 85: 499-505
11. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-1419
12. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-2474
13. Seglen PO. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 1973; 82: 391-398
14. Olynyk JK, Clarke SL. Isolation and primary culture of rat Kupffer cells. J Gastroenterol Hepatol 1998; 13: 842-845
15. Kubo S, Rodriguez T Jr, Roh MS, Oyedeji C, Romsdahl MM, Nishioka K. Stimulation of phagocytic activity of murine Kupffer cells by tuftsin. Hepatology 1994; 19: 1044-1049
16. Hansen J, Cherwitz DL, Allen JI. The role of tumor necrosis factor-alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. Hepatology 1994; 20: 461-474
17. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 2006; 130: 1886-1900
18. Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol 2001; 166: 2651-2657
19. Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology 2009; 136: 1182-1197
20. Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, De Paolis P, Capussotti L, Salizzoni M, Rizzetto M. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-140
21. Kitazawa T, Tsujimoto T, Kawaratani H, Fujimoto M, Fukui H. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. J Gastroenterol Hepatol 2008; 23: e494-e498
22. Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T. Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol 2003; 15: 704-708
23. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN, Feldmann M. Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum 1996; 39: 495-503
24. van Deventer SJ, Elson CO, Fedorak RN. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group. Gastroenterology 1997; 113: 383-389
25. Fukuda T, Hisadome M, Komatsu H. Treatment with Y-40138, a multiple cytokine production modulator, inhibits lipopolysaccharide- or tumour necrosis factor-alpha-induced production of pro-inflammatory cytokines and augments interleukin-10. J Pharm Pharmacol 2005; 57: 1461-1466
26. Fukuda T, Mogami A, Tanaka H, Yoshikawa T, Hisadome M, Komatsu H. Y-40138, a multiple cytokine production modulator, protects against D-galactosamine and lipopolysaccharide-induced hepatitis. Life Sci 2006; 79: 822-827
27. Fukuda T, Sumichika H, Murata M, Hanano T, Adachi K, Hisadome M. A novel dual regulator of tumor necrosis factor-alpha and interleukin-10 protects mice from endotoxin-induced shock. Eur J Pharmacol 2000; 391: 317-320
28. Fukuda T, Mogami A, Hisadome M, Komatsu H. Therapeutic administration of Y-40138, a multiple cytokine modulator, inhibits concanavalin A-induced hepatitis in mice. Eur J Pharmacol 2005; 523: 137-142