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Volumn 22, Issue 6, 2009, Pages 639-644

Primetime for antiangiogenic therapy

Author keywords

Angiogenesis; Antiangiogenic therapy; Malignant glioma

Indexed keywords

ALPHAVBETA5 INTEGRIN; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CEDIRANIB; CILENGITIDE; COLLAGEN TYPE 4; ENZASTAURIN; GELATINASE A; GELATINASE B; IRINOTECAN; PLATELET DERIVED GROWTH FACTOR C; SORAFENIB; STEM CELL FACTOR; SUNITINIB; TEMOZOLOMIDE; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB; VITRONECTIN RECEPTOR; XL 184;

EID: 74049110376     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/WCO.0b013e328332ba28     Document Type: Review
Times cited : (9)

References (56)
  • 1
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with antiangiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with antiangiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7:987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 2
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxyge nation, angiopoietin-1 and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong RT, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxyge nation, angiopoietin-1 and matrix metalloproteinases. Cancer Cell 2004; 6:553-563.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 3
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide in glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide in glioblastoma. N Engl J Med 2005; 10:997-1003.
    • (2005) N Engl J Med , vol.10 , pp. 997-1003
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 4
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblas-tomas in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblas-tomas in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10:459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 5
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • Louis DN. Molecular pathology of malignant gliomas. Annu Rev Pathol 2006; 1:97-117.
    • (2006) Annu Rev Pathol , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 6
    • 0030576517 scopus 로고    scopus 로고
    • Parameters and emerging mechanisms of the angio-genic switch during tumorigenesis
    • Hanahan D, Folkman J. Parameters and emerging mechanisms of the angio-genic switch during tumorigenesis. Cell 1996; 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg R. The hallmarks of cancer. Cell 2000; 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.2
  • 8
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002; 2:727-739.
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 9
    • 34547122001 scopus 로고    scopus 로고
    • WHO classification of tumours of the central nervous system
    • Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114:97-109.
    • (2007) Acta Neuropathol , vol.2007 , Issue.114 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3    The, E.4
  • 10
    • 74049131375 scopus 로고    scopus 로고
    • Anti-VEGF therapies for malignant glioma: Treatment effects and escape mechanisms
    • Miletic H, Niclou SP, Johansson M, Bjerkvig R. Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Expert Opin Ther Targets 2009; 9:231-240.
    • (2009) Expert Opin Ther Targets , vol.9 , pp. 231-240
    • Miletic, H.1    Niclou, S.P.2    Johansson, M.3    Bjerkvig, R.4
  • 11
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 12
    • 0026051419 scopus 로고
    • Acidic and basic fibroblast growth factors are present in glioblastoma multiforme
    • Stefanik DF, Rizkalla LR, Soi A, et al. Acidic and basic fibroblast growth factors are present in glioblastoma multiforme. Cancer Res 1991; 51:5760-5765.
    • (1991) Cancer Res , vol.51 , pp. 5760-5765
    • Stefanik, D.F.1    Rizkalla, L.R.2    Soi, A.3
  • 13
    • 0030975492 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor gene transfer enhances glioma growth and angiogenesis in vivo
    • Laterra J, Nam M, Rosen E, et al. Scatter factor/hepatocyte growth factor gene transfer enhances glioma growth and angiogenesis in vivo. Lab Invest 1997; 76:565-577.
    • (1997) Lab Invest , vol.76 , pp. 565-577
    • Laterra, J.1    Nam, M.2    Rosen, E.3
  • 14
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • Abounader R, Laterra J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol 2005; 7:436-451.
    • (2005) Neuro Oncol , vol.7 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 15
    • 33645772227 scopus 로고    scopus 로고
    • Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
    • Sun L, Hui AM, Su Q, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006; 9:287-300.
    • (2006) Cancer Cell , vol.9 , pp. 287-300
    • Sun, L.1    Hui, A.M.2    Su, Q.3
  • 16
    • 0034867240 scopus 로고    scopus 로고
    • Molecular determinants of glioma cell migration and invasion
    • Wild-Bode C, Weller M, Wick W. Molecular determinants of glioma cell migration and invasion. J Neurosurg 2001; 94:978-984.
    • (2001) J Neurosurg , vol.94 , pp. 978-984
    • Wild-Bode, C.1    Weller, M.2    Wick, W.3
  • 17
    • 73249136703 scopus 로고    scopus 로고
    • Cilengitide modulates attachment and viability of human glioma cells but not sensitivity to irradiation or temozolo-mide in vitro
    • Feb [Epub ahead of print]
    • Maurer GD, Tritschler I, Adams B, et al. Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolo-mide in vitro. Neuro Oncol 2009; Feb [Epub ahead of print].
    • (2009) Neuro Oncol
    • Maurer, G.D.1    Tritschler, I.2    Adams, B.3
  • 18
    • 45549099295 scopus 로고    scopus 로고
    • Brain tumor stem cells: Bringing order to the chaos of brain cancer
    • Dirks PB. Brain tumor stem cells: bringing order to the chaos of brain cancer. J Clin Oncol 2008; 26:2916-2924.
    • (2008) J Clin Oncol , vol.26 , pp. 2916-2924
    • Dirks, P.B.1
  • 19
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor cells
    • Calabrese C, Poppleton H, Kocak M, et al. A perivascular niche for brain tumor cells. Cancer Cell 2007; 11:69-82.
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 20
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan D, Becher OJ, Rosenblum MK, etal. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 2008; 22:436-448.
    • (2008) Genes Dev , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3
  • 22
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006; 66:7843-7848.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 23
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007; 7:733-736.
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 24
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the stem-like cell faction in glioma xenograft tumors
    • Folkins C, Man S, Xu P, et al. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the stem-like cell faction in glioma xenograft tumors. Cancer Res 2007; 67:3560-3564.
    • (2007) Cancer Res , vol.67 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3
  • 25
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucoverin for metastatic colorectal cancer
    • Hurtwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucoverin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurtwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 26
    • 32944482137 scopus 로고    scopus 로고
    • Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma [abstract #342]
    • 5-8 May Edinburgh, Scotland
    • Stark-Vance V. Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma [abstract #342]. In: World Federation of Neuro-Oncology Second Quadrennial Meeting; 5-8 May 2005; Edinburgh, Scotland.
    • (2005) World Federation of Neuro-Oncology Second Quadrennial Meeting
    • Stark-Vance, V.1
  • 28
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009; 27:740-745.
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 29
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    Di Tomaso, E.3
  • 30
    • 74049110639 scopus 로고    scopus 로고
    • Enzastaurin versus lomustine in the treatment of recurrent intracranial glioblastomas: A phase III study
    • in press
    • Wick W, Puduvalli VK, Chamberlain M, et al. Enzastaurin versus lomustine in the treatment of recurrent intracranial glioblastomas: a phase III study. J Clin Oncol (in press).
    • J Clin Oncol
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.3
  • 31
    • 57149108506 scopus 로고    scopus 로고
    • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastomas multiforme
    • Reardon D, Fink KL, Mikkelsen T, et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastomas multiforme. J Clin Oncol 2008; 26:5610-5617.
    • (2008) J Clin Oncol , vol.26 , pp. 5610-5617
    • Reardon, D.1    Fink, K.L.2    Mikkelsen, T.3
  • 33
    • 68649114787 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    • Gutin PH, Iwamoto FM, Beal K, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 2009; 75:156-163.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 156-163
    • Gutin, P.H.1    Iwamoto, F.M.2    Beal, K.3
  • 34
    • 33947531672 scopus 로고    scopus 로고
    • VEGF trap in combination with radiotherapy improves tumor control in U87 glioblastoma
    • Wachsberger PR, Burd R, Cardi C, et al. VEGF trap in combination with radiotherapy improves tumor control in U87 glioblastoma. Int J Radiat Oncol Biol Phys 2007; 67:1526-1537.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1526-1537
    • Wachsberger, P.R.1    Burd, R.2    Cardi, C.3
  • 35
    • 60549106878 scopus 로고    scopus 로고
    • VEGF trap induces antiglioma effect at different stages of disease
    • Gomez-Manzano C, Holash J, Fueyo J, et al. VEGF trap induces antiglioma effect at different stages of disease. Neuro Oncol 2008; 10:940-945.
    • (2008) Neuro Oncol , vol.10 , pp. 940-945
    • Gomez-Manzano, C.1    Holash, J.2    Fueyo, J.3
  • 36
    • 66349121063 scopus 로고    scopus 로고
    • Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
    • Kamoun WS, Ley CD, Farrar CT, et al. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol 2009; 27:2542-2552.
    • (2009) J Clin Oncol , vol.27 , pp. 2542-2552
    • Kamoun, W.S.1    Ley, C.D.2    Farrar, C.T.3
  • 37
    • 0036137647 scopus 로고    scopus 로고
    • Antiangiogenic effects of a protein kinase C beta-selective small molecule
    • Teicher B, Alvarez E, Menon K, et al. Antiangiogenic effects of a protein kinase C beta-selective small molecule. Cancer Chemother Pharmacol 2002; 49:69-77.
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 69-77
    • Teicher, B.1    Alvarez, E.2    Menon, K.3
  • 38
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase C beta-selective inhibitor, enzastaurin (LY317615.HCl) suppresses signaling through the AKT pathway, induces apoptosis, suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff JR, McNulty AM, Hanna KR, et al. The protein kinase C beta-selective inhibitor, enzastaurin (LY317615.HCl) suppresses signaling through the AKT pathway, induces apoptosis, suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005; 65:7462-7469.
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 39
    • 33847677276 scopus 로고    scopus 로고
    • Synergistic antiglioma activity of radiotherapy and enzastaurin
    • Tabatabai G, Frank B, Wick A, et al. Synergistic antiglioma activity of radiotherapy and enzastaurin. Ann Neurol 2007; 61:153-161.
    • (2007) Ann Neurol , vol.61 , pp. 153-161
    • Tabatabai, G.1    Frank, B.2    Wick, A.3
  • 40
    • 50849095153 scopus 로고    scopus 로고
    • Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL
    • Rieger J, Lemke D, Maurer G, et al. Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL. J Neurochem 2008; 106:2436-2448.
    • (2008) J Neurochem , vol.106 , pp. 2436-2448
    • Rieger, J.1    Lemke, D.2    Maurer, G.3
  • 41
    • 0037051697 scopus 로고    scopus 로고
    • Alpha v-integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
    • Taga T, Suzuki A, Gonzales-Gomez I, et al. Alpha v-integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer 2002; 98:690-697.
    • (2002) Int J Cancer , vol.98 , pp. 690-697
    • Taga, T.1    Suzuki, A.2    Gonzales-Gomez, I.3
  • 42
    • 64249086909 scopus 로고    scopus 로고
    • Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency
    • Mikkelsen T, Brodie C, Finiss S, et al. Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency. Int J Cancer 2009; 124:2719-2727.
    • (2009) Int J Cancer , vol.124 , pp. 2719-2727
    • Mikkelsen, T.1    Brodie, C.2    Finiss, S.3
  • 43
    • 0347155579 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of continuous twice weekly intravenous administration of cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    • Eskens FA, Dumez H, Hoekstra R, et al. Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours. Eur J Cancer 2003; 39:917-926.
    • (2003) Eur J Cancer , vol.39 , pp. 917-926
    • Eskens, F.A.1    Dumez, H.2    Hoekstra, R.3
  • 44
    • 39749191543 scopus 로고    scopus 로고
    • Phase i clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012
    • MacDonald TJ, Stewart CF, Kocak M, et al. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol 2008; 26:919-924.
    • (2008) J Clin Oncol , vol.26 , pp. 919-924
    • MacDonald, T.J.1    Stewart, C.F.2    Kocak, M.3
  • 45
    • 56749119313 scopus 로고    scopus 로고
    • Phase I/IIa trial of cilengitide (EMD 121974) and temozolomide with concomitant radiotherapy, followed by temolzolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma [abstract]
    • Stupp R, Goldbrunner R, Neyns B, et al. Phase I/IIa trial of cilengitide (EMD 121974) and temozolomide with concomitant radiotherapy, followed by temolzolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma [abstract]. J Clin Oncol 2007; 25:2000.
    • (2000) J Clin Oncol , vol.2007 , pp. 25
    • Stupp, R.1    Goldbrunner, R.2    Neyns, B.3
  • 46
    • 64149106522 scopus 로고    scopus 로고
    • Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
    • Reynolds AR, Hart IR, Watson AR, et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 2009; 15:392-400.
    • (2009) Nat Med , vol.15 , pp. 392-400
    • Reynolds, A.R.1    Hart, I.R.2    Watson, A.R.3
  • 47
    • 67650491813 scopus 로고    scopus 로고
    • Will integrin inhibitors have proangiogenic effects in the clinic?
    • Weller M, Reardon D, Nabors B, Stupp R. Will integrin inhibitors have proangiogenic effects in the clinic? Nat Med 2009; 15:726.
    • (2009) Nat Med , vol.15 , pp. 726
    • Weller, M.1    Reardon, D.2    Nabors, B.3    Stupp, R.4
  • 48
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel RS. A cancer therapy resistant to resistance. Nature 1997; 390:335-336.
    • (1997) Nature , vol.390 , pp. 335-336
    • Kerbel, R.S.1
  • 50
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel P, Ulbricht U, Bohle P, et al. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res 2001; 61:6624-6628.
    • (2001) Cancer Res , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohle, P.3
  • 51
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hucock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-231.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hucock, J.3
  • 52
    • 68549085490 scopus 로고    scopus 로고
    • Branching morphogenesis and antiangiogenesis candidates: Tip cells lead the way
    • Carmeliet P, De Smet F, Loges S, Mazzone M. Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol 2009; 6:315-326.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 315-326
    • Carmeliet, P.1    De Smet, F.2    Loges, S.3    Mazzone, M.4
  • 53
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • DiTomaso E, London N, Fuja D, et al. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One 2009; 4:e5123.
    • (2009) PLoS One , vol.4
    • Ditomaso, E.1    London, N.2    Fuja, D.3
  • 54
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer C, Jonckx B, Mazzone M, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 2007; 131:463-475.
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3
  • 55
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: Drug targets for antiangiogenic therapy?
    • Fischer C, Mazzone M, Jockx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for antiangiogenic therapy? Nat Rev Cancer 2008; 8:942-956.
    • (2008) Nat Rev Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jockx, B.3    Carmeliet, P.4
  • 56
    • 56749142790 scopus 로고    scopus 로고
    • Advances inneuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas
    • Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Advances inneuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas. Curr Opin Neurol 2008; 21:728-735.
    • (2008) Curr Opin Neurol , vol.21 , pp. 728-735
    • Gerstner, E.R.1    Sorensen, A.G.2    Jain, R.K.3    Batchelor, T.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.