Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1α upregulation in endothelial cells

Journal of Cardiovascular Pharmacology

Volumn 51, Issue 3, 2008, Pages 267-273

  Nishimoto Hazuku, Ai ^a   Hirase, Tetsuaki ^a   Ide, Noriko ^a   Ikeda, Yuji ^a   Node, Koichi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Hypoxia inducible factor 1 ; Rho; Rho kinase; Simvastatin; Vascular endothelial growth factor

Indexed keywords

FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MEVALONIC ACID; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; VASCULOTROPIN;

ADENOVIRUS; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CYTOSOL; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION;

CELL LINE; CELL NUCLEUS; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROTEIN TRANSPORT; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SIMVASTATIN; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 41349103941     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181624b44     Document Type: Article

References (26)

1. Vaughan CJ, Gotto AM Jr. Update on statins: 2003. Circulation. 2004; 110:886-892.
2. Bonetti PO, Lerman LO, Napoli C, et al. Statin effects beyond lipid lowering-are they clinically relevant? Eur Heart J. 2003;24:225-248.
3. Pourati I, Kimmelstiel C, Rand W, et al. Statin use is associated with enhanced collateralization of severely diseased coronary arteries. Am Heart J. 2003;146:876-881.
4. Sata M, Nishimatsu H, Osuga J, et al. Endothelial nitric oxide synthase is essential for HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia. FASEB J. 2001;15:2530-2532.
5. Roy H, Bhardwaj S, Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett. 2006;580:2879-2887.
6. Kureishi Y, Luo Z, Shojima I, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promote angiogenesis in normocholesterolemic animals. Nat Med. 2000;6:1004-1010.
7. Frick M, Dulak J, Cisowski J, et al. Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells. Atherosclerosis. 2003;170:229-236.
8. Siddiqui AJ, Gustafsson T, Fischer H, et al. Simvastatin enhances myocardial angiogenesis induced by vascular endothelial growth factor gene transfer. J Mol Cell Cardiol. 2004;37:1235-1244.
9. Wolfrum S, Jensen KS, Liao JK. Endothelium-dependent effects of statins. Arterioscler Thromb Vasc Biol. 2003;23:729-736.
10. Ferrara N. Vascular endothelial growth factor: Basic science and clinical progress. Endocrine Rev. 2004;25:581-611.
11. Zagorska A, Dulak J. HIF-1: the knows and unknowns of hypoxia sensing. Acta Biochim Pol. 2004;51:563-585.
12. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor 8-regulated antigen established by hybridization. Proc Natl Acad Sci U S A. 1983;80:3734-3737.
13. Hirase T, Kawashima S, Wong E, et al. Regulation of tight junction permeability and occuludin phosphorylation by RhoA-p160ROCK-dependent and -independent mechanisms. J Biol Chem. 2001;276:10423-10431.
14. Amano M, Chihara K, Nakamura N, et al. The COOH terminus of Rhokinase negatively regulates Rho-kinase activity. J Biol Chem. 1999;274:32418-32424.
15. Katsumoto M, Shingu T, Kuwashima R, et al. Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis. Circ J. 2005;69:1547-1555.
16. Vincent L, Chen W, Hong L, et al. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett. 2001;495:159-166.
17. Turcotte S, Desrosiers RR, Beliveau R. HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma. J Cell Sci. 2003;116:2247-2260.
18. Hayashi M, Sakata M, Takeda T, et al. Hypoxia up-regulates hypoxia-inducible factor-1α expression through RhoA activation in trophoblast cells. J Clin Endocrinol Metab. 2005;90:1712-1719.
19. Brahimi-Horn C, Mazure N, Pouyssegur J. Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications. Cell Signal. 2005;17:1-9.
20. Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arteioscler Thromb Vasc Biol. 2003;23:58-63.
21. Chen SD, Hu CJ, Yang DI, et al. Pravastatin attenuates ceramide-induced cytotoxicity in mouse cerebral endothelial cells with HIF-1 activation and VEGF upregulation. Ann N Y Acad Sci. 2005;1042:357-364.
22. Imaizumi T, Itaya H, Nasu S, et al. Expression of vascular endothelial growth factor in human umbilical vein endothelial cells stimulated with interleukin-1alpha - an autocrine regulation of angiogenesis and inflammatory reactions. Thromb Haemost. 2000;83:949-955.
23. Belgore F, Lip GYH, Blann AD. Basic fibroblast growth factor induced the secretion of vascular endothelial growth factor by human aortic smooth muscle but not by endothelial cells. Eur J Clin Invest. 2003;33: 833-839.
24. Gerber HP, McMurtrey A, Kowalski J, et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. J Biol Chem. 1998;273: 30336-30343.
25. Gerber HP, Dixit V, Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 1998;273:13313-13316.
26. Ozawa CR, Banfi A, Glazer NL, et al. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004;113:516-527.