DJ-1 is a Parkinson's disease susceptibility gene in southern Italy

Clinical Genetics

Volumn 77, Issue 2, 2010, Pages 183-188

  De Marco, E V ^a   Annesi, G ^a   Tarantino, P ^a   Nicoletti, G ^b   Civitelli, D ^a   Messina, D ^b   Annesi, F ^a   Arabia, G ^b   Salsone, M ^b   Condino, F ^a   Novellino, F ^b   Provenzano, G ^a   Rocca, F E ^a   Colica, C ^b   Morelli, M ^b   Scornaienchi, V ^a   Greco, V ^a   Giofre L ^b   Quattrone, A ^b  

^a INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Association studies; Haplotype; Parkinson's disease; Polymorphisms; SNPs

Indexed keywords

DJ 1 PROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE IDENTIFICATION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; ITALY; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ITALY; MALE; MIDDLE AGED; ONCOGENE PROTEINS; PARKINSON DISEASE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 73949143397     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2009.01310.x     Document Type: Article

References (24)

1. Biskup S, Gerlach M, Kupsch A. Genes associated with Parkinson syndrome. J Neurol 2008, 255(Suppl. 5):8-17.
2. Nagakubo D, Taira T, Kitaura H. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 1997, 231:509-513.
3. Takahashi K, Taira T, Niki T. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J Biol Chem 2001, 276:37556-37563.
4. Bonifati V, Rizzu P, van Baren MJ. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003, 299:256-259.
5. Abou-Sleiman PM, Healy DG, Quinn N. The role of pathogenic DJ-1 mutations in Parkinson's disease. Ann Neurol 2003, 54:283-286.
6. Hague S, Rogaeva E, Hernandez D. Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation. Ann Neurol 2003, 54:271-274.
7. Hering R, Strauss KM, Tao X. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum Mutat 2004, 24:321-329.
8. Annesi G, Savettieri G, Pugliese P. DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex. Ann Neurol 2005, 58:803-807.
9. Tarantino P, Civitelli D, Annesi F. Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism. Parkinsonism Relat Disord 2009, 15:324-326.
10. Choi J, Sullards MC, Olzmann JA. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 2006, 281:10816-10824.
11. Waragai M, Wei J, Fujita M. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem Biophys Res Commun 2006, 345:967-972.
12. Bonifati V, Oostra BA, Heutink P. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. J Mol Med 2004, 82:163-174.
13. West AB, Maraganore D, Crook J. Functional association of the parkin gene promoter with idiopathic Parkinson's disease. Hum Mol Genet 2002, 11:2787-2792.
14. Maraganore DM, de Andrade M, Elbaz A. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA 2006, 296:661-670.
15. Eerola J, Hernandez D, Launes J. Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD. Neurology 2003, 61:1000-1002.
16. Morris CM, O'brien KK, Gibson AM. Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. Neurosci Lett 2003, 352:151-153.
17. Maraganore DM, Wilkes K, Lesnick TG. A limited role for DJ1 in Parkinson disease susceptibility. Neurology 2004, 63:550-553.
18. Sutherland GT, Halliday GM, Silburn PA. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? Mov Disord 2009, 24:833-838.
19. Grigoletto F, Zappalà G, Anderson DW, Lebowitz BD. Norms for the mini-mental state examination in a healthy population. Neurology 1999, 53:315-320.
20. Jeong H, Kim MS, Kwon J, Kim KS, Seol W. Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor. Neurosci Lett 2006, 396:57-61.
21. Taira T, Takahashi K, Kitagawa R, Iguchi-Ariga SM, Ariga H. Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 2001, 263:285-292.
22. Olzmann JA, Bordelon JR, Muly EC. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol 2007, 500:585-599.
23. Xu J, Zhong N, Wang H. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet 2005, 14:1231-1241.
24. Hattersley AT, Mccarthy MI. What makes a good genetic association study? Lancet 2005, 366:1315-1323.