Cell density-dependent regulation of p73 in breast cancer cells

International Journal of Oncology

Volumn 35, Issue 6, 2009, Pages 1429-1434

  Tophkhane, Chaitali ^a   Yang, Shihe ^a   Zhao, Zhizhuang Joe ^a   Yang, Xiaohe ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; Cell density; E2F 1; ITCH AIP4; p53; p73

Indexed keywords

PROTEIN AIP4; PROTEIN P73; PROTEIN P73ALPHA; PROTEIN P73BETA; PROTEIN TAP73; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ISOPROTEIN; NUCLEAR PROTEIN; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DENSITY; CELL STRAIN MCF 7; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; TRANSCRIPTION REGULATION; BREAST TUMOR; CELL COMMUNICATION; CELL COUNT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL COMMUNICATION; CELL COUNT; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NUCLEAR PROTEINS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 73949130111     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000461     Document Type: Article

References (25)

1. Arrowsmith CH: Structure and function in the p53 family. Cell Death Differ 6: 1169-1173, 1999.
2. Melino G, De Laurenzi V and Vousden KH: p73: Friend or foe in tumorigenesis. Nat Rev Cancer 2: 605-615, 2002.
3. Ueda Y, Hijikata M, Takagi S, Chiba T and Shimotohno K: New p73 variants with altered C-terminal structures have varied transcriptional activities. Oncogene 18: 4993-4998, 1999.
4. Stiewe T and Putzer BM: Role of p73 in malignancy: tumor suppressor or oncogene? Cell Death Differ 9: 237-245, 2002.
5. Gong L, Li Y, Nedeljkovic-Kurepa A and Sarkar FH: Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 22: 4702-4709, 2003.
6. Yuan ZM, Shioya H, Ishiko T, et al: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399: 814-817, 1999.
7. Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG Jr and Liu W: The human p73 promoter: characterization and identification of functional E2F binding sites. Neoplasia 4: 195-203, 2002.
8. Garrett SD, Lee HA, Friar PM and Morgan MR: Validation of a novel estrogen receptor-based microtitration plate assay for the determination of phytoestrogens in soy-based foods. J Agric Food Chem 47: 4106-4111, 1999.
9. Kartasheva NN, Contente A, Lenz-Stoppler C, Roth J and Dobbelstein M: p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop. Oncogene 21: 4715-4727, 2002.
10. Vossio S, Palescandolo E, Pediconi N, Moretti F, Balsano C, Levrero M and Costanzo A: DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene 21: 3796-3803, 2002.
11. Stiewe T and Putzer BM: Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet 26: 464-469, 2000.
12. Watanabe K, Ozaki T, Nakagawa T, et al: Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function. J Biol Chem 277: 15113-15123, 2002.
13. Das S, El-Deiry WS and Somasundaram K: Regulation of the p53 homolog p73 by adenoviral oncogene E1A. J Biol Chem 278: 18313-18320, 2003.
14. Zeng X, Li X, Miller A, et al: The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol 20: 1299-1310, 2000.
15. Agami R, Blandino G, Oren M and Shaul Y: Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399: 809-813, 1999.
16. Distefano M, Scambia G, Ferlini C, et al: Anti-proliferative activity of a new class of taxanes (14beta-hydroxy-10-deacetylbaccatin III derivatives) on multidrug-resistance-positive human cancer cells. Int J Cancer 72: 844-850, 1997.
17. Nozell S, Wu Y, McNaughton K, Liu G, Willis A, Paik JC and Chen X: Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene 22: 4333-4347, 2003.
18. Costanzo A, Merlo P, Pediconi N, et al: DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell 9: 175-186, 2002.
19. Chen X, Zheng Y, Zhu J, Jiang J and Wang J: p73 is transcriptionally regulated by DNA damage, p53, and p73. Oncogene 20: 769-774, 2001.
20. Waltermann A, Kartasheva NN and Dobbelstein M: Differential regulation of p63 and p73 expression. Oncogene 22: 5686-5693, 2003.
21. Rossi M, De Laurenzi V, Munarriz E, et al: The ubiquitinprotein ligase Itch regulates p73 stability. EMBO J 24: 836-848, 2005.
22. Beitzinger M, Hofmann L, Oswald C, et al: p73 poses a barrier to malignant transformation by limiting anchorage-independent growth. EMBO J 27: 792-803, 2008.
23. Oberst A, Rossi M, Salomoni P, Pandolfi PP, Oren M, Melino G and Bernassola F: Regulation of the p73 protein stability and degradation. Biochem Biophys Res Commun 331: 707-712, 2005.
24. De Laurenzi V, Costanzo A, Barcaroli D, et al: Two new p73 splice variants, gamma and delta, with different transcriptional activity. J Exp Med 188: 1763-1768, 1998.
25. Gu J, Nie L, Kawai H and Yuan ZM: Subcellular distribution of p53 and p73 are differentially regulated by MDM2. Cancer Res 61: 6703-6707, 2001.