-
1
-
-
19644373254
-
Wnt signaling in disease and in development
-
Nusse R. 2005. Wnt signaling in disease and in development. Cell Res 15:28-32.
-
(2005)
Cell Res
, vol.15
, pp. 28-32
-
-
Nusse, R.1
-
2
-
-
0026772731
-
Wnt genes
-
Nusse R, Varmus HE. 1992. Wnt genes. Cell 69:1073-1087.
-
(1992)
Cell
, vol.69
, pp. 1073-1087
-
-
Nusse, R.1
Varmus, H.E.2
-
3
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
Gong Y, Slee RB, Fukai N, et al. 2001. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513-523.
-
(2001)
Cell
, vol.107
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
-
4
-
-
0037092049
-
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
-
Kato M, Patel MS, Levasseur R, et al. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157:303-314.
-
(2002)
J Cell Biol
, vol.157
, pp. 303-314
-
-
Kato, M.1
Patel, M.S.2
Levasseur, R.3
-
5
-
-
0037118285
-
High bone density due to a mutation in LDL-receptor-related protein 5
-
Boyden LM, Mao J, Belsky J, et al. 2002. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346:1513-1521.
-
(2002)
N Engl J Med
, vol.346
, pp. 1513-1521
-
-
Boyden, L.M.1
Mao, J.2
Belsky, J.3
-
6
-
-
33747674263
-
The Wnt coreceptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
-
Sawakami K, Robling AG, Ai M, et al. 2006. The Wnt coreceptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem 281:23698-23711.
-
(2006)
J Biol Chem
, vol.281
, pp. 23698-23711
-
-
Sawakami, K.1
Robling, A.G.2
Ai, M.3
-
7
-
-
34547604106
-
Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing
-
Chen Y, Whetstone HC, Lin AC, et al. 2007. Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med 4:1216-1229.
-
(2007)
PLoS Med
, vol.4
, pp. 1216-1229
-
-
Chen, Y.1
Whetstone, H.C.2
Lin, A.C.3
-
8
-
-
22044436959
-
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow
-
Gregory CA, Gunn WG, Reyes E, et al. 2005. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Ann NY Acad Sci 1049:97-106.
-
(2005)
Ann NY Acad Sci
, vol.1049
, pp. 97-106
-
-
Gregory, C.A.1
Gunn, W.G.2
Reyes, E.3
-
9
-
-
3042732142
-
The high bone mass family - the role of Wnt/Lrp5 signaling in the regulation of bone mass
-
Johnson ML. 2004. The high bone mass family - the role of Wnt/Lrp5 signaling in the regulation of bone mass. J Musculoskelet Neuronal Interact 4:135-138.
-
(2004)
J Musculoskelet Neuronal Interact
, vol.4
, pp. 135-138
-
-
Johnson, M.L.1
-
10
-
-
20844449569
-
TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro
-
Hens JR, Wilson KM, Daun P, et al. 2005. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res 20:1103-1113.
-
(2005)
J Bone Miner Res
, vol.20
, pp. 1103-1113
-
-
Hens, J.R.1
Wilson, K.M.2
Daun, P.3
-
11
-
-
34547111836
-
Wnt/betacatenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
-
Armstrong VJ, Muzylak M, Sunters A, et al. 2007. Wnt/betacatenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem 282:20715-20727.
-
(2007)
J Biol Chem
, vol.282
, pp. 20715-20727
-
-
Armstrong, V.J.1
Muzylak, M.2
Sunters, A.3
-
12
-
-
33646902229
-
Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
-
Lau KH, Kapur S, Kesavan C, et al. 2006. Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J Biol Chem 281:9576-9588.
-
(2006)
J Biol Chem
, vol.281
, pp. 9576-9588
-
-
Lau, K.H.1
Kapur, S.2
Kesavan, C.3
-
13
-
-
40849088373
-
Potential interaction of prostaglandin and Wnt signaling pathways mediating bone cell responses to fluid flow
-
abstr. no. F166
-
Kamel M, Holladay B, Johnson ML. 2006. Potential interaction of prostaglandin and Wnt signaling pathways mediating bone cell responses to fluid flow. J Bone Miner Res 21:S92 (abstr. no. F166).
-
(2006)
J Bone Miner Res
, vol.21
-
-
Kamel, M.1
Holladay, B.2
Johnson, M.L.3
-
14
-
-
57649237947
-
beta-Catenin levels influence rapid mechanical responses in osteoblasts
-
Case N, Ma M, Sen B, et al. 2008. beta-Catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem 283:29196-29205.
-
(2008)
J Biol Chem
, vol.283
, pp. 29196-29205
-
-
Case, N.1
Ma, M.2
Sen, B.3
-
15
-
-
38749149224
-
Bone regeneration is regulated by Wnt signaling
-
Kim JB, Leucht P, Lam K, et al. 2007. Bone regeneration is regulated by Wnt signaling. J Bone Miner Res 22:1913-1923.
-
(2007)
J Bone Miner Res
, vol.22
, pp. 1913-1923
-
-
Kim, J.B.1
Leucht, P.2
Lam, K.3
-
16
-
-
2342472717
-
Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells
-
de Boer J, Siddappa R, Gaspar C, et al. 2004. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34:818-826.
-
(2004)
Bone
, vol.34
, pp. 818-826
-
-
de Boer, J.1
Siddappa, R.2
Gaspar, C.3
-
17
-
-
11144296595
-
Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult humanmesenchymal stem cells
-
Boland GM, Perkins G, Hall DJ, et al. 2004. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult humanmesenchymal stem cells. J Cell Biochem93:1210-1230.
-
(2004)
J Cell Biochem93
, pp. 1210-1230
-
-
Boland, G.M.1
Perkins, G.2
Hall, D.J.3
-
18
-
-
43449133833
-
Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner
-
Eijken M, Meijer IMJ, Westbrock I, et al. 2007. Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner. J Cell Biochem 104:568-579.
-
(2007)
J Cell Biochem
, vol.104
, pp. 568-579
-
-
Eijken, M.1
Meijer, I.M.J.2
Westbrock, I.3
-
19
-
-
25444433584
-
Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells
-
van der Horst G, van der Werf SM, Farih-Sips H, et al. 2005. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J Bone Miner Res 20:1867-1877.
-
(2005)
J Bone Miner Res
, vol.20
, pp. 1867-1877
-
-
van der Horst, G.1
van der Werf, S.M.2
Farih-Sips, H.3
-
20
-
-
33645243606
-
Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts
-
Kahler RA, Galindo M, Lian J, et al. 2006. Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. J Cell Biochem 97:969-983.
-
(2006)
J Cell Biochem
, vol.97
, pp. 969-983
-
-
Kahler, R.A.1
Galindo, M.2
Lian, J.3
-
21
-
-
16644381077
-
Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts
-
Jansen JH, Weyts FA, Westbroek I, et al. 2004. Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts. J Cell Biochem 93:542-551.
-
(2004)
J Cell Biochem
, vol.93
, pp. 542-551
-
-
Jansen, J.H.1
Weyts, F.A.2
Westbroek, I.3
-
22
-
-
0036312822
-
Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways
-
Jessop HL, Rawlinson SC, Pitsillides AA, et al. 2002. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 31:186-194.
-
(2002)
Bone
, vol.31
, pp. 186-194
-
-
Jessop, H.L.1
Rawlinson, S.C.2
Pitsillides, A.A.3
-
23
-
-
0141706659
-
Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK
-
Rubin J, Murphy TC, Zhu L, et al. 2003. Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK. J Biol Chem 278:34018-34025.
-
(2003)
J Biol Chem
, vol.278
, pp. 34018-34025
-
-
Rubin, J.1
Murphy, T.C.2
Zhu, L.3
-
24
-
-
0035223876
-
Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells
-
Peverali FA, Basdra EK, Papavassiliou AG. 2001. Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells. Mol Med 7:68-78.
-
(2001)
Mol Med
, vol.7
, pp. 68-78
-
-
Peverali, F.A.1
Basdra, E.K.2
Papavassiliou, A.G.3
-
25
-
-
0017335021
-
Improvements in the ethidium bromide method for direct fluorometric estimation of DNA and RNA in cell and tissue homogenates
-
Karsten U, Wollenberger A. 1977. Improvements in the ethidium bromide method for direct fluorometric estimation of DNA and RNA in cell and tissue homogenates. Anal Biochem 77:464-470.
-
(1977)
Anal Biochem
, vol.77
, pp. 464-470
-
-
Karsten, U.1
Wollenberger, A.2
-
26
-
-
77049163593
-
The quantitative histochemistry of brain. II. Enzyme measurements
-
Lowry OH, Roberts NR, Wu M-L, et al. 1954. The quantitative histochemistry of brain. II. Enzyme measurements. J Biol Chem 207:19-27.
-
(1954)
J Biol Chem
, vol.207
, pp. 19-27
-
-
Lowry, O.H.1
Roberts, N.R.2
Wu, M.-L.3
-
27
-
-
0041767267
-
Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation
-
Weyts FA, Bosmans B, Niesing R, et al. 2003. Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation. Calcif Tissue Int 72:505-512.
-
(2003)
Calcif Tissue Int
, vol.72
, pp. 505-512
-
-
Weyts, F.A.1
Bosmans, B.2
Niesing, R.3
-
28
-
-
7444234984
-
An analysis of the complete strain field within Flexercell membranes
-
Vande Geest JP, Di Martino ES, Vorp DA. 2004. An analysis of the complete strain field within Flexercell membranes. J Biomech 37:1923-1928.
-
(2004)
J Biomech
, vol.37
, pp. 1923-1928
-
-
Vande Geest, J.P.1
Di Martino, E.S.2
Vorp, D.A.3
-
29
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata MF, Horiuchi KY, Manos EJ, et al. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632.
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
-
30
-
-
0030999806
-
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
-
van de Wetering M, Cavallo R, Dooijes D, et al. 1997. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88:789-799.
-
(1997)
Cell
, vol.88
, pp. 789-799
-
-
van de Wetering, M.1
Cavallo, R.2
Dooijes, D.3
-
31
-
-
0142254155
-
A transcriptional response to Wnt protein in human embryonic carcinoma cells
-
Willert J, Epping M, Pollack JR, et al. 2002. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol 2:8.
-
(2002)
BMC Dev Biol
, vol.2
, pp. 8
-
-
Willert, J.1
Epping, M.2
Pollack, J.R.3
-
32
-
-
0032406715
-
Mechanisms of Wnt signaling in development
-
Wodarz A, Nusse R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
-
(1998)
Annu Rev Cell Dev Biol
, vol.14
, pp. 59-88
-
-
Wodarz, A.1
Nusse, R.2
-
33
-
-
33846026749
-
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
-
Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, et al. 2006. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281:31720-31728.
-
(2006)
J Biol Chem
, vol.281
, pp. 31720-31728
-
-
Robinson, J.A.1
Chatterjee-Kishore, M.2
Yaworsky, P.J.3
-
34
-
-
0142241118
-
BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
-
Rawadi G, Vayssiere B, Dunn F, et al. 2003. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 18:1842-1853.
-
(2003)
J Bone Miner Res
, vol.18
, pp. 1842-1853
-
-
Rawadi, G.1
Vayssiere, B.2
Dunn, F.3
-
35
-
-
14744275847
-
Regulation of osteoblastogenesis and bone mass by Wnt10b
-
Bennett CN, Longo KA, Wright WS, et al. 2005. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA 102:3324-3329.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3324-3329
-
-
Bennett, C.N.1
Longo, K.A.2
Wright, W.S.3
-
36
-
-
17844372752
-
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
-
Day TF, Guo X, Garrett-Beal L, et al. 2005. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750.
-
(2005)
Dev Cell
, vol.8
, pp. 739-750
-
-
Day, T.F.1
Guo, X.2
Garrett-Beal, L.3
-
37
-
-
27944444857
-
The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
-
Bodine PV, Billiard J, Moran RA, et al. 2005. The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem 96:1212-1230.
-
(2005)
J Cell Biochem
, vol.96
, pp. 1212-1230
-
-
Bodine, P.V.1
Billiard, J.2
Moran, R.A.3
-
38
-
-
29244446792
-
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
-
Almeida M, Han L, Bellido T, et al. 2005. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem 280:41342-41351.
-
(2005)
J Biol Chem
, vol.280
, pp. 41342-41351
-
-
Almeida, M.1
Han, L.2
Bellido, T.3
-
39
-
-
40849106249
-
Osteocytes, mechanosensing and Wnt signaling
-
Bonewald LF, Johnson ML. 2008. Osteocytes, mechanosensing and Wnt signaling. Bone 42:606-615.
-
(2008)
Bone
, vol.42
, pp. 606-615
-
-
Bonewald, L.F.1
Johnson, M.L.2
-
40
-
-
0030729211
-
Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells
-
Arts J, Kuiper GG, Janssen JM, et al. 1997. Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070.
-
(1997)
Endocrinology
, vol.138
, pp. 5067-5070
-
-
Arts, J.1
Kuiper, G.G.2
Janssen, J.M.3
-
41
-
-
0027478854
-
Establishment and characterization of a simian virus 40-immortalized osteoblastic cell line from normal human bone
-
Chiba H, Sawada N, Ono T, et al. 1993. Establishment and characterization of a simian virus 40-immortalized osteoblastic cell line from normal human bone. Jpn J Cancer Res 84:290-297.
-
(1993)
Jpn J Cancer Res
, vol.84
, pp. 290-297
-
-
Chiba, H.1
Sawada, N.2
Ono, T.3
-
42
-
-
0033485478
-
Estradiol formation by human osteoblasts via multiple pathways: Relation with osteoblast function
-
Janssen JM, Bland R, Hewison M, et al. 1999. Estradiol formation by human osteoblasts via multiple pathways: relation with osteoblast function. J Cell Biochem 75:528-537.
-
(1999)
J Cell Biochem
, vol.75
, pp. 528-537
-
-
Janssen, J.M.1
Bland, R.2
Hewison, M.3
-
43
-
-
14844328091
-
11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation
-
Eijken M, Hewison M, Cooper MS, et al. 2005. 11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol 19:621-631.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 621-631
-
-
Eijken, M.1
Hewison, M.2
Cooper, M.S.3
-
44
-
-
1542347695
-
Convergence of Wnt, beta-catenin, and cadherin pathways
-
Nelson WJ, Nusse R. 2004. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303:1483-1487.
-
(2004)
Science
, vol.303
, pp. 1483-1487
-
-
Nelson, W.J.1
Nusse, R.2
-
45
-
-
65549114494
-
Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate
-
Arnsdorf EJ, Tummala P, Jacobs CR. 2009. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS ONE 4:1-10.
-
(2009)
PLoS ONE
, vol.4
, pp. 1-10
-
-
Arnsdorf, E.J.1
Tummala, P.2
Jacobs, C.R.3
-
46
-
-
0021848241
-
Regulation of bone mass by mechanical strain magnitude
-
Rubin CT, Lanyon LE. 1985. Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37:411-417.
-
(1985)
Calcif Tissue Int
, vol.37
, pp. 411-417
-
-
Rubin, C.T.1
Lanyon, L.E.2
-
47
-
-
0029985585
-
In vivo measurement of human tibial strains during vigorous activity
-
Burr DB, Milgrom C, Fyhrie D, et al. 1996. In vivo measurement of human tibial strains during vigorous activity. Bone 18:405-410.
-
(1996)
Bone
, vol.18
, pp. 405-410
-
-
Burr, D.B.1
Milgrom, C.2
Fyhrie, D.3
|