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Volumn 16, Issue 1, 2010, Pages 3-14

Review: Gimme five: Future challenges in multiple sclerosis. ECTRIMS Lecture 2009

Author keywords

Biomarker; Immunotherapy; Multiple sclerosis; Neuroprotection

Indexed keywords

ALEMTUZUMAB; BETA INTERFERON; BRAIN DERIVED NEUROTROPHIC FACTOR; CLADRIBINE; DACLIZUMAB; FINGOLIMOD; FUMARIC ACID; GLATIRAMER; INTERLEUKIN 17; LAQUINIMOD; MYELIN BASIC PROTEIN; NATALIZUMAB; T LYMPHOCYTE RECEPTOR; TERIFLUNOMIDE; NEUROPROTECTIVE AGENT;

EID: 73949109875     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458509357355     Document Type: Review
Times cited : (16)

References (46)
  • 1
    • 41549132629 scopus 로고    scopus 로고
    • Ethics of placebo-controlled clinical trials in multiple sclerosis: A reassessment
    • Polman CH, Reingold SC, Barkhof F., et al. Ethics of placebo-controlled clinical trials in multiple sclerosis: a reassessment. Neurology 2008 ; 70: 1134-1140.
    • (2008) Neurology , vol.70 , pp. 1134-1140
    • Polman, C.H.1    Reingold, S.C.2    Barkhof, F.3
  • 2
    • 64049119359 scopus 로고    scopus 로고
    • Multiple sclerosis therapeutics: Unexpected outcomes clouding undisputed successes
    • Wiendl H., Hohlfeld R. Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes. Neurology 2009 ; 72: 1008-1015.
    • (2009) Neurology , vol.72 , pp. 1008-1015
    • Wiendl, H.1    Hohlfeld, R.2
  • 3
    • 56349150992 scopus 로고    scopus 로고
    • Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations
    • Wiendl H., Toyka KV, Rieckmann P., et al. Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations. J Neurol 2008 ; 255: 1449-1463.
    • (2008) J Neurol , vol.255 , pp. 1449-1463
    • Wiendl, H.1    Toyka, K.V.2    Rieckmann, P.3
  • 4
    • 70249125817 scopus 로고    scopus 로고
    • Multiple sclerosis: Human model for EAE?
    • Hohlfeld R. Multiple sclerosis: human model for EAE? Eur J Immunol 2009 ; 39: 2036-2039.
    • (2009) Eur J Immunol , vol.39 , pp. 2036-2039
    • Hohlfeld, R.1
  • 5
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R., Linington C., Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006 ; 129: 1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 6
    • 70249106760 scopus 로고    scopus 로고
    • EAE: An immunologists magic eye
    • Krishnamoorthy G., Wekerle H. EAE: An immunologists magic eye. Eur J Immunol 2009 ; 39: 2031-2035.
    • (2009) Eur J Immunol , vol.39 , pp. 2031-2035
    • Krishnamoorthy, G.1    Wekerle, H.2
  • 7
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A., Wekerle H., Cohen IR The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 1981 ; 11: 195-199.
    • (1981) Eur J Immunol , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 8
    • 0344780200 scopus 로고    scopus 로고
    • Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
    • Flãgel A., Willem M., Berkowicz T., et al. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat Med 1999 ; 5: 843-847.
    • (1999) Nat Med , vol.5 , pp. 843-847
    • Flãgel, A.1    Willem, M.2    Berkowicz, T.3
  • 9
    • 70449106029 scopus 로고    scopus 로고
    • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    • Bartholomaus I., Kawakami N., Odoardi F., et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009 ; 462: 94-98.
    • (2009) Nature , vol.462 , pp. 94-98
    • Bartholomaus, I.1    Kawakami, N.2    Odoardi, F.3
  • 10
    • 73949130158 scopus 로고    scopus 로고
    • http://www.nature.com/nature/journal/v462/n7269/ extref/nature08478-s6. mov.
  • 11
    • 33745740498 scopus 로고    scopus 로고
    • Neuroimaging: In vivo imaging of the diseased nervous system
    • Misgeld T., Kerschensteiner M. Neuroimaging: In vivo imaging of the diseased nervous system. Nature Rev Neurosci 2006 ; 7: 449-463.
    • (2006) Nature Rev Neurosci , vol.7 , pp. 449-463
    • Misgeld, T.1    Kerschensteiner, M.2
  • 12
    • 67449116625 scopus 로고    scopus 로고
    • Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    • Pollinger B., Krishnamoorthy G., Berer K., et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med 2009 ; 206: 1303-1316.
    • (2009) J Exp Med , vol.206 , pp. 1303-1316
    • Pollinger, B.1    Krishnamoorthy, G.2    Berer, K.3
  • 13
    • 73949119744 scopus 로고    scopus 로고
    • http://jem.rupress.org/cgi/content/full/jem.20090299/DC1.
  • 15
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C., Hermans G., Pedotti R., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Med 2002 ; 8: 500-508.
    • (2002) Nature Med , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3
  • 16
    • 39849101009 scopus 로고    scopus 로고
    • Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
    • Han MH, Hwang S. -I, Roy DB, et al. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 2008 ; 451: 1076-1082.
    • (2008) Nature , vol.451 , pp. 1076-1082
    • Han, M.H.1    Hwang, S.2    Roy, D.B.3
  • 17
    • 0035941106 scopus 로고    scopus 로고
    • The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
    • Chabas D., Baranzini SE, Mitchell D., et al. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001 ; 294: 1731-1735.
    • (2001) Science , vol.294 , pp. 1731-1735
    • Chabas, D.1    Baranzini, S.E.2    Mitchell, D.3
  • 18
    • 70349267599 scopus 로고    scopus 로고
    • Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity
    • Platten M., Youssef S., Hur EM, et al. Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A 2009 ; 106: 14948-14953.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14948-14953
    • Platten, M.1    Youssef, S.2    Hur, E.M.3
  • 19
    • 0141648547 scopus 로고    scopus 로고
    • T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors
    • Dornmair K., Goebels N., Weltzien HU, et al. T-cell-mediated autoimmunity - Novel techniques to characterize autoreactive T-cell receptors. Am J Pathol 2003 ; 163: 1215-1226.
    • (2003) Am J Pathol , vol.163 , pp. 1215-1226
    • Dornmair, K.1    Goebels, N.2    Weltzien, H.U.3
  • 20
    • 35648948324 scopus 로고    scopus 로고
    • Multiple sclerosis: T-cell receptor expression in distinct brain regions
    • Junker A., Ivanidze J., Malotka J., et al. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 2007 ; 130: 2789-2799.
    • (2007) Brain , vol.130 , pp. 2789-2799
    • Junker, A.1    Ivanidze, J.2    Malotka, J.3
  • 21
    • 33747077896 scopus 로고    scopus 로고
    • Reconstitution of paired T cell receptor β±- And β2-chains from microdissected single cells of human inflammatory tissues
    • Seitz S., Schneider CK, Malotka J., et al. Reconstitution of paired T cell receptor β±- and β2-chains from microdissected single cells of human inflammatory tissues. Proc Natl Acad Sci U S A 2006 ; 103: 12057-12062.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12057-12062
    • Seitz, S.1    Schneider, C.K.2    Malotka, J.3
  • 22
    • 2442604214 scopus 로고    scopus 로고
    • Humanized animal models for autoimmune diseases
    • Gregersen JW, Holmes S., Fugger L. Humanized animal models for autoimmune diseases. Tiss Antigens 2004 ; 63: 383-394.
    • (2004) Tiss Antigens , vol.63 , pp. 383-394
    • Gregersen, J.W.1    Holmes, S.2    Fugger, L.3
  • 23
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B., Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997 ; 120: 393-399.
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3
  • 24
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesion of multiple sclerosis
    • Trapp BD, Peterson J., Ransohoff RM, et al. Axonal transection in the lesion of multiple sclerosis. N Engl J Med 1998 ; 338: 278-285.
    • (1998) N Engl J Med , vol.338 , pp. 278-285
    • Trapp, B.D.1    Peterson, J.2    Ransohoff, R.M.3
  • 25
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann T., Lingfeld T., BitschA, et al. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 2002 ; 125: 2202-2212.
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, T.2    Bitsch, A.3
  • 26
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • Frischer JM, Bramow S., Dal-Bianco A., et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009 ; 135: 1175-1189.
    • (2009) Brain , vol.135 , pp. 1175-1189
    • Frischer, J.M.1    Bramow, S.2    Dal-Bianco, A.3
  • 28
    • 0037369638 scopus 로고    scopus 로고
    • Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases
    • Kerschensteiner M., Stadelmann C., Dechant G., et al. Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Ann Neurol 2003 ; 53: 292-304.
    • (2003) Ann Neurol , vol.53 , pp. 292-304
    • Kerschensteiner, M.1    Stadelmann, C.2    Dechant, G.3
  • 29
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation?
    • Kerschensteiner M., Gallmeier E., Behrens L., et al. Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation? J Exp Med 1999 ; 189: 865-870.
    • (1999) J Exp Med , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3
  • 30
    • 0036154041 scopus 로고    scopus 로고
    • BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells?
    • Stadelmann C., Kerschensteiner M., Misgeld T., et al. BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells? Brain 2002 ; 125: 75-85.
    • (2002) Brain , vol.125 , pp. 75-85
    • Stadelmann, C.1    Kerschensteiner, M.2    Misgeld, T.3
  • 31
    • 70349232336 scopus 로고    scopus 로고
    • Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss
    • Sobottka B., Harrer MD, Ziegler U., et al. Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am J Pathol 2009 ; 175: 1160-1166.
    • (2009) Am J Pathol , vol.175 , pp. 1160-1166
    • Sobottka, B.1    Harrer, M.D.2    Ziegler, U.3
  • 32
    • 59949106172 scopus 로고    scopus 로고
    • Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
    • Trapp BD, Stys PK Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol 2009 ; 8: 280-291.
    • (2009) Lancet Neurol , vol.8 , pp. 280-291
    • Trapp, B.D.1    Stys, P.K.2
  • 33
    • 33747890559 scopus 로고    scopus 로고
    • The brain as a target of inflammation: Common pathways link inflammatory and neurodegenerative diseases
    • Zipp F., Aktas O. The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci 2006 ; 29: 518-527.
    • (2006) Trends Neurosci , vol.29 , pp. 518-527
    • Zipp, F.1    Aktas, O.2
  • 34
    • 34948864286 scopus 로고    scopus 로고
    • Neurofascin as a novel target for autoantibody-mediated axonal injury
    • Mathey EK, Derfuss T., Storch MK, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med 2007 ; 204: 2363-2372.
    • (2007) J Exp Med , vol.204 , pp. 2363-2372
    • Mathey, E.K.1    Derfuss, T.2    Storch, M.K.3
  • 35
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • Bielekova B., Martin R. Development of biomarkers in multiple sclerosis. Brain 2004 ; 127: 1463-1478.
    • (2004) Brain , vol.127 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 36
    • 10344250945 scopus 로고    scopus 로고
    • A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis
    • Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004 ; 364: 2106-2112.
    • (2004) Lancet , vol.364 , pp. 2106-2112
    • Lennon, V.A.1    Wingerchuk, D.M.2    Kryzer, T.J.3
  • 37
    • 72949114659 scopus 로고    scopus 로고
    • Takahashi, et al. Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo
    • Bradl M., Misu T., Takahashi, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009 ; 66: 630-343.
    • (2009) Ann Neurol , vol.66 , pp. 630-343
    • Bradl, M.1    Misu, T.2
  • 38
    • 72949093353 scopus 로고    scopus 로고
    • Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica
    • Bennett JL, Lam C., Kalluri SR, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 2009 ; 66: 617-629.
    • (2009) Ann Neurol , vol.66 , pp. 617-629
    • Bennett, J.L.1    Lam, C.2    Kalluri, S.R.3
  • 39
    • 67650501068 scopus 로고    scopus 로고
    • Neuromyelitis optica: Passive transfer to rats by human immunoglobulin
    • Kinoshita M., Nakatsuji Y., Kimura T., et al. Neuromyelitis optica: Passive transfer to rats by human immunoglobulin. Biochem Biophys Res Commun 2009 ; 386: 623-627.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 623-627
    • Kinoshita, M.1    Nakatsuji, Y.2    Kimura, T.3
  • 40
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/ oligodendrocyte glycoprotein
    • Linington C., Bradl M., Lassmann H., et al. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 1988 ; 130: 443-454.
    • (1988) Am J Pathol , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3
  • 41
    • 0023597814 scopus 로고
    • A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease
    • Schluesener HJ, Sobel RA, Linington C., et al. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol 1987 ; 139: 4016-4021.
    • (1987) J Immunol , vol.139 , pp. 4016-4021
    • Schluesener, H.J.1    Sobel, R.A.2    Linington, C.3
  • 42
    • 71849098862 scopus 로고    scopus 로고
    • Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score
    • De Jager PL, Chibnik LB, Cui J., et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 2009 ; 8: 1111-1119.
    • (2009) Lancet Neurol , vol.8 , pp. 1111-1119
    • De Jager, P.L.1    Chibnik, L.B.2    Cui, J.3
  • 43
    • 70349731730 scopus 로고    scopus 로고
    • Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis
    • Kãmpfel T., Hohlfeld R. Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. Nat Rev Neurol 2009 ; 5: 528-529.
    • (2009) Nat Rev Neurol , vol.5 , pp. 528-529
    • Kãmpfel, T.1    Hohlfeld, R.2
  • 44
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, Jia X., Wang J., et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009 ; 41: 776-782.
    • (2009) Nat Genet , vol.41 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3
  • 45
    • 34547747790 scopus 로고    scopus 로고
    • Late-onset tumor necrosis factor receptor-associated periodic syndrome in multiple sclerosis patients carrying the TNFRSF1A R92Q mutation
    • Kãmpfel T., Hoffmann LA, Rubsamen H., et al. Late-onset tumor necrosis factor receptor-associated periodic syndrome in multiple sclerosis patients carrying the TNFRSF1A R92Q mutation. Arthritis Rheum 2007 ; 56: 2774-2783.
    • (2007) Arthritis Rheum , vol.56 , pp. 2774-2783
    • Kãmpfel, T.1    Hoffmann, L.A.2    Rubsamen, H.3
  • 46
    • 58149240956 scopus 로고    scopus 로고
    • Multiple sclerosis and the TNFRSF1A R92Q mutation: Clinical characteristics of 21 cases
    • Kãmpfel T., Hoffmann LA, Pellkofer H., et al. Multiple sclerosis and the TNFRSF1A R92Q mutation: clinical characteristics of 21 cases. Neurology 2008 ; 71: 1812-1820.
    • (2008) Neurology , vol.71 , pp. 1812-1820
    • Kãmpfel, T.1    Hoffmann, L.A.2    Pellkofer, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.