Effect of intestinal resections on arginine metabolism: Practical implications for nutrition support

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 13, Issue 1, 2010, Pages 65-69

  Crenn, Pascal ^a,b   Cynober, Luc ^a,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c Institut Cochin   (France)

Author keywords

Arginine; Citrulline; Short bowel syndrome

Indexed keywords

ARGININE; CITRULLINE;

AMINO ACID METABOLISM; CELL METABOLISM; DIET SUPPLEMENTATION; ENTERIC FEEDING; HUMAN; INTESTINE ADAPTATION; INTESTINE CELL; INTESTINE RESECTION; NITROGEN METABOLISM; NONHUMAN; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; REVIEW;

ARGININE; CITRULLINE; DIETARY SUPPLEMENTS; HUMANS; INTESTINES; NUTRITIONAL SUPPORT; POSTOPERATIVE COMPLICATIONS; SHORT BOWEL SYNDROME;

EID: 73849151309     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328333c1a8     Document Type: Review

References (36)

1. Moinard C, Cynober L, de Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr 2005; 24:184-197.
2. Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 1998; 336:1-17.
3. Barbul A, Uliyargoli A. Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis. Crit Care Med 2007; 35:S564-S567.
4. Luiking YC, Deutz NE. Exogenous arginine in sepsis. Crit Care Med 2007; 35:S557-S563.
5. Zhou M, Martindale RG. Arginine in the critical care setting. J Nutr 2007; 137:1687S-1692S.
6. Boger RH. L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous? Curr Opin Clin Nutr Metab Care 2008; 11:55-61.
7. Rhoads JM, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 2009; 37:111-122.
8. Deutz NE. The 2007 ESPEN Sir David Cuthbertson Lecture: amino acids between and within organs. The glutamate-glutamine-citrulline-arginine path way. Clin Nutr 2008; 27:321-327.
9. Curis E, Crenn P, CynoberL Citrulline and the gut. Curr Opin Clin Nutr Metab Care 2007; 10:620-626.
10. Castillo L, Chapman TE, Sanchez M, et al. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc Natl Acad Sci U S A 1993; 90:7749-7753.
11. Castillo L, Sanchez M, Vogt J, et al. Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am J Physiol 1995; 268:E360-E367.
12. Urschel KL, Rafii M, Pencharz PB, Ball RO. A multitracer stable isotope quantification of the effects of arginine intake on whole body arginine metabolism in neonatal piglets. Am J Physiol Endocrinol Metab 2007; 293:E811-E81 8.
13. Bertolo RF, Brunton JA, Pencharz PB, Ball RO. Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. Am J Physiol Endocrinol Metab 2003; 284:E915-E922.
14. Fujita T, Yanaga K. Association between glutamine extraction and release of citrulline and glycine by the human small intestine. Life Sci 2007; 80:1846-1850.
15. Kohler ES, Sankaranarayanan S, van Ginneken CJ, et al. The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and-catabolizing enzymes. BMC Dev Biol 2008; 8:107. doi:10.1186/1471-213X-8-107.
16. Popovic PJ, Zeh HJ 3rd, Ochoa JB. Arginine and immunity. J Nutr 2007; 137:1681S-1686S.
17. Wakabayashi Y, Yamada E, Yoshida T, Takahashi H. Arginine becomes an essential amino acid after massive resection of rat small intestine. J Biol Chem 1994; 269:32667-32671.
18. Wakabayashi Y, Yamada E, Yoshida T, Takahashi N. Effect of intestinal resection and arginine-free diet on rat physiology. Am J Physiol 1995; 269:G313-G318.
19. Pita AM, Fernandez-Bustos A, Rodes M, et al. Orotic aciduria and plasma urea cycle-related amino acid alterations in short bowel syndrome, evoked by an arginine-free diet. JPEN J Parenter Enteral Nutr 2004; 28:315-323.
20. Dejong CH, Welters CF, Deutz NE, et al. Renal arginine metabolism in fasted rats with subacute short bowel syndrome. Clin Sci 1998; 95:409-418.
21. Crenn P, Coudray-Lucas C, Thuillier F, et al. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 2000; 119:1496-1505.
22. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr 2008; 27:328-339.
23. Urschel KL, Shoveller AK, Uwiera RR, et al. Citrulline is an effective arginine precursor in enterally fed neonatal piglets. J Nutr 2006; 136:1806-1813.
24. Sukhotnik I, Lerner A, Sabo E, et al. Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. Dig Dis Sci 2003; 48:1346-1351. (Pubitemid 36793913)
25. Sukhotnik I, Mogilner JG, Lerner A, et al. Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model. Pediatr Surg Int 2005; 21:460-465. (Pubitemid 40922378)
26. Jiang X, Zhu W, Li N, et al. Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome. Asia Pac J Clin Nutr 2007; 16:554-560.
27. Camli A, Barlas M, Yagmurlu A. Does L-arginine induce intestinal adaptation by epithelial growth factor? ANZ J Surg 2005; 75:73-75.
28. Hebiguchi T, KatoT, Yoshino H, et al. The effect of arginine supplementation on growth hormone release and intestinal mucosal growth after massive small bowel resection in growing rats. J Pediatr Surg 1997; 32:1149-1153.
29. Ozturk H, Dokucu AI, Yagmur Y, Sari I. Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats. Pediatr Surg Int 2002; 18:332-336.
30. Quirino IE, Correia MI, Cardoso VN. The impact of arginine on bacterial translocation in an intestinal obstruction model in rats. Clin Nutr 2007; 26:335-340.
31. Grimble GK. Adverse gastrointestinal effects of arginine and related amino acids. J Nutr 2007; 137:1693S-1701S.
32. Cynober L. Pharmacokinetics of arginine and related amino acids. J Nutr 2007; 137:1646S-1649S.
33. Bahri S, Curis E, El Wafi FZ, et al. Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells. Clin Nutr 2008; 27:872-880.
34. Osowska S, Moinard C, Neveux N, et al. Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection. Gut 2004; 53:1781-1786.
35. Osowska S, Neveux N, Nakib S, et al. Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supple mented with citrulline compared with arginine. Clin Sci 2008; 115:159-166.
36. Moinard C, Cynober L. Citrulline: a new player in the control of nitrogen homeostasis. J Nutr 2007; 137:1621S-1625S.