Adverse gastrointestinal effects of arginine and related amino acids

Journal of Nutrition

Volumn 137, Issue 6, 2007, Pages

  Grimble, George K ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; CITRULLINE; CYSTINE; ORNITHINE;

AMINO ACID TRANSPORT; BINDING AFFINITY; CONFERENCE PAPER; GASTROINTESTINAL TOXICITY; HUMAN; STANDARDIZATION;

EID: 34249781711     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.6.1693s     Document Type: Conference Paper

References (138)

1. Cynober LA. Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002;18:761-6.
2. Reeds PJ, Burrin DG, Stoll B, Jahoor F. Intestinal glutamate metabolism. J Nutr. 2000;130:978S-82S.
3. Morris SM Jr. Arginine: beyond protein. Am J Clin Nutr. 2006;83:S508-12.
4. Brusilow SW. Hyperammonemic encephalopathy. Medicine (Baltimore). 2002;81:240-9.
5. Morris SM Jr. Arginine metabolism in vascular biology and disease. Vasc Med. 2005;10 Suppl 1:S83-7.
6. Stechmiller JK, Childress B, Cowan L. Arginine supplementation and wound healing. Nutr Clin Pract. 2005;20:52-61.
7. Cherla G, Jaimes EA. Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr. 2004;134:S2801-6.
8. Gornik HL, Creager MA. Arginine and endothelial and vascular health. J Nutr. 2004;134:S2880-7.
9. Lebret T, Herve JM, Gorny P, Worcel M, Botto H. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. 2002;41:608-13.
10. Stromberger C, Bodamer OA, Stockler-Ipsiroglu S. Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism. J Inherit Metab Dis. 2003;26:299-308.
11. Cynober L, Coudray-Lucas C, de Bandt J-P, Guechot J, Aussel C, Salvucci M, Giboudeau J. Action of ornithine a-ketoglutarate, ornithine hydrochloride, and calcium a-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. J Am Coll Nutr. 1990;9:2-12.
12. Kellum JA. Determinants of blood pH in health and disease. Crit Care. 2000;4:6-14.
13. Grimble GK. Protein hydrolysates as vehicles for the application of diand tripeptides in clinical nutrition. In: Grimble GK, Backwell FRC, editors. Peptides in mammalian protein metabolism: tissue utilisation and clinical targeting. 1st ed. London: Portland Press; 1997. p. 119-39.
14. Grimble GK. Quantitative and qualitative aspects of nitrogen supply in enteral nutrition in relation to free amino acids and peptides. In: Cynober L, editor. Amino acid metabolism in health and nutritional diseases. Boca Raton (FL): CRC Press; 2003. p. 529-56.
15. Fahey JL. Toxicity and blood ammonia rise resulting from intravenous amino acid administration in man: the protective effect of L-arginine. J Clin Invest. 1957;36:1647-55.
16. Fazekas JF, Ticktin HE, Shea JG. Effects of L-arginine on hepatic encephalopathy. Am J Med Sci. 1957;234:462-7.
17. Staedt U, Leweling H, Gladisch R, Kortsik C, Hagmuller E, Holm E. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol. 1993;19:424-30.
18. Molimard R, Charpentier C, Lemonnier F. Ornithine alphaketogluta-rate induced changes of plasma amino acids in hepatic encephalopathy. In: Wewalka F, Dragosics B, editors. Aminosauren, Ammoniak und Hepatische Enzephalopathie. Stuttgart, New York: Gustav Fischer Verlag; 1977. p. 200-6.
19. Paris J, Merveille P, Molimard R. 1 (+) ornithine alpha ketoglutarate in hepatic encephalopathy. Presse Med. 1970;78:1367-8.
20. Vita F, Spignoli G, Isidori A. Effects of arginine pyroglutamate (Adiuvant) on growth hormone in children. Clin Trials J. 1987;24:387-90.
21. Chromiak JA, Antonio J. Use of amino acids as growth hormone-releasing agents by athletes. Nutrition. 2002;18:657-61.
22. Bucci L, Hickson JF Jr, Pivarnik JM, Wolinsky I, McMahon JC, Turner SD. Ornithine ingestion and growth hormone release in bodybuilders. Nutr Res. 1990;10:239-45.
23. Colombani PC, Bitzi R, Frey-Rindova P, Frey W, Arnold M, Langhans W, Wenk C. Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run. Eur J Nutr. 1999;38:263-70.
24. Stechmiller JK, Langkamp-Henken B, Childress B, Herrlinger-Garcia KA, Hudgens J, Tian L, Percival SS, Steele R. Arginine supplementation does not enhance serum nitric oxide levels in elderly nursing home residents with pressure ulcers. Biol Res Nurs. 2005;6:289-99.
25. Barbul A, Lazarou SA, Efron DT, Wasserkrug HL, Efron G. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990;108:331-7.
26. Coudray-Lucas C, Le Bever H, Cynober L, De Bandt JP, Carsin H. Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls. Crit Care Med. 2000;28:1772-6.
27. Donati L, Ziegler F, Pongelli G, Signorini MS. Nutritional and clinical efficacy of ornithine a-ketoglutarate in severe burn patients. Clin Nutr. 1999;18:307-11.
28. Bennett-Richards KJ, Kattenhorn M, Donald AE, Oakley GR, Varghese Z, Bruckdorfer KR, Deanfield JE, Rees L. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int. 2002;62:1372-8.
29. Loscalzo J. L-Arginine and atherothrombosis. J Nutr. 2004;134:S2798-800.
30. Smith HA, Canter JA, Christian KG, Drinkwater DC, Scholl FG, Christman BW, Rice GD, Barr FE, Summar ML. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J Thorac Cardiovasc Surg. 2006;132:58-65.
31. Lekakis JP, Papathanassiou S, Papaioannou TG, Papamichael CM, Zakopoulos N, Kotsis V, Dagre AG, Stamatelopoulos K, Protogerou A, et al. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int J Cardiol. 2002;86:317-23.
32. Amin HJ, Zamora SA, McMillan DD, Fick GH, Butzner JD, Parsons HG, Scott RB. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr. 2002;140:425-31.
33. App EM, Baran D, Dab I, Malfroot A, Coffiner M, Vanderbist F, King M. Dose-finding and 24-h monitoring for efficacy and safety of aerosolized Nacystelyn in cystic fibrosis. Eur Respir J. 2002;19:294-302.
34. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006;136:S1652-9.
35. Faintuch J, Aguilar PB, Nadalin W. Relevance of N-acetylcysteine in clinical practice: fact, myth or consequence? Nutrition. 1999;15:177-9.
36. Grimble RF. The effects of sulfur amino acid intake on immune function in humans. J Nutr. 2006;136:S1660-5.
37. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319:1557-62.
38. Izzo AA, Mascolo N, Capasso F. Nitric oxide as a modulator of intestinal water and electrolyte transport. Dig Dis Sci. 1998;43:1605-20.
39. Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology. 1992;103:1928-49.
40. Prins HA, Gosselink MP, Mitales LE, Buise MP, Teerlink T, Esser C, Schouten WR. The effect of oral administration of L-arginine on anal resting pressure and anodermal blood flow in healthy volunteers. Tech Coloproctol. 2005;9:229-32.
41. Kuiken SD, Tytgat GN, Boeckxstaens GE. Role of endogenous nitric oxide in regulating antropyloroduodenal motility in humans. Am J Gastroenterol. 2002;97:1661-7.
42. Kuiken SD, Klooker TK, Tytgat GN, Lei A, Boeckxstaens GE. Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2006;18:115-22.
43. Akisu M, Ozmen D, Baka M, Habif S, Yalaz M, Arslanoglu S, Kultursay N, Bayindir O. Protective effect of dietary supplementation with L-arginine and L-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. Biol Neonate. 2002;81:260-5.
44. Rasaratnam B, Connelly N, Chin-Dusting J. Nitric oxide and the hyperdynamic circulation in cirrhosis: is there a role for selective intestinal decontamination? Clin Sci (Lond). 2004;107:425-34.
45. Perner A, Andresen L, Normark M, Fischer-Hansen B, Sorensen S, Eugen-Olsen J, Rask-Madsen J. Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. Gut. 2001;49:387-94.
46. Phillips SF. Diarrhea: a current view of the pathophysiology. Gastroenterology. 1972;63:495-518.
47. Bliss DZ, Guenter PA, Settle RG. Defining and reporting diarrhea in tube-fed patients: what a mess! Am J Clin Nutr. 1992;55:753-9.
48. Grimble GK, Patil DH, Silk DBA. Assimilation of lactitol, an 'unabsorbed' disaccharide in the normal human colon. Gut. 1988;29:1666-71.
49. Patil DH, Grimble GK, Silk DBA. Lactitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects. Br J Nutr. 1987;57:195-9.
50. Wiggins HS. Nutritional value of sugars and related compounds undigested in the small gut. Proc Nutr Soc. 1984;43:69-75.
51. Briet F, Achour L, Flourie B, Beaugerie L, Pellier P, Franchisseur C, Bornet F, Rambaud JC. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr. 1995;49:501-7.
52. Debongnie JC, Phillips SF. Capacity of the human colon to absorb fluid. Gastroenterology. 1978;74:698-703.
53. Collier SR, Casey DP, Kanaley JA. Growth hormone responses to varying doses of oral arginine. Growth Horm IGF Res. 2005;15:136-9.
54. Apostol AT, Tayek JA. A decrease in glucose production is associated with an increase in plasma citrulline response to oral arginine in normal volunteers. Metabolism. 2003;52:1512-6.
55. Evans RW, Fernstrom JD, Thompson J, Morris SM Jr, Kuller LH. Biochemical responses of healthy subjects during dietary supplementation with L-arginine. J Nutr Biochem. 2004;15:534-9.
56. Barbul A, Sisto DA, Wasserkrug HL, Efron G. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery. 1981;90:244-51.
57. Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF. Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol. 1999;47:261-6.
58. Williams JZ, Abumrad N, Barbul A. Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg. 2002;236:369-74.
59. Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol. 1995;26:1054-61.
60. Clarkson P, Adams MR, Powe AJ, Donald AE, McCredie R, Robinson J, McCarthy SN, Keech A, Celermajer DS, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest. 1996;97:1989-94.
61. Abel T, Knechtle B, Perret C, Eser P, von AP, Knecht H. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism: a randomized, double-blind, placebo-controlled study. Int J Sports Med. 2005;26:344-9.
62. Fogelholm GM, Naveri HK, Kiilavuori KT, Harkonen MH. Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters. Int J Sport Nutr. 1993;3:290-7.
63. Kowalski P, Bieniecki M. Pharmacokinetics and bioavailability study of L-ornithine-L-aspartate in healthy volunteers-a comparative study of two oral formulations. J Pharm Biomed Anal. 2006;41:1061-4.
64. Bednarz B, Jaxa-Chamiec T, Maciejewski P, Szpajer M, Janik K, Gniot J, Kawka-Urbanek T, Drozdowska D, Gessek J, et al. Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of the multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol Pol. 2005;62:421-7.
65. Yin WH, Chen JW, Tsai C, Chiang MC, Young MS, Lin SJ. L-Arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease. Clin Nutr. 2005;24:988-97.
66. Park KGM, Heys SD, Blessing K, Kelly P, McNurlan MA, Eremin O, Garlick PJ. Stimulation of human breast cancers by dietary L-arginine. Clin Sci. 1992;82:413-7.
67. Rector TS, Bank AJ, Mullen KA, Tschumperlin LK, Sih R, Pillai K, Kubo SH. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation. 1996;93:2135-41.
68. Everard ML, Donnelly D. A pilot study of oral L-arginine in cystic fibrosis. J Cyst Fibros. 2005;4:67-9.
69. Kernohan AF, McIntyre M, Hughes DM, Tam SW, Worcel M, Reid JL. An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. Br J Clin Pharmacol. 2005;59:85-93.
70. Lim DS, Mooradian SJ, Goldberg CS, Gomez C, Crowley DC, Rocchini AP, Charpie JR. Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients. Am J Cardiol. 2004;94:828-31.
71. Hladunewich MA, Derby GC, Lafayette RA, Blouch KL, Druzin ML, Myers BD. Effect of L-arginine therapy on the glomerular injury of preeclampsia: a randomized controlled trial. Obstet Gynecol. 2006;107:886-95.
72. Daly JM, Reynolds J, Thom A, Kinsley L, Dietrick-Gallagher M, Shou J, Ruggieri B. Immune and metabolic effects of arginine in the surgical patient. Ann Surg. 1988;208:512-23.
73. Stechmiller JK, Lentz-Slick A, Bender BS, Hoffinger R, Langkamp-Henken B. Arginine vs protein supplementation in HIV-infected men. Nutr Clin Pract. 2001;16:158-64.
74. Stechmiller JK, Childress B, Porter T. Arginine immunonutrition in critically ill patients: a clinical dilemma. Am J Crit Care. 2004;13:17-23.
75. Grimble GK, Coudray-Lucas C, Payne-James JJ, Cynober L, Ziegler F, Silk DBA. Augmentation of plasma arginine and glutamine by ornithine a- ketoglutarate in healthy enterally-fed volunteers. Proc Nutr Soc 1992;51:119A.
76. Payne-James J, Grimble G, Cahill E, Silk DBA. Jejunal absorption of ornithine-oxoglutarate (OKGA) in man. J Parent Ent Nutr. 1989;13(Suppl):22S.
77. Bowling TE, Silk DB. Colonic responses to enteral tube feeding. Gut. 1998;42:147-51.
78. Bowling TE, Raimundo AH, Grimble GK, Silk DBA. Colonic secretory effect in response to enteral feeding in humans. Gut. 1994;35:1734-41.
79. Hellier MD, Holdsworth CD, Perrett D. Dibasic amino acid absorption in man. Gastroenterology. 1973;65:613-8.
80. Hegarty JE, Fairclough PD, Clark ML, Dawson AM. Jejunal water and electrolyte secretion induced by L-arginine in man. Gut. 1981;22:108-13.
81. Maher MM, Gontarek JD, Jimenez RE, Cahill PA, Yeo CJ. Endogenous nitric oxide promotes ileal absorption. J Surg Res. 1995;58:687-92.
82. Turvill JL, Mourad FH, Farthing MJ. Proabsorptive and prosecretory roles for nitric oxide in cholera toxin induced secretion. Gut. 1999;44:33-9.
83. Canani RB, Cirillo P, Buccigrossi V, De MG, Mallardo G, Bruzzese E, Polito G, Guarino A. Nitric oxide produced by the enterocyte is involved in the cellular regulation of ion transport. Pediatr Res. 2003;54:64-8.
84. Neu J. Arginine supplementation and the prevention of necrotizing enterocolitis in very low birth weight infants. J Pediatr. 2002;140:389-91.
85. Shah P, Shah V. Arginine supplementation for prevention of necrotising enterocolitis in preterm infants. Cochrane Database Syst Rev. 2004;4:CD004339.
86. Palacin M, Bertran J, Chillaron J, Estevez R, Zorzano A. Lysinuric protein intolerance: mechanisms of pathophysiology. Mol Genet Metab. 2004;81 Suppl 1:S27-37.
87. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch. 2004;447:532-42.
88. Milne MD, Asatoor AM, Edwards KDG, Loughridge LW. The intestinal absorption defect in cystinuria. Gut. 1961;2:323-37.
89. Thier S, Fox M, Segal S, Rosenberg LE. Cystinuria: in vitro demonstration of an intestinal transport defect. Science. 1964;143:482-4.
90. Rosenberg LE, Crawhall JC, Segal S. Intestinal transport of cystine and cysteine in man: evidence for separate mechanisms. J Clin Invest. 1967;46:30-4.
91. Silk DBA, Perrett D, Clark ML. Jejeunal and ileal absorption of dibasic amino acids and an arginine containing dipeptide in cystinuria. Gastroenterology. 1975;68:1426-32.
92. Asatoor AM, Freedman PS, Gabriel JR, Milne MD, Prosser DI, Roberts JT, Willoughby CP. Amino acid imbalance in cystinuria. J Clin Pathol. 1974;27:500-4.
93. Beck IT. The role of pancreatic enzymes in digestion. Am J Clin Nutr. 1973;26:311-25.
94. Adibi SA, Gray SJ. Intestinal absorption of essential amino acids in man. Gastroenterology. 1967;52:837-45.
95. Adibi SA, Mercer DW. Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals. J Clin Invest. 1973;52:1586-94.
96. Silk DBA, Chung YC, Berger KL, Conley K, Beigler M, Sleisenger MH, Spiller GA, Kim YS. Comparison of oral feeding of peptide and amino acid meals to normal human subjects. Gut. 1979;20:291-9.
97. Rérat A, Nunes CS, Mendy F, Roger L. Amino acid absorption and production of pancreatic hormones in non-anaesthetized pigs after duodenal infusions of a milk enzymic hydrolysate or of free amino acids. Br J Nutr. 1988;60:121-36.
98. Rérat A, Simoes-Nuñes C, Mendy F, Vaissade P, Vaugelade P. Splanchnic fluxes of amino acids after duodenal infusion of carbohydrate solutions containing free amino acids or oligopeptides in the non-anaesthetised pig. Br J Nutr. 1992;68:111-38.
99. Modigliani R, Rambaud JC, Bernier JJ. Validation of the use of a tube with a proximal occlusive balloon for measurement of intestinal absorption in man. Am J Dig Dis. 1978;23:720-2.
100. Dello Strologo L, Rizzoni G. Cystinuria. Acta Paediatr Suppl. 2006;95:31-3.
101. Pfeiffer R, Loffing J, Rossier G, Bauch C, Meier C, Eggermann T, Loffing-Cueni D, Kuhn LC, Verrey F. Luminal heterodimeric amino acid transporter defective in cystinuria. Mol Biol Cell. 1999;10:4135-47.
102. Wenzel U, Meissner B, Döring F, Daniel H. PEPT1-mediated uptake of dipeptides enhances the intestinal absorption of amino acids via transport system b(0,1). J Cell Physiol. 2001;186:251-9.
103. Bode-Boger SM, Boger RH, Creutzig A, Tsikas D, Gutzki FM, Alexander K, Frolich JC. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin Sci (Lond). 1994;87:303-10.
104. Castillo L, Chapman TE, Yu YM, Ajami A, Burke JF, Young VR. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol. 1993;265:E532-9.
105. Borgstrom L, Kagedal B, Paulsen O. Pharmacokinetics of N-acetyl-cysteine in man. Eur J Clin Pharmacol. 1986;31:217-22.
106. Olsson B, Johansson M, Gabrielsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol. 1988;34:77-82.
107. Baker DH. Comparative species utilization and toxicity of sulfur amino acids. J Nutr. 2006;136:S1670-5.
108. Wu G, Jaeger LA, Bazer FW, Rhoads JM. Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications. J Nutr Biochem. 2004;15:442-51.
109. Peterson RE, Imperato-McGinley J. Cortisol metabolism in the perinatal period. Prog Clin Biol Res. 1976;10:141-72.
110. Wu G, Knabe DA. Arginine synthesis in enterocytes of neonatal pigs. Am J Physiol. 1995;269:R621-9.
111. Kelly JJ, Williamson P, Martin A, Whitworth JA. Effects of oral L-arginine on plasma nitrate and blood pressure in cortisol-treated humans. J Hypertens. 2001;19:263-8.
112. Brosnan JT, Man KC, Hall DE, Colbourne SA, Brosnan ME. Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am J Physiol. 1983;244:E151-8.
113. Prior RL, Smith SB. Role of insulin in regulating amino acid metabolism in normal and alloxan-diabetic cattle. J Nutr. 1983;113:1016-31.
114. Wu G, Flynn NE. The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat. Biochem J. 1993;294:113-8.
115. Flodstrom M, Morris SM Jr, Eizirik DL. Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines. Cytokine. 1996;8:642-50.
116. Lux B, May P. Long-term observation of young cystinuric patients under ascorbic acid therapy. Urol Int. 1983;38:91-4.
117. Ragone R. Medical treatment of cystinuria with vitamin C. Am J Kidney Dis. 2000;35:1020.
118. Silk DBA, Perrett D, Stephens AD, Clark ML, Scowen EF. Intestinal absorption of cystine and cysteine in normal human subjects and patients with cystinuria. Clin Sci Mol Med. 1974;47:393-7.
119. Dahm LJ, Jones DP. Secretion of cysteine and glutathione from mucosa to lumen in rat small intestine. Am J Physiol. 1994;267:G292-300.
120. Martensson J, Jain A, Meister A. Glutathione is required for intestinal function. Proc Natl Acad Sci USA. 1990;87:1715-9.
121. Nkabyo YS, Gu LH, Jones DP, Ziegler TR. Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr. 2006;136:1242-8.
122. Dahm LJ, Jones DP. Rat jejunum controls luminal thiol-disulfide redox. J Nutr. 2000;130:2739-45.
123. Sjodin K, Nilsson E, Hallberg A, Tunek A. Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol. 1989;38:3981-5.
124. Marzullo L. An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Curr Opin Pediatr. 2005;17:239-45.
125. Mullins ME, Schmidt RU Jr, Jang TB. What is the rate of adverse events with intravenous versus oral N-acetylcysteine in pediatric patients? Ann Emerg Med. 2004;44:547-8.
126. Wright RO, Anderson AC, Lesko SL, Woolf AD, Linakis JG, Lewander WJ. Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose. J Toxicol Clin Toxicol. 1999;37:35-42.
127. Ternullo S. Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine. J Emerg Nurs. 2006;32:98-100.
128. Kao LW, Kirk MA, Furbee RB, Mehta NH, Skinner JR, Brizendine EJ. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med. 2003;42:741-50.
129. De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson M, Green A, Mitra D, Watanabe N, Nakamura H, et al. N-Acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000;30:915-29.
130. Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R, Jansen HM, MacNee W, Thomeer M, Wallaert B, et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 2005;353:2229-42.
131. Biondi-Zoccai GG, Lotrionte M, Abbate A, Testa L, Remigi E, Burzotta F, Valgimigli M, Romagnoli E, Crea F, et al. Compliance with QUOROM and quality of reporting of overlapping meta-analyses on the role of acetylcysteine in the prevention of contrast associated nephropathy: case study. BMJ. 2006;332:202-9.
132. Gannon MC, Nuttall JA, Nuttall FQ. Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal. Am J Clin Nutr. 2002;76:1016-22.
133. Taylor IL, Byrne WJ, Christie DL, Ament ME, Walsh JH. Effect of individual L-amino acids on gastric acid secretion and serum gastrin and pancreatic polypeptide release in humans. Gastroenterology. 1982;83:273-8.
134. Orihata M, Sarna SK. Inhibition of nitric oxide synthase delays gastric emptying of solid meals. J Pharmacol Exp Ther. 1994;271:660-70.
135. Konturek JW, Thor P, Domschke W. Effects of nitric oxide on antral motility and gastric emptying in humans. Eur J Gastroenterol Hepatol. 1995;7:97-102.
136. Savoye G, Jemaa Y, Mosni G, Savoye-Collet C, Morcamp P, Dechelotte P, Bouin M, Denis P, Ducrotte P. Effects of intragastric L-arginine administration on proximal stomach tone under basal conditions and after an intragastric diet. Dig Dis Sci. 2006;51:2147-53.
137. Smith MW, Witty R, Brown P. Effect of poly-L-arginine on rate of bovine IgG transport by newborn pig intestine. Nature. 1968;220:387-8.
138. Deshayes S, Morris MC, Divita G, Heitz F. Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cell Mol Life Sci. 2005;62:1839-49.