Generation of novel aav variants by directed evolution for improved cftr delivery to human ciliated airway epithelium

Molecular Therapy

Volumn 17, Issue 12, 2009, Pages 2067-2077

  Li, Wuping ^a,c   Zhang, Liqun ^a   Johnson, Jarrod S ^a   Zhijian, Wu ^a   Grieger, Joshua C ^a   Ping Jie, Xiao ^a   Drouin, Lauren M ^b   Agbandje Mckenna, Mavis ^b   Pickles, Raymond J ^a   Samulski, R Jude ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c INSTITUTE OF PATHOGEN BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE ION; PARVOVIRUS VECTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CHLORIDE TRANSPORT; CILIATED EPITHELIUM; CONTROLLED STUDY; CYSTIC FIBROSIS; DIRECTED MOLECULAR EVOLUTION; DRUG EFFICACY; DRUG SAFETY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; RESPIRATORY EPITHELIUM; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CAPSID;

BLOTTING, WESTERN; CELLS, CULTURED; CHLORIDES; CILIA; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DEPENDOVIRUS; EPITHELIUM; GENE THERAPY; GENETIC VECTORS; HELA CELLS; HUMANS; RECOMBINANT PROTEINS; RESPIRATORY SYSTEM; TRANSDUCTION, GENETIC; TRANSFECTION;

ADENO-ASSOCIATED VIRUS; MIRIDAE;

EID: 73849130017     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2009.155     Document Type: Article

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