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Volumn 84, Issue 2, 2010, Pages 976-982

A single amino acid substitution in HIV-1 reverse transcriptase significantly reduces virion release

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; EFAVIRENZ; GAG PROTEIN; LEUCINE; RNA DIRECTED DNA POLYMERASE; TRYPTOPHAN;

EID: 73849112602     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01532-09     Document Type: Article
Times cited : (14)

References (52)
  • 1
    • 0029097067 scopus 로고
    • Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers
    • Arrigo, S. J., and K. Huffman. 1995. Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers. J. Virol. 69:5988-5994.
    • (1995) J. Virol , vol.69 , pp. 5988-5994
    • Arrigo, S.J.1    Huffman, K.2
  • 2
    • 0025992146 scopus 로고
    • A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding
    • Baillon, J. G., N. T. Nashed, A. Kumar, S. H. Wilson, and D. M. Jerina. 1991. A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding. New Biol. 3:1015-1019.
    • (1991) New Biol , vol.3 , pp. 1015-1019
    • Baillon, J.G.1    Nashed, N.T.2    Kumar, A.3    Wilson, S.H.4    Jerina, D.M.5
  • 3
    • 0344980335 scopus 로고    scopus 로고
    • Association of murine leukemia virus Pol with virions, independent of Gag-Pol expression
    • Buchschacher, G. L., Jr., L. Yu, F. Murai, T. Friedmann, and A. Miyanohara. 1999. Association of murine leukemia virus Pol with virions, independent of Gag-Pol expression. J. Virol. 73:9632-9637.
    • (1999) J. Virol , vol.73 , pp. 9632-9637
    • Buchschacher Jr., G.L.1    Yu, L.2    Murai, F.3    Friedmann, T.4    Miyanohara, A.5
  • 4
    • 0029815034 scopus 로고    scopus 로고
    • Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease
    • Bukovsky, A., and H. Gottlinger. 1996. Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease. J. Virol. 70:6820-6825.
    • (1996) J. Virol , vol.70 , pp. 6820-6825
    • Bukovsky, A.1    Gottlinger, H.2
  • 5
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
    • Burns, J. C., T. Friedmann, W. Driever, M. Burrascano, and J. Yee. 1993. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl. Acad. Sci. U. S. A. 90:8033-8037.
    • (1993) Proc. Natl. Acad. Sci. U. S. A , vol.90 , pp. 8033-8037
    • Burns, J.C.1    Friedmann, T.2    Driever, W.3    Burrascano, M.4    Yee, J.5
  • 6
    • 18144399251 scopus 로고    scopus 로고
    • Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation
    • Buxton, P., G. Tachedjian, and J. Mak. 2005. Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation. J. Virol. 79:6338-6348.
    • (2005) J. Virol , vol.79 , pp. 6338-6348
    • Buxton, P.1    Tachedjian, G.2    Mak, J.3
  • 7
    • 0347949560 scopus 로고    scopus 로고
    • Incorporation of Pol into human immunodeficiency virus type 1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-Pol
    • Cen, S., M. Niu, J. Saadatmand, F. Guo, Y. Huang, G. J. Nabel, and L. Kleiman. 2004. Incorporation of Pol into human immunodeficiency virus type 1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-Pol. J. Virol. 78:1042-1049.
    • (2004) J. Virol , vol.78 , pp. 1042-1049
    • Cen, S.1    Niu, M.2    Saadatmand, J.3    Guo, F.4    Huang, Y.5    Nabel, G.J.6    Kleiman, L.7
  • 8
    • 0030729678 scopus 로고    scopus 로고
    • Generation of infectious virus particles by transient co-expression of human immunodeficiency virus type 1 gag mutants
    • Chen, Y. L., P. W. Ts'ai, C. C. Yang, and C. T. Wang. 1997. Generation of infectious virus particles by transient co-expression of human immunodeficiency virus type 1 gag mutants. J. Gen. Virol. 78:2497-2501.
    • (1997) J. Gen. Virol , vol.78 , pp. 2497-2501
    • Chen, Y.L.1    Ts'ai, P.W.2    Yang, C.C.3    Wang, C.T.4
  • 9
    • 58149107293 scopus 로고    scopus 로고
    • Mutations at human immunodeficiency virus type 1 reverse transcriptase tryptophan repeat motif attenuate the inhibitory effect of efavirenz on virus production
    • Chiang, C.-C., S.-M. Wang, Y.-T. Tseng, K.-J. Huang, and C.-T. Wang. 2009. Mutations at human immunodeficiency virus type 1 reverse transcriptase tryptophan repeat motif attenuate the inhibitory effect of efavirenz on virus production. Virology 383:261-270.
    • (2009) Virology , vol.383 , pp. 261-270
    • Chiang, C.-C.1    Wang, S.-M.2    Tseng, Y.-T.3    Huang, K.-J.4    Wang, C.-T.5
  • 10
    • 33646032383 scopus 로고    scopus 로고
    • A domain directly C-terminal to the major homology region of human immunodeficiency type 1 capsid protein plays a crucial role in directing both virus assembly and incorporation of Gag-Pol
    • Chien, A. I., W. H. Liao, D. M. Yang, and C. T. Wang. 2006. A domain directly C-terminal to the major homology region of human immunodeficiency type 1 capsid protein plays a crucial role in directing both virus assembly and incorporation of Gag-Pol. Virology 348:84-95.
    • (2006) Virology , vol.348 , pp. 84-95
    • Chien, A.I.1    Liao, W.H.2    Yang, D.M.3    Wang, C.T.4
  • 11
    • 0036118327 scopus 로고    scopus 로고
    • Coding sequences upstream of the human immunodeficiency virus type 1 reverse transcriptase domain in Gag-Pol are not essential for incorporation of the Pr160(gag-pol) into virus particles
    • Chiu, H. C., S. Y. Yao, and C. T. Wang. 2002. Coding sequences upstream of the human immunodeficiency virus type 1 reverse transcriptase domain in Gag-Pol are not essential for incorporation of the Pr160(gag-pol) into virus particles. J. Virol. 76:3221-3231.
    • (2002) J. Virol , vol.76 , pp. 3221-3231
    • Chiu, H.C.1    Yao, S.Y.2    Wang, C.T.3
  • 15
    • 41249088246 scopus 로고    scopus 로고
    • Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability
    • Figueiredo, A., S. Zelina, N. Sluis-Cremer, and G. Tachedjian. 2008. Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability. Curr. HIV Res. 6:130-137.
    • (2008) Curr. HIV Res , vol.6 , pp. 130-137
    • Figueiredo, A.1    Zelina, S.2    Sluis-Cremer, N.3    Tachedjian, G.4
  • 16
    • 0030008999 scopus 로고    scopus 로고
    • Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization
    • Ghosh, M., P. S. Jacques, D. W. Rodgers, M. Ottman, J. L. Darlix, and S. F. J. Le Grice. 1996. Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization. Biochemistry 35:8553-8562.
    • (1996) Biochemistry , vol.35 , pp. 8553-8562
    • Ghosh, M.1    Jacques, P.S.2    Rodgers, D.W.3    Ottman, M.4    Darlix, J.L.5    Le Grice, S.F.J.6
  • 17
    • 0342394457 scopus 로고
    • Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1
    • Gottlinger, H. G., J. G. Sodroski, and W. A. Haseltine. 1989. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U. S. A. 86:5781-5785.
    • (1989) Proc. Natl. Acad. Sci. U. S. A , vol.86 , pp. 5781-5785
    • Gottlinger, H.G.1    Sodroski, J.G.2    Haseltine, W.A.3
  • 18
    • 0028286320 scopus 로고
    • Folding of the multidomain human immunodeficiency virus type-I integrase
    • Grandgenett, D. P., and G. Goodarzi. 1994. Folding of the multidomain human immunodeficiency virus type-I integrase. Protein Sci. 3:888-897.
    • (1994) Protein Sci , vol.3 , pp. 888-897
    • Grandgenett, D.P.1    Goodarzi, G.2
  • 19
    • 0037379284 scopus 로고    scopus 로고
    • Rapid localization of Gag/GagPol complexes to detergent-resistant membrane during the assembly of human immunodeficiency virus type 1
    • Halwani, R., A. Khorchid, S. Cen, and L. Kleiman. 2003. Rapid localization of Gag/GagPol complexes to detergent-resistant membrane during the assembly of human immunodeficiency virus type 1. J. Virol. 77:3973-3984.
    • (2003) J. Virol , vol.77 , pp. 3973-3984
    • Halwani, R.1    Khorchid, A.2    Cen, S.3    Kleiman, L.4
  • 20
    • 0034947840 scopus 로고    scopus 로고
    • Gag-Pol supplied in trans is efficiently packaged and supports viral function in human immunodeficiency virus type 1
    • Hill, M. K., C. W. Hooker, D. Harrich, S. M. Crowe, and J. Mak. 2001. Gag-Pol supplied in trans is efficiently packaged and supports viral function in human immunodeficiency virus type 1. J. Virol. 75:6835-6840.
    • (2001) J. Virol , vol.75 , pp. 6835-6840
    • Hill, M.K.1    Hooker, C.W.2    Harrich, D.3    Crowe, S.M.4    Mak, J.5
  • 21
    • 0342524024 scopus 로고
    • Expression of Soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants
    • Hizi, A., C. McGill, and S. H. Hughes. 1988. Expression of Soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants. Proc. Natl. Acad. Sci. U. S. A. 85:1218-1222.
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 1218-1222
    • Hizi, A.1    McGill, C.2    Hughes, S.H.3
  • 22
    • 0030986290 scopus 로고    scopus 로고
    • Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein
    • Huang, M., and M. A. Martin. 1997. Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein. J. Virol. 71:4472-4478.
    • (1997) J. Virol , vol.71 , pp. 4472-4478
    • Huang, M.1    Martin, M.A.2
  • 23
    • 0037223722 scopus 로고    scopus 로고
    • Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication
    • Huang, W., A. Gamarnik, K. Limoli, C. J. Petropoulos, and J. M. Whitcomb. 2003. Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication. J. Virol. 77:1512-1523.
    • (2003) J. Virol , vol.77 , pp. 1512-1523
    • Huang, W.1    Gamarnik, A.2    Limoli, K.3    Petropoulos, C.J.4    Whitcomb, J.M.5
  • 24
    • 0023870815 scopus 로고
    • Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
    • Jacks, T., M. D. Power, F. R. Masiarz, P. A. Luciw, P. J. Barr, and H. E. Varmus. 1988. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature 331:280-283.
    • (1988) Nature , vol.331 , pp. 280-283
    • Jacks, T.1    Power, M.D.2    Masiarz, F.R.3    Luciw, P.A.4    Barr, P.J.5    Varmus, H.E.6
  • 25
    • 0028172953 scopus 로고
    • Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization
    • Jacques, P. S., B. M. Wohrl, M. Ottmann, J. L. Darlix, and S. F. Le Grice. 1994. Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization. J. Biol. Chem. 269:26472-26478.
    • (1994) J. Biol. Chem , vol.269 , pp. 26472-26478
    • Jacques, P.S.1    Wohrl, B.M.2    Ottmann, M.3    Darlix, J.L.4    Le Grice, S.F.5
  • 26
    • 0033950079 scopus 로고    scopus 로고
    • The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains
    • Kay, B. K., M. P. Williamson, and M. Sudol. 2000. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J. 14:231-241.
    • (2000) FASEB J , vol.14 , pp. 231-241
    • Kay, B.K.1    Williamson, M.P.2    Sudol, M.3
  • 28
    • 0026322839 scopus 로고
    • Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity
    • Krausslich, H. 1991. Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc. Natl. Acad. Sci. U. S. A. 88:3213-3217.
    • (1991) Proc. Natl. Acad. Sci. U. S. A , vol.88 , pp. 3213-3217
    • Krausslich, H.1
  • 30
    • 5144230443 scopus 로고    scopus 로고
    • Characterization of human immunodeficiency virus type 1 Pr160gag-pol mutants with truncations downstream of the protease domain
    • Liao, W.-H., and C.-T. Wang. 2004. Characterization of human immunodeficiency virus type 1 Pr160gag-pol mutants with truncations downstream of the protease domain. Virology 329:180-188.
    • (2004) Virology , vol.329 , pp. 180-188
    • Liao, W.-H.1    Wang, C.-T.2
  • 31
    • 0023019732 scopus 로고
    • Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus
    • Lightfoote, M. M., J. E. Coligan, T. M. Folks, A. S. Fauci, M. A. Martin, and S. Venkatesan. 1986. Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus. J. Virol. 60:771-775.
    • (1986) J. Virol , vol.60 , pp. 771-775
    • Lightfoote, M.M.1    Coligan, J.E.2    Folks, T.M.3    Fauci, A.S.4    Martin, M.A.5    Venkatesan, S.6
  • 32
    • 0037609791 scopus 로고    scopus 로고
    • Protein-protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces
    • Ma, B., T. Elkayam, H. Wolfson, and R. Nussinov. 2003. Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces. Proc. Natl. Acad. Sci. U. S. A. 100:5772-5777.
    • (2003) Proc. Natl. Acad. Sci. U. S. A , vol.100 , pp. 5772-5777
    • Ma, B.1    Elkayam, T.2    Wolfson, H.3    Nussinov, R.4
  • 33
    • 19444375120 scopus 로고    scopus 로고
    • Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions
    • Mulky, A., S. G. Sarafianos, Y. Jia, E. Arnold, and J. C. Kappes. 2005. Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions. J. Mol. Biol. 349:673-684.
    • (2005) J. Mol. Biol , vol.349 , pp. 673-684
    • Mulky, A.1    Sarafianos, S.G.2    Jia, Y.3    Arnold, E.4    Kappes, J.C.5
  • 34
    • 67650925011 scopus 로고    scopus 로고
    • The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: Role for RNA-Gag binding in the early stages of assembly
    • Ott, D. E., L. V. Coren, and T. Shatzer. 2009. The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: role for RNA-Gag binding in the early stages of assembly. J. Virol. 83:7718-7727.
    • (2009) J. Virol , vol.83 , pp. 7718-7727
    • Ott, D.E.1    Coren, L.V.2    Shatzer, T.3
  • 35
    • 0026018243 scopus 로고
    • Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production
    • Park, J., and C. D. Morrow. 1991. Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production. J. Virol. 65:5111-5117.
    • (1991) J. Virol , vol.65 , pp. 5111-5117
    • Park, J.1    Morrow, C.D.2
  • 36
    • 0024334170 scopus 로고
    • Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity
    • Peng, C., B. K. Ho, T. W. Chang, and N. T. Chang. 1989. Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. J. Virol. 63:2550-2556.
    • (1989) J. Virol , vol.63 , pp. 2550-2556
    • Peng, C.1    Ho, B.K.2    Chang, T.W.3    Chang, N.T.4
  • 37
    • 0029978462 scopus 로고    scopus 로고
    • Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation
    • Quillent, C., A. M. Borman, S. Paulous, C. Dauguet, and F. Clavel. 1996. Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation. Virology 219:29-36.
    • (1996) Virology , vol.219 , pp. 29-36
    • Quillent, C.1    Borman, A.M.2    Paulous, S.3    Dauguet, C.4    Clavel, F.5
  • 38
    • 0028969065 scopus 로고
    • Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity
    • Rose, J. R., L. M. Babe, and C. S. Craik. 1995. Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity. J. Virol. 69:2751-2758.
    • (1995) J. Virol , vol.69 , pp. 2751-2758
    • Rose, J.R.1    Babe, L.M.2    Craik, C.S.3
  • 39
    • 0035138477 scopus 로고    scopus 로고
    • Maintenance of the Gag/Gag-Pol ratio is important for human immunodeficiency virus type 1 RNA dimerization and viral infectivity
    • Shehu-Xhilaga, M., S. M. Crowe, and J. Mak. 2001. Maintenance of the Gag/Gag-Pol ratio is important for human immunodeficiency virus type 1 RNA dimerization and viral infectivity. J. Virol. 75:1834-1841.
    • (2001) J. Virol , vol.75 , pp. 1834-1841
    • Shehu-Xhilaga, M.1    Crowe, S.M.2    Mak, J.3
  • 40
    • 0027340274 scopus 로고
    • Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles
    • Smith, A. J., N. Srinivasakumar, M. L. Hammarskjold, and D. Rekosh. 1993. Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles. J. Virol. 67:2266-2275.
    • (1993) J. Virol , vol.67 , pp. 2266-2275
    • Smith, A.J.1    Srinivasakumar, N.2    Hammarskjold, M.L.3    Rekosh, D.4
  • 41
    • 0029130067 scopus 로고
    • Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation
    • Srinivasakumar, N., M. L. Hammarskjold, and D. Rekosh. 1995. Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation. J. Virol. 69:6106-6114.
    • (1995) J. Virol , vol.69 , pp. 6106-6114
    • Srinivasakumar, N.1    Hammarskjold, M.L.2    Rekosh, D.3
  • 42
    • 0004220419 scopus 로고    scopus 로고
    • J. Coffin, S. Hughes, and H. Varmus ed, Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Swanstrom, R., and J. Wills. 1997. Synthesis, assembly and processing of viral proteins, p. 263-334. In J. Coffin, S. Hughes, and H. Varmus (ed.), Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1997) Synthesis, assembly and processing of viral proteins , pp. 263-334
    • Swanstrom, R.1    Wills, J.2
  • 43
    • 0034612275 scopus 로고    scopus 로고
    • Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase
    • Tachedjian, G., H.-E. G. Aronson, and S. P. Goff. 2000. Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase. Proc. Natl. Acad. Sci. U. S. A. 97:6334-6339.
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , pp. 6334-6339
    • Tachedjian, G.1    Aronson, H.-E.G.2    Goff, S.P.3
  • 44
    • 0037436335 scopus 로고    scopus 로고
    • Tachedjian, G., H.-E. G. Aronson, M. de los Santos, J. Seehra, J. M. McCoy, and S. P. Goff. 2003. Role of residues in the tryptophan repeat motif for HIV-1 reverse transcriptase dimerization. J. Mol. Biol. 326:381-396.
    • Tachedjian, G., H.-E. G. Aronson, M. de los Santos, J. Seehra, J. M. McCoy, and S. P. Goff. 2003. Role of residues in the tryptophan repeat motif for HIV-1 reverse transcriptase dimerization. J. Mol. Biol. 326:381-396.
  • 45
    • 11844282799 scopus 로고    scopus 로고
    • Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation
    • Tachedjian, G., K. L. Moore, S. P. Goff, and N. Sluis-Cremer. 2005. Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation. FEBS Lett. 579:379-384.
    • (2005) FEBS Lett , vol.579 , pp. 379-384
    • Tachedjian, G.1    Moore, K.L.2    Goff, S.P.3    Sluis-Cremer, N.4
  • 46
    • 0035912717 scopus 로고    scopus 로고
    • Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
    • Tachedjian, G., M. Orlova, S. G. Sarafianos, E. Arnold, and S. P. Goff. 2001. Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proc. Natl. Acad. Sci. U. S. A. 98:7188-7193.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 7188-7193
    • Tachedjian, G.1    Orlova, M.2    Sarafianos, S.G.3    Arnold, E.4    Goff, S.P.5
  • 47
    • 33644683832 scopus 로고    scopus 로고
    • Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse Transcriptase
    • Venezia, C. F., K. J. Howard, M. E. Ignatov, L. A. Holladay, and M. D. Barkley. 2006. Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse Transcriptase. Biochemistry 45:2779-2789.
    • (2006) Biochemistry , vol.45 , pp. 2779-2789
    • Venezia, C.F.1    Howard, K.J.2    Ignatov, M.E.3    Holladay, L.A.4    Barkley, M.D.5
  • 48
    • 0034056030 scopus 로고    scopus 로고
    • Assembly and processing of human immunodeficiency virus Gag mutants containing a partial replacement of the matrix domain by the viral protease domain
    • Wang, C.-T., Y.-C. Chou, and C.-C. Chiang. 2000. Assembly and processing of human immunodeficiency virus Gag mutants containing a partial replacement of the matrix domain by the viral protease domain. J. Virol. 74:3418-3422.
    • (2000) J. Virol , vol.74 , pp. 3418-3422
    • Wang, C.-T.1    Chou, Y.-C.2    Chiang, C.-C.3
  • 49
    • 23244448649 scopus 로고    scopus 로고
    • Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
    • Wapling, J., K. L. Moore, S. Sonza, J. Mak, and G. Tachedjian. 2005. Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer. J. Virol. 79:10247-10257.
    • (2005) J. Virol , vol.79 , pp. 10247-10257
    • Wapling, J.1    Moore, K.L.2    Sonza, S.3    Mak, J.4    Tachedjian, G.5
  • 50
    • 0030859022 scopus 로고    scopus 로고
    • Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization
    • Wohrl, B. M., R. Krebs, S. H. Thrall, S. F. Le Grice, A. J. Scheidig, and R. S. Goody. 1997. Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization. J. Biol. Chem. 272:17581-17587.
    • (1997) J. Biol. Chem , vol.272 , pp. 17581-17587
    • Wohrl, B.M.1    Krebs, R.2    Thrall, S.H.3    Le Grice, S.F.4    Scheidig, A.J.5    Goody, R.S.6
  • 51
    • 0031820968 scopus 로고    scopus 로고
    • Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation
    • Yu, Q., M. Ottmann, C. Pechoux, S. Le Grice, and J. L. Darlix. 1998. Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation. J. Virol. 72:7676-7680.
    • (1998) J. Virol , vol.72 , pp. 7676-7680
    • Yu, Q.1    Ottmann, M.2    Pechoux, C.3    Le Grice, S.4    Darlix, J.L.5
  • 52
    • 0029013602 scopus 로고
    • Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing
    • Zybarth, G., and C. Carter. 1995. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing. J. Virol. 69:3878-3884.
    • (1995) J. Virol , vol.69 , pp. 3878-3884
    • Zybarth, G.1    Carter, C.2


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