Coding sequences upstream of the human immunodeficiency virus type 1 reverse transcriptase domain in Gag-Pol are not essential for incorporation of the Pr160gag-pol into virus particles

Journal of Virology

Volumn 76, Issue 7, 2002, Pages 3221-3231

  Chiu, Hsu Chen ^a   Yao, Szu Yung ^a   Wang, Chin Tien ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; MUTANT PROTEIN; PLASMID DNA; POL PROTEIN; PROTEIN P160; PROTEIN PRECURSOR; RNA DIRECTED DNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; SUCROSE DENSITY GRADIENT CENTRIFUGATION; VIRION; VIRUS ASSEMBLY; VIRUS PARTICLE; WESTERN BLOTTING;

CAPSID; CELL LINE; GENE DELETION; GENE PRODUCTS, GAG; GENE PRODUCTS, POL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MYRISTIC ACID; PLASMIDS; PROTEIN PRECURSORS; TRANSFECTION; VIRUS ASSEMBLY;

EID: 0036118327     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.7.3221-3231.2002     Document Type: Article

References (37)

1. Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers
2. Myristoylation-dependent replication and assembly of human immunodeficiency virus 1
3. Association of murine leukemia virus Pol with virions, independent of Gag-Pol expression
4. Assembly and processing of avian retroviral gag polyproteins containing linked protease dimers
5. Complementation of integrase function in HIV-1 virions
6. HIV Gag proteins: Diverse functions in the virus life cycle
7. Role of capsid precursor processing and myristylation in morphogenesis and infectivity of human immunodeficiency virus 1
8. Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: Posttranslational modifications, proteolytic processing, and complete amino acid sequences
9. gag-pol into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein
10. Macromolecular interactions in the assembly of HIV and other retroviruses
11. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
12. The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency
13. Active human immunodeficiency virus protease is required for viral infectivity
14. Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity
15. Standardized and simplified nomenclature for proteins common to all retroviruses
16. The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol protein
17. Role of major homology region of human immunodeficiency virus type 1 in virion morphogenesis
18. The gag gene products of human immunodeficiency virus type 1: Alignment within the gag open reading frame, identification of posttranslation modifications, and evidence for alternative gag precursors
19. Construction and use of a human immunodeficiency virus: Vector for analysis of virus infectivity
20. Myristylation of gag proteins of HIV-1 plays an important role in virus assembly
21. Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production
22. gag and is incorporated into virus-like particles
23. Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase
24. Incorporation of Vpr into human immunodeficiency virus type 1 virions: Requirement for the p6 region of gag and mutational analysis
25. Role of human immunodeficiency virus type 1-specific protease in core particle maturation and viral infectivity
26. Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity
27. gag-pol from human immunodeficiency virus type 1 into virus-like particles
28. Characterization of deletion mutations in the capsid region of human immunodeficiency virus type I that affect particle formation and Gag-Pol precursor incorporation
29. Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants
30. Analysis of minimal human immunodeficiency virus type 1 gag coding sequences capable of virus-like particle assembly and release
31. Assembly and processing of HIV gag mutants containing a partial replacement of the matrix domain by the viral protease domain
32. Assembly of HIV gag-β-galactosidase fusion proteins into virus particles
33. Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant
34. Form, function, and use of retroviral gag proteins
35. Functional RT and IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein
36. Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx
37. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing