The role of hyperglycemia in burned patients: Evidence-based studies

Shock

Volumn 33, Issue 1, 2010, Pages 5-13

  Mecott, Gabriel A ^a,b   Al Mousawi, Ahmed M ^a,b   Gauglitz, Gerd G ^a,b   Herndon, David N ^a,b   Jeschke, Marc G ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Burns; Fenofibrate; Glucose modulation; Intensive insulin; Metformin

Indexed keywords

CYTOKINE; FENOFIBRATE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 6; METFORMIN; PLACEBO;

ADULT; BACTEREMIA; BURN; CHILD; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; IMMUNE SYSTEM; INFECTION RISK; INFECTIOUS COMPLICATION; INSULIN RESISTANCE; INSULIN TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; MORTALITY; PATHOPHYSIOLOGY; PNEUMONIA; REVIEW; WOUND INFECTION;

BLOOD GLUCOSE; BURNS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; METFORMIN; PROCETOFEN;

EID: 73849085396     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181af0494     Document Type: Review

References (124)

1. Demling RH: Burns: what are the pharmacological treatment options. Expert Opin Pharmacother 9(11):1895-1908, 2008.
2. Herndon DN, Tompkins RG: Support of the metabolic response to burn injury. Lancet 363(9424):1895-1902, 2004.
3. American Burn Association/American College of Surgeons: Guidelines for the operation of burn centers. J Burn Care Res 28(1):134-141, 2007.
4. Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN: Pathophysiologic response to severe burn injury. Ann Surg 248(3):387-401, 2008.
5. Gauglitz GG, Herndon DN, Jeschke MG: Insulin resistance postburn: underlying mechanisms and current therapeutic strategies. J Burn Care Res 29(5):683-694, 2008.
6. Bernard C: Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux. 2 Tomes. Edité par Albert Dastre. Paris, France: Baillière et Fils, 1878.
7. Toschlog EA, Newton C, Allen N, Newell MA, Goettler CE, Schenarts PJ, Bard MR, Sagraves SG, Rotondo MF: Morbidity reduction in critically ill trauma patients through use of a computerized insulin infusion protocol: a preliminary study. J Trauma 62(6):1370-1375, 2007; discussion 1375-1376.
8. Goodall M, Stone C, Haynes BW Jr: Urinary output of adrenaline and noradrenaline in severe thermal burns. Ann Surg 145(4):479-487, 1957.
9. Wahl WL, Taddonio M, Maggio PM, Arbabi S, Hemmila MR: Mean glucose values predict trauma patient mortality. J Trauma 65(1):42-47, 2008; discussion 47-48.
10. McCowen KC, Malhotra A, Bistrian BR: Stress-induced hyperglycemia. Crit Care Clin 17(1):107-124, 2001.
11. Hart DW, Wolf SE, Chinkes DL, Gore DC, Mlcak RP, Beauford RB, Obeng MK, Lal S, Gold WF, Wolfe RR, et al.: Determinants of skeletal muscle catabolism after severe burn. Ann Surg 232(4):455-465, 2000.
12. Jeschke MG, Chinkes DL, Finnerty CC, Przkora R, Pereira CT, Herndon DN: Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients. Crit Care Med 35(2):579-583, 2007.
13. Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M: Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 51(3):540-544, 2001.
14. Gelfand RA, Matthews DE, Bier DM, Sherwin RS: Role of counterregulatory hormones in the catabolic response to stress. J Clin Invest 74(6):2238-2248, 1984.
15. Losser MR, Bernard C, Beaudeux JL, Pison C, Payen D: Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits. J Appl Physiol 83(5):1566-1574, 1997.
16. Wilmore DW: Carbohydrate metabolism in trauma. Clin Endocrinol Metab 5(3):731-745, 1976.
17. Holm C, Horbrand F, Mayr M, von Donnersmarck GH, Muhlbauer W: Acute hyperglycaemia following thermal injury: friend or foe? Resuscitation 60(1): 71-77, 2004.
18. Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL: Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery 144(4):629-635, 2008; discussion 635-637.
19. Chatham JC, Not LG, Fulop N, Marchase RB: Hexosamine biosynthesis and protein O-glycosylation: the first line of defense against stress, ischemia, and trauma. Shock 29(4):431-440, 2008.
20. Van Den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in the critically ill patients. N Engl J Med 345(19):1359-1367, 2001.
21. Van Den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P: Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 31(2):359-366, 2003. (Pubitemid 36232926)
22. Van Den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, VanWijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 354(5):449-461, 2006.
23. Merz TM, Finfer S: Intensive insulin treatment. Minerva Anestesiol [Epub ahead of print] 2009.
24. Mann EA, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE: The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers. J Burn Care Res 29(5):718-723, 2008.
25. Tredget EE, Yu YM: The metabolic effects of thermal injury. World J Surg 16(1):68-79, 1992.
26. Finnerty CC, Herndon DN, Przkora R, Pereira CT, Oliveira HM, Queiroz DM, Rocha AM, Jeschke MG: Cytokine expression profile over time in severely burned pediatric patients. Shock 26(1):13-19, 2006.
27. Turina M, Christ-Crain M, Polk HC Jr: Diabetes and hyperglycemia: strict glycemic control. Crit Care Med 34(9 suppl):S291-S300, 2006.
28. Jeschke MG, Micak RP, Finnerty CC, Herndon DN: Changes in liver function and size after a severe thermal injury. Shock 28(2):172-177, 2007.
29. Yu CC, Hua HA, Tong C: Hyperglycaemia after burn injury. Burns 15(3):145-146, 1989.
30. Wolfe RR, Jahoor F, Herndon DN, Miyoshi H: Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. Surgery 110(1):54-67, 1991.
31. Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA: Burn injury causes mitochondrial dysfunction in skeletal muscle. Proc Natl Acad Sci U S A 102(15): 5368-5373, 2005.
32. Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML: Profiling of dynamic changes in hypermetabolic livers. Biotechnol Bioeng 83(4): 400-415, 2003.
33. Harrison TS, Seaton JF, Feller I: Relationship of increased oxygen consumption to catecholamine excretion in thermal burns. Ann Surg 165(2):169-172, 1967.
34. Goodall MC, Alton H: Dopamine (3-hydroxytyramine) replacement and metabolism in sympathetic nerve and adrenal medullary depletions after prolonged thermal injury. J Clin Invest 48(9):1761-1767, 1969.
35. Wolfe RR: Herman Award Lecture, 1996: relation of metabolic studies to clinical nutritionYthe example of burn injury. Am J Clin Nutr 64(5):800Y808, 1996.
36. Vaughan GM, Becker RA, Unger RH, Ziegler MG, Siler-Khodr TM, Pruitt BA Jr, Mason AD Jr: Nonthyroidal control of metabolism after burn injury: possible role of glucagon. Metabolism 34(7):637-641, 1985.
37. Lee SM, Clemens MG: Glucagon increases gap junctional intercellular communication via cAMP in the isolated perfused rat liver. Shock 22(1): 82-87, 2004.
38. Jahoor F, Herndon DN, Wolfe RR: Role of insulin and glucagon in the response of glucose and alanine kinetics in burn-injured patients. J Clin Invest 78(3):807-814, 1986.
39. Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ: Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 341(11):785-792, 1999.
40. Mastorakos G, Chrousos GP, Weber JS: Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 77(6):1690-1694, 1993.
41. Lang CH, Dobrescu C, Bagby GJ: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130(1):43-52, 1992.
42. Akita S, Akino K, Ren SG, Melmed S, Imaizumi T, Hirano A: Elevated circulating leukemia inhibitory factor in patients with extensive burns. J Burn Care Res 27(2):221-225, 2006.
43. Heise T, Heinemann L, Starke AA: Simulated postaggression metabolism in healthy subjects: metabolic changes and insulin resistance. Metabolism 47(10):1263-1268, 1998.
44. Spitzer JJ, Bagby GJ, Meszaros K, Lang CH: Altered control of carbohydrate metabolism in endotoxemia. Prog Clin Biol Res 286:145-165, 1989.
45. Shamoon H, Hendler R, Sherwin RS: Synergistic interactions among antiinsulin hormones in the pathogenesis of stress hyperglycemia in humans. 52(6):1235-1241, 1981.
46. Walker PS, Ramlal T, Sarabi V, Koivisto UM, Bilan PJ, Pessin JE, Klip A: Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription. J Biol Chem 265(3):1516-1523, 1990.
47. D'Angelica M, Yuman Fong M: In Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 18th ed. Philadelphia, Pa: Saunders/Elsevier; 2007: 997-1056.
48. Gammeltoft S, Van Obberghen E: Protein kinase activity of the insulin receptor. Biochem J 235(1):1-11, 1986.
49. Cree MG, Aarsland A, Herndon DN, Wolfe RR: Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med 35 (9 suppl):S476-S483, 2007.
50. Stadie WC, Haugaard N, Vaughan M: The quantitative relation between insulin and its biological activity. J Biol Chem 200(2):745-751, 1953.
51. Chernick SS, Chaikoff IL: Insulin and hepatic utilization of glucose for lipogenesis. J Biol Chem 186(2):535-542, 1950.
52. Martin BR, Denton RM, Pask HT, Randle PJ: Mechanisms regulating adipose-tissue pyruvate dehydrogenase. Biochem J 129(3):763-773, 1972.
53. Navarro P, Valverde AM, Benito M, Lorenzo M: Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner. Exp Cell Res 243(2):213-221, 1998.
54. Flakoll PJ, Hill JO, Abumrad NN: Acute hyperglycemia enhances proteolysis in normal man. Am J Physiol 265(5 Pt 1):E715-E721, 1993.
55. Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK: Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol 4:214, 2008.
56. Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP: Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med 30(11):2438-2442, 2002.
57. Little RA, Henderson A, Frayn KN, Galasko CS, White RH: The disposal of intravenous glucose studied using glucose and insulin clamp techniques in sepsis and trauma in man. Acta Anaesthesiol Belg 38(4):275-279, 1987.
58. Black PR, Brooks DC, Bessey PQ, Wolfe RR, Wilmore DW: Mechanisms of insulin resistance following injury. Ann Surg 196(4):420-435, 1982.
59. Cree MG, Zwetsloot JJ, Herndon DN, Qian T, Morio B, Fram R, Sanford AP, Aarsland A, Wolfe RR: Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg 245(2):214-221, 2007.
60. Carter EA, Burks D, Fischman AJ, White M, Tompkins RG: Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. Int J Mol Med 14(4):653-658, 2004.
61. Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA: Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem 272(40):25289-25295, 1997.
62. Kasper SO, Castle SM, Daley BJ, Enderson BL, Karlstad MD: Blockade of the renin-angiotensin system improves insulin sensitivity in thermal injury. Shock 26(5):485-488, 2006.
63. Shin S, Britt RC, Reed SF, Collins J, Weireter LJ, Britt LD: Early glucose normalization does not improve outcome in the critically ill trauma population. Am Surg 73(8):769-772, 2007; discussion 772.
64. Schenk S, Saberi M, Olefsky JM: Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118(9):2992-3002, 2008.
65. Lim JH, Lee HJ, Ho Jung M, Song J: Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance. Cell Signal 21(1):169-177, 2008.
66. Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M, Yamasaki Y: Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 38(5-6):782-793, 2006.
67. Deng J, Wang G, Huang Q, Yan Y, Li K, Tan W, Jin C, Wang Y, Liu J: Oxidative stress-induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma. Free Radic Biol Med 44(3):375-385, 2008.
68. Murphy JT, Giroir B, Horton JW: Thermal injury alters myocardial sarcoplasmic reticulum calcium channel function. J Surg Res 82(2):244-252, 1999.
69. Gauglitz GG, Song J, Herndon DN, Finnerty CC, Boehning DF, Barral JM, Jeschke MG: Characterization of the inflammatory response during acute and postacute phases after severe burn. Shock 30(5):503-507, 2008.
70. Wellen KE, Hotamisligil GS: Inflammation, stress, and diabetes. J Clin Invest 115(5):1111-1119, 2005.
71. Aguirre V, Uchida T, Yenush L, Davis R, White MF: The c-Jun NH(2)- terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275(12): 9047-9054, 2000.
72. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306(5695): 457-461, 2004.
73. Delarue J, Magnan C: Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care 10(2):142-148, 2007.
74. Koh EH, Lee WJ, Kim MS, Park JY, Lee IK, Lee KU: Intracellular Fatty Acid metabolism in skeletal muscle and insulin resistance. Curr Diabetes Rev 1(3):331-336, 2005.
75. Randle PJ: Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4):263-283, 1998.
76. Li F, Guo ZR, Chai JK, Sheng Z: Effects of escharectomy during shock stage on the plasma lipid and serum free fatty acid levels in scalded rats. Zhonghua Shao Shang Za Zhi 19(4):206-208, 2003.
77. Cree MG, Zwetsloot JJ, Herndon DN, Newcomer BR, Fram RY, Angel C, Green JM, Dohm GL, Sun D, Aarsland A, et al.: Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res 29(4):585-594, 2008.
78. Jeevanandam M, Young DH, Schiller WR: Glucose turnover, oxidation, and indices of recycling in severely traumatized patients. J Trauma 30(5): 582-589, 1990.
79. Cree MG, Fram RY, Herndon DN, Qian T, Angel C, Green JM, Mlcak R, Aarsland A, Wolfe RR: Human mitochondrial oxidative capacity is acutely impaired after burn trauma. Am J Surg 196(2):234-239, 2008.
80. Vanhorebeek I, Ellger B, De Vos R, Boussemaere M, Debaveye Y, Vander Perre S, Rabbani N, Thornalley PJ, Van Den Berghe G: Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Crit Care Med 37(4):1355-1364, 2009.
81. Kelley DE, He J, Menshikova EV, Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51(10):2944-2950, 2002.
82. Gauglitz GG, Herndon DN, Kulp GA, Meyer WJ 3rd, Jeschke MG: Abnormal Insulin Sensitivity Persists up to Three Years in Pediatric Patients Post-Burn. J Clin Endocrinol Metab 94(5):1656-1664, 2009.
83. Tuggle DW, Kuhn MA, Jones SK, Garza JJ, Skinner S: Hyperglycemia and infections in pediatric trauma patients. Am Surg 74(3):195-198, 2008.
84. Black CT, Hennessey PJ, Andrassy RJ: Short-term hyperglycemia depresses immunity through nonenzymatic glycosylation of circulating immunoglobulin. J Trauma 30(7):830-832, 1990; discussion 832-833.
85. Reinhold D, Ansorge S, Schleicher ED: Elevated glucose levels stimulate transforming growth factor-beta 1 (TGF-beta 1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Horm Metab Res 28(6):267-270, 1996.
86. Verhofstad MH, Hendriks T: Complete prevention of impaired anastomotic healing in diabetic rats requires preoperative blood glucose control. Br J Surg 83(12):1717-1721, 1996.
87. Mowlavi A, Andrews K, Milner S, Herndon DN, Heggers JP: The effects of hyperglycemia on skin graft survival in the burn patient. Ann Plast Surg 45(6):629-632, 2000.
88. Childs C, Heath DF, Little RA, Brotherston M: Glucose metabolism in children during the first day after burn injury. Arch Emerg Med 7(3): 135-147, 1990.
89. Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM: Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 59(1):80-83, 2005. (Pubitemid 41271642)
90. Bochicchio GV, Salzano L, Joshi M, Bochicchio K, Scalea TM: Admission preoperative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg 71(2): 171-174, 2005.
91. Sperry JL, Frankel HL, Vanek SL, Nathens AB, Moore EE, Maier RV, Minei JP: Early hyperglycemia predicts multiple organ failure and mortality but not infection. J Trauma 63(3):487-493, 2007; discussion 493-494.
92. Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA 290(15):2041-2047, 2003.
93. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al.: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36(1):296-327, 2008.
94. The George Institute: Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm RegulationVNICE-SUGAR. 2007. Available at: http://www.thegeorgeinstitute.org/research/critical-care-&- trauma/research/normoglycaemia-in-intensive-care-evaluation-nice.cfm. Accessed: January 21, 2009.
95. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, et al.: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360(13):1283-1297, 2009.
96. Langouche L, Vanhorebeek I, Van Den Berghe G: Therapy insight: the effect of tight glycemic control in acute illness. Nat Clin Pract Endocrinol Metab 3(3):270Y278, 2007.
97. Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79(8):992-1000, 2004.
98. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, et al.: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358(2):125-139, 2008.
99. Pham TN, Warren AJ, Phan HH, Molitor F, Greenhalgh DG, Palmieri TL: Impact of tight glycemic control in severely burned children. J Trauma 59(5):1148-1154, 2005.
100. Cochran A, Davis L, Morris SE, Saffle JR: Safety and efficacy of an intensive insulin protocol in a burn-trauma intensive care unit. J Burn Care Res 29(1):187-191, 2008.
101. Dugo L, Collin M, Thiemermann C: Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock 27(2):113-123, 2007.
102. de Oliveira Martins J, Meyer-Pflug AR, Alba-Loureiro TC, Melbostad H, Costa da Cruz JW, Coimbra R, Curi R, Sannomiya P: Modulation of lipopolysaccharide-induced acute lung inflammation: Role of insulin. Shock 25(3):260Y266, 2006. (Pubitemid 43755951)
103. Wheeler EE, Challacombe DN: The trophic action of growth hormone, insulin-like growth factor-I, and insulin on human duodenal mucosa cultured in vitro. Gut 40(1):57-60, 1997.
104. Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai M, Wolfe RR, Herndon DN: Effects of insulin on wound healing. J Trauma 44(2):342-345, 1998.
105. Ottlecz A, Koltai M, Blazso G, Minker E: Contribution to the regulatory role of insulin in inflammation and anaphylaxis. Int Arch Allergy Appl Immunol 56(3):284-286, 1978. (Pubitemid 8262429)
106. Burton JL, Elsasser TH, Rumsey TS, Lunney JK, McBride BW: Immune responses of growing beef steers treated with estrogen/progesterone implants or insulin injections. Domest Anim Endocrinol 10(1):31-44, 1993.
107. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van Den Berghe G: Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 88(3):1082-1088, 2003.
108. Cuschieri J, Bulger E, Grinsell R, Garcia I, Maier RV: Insulin regulates macrophage activation through activin A. Shock 29(2):285-290, 2008.
109. Przkora R, Herndon DN, Finnerty CC, Jeschke MG: Insulin attenuates the cytokine response in a burn wound infection model. Shock 27(2):205-208, 2007.
110. Porte D Jr, Schwartz MW: Diabetes complications: why is glucose potentially toxic? Science 272(5262):699-700, 1996.
111. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulin-dependent diabetes mellitus. N Engl J Med 329(14):977-986, 1993.
112. Gore DC, Herndon DN, Wolfe RR: Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury. J Trauma 59(2):316-322, 2005; discussion 322-323.
113. Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE: Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333(9):550-554, 1995.
114. Wollen N, Bailey CJ: Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin. Biochem Pharmacol 37(22):4353-4358, 1988.
115. Gore DC, Wolf SE, Herndon DN, Wolfe RR: Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients. JPEN J Parenter Enteral Nutr 26(5):271-277, 2002.
116. Riesenman PJ, Braithwaite SS, Cairns BA: Metformin-associated lactic acidosis in a burn patient. J Burn Care Res 28(2):342-347, 2007.
117. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 163(21):2594-2602, 2003.
118. Gore DC, Wolf SE, Herndon DN, Wolfe RR: Metformin blunts stressinduced hyperglycemia after thermal injury. J Trauma 54(3):555-561, 2003.
119. Gore DC, Wolf SE, Sanford A, Herndon DN, Wolfe RR: Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. Ann Surg 241(2):334-342, 2005.
120. Song J, Wolf SE, Herndon DN, Wu XW, Jeschke MG: Second hit post burn increased proximal gut mucosa epithelial cells damage. Shock 30(2): 184-188, 2008.
121. Nonogaki K, Iguchi A: Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines. Trends Endocrinol Metab 8(5):192-197, 1997.
122. Metzger S, Nusair S, Planer D, Barash V, Pappo O, Shilyansky J, Chajek- Shaul T: Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development of hypoglycemia in mice bearing interleukin-1beta- secreting tumor. Endocrinology 145(11):5150Y5156, 2004.
123. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D: Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106(16):2067-2072, 2002.
124. Quinn JA, Snyder SL, Berghoff JL, Colombo CS, Jacobi J: A practical approach to hyperglycemia management in the intensive care unit evaluation of an intensive insulin infusion protocol. Pharmacotherapy 26(10):1410-1420, 2006.