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Volumn 74, Issue 3, 2009, Pages 191-205

Evolutionary Conservation of the Signaling Proteins Upstream of Cyclic aMP-dependentKinase and Protein Kinase C in Gastropod Mollusks Kinase and Protein Kinase C in gastropod mollusks

Author keywords

Adenylate cyclase; Aplysia; Learning and memory; Phospholipase C; Protein kinase A; Serotonin; Signal transduction; Synaptic plasticity

Indexed keywords

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EVOLUTION; GASTROPODA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONAL PLASTICITY; PROTEIN KINASE C; TYPE C PHOSPHOLIPASES;

EID: 73649119541     PISSN: 00068977     EISSN: None     Source Type: Journal    
DOI: 10.1159/000258666     Document Type: Review
Times cited : (16)

References (122)
  • 1
    • 0025790169 scopus 로고
    • Biochemical studies of stimulus convergence during classical conditioning in Aplysia : DDual regulation of adenylate cyclase by Ca2+/ calmodulin and transmitter
    • Abrams TW, Karl KA, Kandel ER (1991) Biochemical studies of stimulus convergence during classical conditioning in Aplysia : Dual regulation of adenylate cyclase by Ca2+/ calmodulin and transmitter. J Neurosci 11: 2655-2665.
    • (1991) J Neurosci , vol.11 , pp. 2655-2665
    • Abrams, T.W.1    Karl, K.A.2    Kandel, E.R.3
  • 2
    • 0031954502 scopus 로고    scopus 로고
    • Analysis of sequence-dependent interactions between transient calcium and transmitter stimuli in activating adenylyl cyclase in Aplysia : PPossible contribution to CS-US sequence requirement during conditioning
    • Abrams TW, Yovell Y, Onyike CU, Cohen JE, Jarrard HE (1998) Analysis of sequence-dependent interactions between transient calcium and transmitter stimuli in activating adenylyl cyclase in Aplysia : Possible contribution to CS-US sequence requirement during conditioning. Learn Mem 4: 496-509.
    • (1998) Learn Mem , vol.4 , pp. 496-509
    • Abrams, T.W.1    Yovell, Y.2    Onyike, C.U.3    Cohen, J.E.4    Jarrard, H.E.5
  • 3
    • 0032222415 scopus 로고    scopus 로고
    • Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory
    • Antoni FA, Palkovits M, Simpson J, Smith SM, Leitch AL, Rosie R, Fink G, Paterson JM (1998) Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. J Neurosci 18: 9650-9661.
    • (1998) J Neurosci , vol.18 , pp. 9650-9661
    • Antoni, F.A.1    Palkovits, M.2    Simpson, J.3    Smith, S.M.4    Leitch, A.L.5    Rosie, R.6    Fink, G.7    Paterson, J.M.8
  • 4
    • 0037427024 scopus 로고    scopus 로고
    • Activity-dependent presynaptic facilitation and Hebbian LTP are both required and interact during classical conditioning in Aplysia
    • Antonov I, Antonova I, Kandel ER, Hawkins RD (2003) Activity-dependent presynaptic facilitation and Hebbian LTP are both required and interact during classical conditioning in Aplysia . Neuron 37: 135-147.
    • (2003) Neuron , vol.37 , pp. 135-147
    • Antonov, I.1    Antonova, I.2    Kandel, E.R.3    Hawkins, R.D.4
  • 5
    • 0025582114 scopus 로고
    • Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons of Aplysia
    • Azhderian EM, Kaczmarek LK (1990) Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons of Aplysia . J Mol Neurosci 2: 61-70.
    • (1990) J Mol Neurosci , vol.2 , pp. 61-70
    • Azhderian, E.M.1    Kaczmarek, L.K.2
  • 6
    • 2942566606 scopus 로고    scopus 로고
    • Structure, function and evolution of microbial adenylyl and guanylyl cyclases
    • Baker DA, Kelly JM (2004) Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol 52: 1229-1242.
    • (2004) Mol Microbiol , vol.52 , pp. 1229-1242
    • Baker, D.A.1    Kelly, J.M.2
  • 7
    • 0032504229 scopus 로고    scopus 로고
    • Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7a receptor
    • Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR (1998) Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7a receptor. J Biol Chem 273: 17469-17476.
    • (1998) J Biol Chem , vol.273 , pp. 17469-17476
    • Baker, L.P.1    Nielsen, M.D.2    Impey, S.3    Metcalf, M.A.4    Poser, S.W.5    Chan, G.6    Obrietan, K.7    Hamblin, M.W.8    Storm, D.R.9
  • 8
    • 0026533419 scopus 로고
    • A regulatory subunit of the cAMP-dependent protein kinase down-regulated in Aplysia sensory neurons during long-term sensitization
    • Bergold PJ, Beushausen SA, Sacktor TC, Cheley S, Bayley H, Schwartz JH (1992) A regulatory subunit of the cAMP-dependent protein kinase down-regulated in Aplysia sensory neurons during long-term sensitization. Neuron 8: 387-397.
    • (1992) Neuron , vol.8 , pp. 387-397
    • Bergold, P.J.1    Beushausen, S.A.2    Sacktor, T.C.3    Cheley, S.4    Bayley, H.5    Schwartz, J.H.6
  • 9
    • 0020443224 scopus 로고
    • Facilitatory transmitter causes a selective and prolonged increase in adenosine 3′ :5′ -monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia
    • Bernier L, Castellucci VF, Kandel ER, Schwartz JH (1982) Facilitatory transmitter causes a selective and prolonged increase in adenosine 3′ :5′ -monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia . J Neurosci 2: 1682-1691.
    • (1982) J Neurosci , vol.2 , pp. 1682-1691
    • Bernier, L.1    Castellucci, V.F.2    Kandel, E.R.3    Schwartz, J.H.4
  • 10
    • 58149161907 scopus 로고    scopus 로고
    • Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKAc3
    • Bettencourt da Cruz A, Wentzell J, Kretzschmar D (2008) Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKAc3. J Neurosci 28: 10885-10892.
    • (2008) J Neurosci , vol.28 , pp. 10885-10892
    • Bettencourt Da Cruz, A.1    Wentzell, J.2    Kretzschmar, D.3
  • 11
    • 0024108958 scopus 로고
    • Two catalytic subunits of cAMP-dependent protein kinase generated by alternative RNA splicing are expressed in Aplysia neurons
    • Beushausen S, Bergold P, Sturner S, Elste A, Roytenberg V, Schwartz JH, Bayley H (1988) Two catalytic subunits of cAMP-dependent protein kinase generated by alternative RNA splicing are expressed in Aplysia neurons. Neuron 1: 853-864.
    • (1988) Neuron , vol.1 , pp. 853-864
    • Beushausen, S.1    Bergold, P.2    Sturner, S.3    Elste, A.4    Roytenberg, V.5    Schwartz, J.H.6    Bayley, H.7
  • 12
    • 0025201183 scopus 로고
    • A relative of the catalytic subunit of cyclic AMP-dependent protein kinase in Aplysia spermatozoa
    • Beushausen S, Bayley H (1990) A relative of the catalytic subunit of cyclic AMP-dependent protein kinase in Aplysia spermatozoa. Mol Cell Biol 10: 6775-6780.
    • (1990) Mol Cell Biol , vol.10 , pp. 6775-6780
    • Beushausen, S.1    Bayley, H.2
  • 13
    • 0025185898 scopus 로고
    • Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons
    • Blumenfeld H, Spira ME, Kandel ER, Siegelbaum SA (1990) Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons. Neuron 5: 487-499.
    • (1990) Neuron , vol.5 , pp. 487-499
    • Blumenfeld, H.1    Spira, M.E.2    Kandel, E.R.3    Siegelbaum, S.A.4
  • 14
    • 0032459027 scopus 로고    scopus 로고
    • Multiple memory processes following training that a food is inedible in Aplysia
    • Botzer D, Markovich S, Susswein AJ (1998) Multiple memory processes following training that a food is inedible in Aplysia . Learn Mem 5: 204-219.
    • (1998) Learn Mem , vol.5 , pp. 204-219
    • Botzer, D.1    Markovich, S.2    Susswein, A.J.3
  • 16
    • 0017094614 scopus 로고
    • Synaptic facilitation and behavioral sensitization in Aplysia : PPossible role of serotonin and cyclic AMP
    • Brunelli M, Castellucci V, Kandel ER (1976) Synaptic facilitation and behavioral sensitization in Aplysia : Possible role of serotonin and cyclic AMP. Science 194: 1178-1181.
    • (1976) Science , vol.194 , pp. 1178-1181
    • Brunelli, M.1    Castellucci, V.2    Kandel, E.R.3
  • 17
    • 0030065380 scopus 로고    scopus 로고
    • Presynaptic facilitation revisited: State and time dependence
    • Byrne JH, Kandel ER (1996) Presynaptic facilitation revisited: State and time dependence. J Neurosci 16: 425-435.
    • (1996) J Neurosci , vol.16 , pp. 425-435
    • Byrne, J.H.1    Kandel, E.R.2
  • 18
    • 0036132994 scopus 로고    scopus 로고
    • Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family
    • Canaves JM, Taylor SS (2002) Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol 54: 17-29.
    • (2002) J Mol Evol , vol.54 , pp. 17-29
    • Canaves, J.M.1    Taylor, S.S.2
  • 19
    • 0034021646 scopus 로고    scopus 로고
    • A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster
    • Cann MJ, Chung E, Levin LR (2000) A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster . Dev Genes Evol 210: 200-206.
    • (2000) Dev Genes Evol , vol.210 , pp. 200-206
    • Cann, M.J.1    Chung, E.2    Levin, L.R.3
  • 20
    • 0020366664 scopus 로고
    • Inhibitor of adenosine 3′ :5′ -monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia
    • Castellucci VF, Nairn A, Greengard P, Schwartz JH, Kandel ER (1982) Inhibitor of adenosine 3′ :5′ -monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia . J Neurosci 2: 1673-1681.
    • (1982) J Neurosci , vol.2 , pp. 1673-1681
    • Castellucci, V.F.1    Nairn, A.2    Greengard, P.3    Schwartz, J.H.4    Kandel, E.R.5
  • 22
    • 12944260709 scopus 로고    scopus 로고
    • Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in Aplysia sensory neurons
    • Chang DJ, Li XC, Lee YS, Kim HK, Kim US, Cho NJ, Lo X, Weiss KR, Kandel ER, Kaang BK (2000) Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in Aplysia sensory neurons. Proc Natl Acad Sci USA 97: 1829-1834.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1829-1834
    • Chang, D.J.1    Li, X.C.2    Lee, Y.S.3    Kim, H.K.4    Kim, U.S.5    Cho, N.J.6    Lo, X.7    Weiss, K.R.8    Kandel, E.R.9    Kaang, B.K.10
  • 23
    • 0037447206 scopus 로고    scopus 로고
    • Synaptic facilitation by ectopic octopamine and 5-HT receptors in Aplysia
    • Chang DJ, Lim CS, Lee JA, Kaang BK (2003) Synaptic facilitation by ectopic octopamine and 5-HT receptors in Aplysia . Brain Res Bull 60: 73-79.
    • (2003) Brain Res Bull , vol.60 , pp. 73-79
    • Chang, D.J.1    Lim, C.S.2    Lee, J.A.3    Kaang, B.K.4
  • 24
  • 25
    • 33645457226 scopus 로고    scopus 로고
    • Synergistic control of protein kinase C gamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons
    • Codazzi F, Di Cesare A, Chiulli N, Albanese A, Meyer T, Zacchetti D, Grohovaz F (2006) Synergistic control of protein kinase C gamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons. J Neurosci 26: 3404-3411.
    • (2006) J Neurosci , vol.26 , pp. 3404-3411
    • Codazzi, F.1    Di Cesare, A.2    Chiulli, N.3    Albanese, A.4    Meyer, T.5    Zacchetti, D.6    Grohovaz, F.7
  • 26
    • 0242468744 scopus 로고    scopus 로고
    • Regulation and organization of adenylyl cyclases and cAMP
    • Cooper DM (2003) Regulation and organization of adenylyl cyclases and cAMP. Biochem J 375: 517-529.
    • (2003) Biochem J , vol.375 , pp. 517-529
    • Cooper, D.M.1
  • 27
    • 0026614881 scopus 로고
    • Modulation of IK, Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia
    • Critz SD, Byrne JH (1992) Modulation of IK, Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia . J Neurophysiol 68: 1079-1086.
    • (1992) J Neurophysiol , vol.68 , pp. 1079-1086
    • Critz, S.D.1    Byrne, J.H.2
  • 28
    • 3042552852 scopus 로고    scopus 로고
    • Novel regulatory properties of human type 9 adenylate cyclase
    • Cumbay MG, Watts VJ (2004) Novel regulatory properties of human type 9 adenylate cyclase. J Pharmacol Exp Ther 310: 108-115.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 108-115
    • Cumbay, M.G.1    Watts, V.J.2
  • 29
    • 15744404251 scopus 로고    scopus 로고
    • Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway
    • Cumbay MG, Watts VJ (2005) Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway. Biochem Pharmacol 69: 1247-1256.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1247-1256
    • Cumbay, M.G.1    Watts, V.J.2
  • 30
    • 67649529141 scopus 로고    scopus 로고
    • Molecular identification of candidate chemoreceptor genes and signal transduction components in the sensory epithelium of Aplysia
    • Cummins SF, Leblanc L, Degnan BM, Nagle GT (2009) Molecular identification of candidate chemoreceptor genes and signal transduction components in the sensory epithelium of Aplysia . J Exp Biol 212: 2037-2044.
    • (2009) J Exp Biol , vol.212 , pp. 2037-2044
    • Cummins, S.F.1    Leblanc, L.2    Degnan, B.M.3    Nagle, G.T.4
  • 32
    • 0021928377 scopus 로고
    • Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C
    • DeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK (1985) Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature 313: 313-316.
    • (1985) Nature , vol.313 , pp. 313-316
    • Deriemer, S.A.1    Strong, J.A.2    Albert, K.A.3    Greengard, P.4    Kaczmarek, L.K.5
  • 33
    • 0021274328 scopus 로고
    • Adenylate cyclase in the Drosophila memory mutant rutabaga displays an altered Ca2+ sensitivity
    • Dudai Y, Zvi S (1984) Adenylate cyclase in the Drosophila memory mutant rutabaga displays an altered Ca2+ sensitivity. Neurosci Lett 47: 119-124.
    • (1984) Neurosci Lett , vol.47 , pp. 119-124
    • Dudai, Y.1    Zvi, S.2
  • 34
    • 0028044749 scopus 로고
    • Pairing-specific, activity-dependent presynaptic facilitation at Aplysia sensorymotor neuron synapses in isolated cell culture
    • Eliot LS, Hawkins RD, Kandel ER, Schacher S (1994) Pairing-specific, activity-dependent presynaptic facilitation at Aplysia sensorymotor neuron synapses in isolated cell culture. J Neurosci 14: 368-383.
    • (1994) J Neurosci , vol.14 , pp. 368-383
    • Eliot, L.S.1    Hawkins, R.D.2    Kandel, E.R.3    Schacher, S.4
  • 35
    • 0029941317 scopus 로고    scopus 로고
    • Functional co-localization of transfected Ca(2+)- stimulable adenylyl cyclases with capacitative Ca2+ entry sites
    • Fagan KA, Mahey R, Cooper DM (1996) Functional co-localization of transfected Ca(2+)- stimulable adenylyl cyclases with capacitative Ca2+ entry sites. J Biol Chem 271: 12438-12444.
    • (1996) J Biol Chem , vol.271 , pp. 12438-12444
    • Fagan, K.A.1    Mahey, R.2    Cooper, D.M.3
  • 36
    • 69049118117 scopus 로고    scopus 로고
    • PKC translocation differentiates spaced and massed training in Aplysia
    • Farah C, Weatherill D, Sossin WS (2009) PKC translocation differentiates spaced and massed training in Aplysia . J Neurosci 29: 10281-10286.
    • (2009) J Neurosci , vol.29 , pp. 10281-10286
    • Farah, C.1    Weatherill, D.2    Sossin, W.S.3
  • 37
    • 47949111533 scopus 로고    scopus 로고
    • Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons
    • Farah CA, Nagakura I, Weatherill D, Fan X, Sossin WS (2008) Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons. Mol Cell Biol 28: 4719-4733.
    • (2008) Mol Cell Biol , vol.28 , pp. 4719-4733
    • Farah, C.A.1    Nagakura, I.2    Weatherill, D.3    Fan, X.4    Sossin, W.S.5
  • 38
    • 55249119741 scopus 로고    scopus 로고
    • The potential role of postsynaptic phospholipase C activity in synaptic facilitation and behavioral sensitization in Aplysia
    • Fulton D, Condro MC, Pearce K, Glanzman DL (2008) The potential role of postsynaptic phospholipase C activity in synaptic facilitation and behavioral sensitization in Aplysia . J Neurophysiol 100: 108-116.
    • (2008) J Neurophysiol , vol.100 , pp. 108-116
    • Fulton, D.1    Condro, M.C.2    Pearce, K.3    Glanzman, D.L.4
  • 39
    • 0026800953 scopus 로고
    • Roles of PKA and PKCin facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons
    • Ghirardi M, Braha O, Hochner B, Montarolo PG, Kandel ER, Dale N (1992) Roles of PKA and PKCin facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons. Neuron 9: 479-489.
    • (1992) Neuron , vol.9 , pp. 479-489
    • Ghirardi, M.1    Braha, O.2    Hochner, B.3    Montarolo, P.G.4    Kandel, E.R.5    Dale, N.6
  • 40
    • 0028800809 scopus 로고
    • A novel intermediate stage in the transition between short-and long-term facilitation in the sensory to motor neuron synapse of Aplysia
    • Ghirardi M, Montarolo PG, Kandel ER (1995) A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of Aplysia . Neuron 14: 413-420.
    • (1995) Neuron , vol.14 , pp. 413-420
    • Ghirardi, M.1    Montarolo, P.G.2    Kandel, E.R.3
  • 41
    • 0025998532 scopus 로고
    • Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase
    • Goldsmith BA, Abrams TW (1991) Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase. Proc Natl Acad Sci USA 88: 9021-9025.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9021-9025
    • Goldsmith, B.A.1    Abrams, T.W.2
  • 42
    • 67349139927 scopus 로고    scopus 로고
    • Insights into a molecular switch that gates sensory neuron synapses during habituation in Aplysia
    • Gover TD, Abrams TW (2009) Insights into a molecular switch that gates sensory neuron synapses during habituation in Aplysia . Neurobiol Learn Mem 92: 155-165.
    • (2009) Neurobiol Learn Mem , vol.92 , pp. 155-165
    • Gover, T.D.1    Abrams, T.W.2
  • 43
    • 0033583074 scopus 로고    scopus 로고
    • Calmodulin-binding sites on adenylyl cyclase type VIII
    • Gu C, Cooper DM (1999) Calmodulin-binding sites on adenylyl cyclase type VIII. J Biol Chem 274: 8012-8021.
    • (1999) J Biol Chem , vol.274 , pp. 8012-8021
    • Gu, C.1    Cooper, D.M.2
  • 44
    • 0033544949 scopus 로고    scopus 로고
    • Inhibition by calcium of mammalian adenylyl cyclases
    • Guillou JL, Nakata H, Cooper DM (1999) Inhibition by calcium of mammalian adenylyl cyclases. J Biol Chem 274: 35539-35545.
    • (1999) J Biol Chem , vol.274 , pp. 35539-35545
    • Guillou, J.L.1    Nakata, H.2    Cooper, D.M.3
  • 45
    • 0020681414 scopus 로고
    • A cellular mechanism of classical conditioning in Aplysia : AActivity-dependent amplification of presynaptic facilitation
    • Hawkins RD, Abrams TW, Carew TJ, Kandel ER (1983) A cellular mechanism of classical conditioning in Aplysia : Activity-dependent amplification of presynaptic facilitation. Science 219: 400-405.
    • (1983) Science , vol.219 , pp. 400-405
    • Hawkins, R.D.1    Abrams, T.W.2    Carew, T.J.3    Kandel, E.R.4
  • 46
    • 33745700968 scopus 로고    scopus 로고
    • Molecular mechanisms of memory storage in Aplysia
    • Hawkins RD, Kandel ER, Bailey CH (2006) Molecular mechanisms of memory storage in Aplysia . Biol Bull 210: 174-191.
    • (2006) Biol Bull , vol.210 , pp. 174-191
    • Hawkins, R.D.1    Kandel, E.R.2    Bailey, C.H.3
  • 47
    • 0027304239 scopus 로고
    • Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: A molecular mechanism underlying long-term synaptic plasticity
    • Hegde AN, Goldberg AL, Schwartz JH (1993) Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: A molecular mechanism underlying long-term synaptic plasticity. Proc Natl Acad Sci USA 90: 7436-7440.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7436-7440
    • Hegde, A.N.1    Goldberg, A.L.2    Schwartz, J.H.3
  • 49
    • 0141890287 scopus 로고    scopus 로고
    • Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory
    • Hernandez AI, Blace N, Crary JF, Serrano PA, Leitges M, Libien JM, Weinstein G, Tcherapanov A, Sacktor TC (2003) Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem 278: 40305-40316.
    • (2003) J Biol Chem , vol.278 , pp. 40305-40316
    • Hernandez, A.I.1    Blace, N.2    Crary, J.F.3    Serrano, P.A.4    Leitges, M.5    Libien, J.M.6    Weinstein, G.7    Tcherapanov, A.8    Sacktor, T.C.9
  • 50
    • 34548094562 scopus 로고    scopus 로고
    • Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity
    • Hu JY, Chen Y, Schacher S (2007) Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity. J Neurosci 27: 8927-8939.
    • (2007) J Neurosci , vol.27 , pp. 8927-8939
    • Hu, J.Y.1    Chen, Y.2    Schacher, S.3
  • 51
    • 32644431882 scopus 로고    scopus 로고
    • Two signaling pathways regulate the expression and secretion of a neuropeptide required for longterm facilitation in Aplysia
    • Hu JY, Wu F, Schacher S (2006) Two signaling pathways regulate the expression and secretion of a neuropeptide required for longterm facilitation in Aplysia . J Neurosci 26: 1026-1035.
    • (2006) J Neurosci , vol.26 , pp. 1026-1035
    • Hu, J.Y.1    Wu, F.2    Schacher, S.3
  • 52
    • 21544452743 scopus 로고    scopus 로고
    • Epac mediates a cAMP-to-PKC signaling in inflammatory pain: An isolectin b4(+) neuron-specific mechanism
    • Hucho TB, Dina OA, Levine JD (2005) Epac mediates a cAMP-to-PKC signaling in inflammatory pain: An isolectin b4(+) neuron-specific mechanism. J Neurosci 25: 6119-6126.
    • (2005) J Neurosci , vol.25 , pp. 6119-6126
    • Hucho, T.B.1    Dina, O.A.2    Levine, J.D.3
  • 53
    • 0033979352 scopus 로고    scopus 로고
    • A calcium-inhibited Drosophila adenylyl cyclase
    • Iourgenko V, Levin LR (2000) A calcium-inhibited Drosophila adenylyl cyclase. Biochim Biophys Acta 1495: 125-139.
    • (2000) Biochim Biophys Acta , vol.1495 , pp. 125-139
    • Iourgenko, V.1    Levin, L.R.2
  • 54
  • 55
    • 0035809917 scopus 로고    scopus 로고
    • Protein kinase C activation promotes microtubule advance in neuronal growth cones by increasing average microtubule growth lifetimes
    • Kabir N, Schaefer AW, Nakhost A, Sossin WS, Forscher P (2001) Protein kinase C activation promotes microtubule advance in neuronal growth cones by increasing average microtubule growth lifetimes. J Cell Biol 152: 1033-1044.
    • (2001) J Cell Biol , vol.152 , pp. 1033-1044
    • Kabir, N.1    Schaefer, A.W.2    Nakhost, A.3    Sossin, W.S.4    Forscher, P.5
  • 56
    • 0021224475 scopus 로고
    • A voltageclamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
    • Kaczmarek LK, Strumwasser F (1984) A voltageclamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia . J Neurophysiol 52: 340-349.
    • (1984) J Neurophysiol , vol.52 , pp. 340-349
    • Kaczmarek, L.K.1    Strumwasser, F.2
  • 59
    • 0032515189 scopus 로고    scopus 로고
    • Phospholipase C cDNAs from sponge and hydra: Antiquity of genes involved in the inositol phospholipid signaling pathway
    • Koyanagi M, Ono K, Suga H, Iwabe N, Miyata T (1998) Phospholipase C cDNAs from sponge and hydra: Antiquity of genes involved in the inositol phospholipid signaling pathway. FEBS Lett 439: 66-70.
    • (1998) FEBS Lett , vol.439 , pp. 66-70
    • Koyanagi, M.1    Ono, K.2    Suga, H.3    Iwabe, N.4    Miyata, T.5
  • 60
    • 0025939414 scopus 로고
    • Cloning and characterization of Ca(2+)-dependent and Ca(2+)-independent PKCs expressed in Aplysia sensory cells
    • Kruger KE, Sossin WS, Sacktor TC, Bergold PJ, Beushausen S, Schwartz JH (1991) Cloning and characterization of Ca(2+)-dependent and Ca(2+)-independent PKCs expressed in Aplysia sensory cells. J Neurosci 11: 2303-2313.
    • (1991) J Neurosci , vol.11 , pp. 2303-2313
    • Kruger, K.E.1    Sossin, W.S.2    Sacktor, T.C.3    Bergold, P.J.4    Beushausen, S.5    Schwartz, J.H.6
  • 61
    • 0018559096 scopus 로고
    • Modulatory actions of neurotransmitters
    • Kupfermann I (1979) Modulatory actions of neurotransmitters. Ann Rev Neurosci 2: 447-465.
    • (1979) Ann Rev Neurosci , vol.2 , pp. 447-465
    • Kupfermann, I.1
  • 62
    • 34250194664 scopus 로고    scopus 로고
    • Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons
    • Kurosu T, Hernandez AI, Schwartz JH (2007) Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons. Biochem Biophys Res Commun 359: 563-567.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 563-567
    • Kurosu, T.1    Hernandez, A.I.2    Schwartz, J.H.3
  • 64
    • 70149104584 scopus 로고    scopus 로고
    • Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning- related heterosynaptic facilitation in Aplysia
    • Lee YS, Choi SL, Lee SH, Kim H, Park H, Lee N, Chae YS, Jang DJ, Kandel ER, Kaang BK (2009) Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning- related heterosynaptic facilitation in Aplysia . Proc Natl Acad Sci USA 106: 14634-14639.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14634-14639
    • Lee, Y.S.1    Choi, S.L.2    Lee, S.H.3    Kim, H.4    Park, H.5    Lee, N.6    Chae, Y.S.7    Jang, D.J.8    Kandel, E.R.9    Kaang, B.K.10
  • 65
    • 0026567423 scopus 로고
    • The Drosophila learning and memory gene rutabaga encodes a Ca2+/calmodulin-responsive adenylyl cyclase
    • Levin LR, Han PL, Hwang PM, Feinstein PG, Davis RL, Reed RR (1992) The Drosophila learning and memory gene rutabaga encodes a Ca2+/calmodulin- responsive adenylyl cyclase. Cell 68: 479-489.
    • (1992) Cell , vol.68 , pp. 479-489
    • Levin, L.R.1    Han, P.L.2    Hwang, P.M.3    Feinstein, P.G.4    Davis, R.L.5    Reed, R.R.6
  • 66
    • 0028937625 scopus 로고
    • Identification of functional domains of adenylyl cyclase using in vivo chimeras
    • Levin LR, Reed RR (1995) Identification of functional domains of adenylyl cyclase using in vivo chimeras. J Biol Chem 270: 7573-7579.
    • (1995) J Biol Chem , vol.270 , pp. 7573-7579
    • Levin, L.R.1    Reed, R.R.2
  • 67
    • 0023413456 scopus 로고
    • Augmentation of bursting pacemaker activity by egg-laying hormone in Aplysia neuron R15 is mediated by a cyclic AMP-dependent increase in Ca2+ and K+ currents
    • Levitan ES, Kramer RH, Levitan IB (1987) Augmentation of bursting pacemaker activity by egg-laying hormone in Aplysia neuron R15 is mediated by a cyclic AMP-dependent increase in Ca2+ and K+ currents. Proc Natl Acad Sci USA 84: 6307-6311.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6307-6311
    • Levitan, E.S.1    Kramer, R.H.2    Levitan, I.B.3
  • 68
    • 20444387895 scopus 로고    scopus 로고
    • Synaptic facilitation and behavioral dishabituation in Aplysia : DDependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy
    • Li Q, Roberts AC, Glanzman DL (2005) Synaptic facilitation and behavioral dishabituation in Aplysia : Dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy. J Neurosci 25: 5623-5637.
    • (2005) J Neurosci , vol.25 , pp. 5623-5637
    • Li, Q.1    Roberts, A.C.2    Glanzman, D.L.3
  • 70
    • 1542267750 scopus 로고    scopus 로고
    • The two regulatory subunits of Aplysia cAMPdependent protein kinase mediate distinct functions in producing synaptic plasticity
    • Liu J, Hu JY, Schacher S, Schwartz JH (2004) The two regulatory subunits of Aplysia cAMPdependent protein kinase mediate distinct functions in producing synaptic plasticity. J Neurosci 24: 2465-2474.
    • (2004) J Neurosci , vol.24 , pp. 2465-2474
    • Liu, J.1    Hu, J.Y.2    Schacher, S.3    Schwartz, J.H.4
  • 71
    • 0021174051 scopus 로고
    • Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant
    • Livingstone MS, Sziber PP, Quinn WG (1984) Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant. Cell 37: 205-215.
    • (1984) Cell , vol.37 , pp. 205-215
    • Livingstone, M.S.1    Sziber, P.P.2    Quinn, W.G.3
  • 72
    • 0021279375 scopus 로고
    • Evidence for parallel actions of a molluscan neuropeptide and serotonin in mediating arousal in Aplysia
    • Lloyd PE, Kupfermann I, Weiss KR (1984) Evidence for parallel actions of a molluscan neuropeptide and serotonin in mediating arousal in Aplysia . Proc Natl Acad Sci USA 81: 2934-2937.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 2934-2937
    • Lloyd, P.E.1    Kupfermann, I.2    Weiss, K.R.3
  • 73
    • 48149083181 scopus 로고    scopus 로고
    • Molecular mechanisms underlying a cellular analog of operant reward learning
    • Lorenzetti FD, Baxter DA, Byrne JH (2008) Molecular mechanisms underlying a cellular analog of operant reward learning. Neuron 59: 815-828.
    • (2008) Neuron , vol.59 , pp. 815-828
    • Lorenzetti, F.D.1    Baxter, D.A.2    Byrne, J.H.3
  • 74
    • 0024802250 scopus 로고
    • Identified serotonergic neurons lcb1 and rcb1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons
    • Mackey SL, Kandel ER, Hawkins RD (1989) Identified serotonergic neurons lcb1 and rcb1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons. J Neurosci 9: 4227-4235.
    • (1989) J Neurosci , vol.9 , pp. 4227-4235
    • MacKey, S.L.1    Kandel, E.R.2    Hawkins, R.D.3
  • 75
    • 0036138057 scopus 로고    scopus 로고
    • Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain
    • Magoski NS, Wilson GF, Kaczmarek LK (2002) Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain. J Neurosci 22: 1-9.
    • (2002) J Neurosci , vol.22 , pp. 1-9
    • Magoski, N.S.1    Wilson, G.F.2    Kaczmarek, L.K.3
  • 76
    • 24344487376 scopus 로고    scopus 로고
    • Association/ dissociation of a channel-kinase complex underlies state-dependent modulation
    • Magoski NS, Kaczmarek LK (2005) Association/ dissociation of a channel-kinase complex underlies state-dependent modulation. J Neurosci 25: 8037-8047.
    • (2005) J Neurosci , vol.25 , pp. 8037-8047
    • Magoski, N.S.1    Kaczmarek, L.K.2
  • 77
    • 0035864366 scopus 로고    scopus 로고
    • Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed Aplysia sensorimotor synapses
    • Manseau F, Fan X, Hueftlein T, Sossin W, Castellucci VF (2001) Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed Aplysia sensorimotor synapses. J Neurosci 21: 1247-1256.
    • (2001) J Neurosci , vol.21 , pp. 1247-1256
    • Manseau, F.1    Fan, X.2    Hueftlein, T.3    Sossin, W.4    Castellucci, V.F.5
  • 78
    • 0037088924 scopus 로고    scopus 로고
    • Serotonin release evoked by tail nerve stimulation in the CNS of Aplysia : CCharacterization and relationship to heterosynaptic plasticity
    • Marinesco S, Carew TJ (2002) Serotonin release evoked by tail nerve stimulation in the CNS of Aplysia : Characterization and relationship to heterosynaptic plasticity. J Neurosci 22: 2299-2312.
    • (2002) J Neurosci , vol.22 , pp. 2299-2312
    • Marinesco, S.1    Carew, T.J.2
  • 79
    • 0031444409 scopus 로고    scopus 로고
    • Synapse-specific, long-term facilitation of Aplysia sensory to motor synapses: A function for local protein synthesis in memory storage
    • Martin KC, Casadio A, Zhu H, Yaping E, Rose JC, Chen M, Bailey CH, Kandel ER (1997) Synapse-specific, long-term facilitation of Aplysia sensory to motor synapses: A function for local protein synthesis in memory storage. Cell 91: 927-938.
    • (1997) Cell , vol.91 , pp. 927-938
    • Martin, K.C.1    Casadio, A.2    Zhu, H.3    Yaping, E.4    Rose, J.C.5    Chen, M.6    Bailey, C.H.7    Kandel, E.R.8
  • 80
  • 81
    • 52949100584 scopus 로고    scopus 로고
    • Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
    • Mozzachiodi R, Lorenzetti FD, Baxter DA, Byrne JH (2008) Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning. Nat Neurosci 11: 1146-1148.
    • (2008) Nat Neurosci , vol.11 , pp. 1146-1148
    • Mozzachiodi, R.1    Lorenzetti, F.D.2    Baxter, D.A.3    Byrne, J.H.4
  • 82
    • 0029817791 scopus 로고    scopus 로고
    • Enhancement of sensorimotor connections by conditioning- related stimulation in Aplysia depends upon postsynaptic Ca2+
    • Murphy GG, Glanzman DL (1996) Enhancement of sensorimotor connections by conditioning- related stimulation in Aplysia depends upon postsynaptic Ca2+. Proc Natl Acad Sci USA 93: 9931-9936.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9931-9936
    • Murphy, G.G.1    Glanzman, D.L.2
  • 83
    • 0030700543 scopus 로고    scopus 로고
    • Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses
    • Murphy GG, Glanzman DL (1997) Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses. Science 278: 467-471.
    • (1997) Science , vol.278 , pp. 467-471
    • Murphy, G.G.1    Glanzman, D.L.2
  • 84
    • 0033507083 scopus 로고    scopus 로고
    • Cellular analog of differential classical conditioning in Aplysia : DDisruption by the NMDA receptor antagonist dl-2-amino-5-phosphonovalerate
    • Murphy GG, Glanzman DL (1999) Cellular analog of differential classical conditioning in Aplysia : Disruption by the NMDA receptor antagonist dl-2-amino-5-phosphonovalerate. J Neurosci 19: 10595-10602.
    • (1999) J Neurosci , vol.19 , pp. 10595-10602
    • Murphy, G.G.1    Glanzman, D.L.2
  • 85
    • 1842279418 scopus 로고
    • Associative conditioning analog selectively increases cAMP levels of tail sensory neurons in Aplysia
    • Ocorr KA, Walters ET, Byrne JH (1985) Associative conditioning analog selectively increases cAMP levels of tail sensory neurons in Aplysia . Proc Natl Acad Sci USA 82: 2548-2552.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2548-2552
    • Ocorr, K.A.1    Walters, E.T.2    Byrne, J.H.3
  • 86
    • 34247124160 scopus 로고    scopus 로고
    • Epac-mediated activation of phospholipase C (epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
    • Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV (2007) Epac-mediated activation of phospholipase C (epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem 282: 5488-5495.
    • (2007) J Biol Chem , vol.282 , pp. 5488-5495
    • Oestreich, E.A.1    Wang, H.2    Malik, S.3    Kaproth-Joslin, K.A.4    Blaxall, B.C.5    Kelley, G.G.6    Dirksen, R.T.7    Smrcka, A.V.8
  • 87
    • 59449094232 scopus 로고    scopus 로고
    • Epac and phospholipase C epsilon regulate Ca2+ release in the heart by activation of protein kinase C epsilon and calciumcalmodulin kinase II
    • Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV (2009) Epac and phospholipase C epsilon regulate Ca2+ release in the heart by activation of protein kinase C epsilon and calciumcalmodulin kinase II. J Biol Chem 284: 1514-1522.
    • (2009) J Biol Chem , vol.284 , pp. 1514-1522
    • Oestreich, E.A.1    Malik, S.2    Goonasekera, S.A.3    Blaxall, B.C.4    Kelley, G.G.5    Dirksen, R.T.6    Smrcka, A.V.7
  • 91
    • 0025220716 scopus 로고
    • Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons
    • Sacktor TC, Schwartz JH (1990) Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons. Proc Natl Acad Sci USA 87: 2036-2039.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2036-2039
    • Sacktor, T.C.1    Schwartz, J.H.2
  • 92
    • 0024290457 scopus 로고
    • CAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis
    • Schacher S, Castellucci VF, Kandel ER (1988) cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis. Science 240: 1667-1669.
    • (1988) Science , vol.240 , pp. 1667-1669
    • Schacher, S.1    Castellucci, V.F.2    Kandel, E.R.3
  • 93
    • 0024290484 scopus 로고
    • Intracellular injection of cAMP induces a long-term reduction of neuronal K+ currents
    • Scholz KP, Byrne JH (1988) Intracellular injection of cAMP induces a long-term reduction of neuronal K+ currents. Science 240: 1664-1666.
    • (1988) Science , vol.240 , pp. 1664-1666
    • Scholz, K.P.1    Byrne, J.H.2
  • 94
    • 58149218239 scopus 로고    scopus 로고
    • Temporal phases of activity-dependent plasticity and memory are mediated by compartmentalized routing of MAPK signaling in Aplysia sensory neurons
    • Shobe JL, Zhao Y, Stough S, Ye X, Hsuan V, Martin KC, Carew TJ (2009) Temporal phases of activity-dependent plasticity and memory are mediated by compartmentalized routing of MAPK signaling in Aplysia sensory neurons. Neuron 61: 113-125.
    • (2009) Neuron , vol.61 , pp. 113-125
    • Shobe, J.L.1    Zhao, Y.2    Stough, S.3    Ye, X.4    Hsuan, V.5    Martin, K.C.6    Carew, T.J.7
  • 95
    • 0022005993 scopus 로고
    • Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+ channels of Aplysia sensory neurons in cellfree membrane patches
    • Shuster MJ, Camardo JS, Siegelbaum SA, Kandel ER (1985) Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+ channels of Aplysia sensory neurons in cellfree membrane patches. Nature 313: 392-395.
    • (1985) Nature , vol.313 , pp. 392-395
    • Shuster, M.J.1    Camardo, J.S.2    Siegelbaum, S.A.3    Kandel, E.R.4
  • 96
    • 0027480323 scopus 로고
    • Characterization of two isoforms of protein kinase C in the nervous system of Aplysia californica
    • Sossin WS, Diaz AR, Schwartz JH (1993) Characterization of two isoforms of protein kinase C in the nervous system of Aplysia californica . J Biol Chem 268: 5763-5768.
    • (1993) J Biol Chem , vol.268 , pp. 5763-5768
    • Sossin, W.S.1    Diaz, A.R.2    Schwartz, J.H.3
  • 97
    • 34247251277 scopus 로고    scopus 로고
    • Isoform specificity of protein kinase Cs in synaptic plasticity
    • Sossin WS (2007) Isoform specificity of protein kinase Cs in synaptic plasticity. Learn Mem 14: 236-246.
    • (2007) Learn Mem , vol.14 , pp. 236-246
    • Sossin, W.S.1
  • 98
    • 0023122109 scopus 로고
    • Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons
    • Strong JA, Fox AP, Tsien RW, Kaczmarek LK (1987) Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons. Nature 325: 714-717.
    • (1987) Nature , vol.325 , pp. 714-717
    • Strong, J.A.1    Fox, A.P.2    Tsien, R.W.3    Kaczmarek, L.K.4
  • 99
    • 0026768136 scopus 로고
    • Involvement of protein kinase C in serotonin- induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia
    • Sugita S, Goldsmith JR, Baxter DA, Byrne JH (1992) Involvement of protein kinase C in serotonin- induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia . J Neurophysiol 68: 643-651.
    • (1992) J Neurophysiol , vol.68 , pp. 643-651
    • Sugita, S.1    Goldsmith, J.R.2    Baxter, D.A.3    Byrne, J.H.4
  • 100
    • 0030799381 scopus 로고    scopus 로고
    • Modulation of a cAMP/protein kinase A cascade by protein kinase C in sensory neurons of Aplysia
    • Sugita S, Baxter DA, Byrne JH (1997) Modulation of a cAMP/protein kinase A cascade by protein kinase C in sensory neurons of Aplysia . J Neurosci 17: 7237-7244.
    • (1997) J Neurosci , vol.17 , pp. 7237-7244
    • Sugita, S.1    Baxter, D.A.2    Byrne, J.H.3
  • 102
    • 0022534587 scopus 로고
    • Learned changes of feeding behavior in Aplysia in response to edible and inedible foods
    • Susswein AJ, Schwarz M, Feldman E (1986) Learned changes of feeding behavior in Aplysia in response to edible and inedible foods. J Neurosci 6: 1513-1527.
    • (1986) J Neurosci , vol.6 , pp. 1513-1527
    • Susswein, A.J.1    Schwarz, M.2    Feldman, E.3
  • 103
    • 0033695279 scopus 로고    scopus 로고
    • Parallel molecular pathways mediate expression of distinct forms of intermediate-term facilitation at tail sensory-motor synapses in Aplysia
    • Sutton MA, Carew TJ (2000) Parallel molecular pathways mediate expression of distinct forms of intermediate-term facilitation at tail sensory-motor synapses in Aplysia . Neuron 26: 219-231.
    • (2000) Neuron , vol.26 , pp. 219-231
    • Sutton, M.A.1    Carew, T.J.2
  • 104
    • 0034889241 scopus 로고    scopus 로고
    • Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia
    • Sutton MA, Masters SE, Bagnall MW, Carew TJ (2001) Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia . Neuron 31: 143-154.
    • (2001) Neuron , vol.31 , pp. 143-154
    • Sutton, M.A.1    Masters, S.E.2    Bagnall, M.W.3    Carew, T.J.4
  • 105
    • 1842631465 scopus 로고    scopus 로고
    • Intermediate-term memory for site-specific sensitization in Aplysia is maintained by persistent activation of protein kinase C
    • Sutton MA, Bagnall MW, Sharma SK, Shobe J, Carew TJ (2004) Intermediate-term memory for site-specific sensitization in Aplysia is maintained by persistent activation of protein kinase C. J Neurosci 24: 3600-3609.
    • (2004) J Neurosci , vol.24 , pp. 3600-3609
    • Sutton, M.A.1    Bagnall, M.W.2    Sharma, S.K.3    Shobe, J.4    Carew, T.J.5
  • 106
    • 0026418426 scopus 로고
    • Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits
    • Tang WJ, Gilman AG (1991) Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science 254: 1500-1503.
    • (1991) Science , vol.254 , pp. 1500-1503
    • Tang, W.J.1    Gilman, A.G.2
  • 107
    • 0025874613 scopus 로고
    • Expression and characterization of calmodulin- activated (type I) adenylylcyclase
    • Tang WJ, Krupinski J, Gilman AG (1991) Expression and characterization of calmodulin- activated (type I) adenylylcyclase. J Biol Chem 266: 8595-8603.
    • (1991) J Biol Chem , vol.266 , pp. 8595-8603
    • Tang, W.J.1    Krupinski, J.2    Gilman, A.G.3
  • 108
    • 0028133063 scopus 로고
    • Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases
    • Taussig R, Tang WJ, Hepler JR, Gilman AG (1994) Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J Biol Chem 269: 6093-6100.
    • (1994) J Biol Chem , vol.269 , pp. 6093-6100
    • Taussig, R.1    Tang, W.J.2    Hepler, J.R.3    Gilman, A.G.4
  • 109
    • 2642689663 scopus 로고    scopus 로고
    • Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammas
    • Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR (1997) Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammas. Science 278: 1907-1916.
    • (1997) Science , vol.278 , pp. 1907-1916
    • Tesmer, J.J.1    Sunahara, R.K.2    Gilman, A.G.3    Sprang, S.R.4
  • 110
    • 15444378906 scopus 로고    scopus 로고
    • Serotonininduced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons
    • Udo H, Jin I, Kim JH, Li HL, Youn T, Hawkins RD, Kandel ER, Bailey CH (2005) Serotonininduced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons. Neuron 45: 887-901.
    • (2005) Neuron , vol.45 , pp. 887-901
    • Udo, H.1    Jin, I.2    Kim, J.H.3    Li, H.L.4    Youn, T.5    Hawkins, R.D.6    Kandel, E.R.7    Bailey, C.H.8
  • 111
    • 65549138943 scopus 로고    scopus 로고
    • Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica
    • Villareal G, Li Q, Cai D, Fink AE, Lim T, Bougie JK, Sossin WS, Glanzman DL (2009) Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica . J Neurosci 29: 5100-5107.
    • (2009) J Neurosci , vol.29 , pp. 5100-5107
    • Villareal, G.1    Li, Q.2    Cai, D.3    Fink, A.E.4    Lim, T.5    Bougie, J.K.6    Sossin, W.S.7    Glanzman, D.L.8
  • 112
    • 0020680046 scopus 로고
    • Associative conditioning of single sensory neurons suggests a cellular mechanism for learning
    • Walters ET, Byrne JH (1983) Associative conditioning of single sensory neurons suggests a cellular mechanism for learning. Science 219: 405-408.
    • (1983) Science , vol.219 , pp. 405-408
    • Walters, E.T.1    Byrne, J.H.2
  • 113
    • 0028152433 scopus 로고
    • Synergistic activation of the type i adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo
    • Wayman GA, Impey S, Wu Z, Kindsvogel W, Prichard L, Storm DR (1994) Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo. J Biol Chem 269: 25400-25405.
    • (1994) J Biol Chem , vol.269 , pp. 25400-25405
    • Wayman, G.A.1    Impey, S.2    Wu, Z.3    Kindsvogel, W.4    Prichard, L.5    Storm, D.R.6
  • 114
    • 0029796296 scopus 로고    scopus 로고
    • Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo
    • Wei J, Wayman G, Storm DR (1996) Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. J Biol Chem 271: 24231-24235.
    • (1996) J Biol Chem , vol.271 , pp. 24231-24235
    • Wei, J.1    Wayman, G.2    Storm, D.R.3
  • 115
    • 0032169001 scopus 로고    scopus 로고
    • Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: A mechanism for attenuation of olfactory signals
    • Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR (1998) Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: A mechanism for attenuation of olfactory signals. Neuron 21: 495-504.
    • (1998) Neuron , vol.21 , pp. 495-504
    • Wei, J.1    Zhao, A.Z.2    Chan, G.C.3    Baker, L.P.4    Impey, S.5    Beavo, J.A.6    Storm, D.R.7
  • 116
    • 0018761546 scopus 로고
    • Modulation of buccal muscle contractility by serotonergic metacerebral cells in Aplysia : EEvidence for a role of cyclic adenosine monophosphate
    • Weiss KR, Mandelbaum DE, Schonberg M, Kupfermann I (1979) Modulation of buccal muscle contractility by serotonergic metacerebral cells in Aplysia : Evidence for a role of cyclic adenosine monophosphate. J Neurophysiol 42: 791-803.
    • (1979) J Neurophysiol , vol.42 , pp. 791-803
    • Weiss, K.R.1    Mandelbaum, D.E.2    Schonberg, M.3    Kupfermann, I.4
  • 117
    • 0035930551 scopus 로고    scopus 로고
    • Activation of phospholipase C-epsilon by heterotrimeric G protein beta/gamma-subunits
    • Wing MR, Houston D, Kelley GG, Der CJ, Siderovski DP, Harden TK (2001) Activation of phospholipase C-epsilon by heterotrimeric G protein beta/gamma-subunits. J Biol Chem 276: 48257-48261.
    • (2001) J Biol Chem , vol.276 , pp. 48257-48261
    • Wing, M.R.1    Houston, D.2    Kelley, G.G.3    Der, C.J.4    Siderovski, D.P.5    Harden, T.K.6
  • 118
    • 0142135070 scopus 로고    scopus 로고
    • Direct activation of phospholipase Cepsilon by rho
    • Wing MR, Snyder JT, Sondek J, Harden TK (2003) Direct activation of phospholipase Cepsilon by rho. J Biol Chem 278: 41253-41258.
    • (2003) J Biol Chem , vol.278 , pp. 41253-41258
    • Wing, M.R.1    Snyder, J.T.2    Sondek, J.3    Harden, T.K.4
  • 119
  • 120
    • 0027496709 scopus 로고
    • Modification of the calcium and calmodulin sensitivity of the type i adenylyl cyclase by mutagenesis of its calmodulin binding domain
    • Wu Z, Wong ST, Storms DR (1993) Modification of the calcium and calmodulin sensitivity of the type I adenylyl cyclase by mutagenesis of its calmodulin binding domain. J Biol Chem 268: 23766-23768.
    • (1993) J Biol Chem , vol.268 , pp. 23766-23768
    • Wu, Z.1    Wong, S.T.2    Storms, D.R.3
  • 121
    • 40449113430 scopus 로고    scopus 로고
    • PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane
    • Zhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA (2008) PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane. J Neurosci 28: 2601-2612.
    • (2008) J Neurosci , vol.28 , pp. 2601-2612
    • Zhang, Y.1    Helm, J.S.2    Senatore, A.3    Spafford, J.D.4    Kaczmarek, L.K.5    Jonas, E.A.6
  • 122
    • 33748255729 scopus 로고    scopus 로고
    • Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC Apl i in the induction of intermediate-term facilitation
    • Zhao Y, Leal K, Abi-Farah C, Martin KC, Sossin WS, Klein M (2006) Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC Apl I in the induction of intermediate-term facilitation. J Neurosci 26: 8847-8856.
    • (2006) J Neurosci , vol.26 , pp. 8847-8856
    • Zhao, Y.1    Leal, K.2    Abi-Farah, C.3    Martin, K.C.4    Sossin, W.S.5    Klein, M.6


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