Gαq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway

Biochemical Pharmacology

Volumn 69, Issue 8, 2005, Pages 1247-1256

  Cumbay, Medhane G ^a   Watts, Val J ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Adenylate cyclase; Calmodulin; G alpha q; Learning and memory; Muscarinic receptor; Protein kinase C

Indexed keywords

ADENYLATE CYCLASE; BISINDOLYLMALEIMIDE; CALCIMYCIN; CALCIUM ION; CALMODULIN; CARBACHOL; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ISOPRENALINE; MUSCARINIC M5 RECEPTOR; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOTRANSFERASE; PROTEIN KINASE C; QUINPIROLE; RECEPTOR; SEROTONIN; SEROTONIN 2A RECEPTOR; THAPSIGARGIN; ADENYLATE CYCLASE TYPE 9, HUMAN; BENZYLAMINE DERIVATIVE; CALCIUM; ENZYME INHIBITOR; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MUSCARINIC RECEPTOR; SEROTONIN 2 RECEPTOR; SULFONAMIDE;

ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; BENZYLAMINES; CALCIUM; CALMODULIN; CELL LINE; CYCLIC AMP; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; INDOLES; ISOPROTERENOL; MALEIMIDES; MUTATION; PROTEIN KINASE C; RECEPTORS, MUSCARINIC; RECEPTORS, SEROTONIN, 5-HT2; SIGNAL TRANSDUCTION; SULFONAMIDES; THAPSIGARGIN;

EID: 15744404251     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.02.001     Document Type: Article

References (39)

1. R.K. Sunahara, and R. Taussig Isoforms of mammalian adenylyl cyclase: multiplicities of signaling Mol Interven 2 2002 168 184
2. B.M. Hacker, J.E. Tomlinson, G.A. Wayman, R. Sultana, G. Chan, and E. Villacres Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9) Genomics 50 1998 97 104
3. 2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory J Neurosci 18 1998 9650 9661
4. 2+/calcineurin and differential mRNA polyadenylation J Neurochem 75 2000 1358 1367
5. S.A. Sosunov, S.P. Kemaikin, I.A. Kurnikova, F.A. Antoni, and A.A. Sosunov Expression of adenylyl cyclase type IX and calcineurin in synapses of the central nervous system Bull Exp Biol Med 2 2001 172 175
6. J.M. Paterson, S.M. Smith, A.J. Harmar, and F.A. Antoni Control of a novel adenylyl cyclase by calcineurin Biochem Biophys Res Commun 214 1995 1000 1008
7. M.G. Cumbay, and V.J. Watts Novel regulatory properties of human type 9 adenylate cyclase (AC9) J Pharmacol Exp Ther 310 2004 108 115
8. 2+ and Gs-coupled receptors in vivo J Biol Chem 269 1994 25400 25405
9. E.-J. Choi, W.T. Wong, T.R. Hinds, and D.R. Storm Calcium and muscarinic agonist stimulation of type I adenylylcyclase in whole cells J Biol Chem 267 1992 12440 12442
10. K.D. Lustig, B.R. Conklin, P. Herzmark, R. Taussig, and H.R. Bourne Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq J Biol Chem 268 1993 13900 13905
11. R.C. Tsu, and Y.H. Wong Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment J Neurosci 16 1996 1317 1323
12. M.G. Cumbay, and V.J. Watts Heterologous sensitization of recombinant adenylate cyclases by activation of D2 dopamine receptors J Pharmacol Exp Ther 297 2001 1201 1209
13. 2+ entry sites J Biol Chem 271 1996 12438 12444
14. V.J. Watts, and K.A. Neve Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors Mol Pharmacol 50 1996 966 976
15. K. Hellevuo, M. Yoshimura, M. Kao, P.L. Hoffman, Cooper DMF, and B. Tabakoff A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line Biochem Biophys Res Commun 192 1993 311 318
16. A.D. Federman, B.R. Conklin, K.A. Schrader, R.R. Reed, and H.R. Bourne Hormonal stimulation of adenylyl cyclase through Gi-protein bg subunits Nature 356 1992 159 161
17. P. Crespo, X. Wu, W.F. Simonds, and J.S. Gutkind Ras-dependent activation of MAP kinase pathway mediated by G-protein bg subunits Nature 369 1994 418 420
18. M. Faure, T.A. Voyno-Yasenetskaya, and H.R. Bourne cAMP and bg subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells J Biol Chem 269 1994 7851 7854
19. J.A. Pitcher, J. Inglese, J.B. Higgins, J.L. Arriza, P.J. Casey, and C. Kim Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors Science 257 1992 1264 1267
20. 2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase Proc Natl Acad Sci U S A 87 1990 2466 2470
21. H. Wang, and D.R. Storm Calmoduln-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system Mol. Pharmacol. 63 2003 463 468
22. R.T. Premont, I. Matsuoka, M.G. Mattei, Y. Pouille, N. Defer, and J. Hanoune Identification and characterization of a widely expressed form of adenylyl cyclase J Biol Chem 271 1996 13900 13907
23. R. Taussig, and G. Zimmerman Type-specific regulation of mammalian adenylyl cyclases by G protein pathways Adv Sec Mess Phospho Res 32 1998 81 98
24. J.G. Meszaros, A.M. Gonzalez, Y. Endo-Mochizuki, S. Villegas, F. Villarreal, and L.L. Brunton Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between G(q) and G(s) Am J Physiol Cell Physiol 278 2000 C154 C162
25. 2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts J Biol Chem 278 2003 24461 24468
26. F.A. Antoni, R.J. Barnard, M.J. Shipston, S.M. Smith, J. Simpson, and J.M. Paterson Calcineurin feedback inhibition of agonist-evoked cAMP formation J Biol Chem 270 1995 28055 28061
27. 2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels Recent Prog Horm Res 55 2000 127 161 discussion 61-2
28. 2+ entry J Biol Chem 273 1998 9297 9305
29. P. Wang, Y.L. Wu, T.H. Zhou, Y. Sun, and G. Pei Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin- dependent protein kinase II with different activities FEBS Lett 475 2000 107 110
30. 2+ current J Biol Chem 278 2003 33730 33737
31. T.V. Bliss, and G.L. Collingridge A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 1993 31 39
32. D.M. Chetkovich, and J.D. Sweatt nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase J Neurochem 61 1993 1933 1942
33. 2+/ calmodulin-stimulable adenylyl cyclases as molecular coincidence detectors in memory formation Cell Mol Life Sci 55 1999 525 533
34. R.D. Blitzer, T. Wong, R. Nouranifar, R. Iyengar, and E.M. Landau Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region Neuron 15 1995 1403 1414
35. 2+-stimulated adenylyl cyclases in LTP and memory formation Int J Dev Neurosci 19 2001 387 394
36. S.T. Wong, J. Athos, X.A. Figueroa, V.V. Pineda, M.L. Scheafer, and C.C. Chavkin Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP Neuron 23 1999 787 798
37. R. Lujan, Z. Nusser, J.D. Roberts, R. Shigemoto, and P. Somogyi Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus Eur J Neurosci 8 1996 1488 1500
38. Y.M. Lu, Z. Jia, C. Janus, J.T. Henderson, R. Gerlai, and J.M. Wojtowicz Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP J Neurosci 17 1997 5196 5205
39. M. Miura, M. Watanabe, S. Offermanns, M.I. Simon, and M. Kano Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1 J Neurosci 22 2002 8379 8390