Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine

European Journal of Pharmacology

Volumn 628, Issue 1-3, 2010, Pages 274-281

  Kheradpezhouh, Ehsan ^a,b   Panjehshahin, Mohammad Reza ^a,b   Miri, Ramin ^b   Javidnia, Katayoun ^b   Noorafshan, Ali ^a   Monabati, Ahmad ^a   Dehpour, Ahmad Reza ^c  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

(Rat); Acetaminophen; Curcumin; Hepatorenal toxicity; N acetyl cysteine

Indexed keywords

ACETYLCYSTEINE; CATALASE; CURCUMIN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CURCUMA LONGA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENTIATION; HISTOPATHOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

ACETAMINOPHEN; ACETYLCYSTEINE; ANIMALS; BIOLOGICAL MARKERS; CATALASE; CURCUMIN; DRUG SYNERGISM; GLUTATHIONE PEROXIDASE; KIDNEY; KIDNEY DISEASES; LIVER; LIVER DISEASES; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SEROLOGIC TESTS;

EID: 73649119146     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.027     Document Type: Article

References (44)

1. Appelboam A.V., Dargan P.I., and Knighton J. Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg. Med. J. 19 (2002) 594-595
2. Arora R.B., Kapoor V., Basu N., and Jain A.P. Anti-inflammatory studies on Curcuma longa (turmeric). Indian J. Med. Res. 59 (1971) 1289-1295
3. Bailey B., and McGuigan M.A. Management of anaphylactoid reactions to N-acetylcysteine. Ann. Emerg. Med. 31 (1998) 710-715
4. Bessems J.G., and Vermeulen N.P. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanism, analogues, and protective approaches. Crit. Rev. Toxicol. 31 (2001) 55-138
5. Blakely P., and McDonaldm B.R. Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. J. Am. Soc. Nephrol. 6 (1995) 48-53
6. Cekmen M., Ilbey Y.O., Ozbek E., Simsek A., Somay A., and Ersoz C. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem. Toxicol. 47 (2009) 1480-1484
7. Chandra D., and Gupta S. Anti-inflammatory and antiarthritic activity of volatile oil of Curcuma longa (Haldi). Indian J. Med. Res. 60 (1972) 138-142
8. Cobden I., Record C.O., Ward M.K., and Kerr D.N.S. Paracetamol induced acute renal failure in the absence of fulminant liver damage. Br. Med. J. 284 (1982) 21-22
9. Zhao C., Sheryl D., and Zhou Y.X. Effects of combined use of diallyl disulfide and Nacetyl-cysteine on acetaminophen hepatotoxicity in β-naphthoflavone pretreated mice. World J. Gastroenterol. 4 (1998) 153-157
10. Corson T.W., and Crews C.M. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130 (2007) 769-774
11. Dahlin D.C., Miwa G.T., Lu A.Y., and Nelson S.D. Nacetyl p-benzoquinimine: a cytochrome P450 mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 1327-1331
12. Dawson A.H., Henry D.A., and McEwen J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med. J. Aust. 150 (1989) 329-331
13. Deshpande U.R., Gadre S.G., Raste A.S., Pillai D., Bhide S.V., and Samuel A.M. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats. Indian J. Exp. Biol. 36 (1998) 573-577
14. Eguia L., and Materson B.J. Acetaminophen related acute renal failure without fulminant hepatic failure. Pharmacotherapy 17 (1997) 363-370
15. El-Beshbishy H.A. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J. Biochem. Mol. Biol. 38 (2005) 300-306
16. Fagan E., and Wannan G. Reducing paracetamol overdoses. Br. Med. J. 313 (1996) 1417-1418
17. Gu J., Cui H., Behr M., Zhang Q.Y., Yang W., Hinson J.A., et al. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P-450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol. Pharmacol. 67 (2005) 623-630
18. Hart S.G., Beierschmitt W.P., Wyand D.S., Khairallah E.A., and Cohen S.D. Acetaminophen toxicity in CD-1 mice. I. Evidence of a role for in situ activation in selective covalent binding and toxicity. Toxicol. Appl. Pharmacol. 126 (1994) 267-275
19. Ho S.W., and Beilin L.J. Asthma associated with N-acetylcysteine infusion and paracetamol poisoning:report of two cases. Br. Med. J. 287 (1983) 876-877
20. Inano H., Onoda M., Inafuku N., Kubota M., Kamada Y., Osawa T., Kobayashi H., and Wakabayashi K. Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21 (2000) 1835-1841
21. Jobin C., Bradham C.A., Russo M.P., Juma B., Narula A.S., Brenner D.A., and Sartor R.B. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J. Immunol. 163 (1999) 3474-3483
22. Kao L.W., Kirk M.A., Furbee R.B., Mehta N.H., Skinner J.R., and Brizendine E.J. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?. Ann. Emerg. Med. 42 (2003) 741-750
23. Kiso Y., Suzuki Y., Watanabe N., Oshima Y., and Hikino H. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. 49 (1983) 185-187
24. Knight T.R., Kurtz A., Bajt M.L., Hinson J.A., and Jaeschkae H. Vascular and hepatocellular peroxonitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol. Sci. 62 (2001) 212-220
25. Lin C.C., Hsu Y.F., Lin T.C., and Hsu H.Y. Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats. Phytother. Res. 15 (2001) 206-212
26. Ma Z., Shayeganpour A., Brocks D.R., Lavasanifar A., and Samuel J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed. Chromatogr. 21 (2007) 546-552
27. Mansour H.H., Hafez H.F., and Fahmy N.M. Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats. J. Biochem. Mol. Biol. 39 (2006) 656-661
28. Mant T.G., Tempowski J.H., Volans G.N., and Talbot J.C.L. Adverse reactions to acetylcysteine and effects of overdose. Br. Med. J. 289 (1984) 217-219
29. Michael S.L., Pumford N.R., Mayeux P.R., Niesman M.R., and Hinson J.A. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology 30 (1999) 186-195
30. Mitchell J.R., Jollow D.J., Potter W.Z., Gillete J.R., and Brodie B.B. Acetaminophen induced hepatic necrosis. J. Biochem. Mol. Biol. 39 (1973) 656-661
31. Montilla P., Barcos M., Munoz M.C., Bujalance I., Munoz-Castaneda J.R., and Tunez I. Red wine prevents brain oxidative stress and nephropathy in streptozotocin-induced diabetic rats. J. Biochem. Mol. Biol. 38 (2005) 539-544
32. Mukhopadhyay A., Basu N., Ghatak N., and Gujral P.K. Antiinflammatory and irritant activities of curcumin analogues in rats. Agents Actions 12 (1982) 508-515
33. Nakae D., Yamamoto K., Yoshij H., Kinugasa T., Marayuma H., Farber J.L., and Konishi Y. Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen. Am. J. Pathol. 136 (1990) 787-795
34. Pan M.H., Lin-Shiau S.Y., and Lin J.K. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages. Biochem. Pharmacol. 60 (2000) 1665-1676
35. Piper J.T., Singhal S.S., Salameh M.S., Torman R.T., Awasthi Y.C., and Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Int. J. Biochem. Cell Biol. 30 (1998) 445-456
36. Proudfoot A.T., and Wright N. Acute paracetamol poisoning. Br. Med. J. 3 (1970) 557-558
37. Rao C.V., Rivenson A., Simi B., and Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55 (1995) 259-266
38. Reddy A.C., and Lokesh B.R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol. Cell. Biochem. 137 (1994) 1-8
39. Roomi M.W., Kalinovsky T., Ivanov V., Rath M., and Niedzwiecki A. A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice. Hum. Exp. Toxicol. 27 (2008) 223-230
40. Ross D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol. Ther. 37 (1998) 231-249
41. Sener G., Sehirli A.O., and Ayanoǧlu-Dülger G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. J. Pineal Res. 35 (2003) 61-68
42. Srimal R.C., and Dhawan B.N. Pharmacology of diferuloyl methane (curcumin), a nonsteroidal anti-inflammatory agent. J. Pharm. Pharmacol. 25 (1973) 447-452
43. Thomas S.H.L. Paracetamol (acetaminophen) poisoning. Pharmacol. Ther. 60 (1993) 91-120
44. Zhang Z., Cai Q., Michea L., Dmitrieva N., Andrews P., and Burg M. Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture. Am. J. Physiol. Renal Physiol. 283 (2002) 203-208