Estrogen receptor-α as a drug target candidate for preventing lung inflammation

Endocrinology

Volumn 151, Issue 1, 2010, Pages 174-184

  Vegeto, Elisabetta ^a   Cuzzocrea, Salvatore ^b   Crisafulli, Concetta ^b   Mazzon, Emanuela ^b   Sala, Angelo ^a   Krust, Andreè ^c   Maggi, Adriana ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HORMONE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DRUG TARGETING; FEMALE; GENDER; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LUNG; MALE; MEDIATOR; MOUSE; NONHUMAN; OVARIECTOMY; PLEURA; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEPLETION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SHAM PROCEDURE; SIGNAL TRANSDUCTION; WILD TYPE;

AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVARIECTOMY; PNEUMONIA; SEX CHARACTERISTICS;

EID: 73649112085     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0876     Document Type: Article

References (39)

1. Sweezey N, Tchepichev S, Gagnon S, Fertuck K, O'Brodovich H 1998 Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel.AmJ Physiol 274:C379-C386
2. Torday JS, Nielsen HC 1987 The sex difference in fetal lung surfactant production. Exp Lung Res 12:1-19
3. Carey MA, Card JW, Voltz JW, Germolec DR, Korach KS, Zeldin DC 2007 The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies.AmJ Physiol Lung CellMol Physiol 293:L272-L278
4. Massaro GD, Mortola JP, Massaro D 1996 Estrogen modulates the dimensions of the lung's gas-exchange surface area and alveoli in female rats. Am J Physiol 270:L110-L114
5. Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabrò G, Serraino I, Caputi AP, Maggi A 2000 17β-Estradiol antiinflammatory activity in CAR-induced pleurisy. Endocrinology 141:1455-1463
6. Ligeiro de Oliveira AP, Oliveira-Filho RM, da Silva ZL, Borelli P, Tavares de LimaW2004 Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone. Neuroimmunomodulation 11:20-27
7. Carey MA, Card JW, Voltz JW, Arbes Jr SJ, Germolec DR, Korach KS, Zeldin DC 2007 It's all about sex: gender, lung development and lung disease. Trends Endocrinol Metab 18:308-313
8. Greally P, Hussein MJ, Cook AJ, Sampson AP, Piper PJ, Price JF 1993 Sputum tumour necrosis factor-α and leukotriene concentrations in cystic fibrosis. Arch Dis Child 68:389-392
9. Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, BergerM1995 Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 152:2111-2118
10. Cheskis BJ, Greger JG, Nagpal S, Freedman LP 2007 Signaling by estrogens. J Cell Physiol 213:610-617
11. Massaro D, Massaro GD 2006 Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in mice. Am J Physiol Lung Cell Mol Physiol 290:L866-L870
12. Patrone C, Cassel TN, Pettersson K, Piao YS, Cheng G, Ciana P, Maggi A, Warner M, Gustafsson JA, Nord M 2003 Regulation of postnatal lung development and homeostasis by estrogen receptorβ. Mol Cell Biol 23:8542-8552
13. Vegeto E, Ciana P, Maggi A 2002 Estrogen and inflammation: hormone generous action spreads to the brain. Mol Psychiatry 7:236-238
14. Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC 2006 Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation. J Immunol 177:621-630
15. Speyer CL, Rancilio NJ, McClintock SD, Crawford JD, Gao H, Sarma JV, Ward PA 2005 Regulatory effects of estrogen on acute lung inflammation in mice. Am J Physiol Cell Physiol 288:C881-C890
16. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, MarkM 2000 Development 127:4277-4291
17. Cuzzocrea S, Mazzon E, Sautebin L, Serraino I, Dugo L, Calabró G, Caputi AP, Maggi A 2001 The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat. Mol Med 7:478 -487
18. Mullane KM, Kraemer R, Smith B 1985 Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167
19. Vegeto E, Bonincontro C, Pollio G, Sala A, Viappiani S, Nardi F, Brusadelli A, Viviani B, Ciana P, Maggi A 2001 Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. J Neurosci 21:1809-1818
20. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2[-ΔΔC(T)] method. Methods 25:402-408
21. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS 1997 Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse. Endocrinology 138:4613-4621
22. Massaro D, Massaro GD 2004 Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice. Am J Physiol Lung Cell Mol Physiol 287:L1154-L1159
23. Igarashi H, Kouro T, Yokota T, Comp PC, Kincade PW 2001 Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc Natl Acad Sci USA 98:15131-15136
24. Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, ZeldinDC2007 Spontaneous airway hyperresponsiveness in estrogen receptor-α-deficient mice.AmJ Respir Crit Care Med 175:126-135
25. Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM 2001 Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 98:1952-1957
26. Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P, Maggi A 2003 Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci USA 100:9614-9619
27. Polanczyk M, Yellayi S, Zamora A, Subramanian S, Tovey M, VandenbarkAA,Offner H, Zachary JF, Fillmore PD, Blankenhorn EP, Gustafsson JA, Teuscher C 2004 Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Am J Pathol 164:1915-1924
28. Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, Arnal JF 2001 Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-α but not estrogen receptor-β. Circulation 103:423-428
29. Massaro D, Clerch LB, Massaro GD 2007 Estrogen receptor-β regulates pulmonary alveolar loss and regeneration in female mice: morphometric and gene expression studies. Am J Physiol Lung Cell Mol Physiol 293:L222-L228
30. Yu HP, Hsieh YC, Suzuki T, Shimizu T, Choudhry MA, Schwacha MG, Chaudry IH 2006 Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 290:L1004-L1009
31. Catley MC, Birrell MA, Hardaker EL, de Alba J, Farrow S, Haj-Yahia S, Belvisi MG 2008 Estrogen receptor β: expression profile and possible anti-inflammatory role in disease. J Pharmacol Exp Ther 326:83-88
32. Adcock IM, Ford PA, Bhavsar P, Ahmad T, Chung KF 2008 Steroid resistance in asthma: mechanisms and treatment options. Curr Allergy Asthma Rep 8:171-178
33. Falk JA, Minai OA, Mosenifar Z 2008 Inhaled and systemic corticosteroids in chronic obstructive pulmonary disease. Proc Am Thorac Soc 5:506-512
34. Labaree DC, Reynolds TY, Hochberg RB 2001 Estradiol-16α- carboxylic acid esters as locally active estrogens. J Medicinal Chem 44:1802-1814
35. Ghisletti S, Meda C, Maggi A, Vegeto E 2005 17β-Estradiol inhibits inflammatory gene expression by controlling NF-κB intracellular localization. Mol Cell Biol 25:2957-2968
36. Cailhier JF, Sawatzky DA, Kipari T, Houlberg K, Walbaum D, Watson S, Lang RA, Clay S, Kluth D, Savill J, Hughes J 2006 Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation.AmJ Respir Crit Care Med 173:540-547
37. Paharkova-Vatchkova V, Maldonado R, Kovats S 2004 Estrogen preferentially promotes the differentiation of CD11c+ CD11b(intermediate) dendritic cells from bone marrow precursors. J Immunol 172:1426-1436
38. Gharaee-Kermani M, Gyetko MR, Hu B, Phan SH 2007 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy. Pharm Res 24:819-841
39. Corsini E, Di Paola R, Viviani B, Genovese T, Mazzon E, Lucchi L, Marinovich M, Galli CL, Cuzzocrea S 2005 Increased carrageenan-induced acute lung inflammation in old rats. Immunology 115:253-261