Molecular mechanisms behind the resistance of cisplatin in germ cell tumours

Clinical and Translational Oncology

Volumn 11, Issue 12, 2009, Pages 780-786

  Piulats, Josep Ma ^a,b   Jiménez, Laura ^a,b   García Del Muro, Xavier ^a,b   Villanueva, Alberto ^b   Viñals, Francesc ^b   Germà Lluch, José R ^a  

^a HOSPITAL DURAN I REYNALS   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Cisplatin resistance; Germ Cell tumors; Testicular cancer

Indexed keywords

CISPLATIN; DNA; ETOPOSIDE; SUNITINIB;

ANTINEOPLASTIC ACTIVITY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARCINOMA IN SITU; CHEMOSENSITIVITY; CHORIOCARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE MODEL; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENTIATION; EMBRYONAL CARCINOMA; GENE MUTATION; GENETIC PREDISPOSITION; GERM CELL TUMOR; HUMAN; MOLECULAR GENETICS; MOLECULAR MECHANICS; NONHUMAN; REVIEW; TESTIS CANCER;

EID: 73549121719     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-009-0446-3     Document Type: Review

References (62)

1. J.W. Oosterhuis L.H. Looijenga 2005 Testicular germ-cell tumours in a broader perspective Nat Rev Cancer 5 210 222 10.1038/nrc1568 1:CAS:528:DC%2BD2MXhslSnt7Y%3D 15738984 (Pubitemid 40314952)
2. S. Krege J. Beyer R. Souchon, et al. 2008 European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I Eur Urol 53 478 496 10.1016/j.eururo.2007.12.024 18191324
3. S. Krege J. Beyer R. Souchon, et al. 2008 European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II Eur Urol 53 497 513 10.1016/j.eururo.2007.12.025 18191015
4. J.R. Germa-Lluch X. Garcia del Muro P. Maroto, et al. 2002 Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish Germ-Cell Cancer Group (GG) Eur Urol 42 553 562 10.1016/S0302-2838(02)00439-6 1:STN:280:DC%2BD38jhsFKrsA%3D%3D 12477650 (Pubitemid 35462333)
5. L. Kelland 2007 The resurgence of platinumbased cancer chemotherapy Nat Rev Cancer 7 573 584 10.1038/nrc2167 1:CAS:528:DC%2BD2sXotVKru7c%3D 17625587
6. L.C. Stevens C.C. Little 1954 Spontaneous testicular teratomas in an inbred strain of mice Proc Natl Acad Sci U S A 40 1080 1087 10.1073/pnas.40.11. 1080 1:STN:280:DC%2BD28zitVyjsQ%3D%3D 16578442
7. K.K. Youngren D. Coveney X. Peng, et al. 2005 The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours Nature 435 360 364 10.1038/nature03595 1:CAS:528:DC%2BD2MXkt1WktLw%3D 15902260 (Pubitemid 40745546)
8. H. Walt J.W. Oosterhuis L.C. Stevens 1993 Experimental testicular germ cell tumorigenesis in mouse strains with and without spontaneous tumours differs from development of germ cell tumours of the adult human testis Int J Androl 16 267 271 10.1111/j.1365-2605.1993.tb01190.x 1:STN:280:DyaK2c%2Fos1Wguw%3D%3D 8262659
9. N.B. Atkin M.C. Baker 1982 Specific chromosome change, i(12p), in testicular tumours? Lancet 2 1349 10.1016/S0140-6736(82)91557-4 1:STN:280:DyaL3s%2FmtFGlsw%3D%3D 6128640
10. L.H. Looijenga R.A. Olie I. van der Gaag, et al. 1994 Seminomas of the canine testis. Counterpart of spermatocytic seminoma of men? Lab Invest 71 490 496 1:STN:280:DyaK2M%2FlslSisg%3D%3D 7967505
11. Piulats JM, Vidal A, Nadal M et al (2006) Development of a human testicular germ cell tumor model in athymic mice. AACR Meeting Abstracts (#649)
12. W. Castillo-Avila J.M. Piulats X. Garcia Del Muro, et al. 2009 Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors Clin Cancer Res 15 3384 3395 10.1158/1078-0432.CCR-08-2170 1:CAS:528: DC%2BD1MXmtVKmu70%3D 19417025
13. B. Rosenberg L. Vancamp T. Krigas 1965 Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode Nature 205 698 699 10.1038/205698a0 1:CAS:528:DyaF2MXns1aruw%3D%3D 14287410
14. J.W. Oosterhuis P.W. Andrews B.B. Knowles, et al. 1984 Effects of cis-platinum on embryonal carcinoma cell lines in vitro Int J Cancer 34 133 139 10.1002/ijc.2910340123 1:CAS:528:DyaL2cXlsVelurg%3D 6540246
15. J. Cairns 2002 Somatic stem cells and the kinetics of mutagenesis and carcinogenesis Proc Natl Acad Sci U S A 99 10567 10570 10.1073/pnas.162369899 1:CAS:528:DC%2BD38Xmt1ChsLw%3D 12149477 (Pubitemid 34907017)
16. Y. Hong P.J. Stambrook 2004 Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation Proc Natl Acad Sci U S A 101 14443 14448 10.1073/pnas.0401346101 1:CAS:528: DC%2BD2cXovVertbc%3D 15452351 (Pubitemid 39346768)
17. A.M. Kersemaekers F. Mayer M. Molier, et al. 2002 Role of P53 and MDM2 in treatment response of human germ cell tumors J Clin Oncol 20 1551 1561 10.1200/JCO.20.6.1551 1:CAS:528:DC%2BD38XivFeitr0%3D 11896104 (Pubitemid 34260535)
18. J.R. Masters B. Koberle 2003 Curing metastatic cancer: lessons from testicular germ-cell tumours Nat Rev Cancer 3 517 525 10.1038/nrc1120 1:CAS:528:DC%2BD3sXltVSqtr4%3D 12835671
19. B. Koberle J.R. Masters J.A. Hartley, et al. 1999 Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours Curr Biol 9 273 276 10.1016/S0960-9822(99)80118-3 1:CAS:528:DyaK1MXhvFejt74%3D 10074455 (Pubitemid 29139312)
20. D.B. Zamble Y. Mikata C.H. Eng, et al. 2002 Testis-specific HMG-domain protein alters the responses of cells to cisplatin J Inorg Biochem 91 451 462 10.1016/S0162-0134(02)00472-5 1:CAS:528:DC%2BD38XmtlCmur8%3D 12175937 (Pubitemid 34888110)
21. D.C. Spierings E.G. de Vries E. Vellenga, et al. 2003 The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis-inducing stimuli J Pathol 200 137 148 10.1002/path.1373 1:CAS:528:DC%2BD3sXlsFeju7c%3D 12754734 (Pubitemid 36748022)
22. P.W. Schenk H. Stoop C. Bokemeyer, et al. 2004 Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1 Neoplasia 6 297 301 10.1593/neo.03406 1:CAS:528:DC%2BD2cXmslWlurg%3D 15256051 (Pubitemid 38924844)
23. L.R. Kelland P. Mistry G. Abel, et al. 1992 Mechanism-related circumvention of acquired cisdiamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates Cancer Res 52 3857 3864 1:CAS:528:DyaK38XkvVejtLg%3D 1617660
24. D.P. Gately S.B. Howell 1993 Cellular accumulation of the anticancer agent cisplatin: a review Br J Cancer 67 1171 1176 1:CAS:528: DyaK2cXksVymsQ%3D%3D 8512802
25. S. Ishida J. Lee D.J. Thiele, et al. 2002 Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals Proc Natl Acad Sci U S A 99 14298 14302 10.1073/pnas.162491399 1:CAS:528: DC%2BD38XosF2iurs%3D 12370430 (Pubitemid 35257666)
26. A.K. Holzer S.B. Howell 2006 The internalization and degradation of human copper transporter 1 following cisplatin exposure Cancer Res 66 10944 10952 10.1158/0008-5472.CAN-06-1710 1:CAS:528:DC%2BD2sXivVyqtrk%3D 17108132 (Pubitemid 44876993)
27. P. Borst R. Evers M. Kool, et al. 2000 A family of drug transporters: the multidrug resistance-associated proteins J Natl Cancer Inst 92 1295 1302 10.1093/jnci/92.16.1295 1:CAS:528:DC%2BD3cXmtlektr8%3D 10944550
28. G.L. Scheffer A.B. Schroeijers M.A. Izquierdo, et al. 2000 Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer Curr Opin Oncol 12 550 556 10.1097/00001622-200011000-00007 1:CAS:528:DC%2BD3cXos1ygtL4%3D 11085454 (Pubitemid 32039654)
29. A.J. Zurita J.E. Diestra E. Condom, et al. 2003 Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours Br J Cancer 88 879 886 10.1038/sj.bjc.6600803 1:STN:280: DC%2BD3s7ivFOgtQ%3D%3D 12644825 (Pubitemid 36520875)
30. F. Mayer H. Stoop G.L. Scheffer, et al. 2003 Molecular determinants of treatment response in human germ cell tumors Clin Cancer Res 9 767 773 1:CAS:528:DC%2BD3sXhtVKksb8%3D 12576448 (Pubitemid 36182613)
31. M. Kool M. de Haas G.L. Scheffer, et al. 1997 Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines Cancer Res 57 3537 3547 1:CAS:528:DyaK2sXls1Sgsr0%3D 9270026
32. R. Safaei A.K. Holzer K. Katano, et al. 2004 The role of copper transporters in the development of resistance to Pt drugs J Inorg Biochem 98 1607 1613 10.1016/j.jinorgbio.2004.05.006 1:CAS:528:DC%2BD2cXotF2mtbo%3D 15458823 (Pubitemid 39359155)
33. G. Samimi R. Safaei K. Katano, et al. 2004 Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells Clin Cancer Res 10 4661 4669 10.1158/1078-0432.CCR-04-0137 1:CAS:528:DC%2BD2cXlvVehu7g%3D 15269138 (Pubitemid 38955516)
34. B.A. Jansen J. Brouwer J. Reedijk 2002 Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs J Inorg Biochem 89 197 202 10.1016/S0162-0134(02)00381-1 1:CAS:528:DC%2BD38XjtVSitLs%3D 12062123 (Pubitemid 34327260)
35. T. Ishikawa 1992 The ATP-dependent glutathione S-conjugate export pump Trends Biochem Sci 17 463 468 10.1016/0968-0004(92)90489-V 1:CAS:528: DyaK3sXhvVSltQ%3D%3D 1455517
36. J.R. Masters R. Thomas A.G. Hall, et al. 1996 Sensitivity of testis tumour cells to chemotherapeutic drugs: role of detoxifying pathways Eur J Cancer 32A 1248 1253 10.1016/0959-8049(96)00033-0 1:CAS:528:DyaK28Xkslagurk%3D 8758261 (Pubitemid 26231811)
37. J. Koropatnick D.M. Kloth S. Kadhim, et al. 1995 Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line J Pharmacol Exp Ther 275 1681 1687 1:CAS:528:DyaK28XhvV2htQ%3D%3D 8531144
38. M.W. Sark H. Timmer-Bosscha C. Meijer, et al. 1995 Cellular basis for differential sensitivity to cisplatin in human germ cell tumour and colon carcinoma cell lines Br J Cancer 71 684 690 1:CAS:528:DyaK2MXmtF2ksL0%3D 7710929
39. C. Meijer A. Timmer E.G. De Vries, et al. 2000 Role of metallothionein in cisplatin sensitivity of germ-cell tumours Int J Cancer 85 777 781 10.1002/(SICI)1097-0215(20000315)85:6<777::AID-IJC6>3.0.CO;2-D 1:CAS:528:DC%2BD3cXitVeiu7w%3D 10709094 (Pubitemid 30131464)
40. S.W. Johnson P.A. Swiggard L.M. Handel, et al. 1994 Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells Cancer Res 54 5911 5916 1:CAS:528:DyaK2MXitV2qs7s%3D 7954422
41. E. Reed 1998 Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy Cancer Treat Rev 24 331 344 10.1016/S0305- 7372(98)90056-1 1:CAS:528:DyaK1MXitVCqtg%3D%3D 9861196
42. B. Koberle V. Roginskaya K.S. Zima, et al. 2008 Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiation Mol Carcinog 47 580 586 10.1002/mc.20418 1:CAS:528: DC%2BD1cXpt1Witrk%3D 18240296
43. F. Honecker F. Mayer H. Stoop, et al. 2003 Xeroderma pigmentosum group a protein and chemotherapy resistance in human germ cell tumors Lab Invest 83 1489 1495 10.1097/01.LAB.0000090221.95883.41 1:CAS:528:DC%2BD3sXnvVajtb4%3D 14563950 (Pubitemid 37267832)
44. Azambuja AA, Viola LS, Piccoli J et al (2008) ERCC1 expression is a predictor of clinical outcome in germ cell tumors treated with standard cisplatin based chemotherapy. ASCO Meeting Abstracts (#16013)
45. Hernandez CH (2008) Role of XPA, ERCC1, mt-TFA on the survival of patients with metastatic germ cell tumors of testis treated with cisplatin. ASCO Meeting Abstracts (#5090)
46. B.B. Zhou S.J. Elledge 2000 The DNA damage response: putting checkpoints in perspective Nature 408 433 439 10.1038/35044005 1:CAS:528: DC%2BD3cXos1Srsb0%3D 11100718
47. S. Aebi B. Kurdi-Haidar R. Gordon, et al. 1996 Loss of DNA mismatch repair in acquired resistance to cisplatin Cancer Res 56 3087 3090 1:CAS:528:DyaK28XjvFCkt7c%3D 8674066 (Pubitemid 26199755)
48. H. Lage M. Dietel 1999 Involvement of the DNA mismatch repair system in antineoplastic drug resistance J Cancer Res Clin Oncol 125 156 165 10.1007/s004320050258 1:CAS:528:DyaK1MXitlKltLs%3D 10235469 (Pubitemid 29172506)
49. R.A. Lothe P. Peltomaki N. Tommerup, et al. 1995 Molecular genetic changes in human male germ cell tumors Lab Invest 73 606 614 1:CAS:528:DyaK28Xit12gtLo%3D 7474934
50. M. Devouassoux-Shisheboran C. Mauduit R. Bouvier, et al. 2001 Expression of hMLH1 and hMSH2 and assessment of microsatellite instability in testicular and mediastinal germ cell tumours Mol Hum Reprod 7 1099 1105 10.1093/molehr/7.12.1099 1:CAS:528:DC%2BD38XisFOjtA%3D%3D 11719586
51. F. Mayer A.J. Gillis W. Dinjens, et al. 2002 Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment Cancer Res 62 2758 2760 1:CAS:528:DC%2BD38XjvFSmtrw%3D 12019150
52. F. Honecker H. Wermann F. Mayer, et al. 2009 Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors J Clin Oncol 27 2129 2136 10.1200/JCO.2008.18.8623 1:CAS:528: DC%2BD1MXlvFOgsrs%3D 19289622
53. A.J. Levine 1997 p53, the cellular gatekeeper for growth and division Cell 88 323 331 10.1016/S0092-8674(00)81871-1 1:CAS:528:DyaK2sXhtFahtLg%3D 9039259 (Pubitemid 27131374)
54. J. Houldsworth H. Xiao V.V. Murty, et al. 1998 Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation Oncogene 16 2345 2349 10.1038/sj.onc.1201770 1:CAS:528:DyaK1cXjt12msbY%3D 9620551 (Pubitemid 28226881)
55. F. Mayer F. Honecker L.H. Looijenga, et al. 2003 Towards an understanding of the biological basis of response to cisplatin-based chemotherapy in germ-cell tumors Ann Oncol 14 825 832 10.1093/annonc/mdg242 1:STN:280: DC%2BD3s3mvFGnsg%3D%3D 12796018 (Pubitemid 36827197)
56. C.M. Chresta J.R. Masters J.A. Hickman 1996 Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio Cancer Res 56 1834 1841 1:CAS:528: DyaK28Xitlyks7g%3D 8620501
57. H. Burger K. Nooter A.W. Boersma, et al. 1998 Expression of p53, Bcl-2 and Bax in cisplatininduced apoptosis in testicular germ cell tumour cell lines Br J Cancer 77 1562 1567 1:CAS:528:DyaK1cXjvVChur4%3D 9635829 (Pubitemid 28230454)
58. S. Baltaci D. Orhan K. Turkolmez, et al. 2001 P53, bcl-2 and bax immunoreactivity as predictors of response and outcome after chemotherapy for metastatic germ cell testicular tumours BJU Int 87 661 666 10.1046/j.1464-410x. 2001.02151.x 1:STN:280:DC%2BD3M3lt1aitg%3D%3D 11350408 (Pubitemid 34293759)
59. P.H. Rao J. Houldsworth N. Palanisamy, et al. 1998 Chromosomal amplification is associated with cisplatin resistance of human male germ cell tumors Cancer Res 58 4260 4263 1:CAS:528:DyaK1cXmsVyqs7c%3D 9766648 (Pubitemid 28450021)
60. C. Wilson J. Yang J.C. Strefford, et al. 2005 Overexpression of genes on 16q associated with cisplatin resistance of testicular germ cell tumor cell lines Genes Chromosomes Cancer 43 211 216 10.1002/gcc.20173 1:CAS:528: DC%2BD2MXjslantr0%3D 15761863 (Pubitemid 40570742)
61. E.E. Noel J. Perry T. Chaplin, et al. 2008 Identification of genomic changes associated with cisplatin resistance in testicular germ cell tumor cell lines Genes Chromosomes Cancer 47 604 613 10.1002/gcc.20564 1:CAS:528: DC%2BD1cXmsVOqsrw%3D 18384131 (Pubitemid 351748346)
62. Piulats JM, Nadal M, Martinez-Iniesta M et al (2009) Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment. ASCO Meeting Abstracts (#e16143)