Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment

Cancer Research

Volumn 62, Issue 10, 2002, Pages 2758-2760

  Mayer, Frank ^a,b   Gillis, Ad J M ^a   Dinjens, Winand ^a   Oosterhuis, J Wolter ^a   Bokemeyer, Carsten ^b   Looijenga, Leendert H J ^a  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTOTOXIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER MODEL; CANCER SURVIVAL; CONTROLLED STUDY; EMBRYONAL CARCINOMA; GERM CELL TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; SEMINOMA; TERATOMA; TREATMENT FAILURE; YOLK SAC TUMOR;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARRIER PROTEINS; CISPLATIN; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; GERMINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; SEMINOMA; TESTICULAR NEOPLASMS;

EID: 0037092963     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Testicular cancer in nine nothern european countries
2. High-dose chemotherapy as primary treatment for poor-risk germ-cell tumors: The Memorial Sloan-Kettering experience (1988-1999)
3. Role of P53 and MDM2 in treatment response of human germ cell tumors
4. Microsatellite instability in human cancer: A prognostic marker for chemotherapy?
5. Molecular genetic changes in human male germ cell tumors
6. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
7. Expression of hMLH1 and hMSH2 and assessment of microsatellite instability in testicular and mediastinal germ cell tumours
8. Replication error-type genetic instability at 1q42-43 in human male germ cell tumors
9. Heterogeneous X-inactivation in human female full term placenta's
10. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
11. HMSH6 alterations in patients with microsatellite instability-low colorectal cancer
12. Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation
13. Loss of DNA mismatch repair in acquired resistance to cisplatin
14. In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
15. Involvement of the DNA mismatch repair system in antineoplastic drug resistance
16. Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress
17. A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer
18. Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers
19. Immunohistochemistry for hMLH1 and hMSH2: A practical test for DNA mismatch repair-deficient tumors
20. Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and HMLH1
21. Defects of DNA mismatch repair in human prostate cancer