How does oxygen inhibit central metabolism in the obligate anaerobe Bacteroides thetaiotaomicron?

Molecular Microbiology

Volumn 39, Issue 6, 2001, Pages 1562-1571

  Pan, N ^a   Imlay, J A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; CARBOHYDRATE; FERREDOXIN; FUMARATE HYDRATASE; IRON BINDING PROTEIN; OXIDOREDUCTASE; OXYGEN; PROPIONIC ACID; PYRUVIC ACID; SUCCINIC ACID; SULFUR; SUPEROXIDE;

AERATION; ANAEROBIC METABOLISM; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIUM CULTURE; BACTEROIDES THETAIOTAOMICRON; ENZYME METABOLISM; FERMENTATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

BACTEROIDES; ENZYME ACTIVATION; FERMENTATION; FUMARATE HYDRATASE; IRON-SULFUR PROTEINS; KETONE OXIDOREDUCTASES; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; OXYGEN; PROPIONIC ACIDS; PYRUVATE SYNTHASE; SUCCINIC ACID;

BACTERIA (MICROORGANISMS); BACTEROIDES THETAIOTAOMICRON; NEGIBACTERIA;

EID: 0035062654     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02343.x     Document Type: Article

References (47)

1. Oxygen and toxicity: Inhibition of amino acid biosynthesis
2. Isolation of superoxide dismutase mutants in Escherichia coli: Is superoxide dismutase necessary for aerobic life?
3. Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase
4. The inactivation of Fe-S cluster containing hydrolyases by superoxide
5. Superoxide sensitivity of the Escherichia coli aconitase
6. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
7. Superoxide radical and iron modulate aconitase activity in mammalian cells
8. Balance between endogenous superoxide stress and antioxidant defenses
9. Null mutants of Saccharomyces cerevisiae Cu, Zn superoxide dismutase: Characterization and spontaneous mutation rates
10. Superoxide dismutase in anaerobes: Survey
11. Fumarase
12. Glyceraldehyde 3-phosphate dehydrogenase mutants of Escherichia coli
13. Ironsulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: Correlation of the cluster type with enzymatic activity
14. A metabolic enzyme that rapidly produces superoxide, fumarate reductase of Escherichia coli
15. Assay of metabolic superoxide production in Escherichia coli
16. Biosynthesis of lipoic acid and posttranslational modification with lipoic acid in Escherichia coli
17. The role of iron in the activation-inactivation of aconitase
18. Superoxide accelerates DNA damage by elevating free-iron levels
19. Inactivation of dehydratase [4Fe-4S] clusters and disruption of iron homeostasis upon cell exposure to peroxynitrite
20. 2-hydroxyglutaryl-CoA dehydratase from Fusobacterium nucleatum (subsp. nucleatum): An iron-sulfur flavoprotein
21. Purification and characterization of fumarase from the syntrophic propionate-oxidizing strain MPOB
22. α,βdihydroxyisovalerate dehydratase: A superoxide-sensitive enzyme
23. Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon
24. The role of superoxide in the production of hydroxyl radical: In vitro and in vivo
25. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
26. An enzyme-based theory of obligate anaerobiosis: The physiological function of superoxide dismutase
27. Evidence for cytochrome involvement in fumarate reduction and adenosine 5′-triphosphate synthesis by Bacteroides fragilis grown in the presence of hemin
28. Pathway of succinate and propionate formation in Bacteroides fragilis
29. The identification of primary sites of superoxide and hydrogen peroxide formation in the aerobic respiratory chain and sulfite reductase complex of Escherichia coli
30. The pathway of formation of acetate and succinate from pyruvate by Bacteroides succinogenes
31. Distribution of metronidazole susceptibility factors in obligate anaerobes
32. Pyruvate carboxylase in Rhodopseudomonas sphaeroides
33. Isolation and analysis of the gene encoding the pyruvate-ferredoxin oxidoreductase of Desulfovibrio africanus, production of the recombinant enzyme in Escherichia coli, and effect of carboxy-terminal deletions on its stability
34. Purification and resolution of the pyruvate dehydrogenase complex (Escherichia coli)
35. Assays of enzymes of the tricarboxylic acid and glyoxylate cycles
36. Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate anaerobe Bacteroides fragilis
37. Studies in rumen bacteriology. V. Carboxylation of phosphoenolpyruvate
38. Succinate-ethanol fermentation in Clostridium kluyveri: Purification and characterisation of 4hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3delta 2-isomerase
39. Evidence that the clindamycin resistance gene of the Bacteroides plasmid pBF4 is on a transposable element
40. Requirement of heme for growth of Bacteroides fragilis
41. Oxidative stress
42. Pyruvate dehydrogenase activity and metronidazole susceptibility in Bacterioides fragilis
43. Characterization of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis: Isolation of a B. fragilis mutant with reduced aerotolerance and impaired growth in in vivo model systems
44. Nutritional features of Bacteroides fragilis subsp. fragilis
45. Regulation of synthesis of pyruvate carboxylase in the photosynthetic bacterium Rhodobacter capsulatus
46. Rubredoxin from the green sulfur bacterium chlorobium tepidum functions as an electron acceptor for pyruvate ferredoxin oxidoreductase