Synthesis and cytotoxic evaluation of β-alkyl or β-aryl-δ-methyl-α-methylene-δ-lactones. Comparison with the corresponding γ-lactones

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 710-718

  Albrecht, Łukasz ^a   Wojciechowski, Jakub ^a   Albrecht, Anna ^a   Wolf, Wojciech M ^a   Janecka, Anna ^b   Studzian, Kazimierz ^b   Krajewska, Urszula ^b   Rózalski, Marek ^b   Janecki, Tomasz ^a   Krawczyk, Henryk ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Methylene lactones; Methylene lactones; Cytotoxic activity; Diastereoselective synthesis; Horner Wadsworth Emmons reaction

Indexed keywords

4 (2 METHOXYPHENYL) 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 4 (4 BROMOPHENYL) 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 4 (4 METHOXYPHENYL) 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 4 (BENZO[D][1,3]DIOXOL 5 YL) 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 4 CYCLOHEXYL 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 4 ISOPROPYL 6 METHYL 3 METHYLENETETRAHYDRO 2H PIRAN 2 ONE; 6 METHYL 3 METHYLENE 4 (4 NITROPHENYL)TETRAHYDRO 2H PIRAN 2 ONE; ACETONE; ALKYL GROUP; CARBONYL DERIVATIVE; FORMALDEHYDE; GAMMA LACTONE DERIVATIVE; LACTONE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LACTONIZATION; LEUKEMIA L 1210; MICHAEL ADDITION; MOUSE; NONHUMAN; REDUCTION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LACTONES; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

EID: 73549102167     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.018     Document Type: Article

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