Novel synthesis, cytotoxic evaluation, and structure-activity relationship studies of a series of α-alkylidene-γ-lactones and lactams

Journal of Medicinal Chemistry

Volumn 48, Issue 10, 2005, Pages 3516-3521

  Janecki, Tomasz ^a   Błaszczyk, Edyta ^a   Studzian, Kazimierz ^b   Janecka, Anna ^b   Krajewska, Urszula ^b   Rózalski, Marek ^b  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3,4 DIMETHOXYPHENYLMETHYL) 3 METHYLENE 4,5 DIHYDROFURAN 2 ONE; 5 (3,4 DIMETHOXYPHENYLMETHYL) 3 METHYLENEPYRROLIDYN 2 ONE; 5 BENZYL 3 (2 METHYLPROPYLIDENE) 4,5 DIHYROFURAN 2 ONE; LACTAM DERIVATIVE; LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LIPOPHILICITY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTAMS; LACTONES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18644380296     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm048970a     Document Type: Article

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