Obesity promotes melanoma tumor growth: Role of leptin

Cancer Biology and Therapy

Volumn 8, Issue 19, 2009, Pages 1871-1879

  Brandon, Elizabeth L ^a   Gu, Jian Wei ^a   Cantwell, Lauren ^a   He, Zhi ^a   Wallace, Gray ^a   Hall, John E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Cancer; Leptin; Melanoma; Obesity; VEGF

Indexed keywords

LEPTIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GROWTH RATE; MELANOMA; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION;

ANIMALS; HUMANS; LEPTIN; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; RATS; RATS, ZUCKER; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 73549090981     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.19.9650     Document Type: Article

References (31)

1. Flegal KM, Carroll MD, Ogden CL, Johnson CCL. Prevalence and trends in obesity among US adults 1999-2000. JAMA 2002; 288:1723-7.
2. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents. JAMA 2002; 288:1728-32.
3. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348:1625-38.
4. Stattin P, Lukanova A, Biessy C, Soderberg S, Palmqvist R, Kaaks R, et al. Obesity and colon cancer: does leptin provide a link? International Journal of Cancer 2004; 109:149-52.
5. Chang S, Hursting SD, Contois JH, Strom SS, Yamamura Y, Babaian RJ, et al. Leptin and prostate cancer. The Prostate 2001; 46:62-7.
6. Saglam K, Aydur E, Yilmaz M, Goktas K. Leptin influences cellular differentiation and progression in prostate cancer. J Urol 2003; 169:1308-11.
7. +/+ colonic epithelial cell lines. Cancer Epidemiol Biomarkers Prev 2005; 14:1646-52.
8. Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circulation 1998; 83:1059-66.
9. Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, et al. Genetically obese MMTV-TGFalpha/Lep (ob) Lep (ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 2003; 77:205-15.
10. Cleary MP, Grande JP, Maihle NJ. Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGFα mice. Int J Obes Relat Metab Disord 2004; 28:956-62.
11. Gonzalez RR, Cherfils S, Escobar M, Yoo JH, Carino C, Styer AK, et al. Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 2006; 281:26320-8.
12. Hakkak R, Holley AW, Macleod SL, Simpsom PM, Fuchs GJ, Jo CH, et al. Obesity promotes 7,12 dimethylbenz (a) anthracene-induced mammary tumor development in female zucker rats. Breast Cancer Res 2005; 7:627-33.
13. Tallam LS, da Silva AA, Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 2006; 48:58-64.
14. Chung WK, Belfi K, Chua M, Wiley J, Mackintosh R, Nicolson M, et al. Heterozygosity for Lep (ob) or Lep (rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol 1998; 274:985-90.
15. Bergstrom A, Pisani P, Tenet V, Wolk A, Adami HO. Overweight as an avoidable cause of cancer in Europe. Int J Cancer 2001; 91:421-30.
16. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci USA 2002; 99:10730-5.
17. Cleary MP, Jacobson MK, Phillips FC, Getzin SC, Grande JP, Maihle NJ. Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice. Cancer Epidemiol Biomarkers Prev 2002; 11:836-43.
18. Cleary MP, Hu X, Grossmann ME, Juneja SC, Dongan S, Grande JP, et al. Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Exp Biol Med 2007; 232:70-80.
19. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281:1683-6.
20. Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proc Natl Acad Sci USA 2001; 98:6390-5.
21. Zhao X, Huang K, Zhu Z, Chen S, Hu R. Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer. J Gastroenterol Hepatol 2007; 22:1317-21.
22. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewka J, et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006; 12:447-53.
23. Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004; 10:4325-31.
24. Koda M, Sulkowska M, Kanczuga-Koda L, Surmacz E, Sulkowski S. Overexpression of the obesity hormone leptin in human colorectal cancer. J Clin Pathol 2007; 60:902-6.
25. Horiguchi A, Sumitomo M, Asakuma J, Asano A, Zheng R, Nanus DM, et al. Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway. J Urol 2006; 176:1636-41.
26. Koda M, Sulkowska M, Wincewicz A, Kanczuga-Koda L, Musiatowicz B, Szymanska M, et al. Expression of leptin, leptin receptor and hypoxia-inducible factor 1alpha in human endometrial cancer. Ann N Y Acad Sci 2007; 1095:90-8.
27. Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, Chrousos GP, et al. Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study. Ann Oncol 2008; 19:384-9.
28. Ablamunits V, Cohen Y, Brazee IB, Gaetz HP, Vinson C, Klebanov S. Susceptibility to induced and spontaneous carcinogenesis is increased in fatless A-ZIP/F-1 but not in obese ob/ob mice. Cancer Res 2006; 66:8897-902.
29. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4:579-91.
30. Flatt PR, Bailey CJ. Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 1981; 20:573-7.
31. Gu JW, Bailey AP, Sartin A, Makey I, Brady AL. Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos. Cancer 2005; 103:422-31.