메뉴 건너뛰기




Volumn 298, Issue 1, 2010, Pages

Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis

Author keywords

Apoptosis; Enzastaurin; Liver fibrosis; Pravastatin

Indexed keywords

4',6 DIAMINDINO 2 PHENYLINDOLE; ALPHA SMOOTH MUSCLE ACTIN; BIOTIN; CARBON TETRACHLORIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; ENZASTAURIN; INDOLE DERIVATIVE; PRAVASTATIN; THIOACETAMIDE; UNCLASSIFIED DRUG;

EID: 73549090321     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00299.2009     Document Type: Article
Times cited : (29)

References (35)
  • 1
    • 40949084831 scopus 로고    scopus 로고
    • Atorvastatin induces apoptosis by a caspase-9-dependent pathway: An in vitro study on activated rat hepatic stellate cells
    • Aprigliano I, Dudas J, Ramadori G, Saile B. Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. Liver Int 28: 546-557, 2008.
    • (2008) Liver Int , vol.28 , pp. 546-557
    • Aprigliano, I.1    Dudas, J.2    Ramadori, G.3    Saile, B.4
  • 2
    • 34948856003 scopus 로고    scopus 로고
    • Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits
    • Bao N, Minatoguchi S, Kobayashi H, Yasuda S, Kawamura I, Iwasa M, Yamaki T, Sumi S, Misao Y, Arai M, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H. Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Circ J 71: 1622-1628, 2007.
    • (2007) Circ J , vol.71 , pp. 1622-1628
    • Bao, N.1    Minatoguchi, S.2    Kobayashi, H.3    Yasuda, S.4    Kawamura, I.5    Iwasa, M.6    Yamaki, T.7    Sumi, S.8    Misao, Y.9    Arai, M.10    Nishigaki, K.11    Takemura, G.12    Fujiwara, T.13    Fujiwara, H.14
  • 4
    • 0034100952 scopus 로고    scopus 로고
    • Is liver fibrosis reversible?
    • Benyon RC, Iredale JP. Is liver fibrosis reversible? Gut 46: 443-446, 2000.
    • (2000) Gut , vol.46 , pp. 443-446
    • Benyon, R.C.1    Iredale, J.P.2
  • 6
    • 23144461629 scopus 로고    scopus 로고
    • Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation
    • Chang ML, Yeh CT, Chang PY, Chen JC. Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World J Gastroenterol 11: 4167-4172, 2005.
    • (2005) World J Gastroenterol , vol.11 , pp. 4167-4172
    • Chang, M.L.1    Yeh, C.T.2    Chang, P.Y.3    Chen, J.C.4
  • 10
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576, 2007.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 11
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - from bench to bedside
    • Friedman SL. Liver fibrosis - from bench to bedside. J Hepatol 38, Suppl 1: S38-S53, 2003.
    • (2003) J Hepatol , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 14
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 117: 539-548, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 15
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102: 538-549, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6    Hovell, C.7    Arthur, M.J.8
  • 16
    • 0032911163 scopus 로고    scopus 로고
    • Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3- methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver
    • Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3- methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos 27: 173-179, 1999.
    • (1999) Drug Metab Dispos , vol.27 , pp. 173-179
    • Jacobsen, W.1    Kirchner, G.2    Hallensleben, K.3    Mancinelli, L.4    Deters, M.5    Hackbarth, I.6    Benet, L.Z.7    Sewing, K.F.8    Christians, U.9
  • 17
    • 0037446216 scopus 로고    scopus 로고
    • Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin
    • Jaster R, Brock P, Sparmann G, Emmrich J, Liebe S. Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin. Biochem Pharmacol 65: 1295-1303, 2003.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1295-1303
    • Jaster, R.1    Brock, P.2    Sparmann, G.3    Emmrich, J.4    Liebe, S.5
  • 19
    • 67349105662 scopus 로고    scopus 로고
    • Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma
    • Kim W, Yoon JH, Kim JR, Jang IJ, Bang YJ, Kim YJ, Lee HS. Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma. Cancer Chemother Pharmacol 64: 497-507, 2009.
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 497-507
    • Kim, W.1    Yoon, J.H.2    Kim, J.R.3    Jang, I.J.4    Bang, Y.J.5    Kim, Y.J.6    Lee, H.S.7
  • 20
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol 97: 52C-60C, 2006.
    • (2006) Am J Cardiol , vol.97
    • Law, M.1    Rudnicka, A.R.2
  • 22
    • 33646355930 scopus 로고    scopus 로고
    • Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin
    • Louneva N, Huaman G, Fertala J, Jimenez SA. Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum 54: 1298-1308, 2006.
    • (2006) Arthritis Rheum , vol.54 , pp. 1298-1308
    • Louneva, N.1    Huaman, G.2    Fertala, J.3    Jimenez, S.A.4
  • 24
    • 67649866059 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells
    • Myung SJ, Yoon JH, Kim BH, Lee JH, Jung EU, Lee HS. Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells. J Pharmacol Exp Ther 330: 276-282, 2009.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 276-282
    • Myung, S.J.1    Yoon, J.H.2    Kim, B.H.3    Lee, J.H.4    Jung, E.U.5    Lee, H.S.6
  • 25
    • 14944343292 scopus 로고    scopus 로고
    • Fibrosis in chronic liver diseases: Diagnosis and management
    • Pinzani M, Rombouts K, Colagrande S. Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol 42, Suppl 1: S22-S36, 2005.
    • (2005) J Hepatol , vol.42 , Issue.SUPPL. 1
    • Pinzani, M.1    Rombouts, K.2    Colagrande, S.3
  • 26
    • 0037382326 scopus 로고    scopus 로고
    • Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation
    • Ramm GA, Li L, Britton RS, O'Neill R, Bacon BR. Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation. Dig Dis Sci 48: 790-796, 2003.
    • (2003) Dig Dis Sci , vol.48 , pp. 790-796
    • Ramm, G.A.1    Li, L.2    Britton, R.S.3    O'Neill, R.4    Bacon, B.R.5
  • 28
    • 0038555527 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    • Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. J Hepatol 38: 564-572, 2003.
    • (2003) J Hepatol , vol.38 , pp. 564-572
    • Rombouts, K.1    Kisanga, E.2    Hellemans, K.3    Wielant, A.4    Schuppan, D.5    Geerts, A.6
  • 29
    • 33845546752 scopus 로고    scopus 로고
    • Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: Potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway
    • Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda A, Izawa H, Nagata K, Yokota M. Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. Clin Exp Pharmacol Physiol 33: 1164-1171, 2006.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 1164-1171
    • Saka, M.1    Obata, K.2    Ichihara, S.3    Cheng, X.W.4    Kimata, H.5    Noda, A.6    Izawa, H.7    Nagata, K.8    Yokota, M.9
  • 30
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
    • Shitara Y, Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. Pharmacol Ther 112: 71-105, 2006.
    • (2006) Pharmacol Ther , vol.112 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 31
    • 0035029397 scopus 로고    scopus 로고
    • Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells
    • Svegliati-Baroni G, Ridolfi F, Di Sario A, Saccomanno S, Bendia E, Benedetti A, Greenwel P. Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology 33: 1130-1140, 2001.
    • (2001) Hepatology , vol.33 , pp. 1130-1140
    • Svegliati-Baroni, G.1    Ridolfi, F.2    Di Sario, A.3    Saccomanno, S.4    Bendia, E.5    Benedetti, A.6    Greenwel, P.7
  • 32
    • 0013640830 scopus 로고    scopus 로고
    • Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders
    • Tan A, Levrey H, Dahm C, Polunovsky VA, Rubins J, Bitterman PB. Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders. Am J Respir Crit Care Med 159: 220-227, 1999.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 220-227
    • Tan, A.1    Levrey, H.2    Dahm, C.3    Polunovsky, V.A.4    Rubins, J.5    Bitterman, P.B.6
  • 33
    • 3042627230 scopus 로고    scopus 로고
    • Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation
    • Tanaka K, Honda M, Takabatake T. Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation. Clin Exp Pharmacol Physiol 31: 360-364, 2004.
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , pp. 360-364
    • Tanaka, K.1    Honda, M.2    Takabatake, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.