Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection

Phytotherapy Research

Volumn 23, Issue 12, 2009, Pages 1771-1777

  Petrera, Erina ^a   Coto, Celia E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antiviral; HSV 2; Melia azedarach L.; Meliacine; Microbicide; Mouse genital infection

Indexed keywords

GAMMA INTERFERON; MELIA AZEDARACH EXTRACT; MELIACINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; LIFESPAN; MELIA AZEDARACH; MOUSE; NONHUMAN; SURVIVAL; VAGINA DISCHARGE; VIRUS SHEDDING; VIRUS STRAIN;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIVIRAL AGENTS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; INTERFERON-GAMMA; MEDICINE, TRADITIONAL; MELIA AZEDARACH; MICE; MICE, INBRED BALB C; PEPTIDES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VAGINA; VIRUS REPLICATION;

ANIMALIA; HUMAN HERPESVIRUS 2; MELIA AZEDARACH; MUS;

EID: 73449139459     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2850     Document Type: Article

References (37)

1. Alché LE, Barquero AA, Sanjuan NA, Coto CE. 2002. An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains herpes simplex virus type 1 propagation. Phytother Res 16: 348-352.
2. Alché LE, Berra A, Veloso MJ, Coto CE. 2000. Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice. J Med Virol 61: 474-480.
3. Andrei GM, Damonte EB, de Torres RA, Coto CE. 1988. Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L. Antiviral Res 9: 221-231.
4. Balunas MJ, Kinghorn AD. 2005. Drug discovery from medicinal plants. Life Sci 78: 431-441.
5. Barquero AA, Villamil SM. 1997. [Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model]. Rev Argent Microbiol 29: 32-37.
6. Bhakuni DS, Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN. 1969. Screening of Indian plants for biological activity. II. Indian J Exp Biol 7: 250-262.
7. Bray DH, Warhurst DC, Connolly JD, O'Neill MJ, Phillipson JD. 1990. Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids. Phytother Res 4: 29-35.
8. Chuanasa T, Phromjai J, Lipipun V et al. 2008. Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice. Antiviral Res 80: 62-70.
9. Corey L, Wald A, Celum CL, Quinn TC. 2004. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr 35: 435-445.
10. Cragg GM, Newman DJ. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79.
11. De Clercq E. 2000. Guanosine analogues as anti-herpesvirus agents. Nucleosides Nucleotides Nucleic Acids 19: 1531-1541.
12. Ellermann-Eriksen S. 2005. Macrophages and cytokines in the early defence against herpes simplex virus. Virol J 2: 59.
13. Fleming DT, McQuillan GM, Johnson RE et al. 1997. Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 337: 1105-1111.
14. Harandi AM, Eriksson K, Holmgren J. 2003. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol 77: 953-962.
15. Herbst-Kralovetz M, Pyles R. 2006. Toll-like receptors, innate immunity and HSV pathogenesis. Herpes 13: 37- 41.
16. Herold BC, Kirkpatrick R, Marcellino D et al. 1999. Bile salts: natural detergents for the prevention of sexually transmitted diseases. Antimicrob Agents Chemother 43: 745-751.
17. Jones WP, Chin YW, Kinghorn AD. 2006. The role of pharmacognosy in modern medicine and pharmacy. Curr Drug Targets 7: 247-264.
18. Kapoor LD. 1993. Ayurvedic medicine of India. J Herbs Spices Med Plants 1: 37-219.
19. Khan MT, Ather A, Thompson KD, Gambari R. 2005. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Res 67: 107-119.
20. Koelle DM, Wald A. 2000. Herpes simplex virus: the importance of asymptomatic shedding. J Antimicrob Chemother 45(Suppl T3): 1- 8.
21. Kokuba HL, Aurelian L, Neurath AR. 1998. 3-Hydroxyphthaloyl beta-lactoglobulin. IV Antiviral activity in the mouse model of genital herpesvirus infection. Antivir Chem Chemother 9: 353-357.
22. McCluskie MJ, Krieg AM. 2006. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr Top Microbiol Immunol 311: 155-178.
23. Mertz KJ, Trees D, Levine WC et al. 1998. Etiology of genital ulcers and prevalence of human immunodeficiency virus coinfection in 10 US cities. The Genital Ulcer Disease Surveillance Group. J Infect Dis 178: 1795-1798.
24. Naesens L, De Clercq E. 2001. Recent developments in herpesvirus therapy. Herpes 8: 12-16.
25. Petrera E, Coto CE. 2003. Effect of meliacine, a plant derived antiviral, on tumor necrosis factor alpha. Fitoterapia 74: 77-83.
26. Pifarré MP, Berra A, Coto CE, Alché LE. 2002. Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice. Exp Eye Res 75: 327-334.
27. Roos KL. 1999. Encephalitis. Neurol Clin 17: 813-833.
28. Superti F, Ammendolia MG, Marchetti M. 2008. New advances in anti-HSV chemotherapy. Curr Med Chem 15: 900-911.
29. Tan G, Gyllenhaal C, Soejarto DD. 2006. Biodiversity as a source of anticancer drugs. Curr Drug Targets 7: 265-277.
30. Villamil SM, Alché LE, Coto CE. 1995 Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin. Antivir Chem Chemother 6: 239-244.
31. Wachsman MB, Castilla V, Coto CE. 1998. Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L leaves. Arch Virol 143: 581-590.
32. Wachsman MB, Damonte EB, Coto CE, de Torres RA. 1987. Antiviral effects of Melia azedarach L. leaves extracts on Sindbis virus-infected cells. Antiviral Res 8: 1-12.
33. Wachsman MB, Martino V, Gutkind GO, Coussio D, Coto CE, de Torres RA. 1982. Antiviral activity of a Melia azedarach L. plant extract. Fitoterapia 53: 167-170.
34. Walz MA, Price RW, Hayashi K, Katz BJ, Notkins AL. 1977. Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus type 1 and 2. J Infect Dis 135: 744-752.
35. Whitley RJ, Kimberlin DW, Roizman B. 1998. Herpes simplex viruses. Clin Infect Dis 26: 541-553.
36. Yang D, Chertov O, Oppenheim JJ. 2001. Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37). J Leukoc Biol 69: 691-697.
37. Yasin B, Wang W, Pang M et al. 2004. Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol 78: 5147-5156.