Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 12, 2009, Pages 1986-1990

  Zhou, Xiao Ping ^a   Zhang, Mu Xin ^a   Sun, Wei ^a   Yang, Xiao Hong ^a   Wang, Guang Shu ^a   Sui, Da Yuan ^a   Yu, Xiao Feng ^a   Qu, Shao Chun ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

4,5 Diaryloxazole; Analgesic activity; Anti inflammatory activity; Oxaprozin analogue

Indexed keywords

3 (4 (4 FLUOROPHENYL) 5 (4 AMINOSULFONYL 3 FLUOROPHENYL) OXAZOLE 2 YL) PROPANOIC ACID; ACETIC ACID; CARRAGEENAN; CYCLOOXYGENASE 2; NC 2142; NONSTEROID ANTIINFLAMMATORY AGENT; OXAPROZIN; OXAZOLE DERIVATIVE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SALVAGE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL SYMPTOM; IN VIVO STUDY; MALE; METATARSAL BONE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH LESION; STRUCTURE ACTIVITY RELATION; ULCEROGENESIS; WISTAR RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; CHEMISTRY, PHARMACEUTICAL; CYCLOOXYGENASE 2; EDEMA; FEMALE; MALE; METATARSAL BONES; MICE; MICE, INBRED STRAINS; PAIN; PROPIONIC ACIDS; RATS; RATS, WISTAR; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 73449136381     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.1986     Document Type: Article

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