Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis of the hip: A randomized, double-blind, placebo-controlled comparison with naproxen

Osteoarthritis and Cartilage

Volumn 10, Issue 4, 2002, Pages 290-296

  Makarowski, W ^a   Zhao, William W ^b   Bevirt, Terry ^b   Recker, David P ^b  

^a Rheumatology Associates   (United States)

^b PFIZER INC   (United States)

Author keywords

COX 2 specific inhibitors; NSAIDs; Osteoarthritis; Valdecoxib

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; NAPROXEN; OXAPROZIN; PIROXICAM; PLACEBO; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; VALDECOXIB;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLEEDING; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COXITIS; DIARRHEA; DIVERTICULITIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MONITORING; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPEPSIA; FEMALE; FLATULENCE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASE; HEADACHE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINUSITIS; VISUAL ANALOG SCALE;

EID: 0036245462     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.2001.0510     Document Type: Article

References (21)

1. NSAIDs: A profile of adverse effects
2. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis
3. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs
4. Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis
5. Cyclooxygenase in biology and disease
6. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
7. Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: A randomized controlled trial
8. A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis
9. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial
10. 4-[5-Methyl-3-phenyl-isoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2
11. The American College of Rheumatology criteria for the classification and reportings of osteoarthritis of the knee
12. A seven-day variability study of 499 patients with peripheral rheumatoid arthritis
13. Comparison of auranofin, gold sodium thiomalate, and placebo in the treatment of rheumatoid arthritis. Subsets of responses
14. A sharper Bonferroni procedure for multiple tests of significance
15. A double-blind, placebo-controlled dose ranging study to evaluate the efficacy of valdecoxib, a novel COX-2 specific inhibitor, in treating the signs and symptoms of osteoarthritis of the knee
16. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide
17. Carrageenan-induced hyperalgesia is associated with increased cyclooxygenase-2 expression in spinal cord
18. NSAID induced gastrointestinal complications: The ARAMIS perspective-1997
19. Gastrointestinal tract complications of non-steroidal anti-inflammatory drug treatment in rheumatoid arthritis. A prospective observational cohort study