메뉴 건너뛰기




Volumn 26, Issue 5, 2009, Pages 469-487

Cardiovascular risk reduction: What do recent trials with rosuvastatin tell us?

Author keywords

Cardiovascular risk factors; HDL C; Hypercholesterolemia; LDL C; Primary prevention; Secondary prevention; Statin therapy

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; TORCETRAPIB;

EID: 73449136164     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12325-009-0025-6     Document Type: Review
Times cited : (13)

References (100)
  • 1
    • 2542421760 scopus 로고    scopus 로고
    • The global burden of chronic diseases: Overcoming impediments to prevention and control
    • DOI 10.1001/jama.291.21.2616
    • D. Yach C. Hawkes C.L. Gould K.J. Hofman 2004 The global burden of chronic diseases: overcoming impediments to prevention and control JAMA 291 2616 2622 15173153 10.1001/jama.291.21.2616 1:CAS:528:DC%2BD2cXkslWns78%3D (Pubitemid 38702780)
    • (2004) Journal of the American Medical Association , vol.291 , Issue.21 , pp. 2616-2622
    • Yach, D.1    Hawkes, C.2    Gould, C.L.3    Hofman, K.J.4
  • 2
    • 54349108294 scopus 로고    scopus 로고
    • February 2007. World Health Organization web site. Available at: www.who.int. Accessed April 2009
    • Cardiovascular diseases. Fact sheet no. 317. February 2007. World Health Organization web site. Available at: www.who.int. Accessed April 2009.
    • Cardiovascular Diseases. Fact Sheet No. 317
  • 4
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group.
    • Scandinavian Simvastatin Survival Study Group. 1994 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 344 1383 1389
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 6
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
    • DOI 10.1016/S0140-6736(02)09327-3
    • Heart Protection Study Collaborative Group. 2002 MRC/BHF Heart Protection Study of cholesterol loweringwith simvastatin in 20536 high-risk individuals: a randomized placebo controlled trial Lancet 360 7 22 10.1016/S0140-6736(02) 09327-3 (Pubitemid 34756487)
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 7-22
    • Collins, R.1    Armitage, J.2    Parish, S.3    Sleight, P.4    Peto, R.5
  • 9
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group
    • 7566020 10.1056/NEJM199511163332001 1:CAS:528:DyaK28Xhslemsw%3D%3D
    • J. Shepherd S.M. Cobbe I. Ford, et al. 1995 Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group N Engl J Med 333 1301 1317 7566020 10.1056/NEJM199511163332001 1:CAS:528:DyaK28Xhslemsw%3D%3D
    • (1995) N Engl J Med , vol.333 , pp. 1301-1317
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 10
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
    • DOI 10.1016/S0140-6736(05)67394-1, PII S0140673605673941
    • C. Baigent A. Keech P.M. Kearney, et al. 2005 Cholesterol Treatment Trialist' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 1267 1278 16214597 10.1016/S0140- 6736(05)67394-1 1:CAS:528:DC%2BD2MXhtVOlu7fM (Pubitemid 41416582)
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
  • 11
    • 33746355566 scopus 로고    scopus 로고
    • Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy
    • DOI 10.1016/j.jacc.2006.04.070, PII S0735109706011752
    • C.P. Cannon B.A. Steimberg S.A. Murphy, et al. 2006 Metaanalysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy J Am Coll Cardiol 48 438 445 16875966 10.1016/j.jacc.2006.04.070 1:CAS:528:DC%2BD28XntlWjsLo%3D (Pubitemid 44109954)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.3 , pp. 438-445
    • Cannon, C.P.1    Steinberg, B.A.2    Murphy, S.A.3    Mega, J.L.4    Braunwald, E.5
  • 17
    • 10344241455 scopus 로고    scopus 로고
    • Statins: Can the new generation make an impression?
    • DOI 10.1517/14728214.9.2.269
    • R. Rosensen 2004 Statins: can the new generation make an impression? Expert Opin Emerg Drugs. 9 269 279 10.1517/14728214.9.2.269 (Pubitemid 39627129)
    • (2004) Expert Opinion on Emerging Drugs , vol.9 , Issue.2 , pp. 269-279
    • Rosenson, R.S.1
  • 18
    • 27744522317 scopus 로고    scopus 로고
    • The forgotten majority: Unfinished business in cardiovascular risk reduction
    • DOI 10.1016/j.jacc.2005.07.006, PII S0735109705015688
    • P. Libby 2005 The forgotten majority: unfinished business in cardiovascular risk reduction J Am Coll Cardiol. 46 1225 1228 16198835 10.1016/j.jacc.2005.07.006 (Pubitemid 41615541)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.7 , pp. 1225-1228
    • Libby, P.1
  • 19
    • 27744603554 scopus 로고    scopus 로고
    • Reducing residual risk for patients on statin therapy: The potential role of combination therapy
    • DOI 10.1016/j.amjcard.2005.08.002, PII S0002914905013639
    • M.H. Davidson 2005 Reducing residual risk for patients on statin therapy: the potential role of combination therapy Am J Cardiol. 96 3K 13K 16291008 10.1016/j.amjcard.2005.08.002 1:CAS:528:DC%2BD2MXhtlGgs7vM (Pubitemid 41598106)
    • (2005) American Journal of Cardiology , vol.96 , Issue.9 SUPPL. 1
    • Davidson, M.H.1
  • 20
    • 0028912054 scopus 로고
    • Baseline characteristics in the Cholesterol and Recurrent Events (CARE) trial of secondary prevention in patients with average serum cholesterol levels
    • 7887392 10.1016/S0002-9149(99)80631-6 1:STN:280:DyaK2M7ptlOlsQ%3D%3D
    • F.M. Sacks J.L. Rouleau L.A. Moye, et al. 1995 Baseline characteristics in the Cholesterol and Recurrent Events (CARE) trial of secondary prevention in patients with average serum cholesterol levels Am J Cardiol 75 621 623 7887392 10.1016/S0002-9149(99)80631-6 1:STN:280:DyaK2M7ptlOlsQ%3D%3D
    • (1995) Am J Cardiol , vol.75 , pp. 621-623
    • Sacks, F.M.1    Rouleau, J.L.2    Moye, L.A.3
  • 22
    • 12744271984 scopus 로고    scopus 로고
    • Aerobic exercise and lipids and lipoproteins in women: A meta-analysis of randomized controlled trial
    • 10.1089/jwh.2004.13.1148
    • G.A. Kelley K.S. Kelley Z.V. Tran 2004 Aerobic exercise and lipids and lipoproteins in women: a meta-analysis of randomized controlled trial J Womens Health 13 1148 1164 10.1089/jwh.2004.13.1148
    • (2004) J Womens Health , vol.13 , pp. 1148-1164
    • Kelley, G.A.1    Kelley, K.S.2    Tran, Z.V.3
  • 23
    • 33644907160 scopus 로고    scopus 로고
    • Aerobic exercise and lipids and lipoproteins in men: A meta-analysis of randomized controlled trials
    • DOI 10.1016/j.jmhg.2005.09.003, PII S1571891305001731
    • G.A. Kelley K.S. Kelley 2006 Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trial J Mens Health Gend 3 61 70 18645633 10.1016/j.jmhg.2005.09.003 (Pubitemid 43384010)
    • (2006) Journal of Men's Health and Gender , vol.3 , Issue.1 , pp. 61-70
    • Kelley, G.A.1    Kelley, K.S.2
  • 24
    • 4444382796 scopus 로고    scopus 로고
    • Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study
    • DOI 10.1016/S0140-6736(04)17018-9, PII S0140673604170189
    • S. Yusuf S. Hawkan S. Ounpuu 2004 INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (INTERHEART Study): a case-control study Lancet 364 937 952 15364185 10.1016/S0140-6736(04)17018-9 (Pubitemid 39208455)
    • (2004) Lancet , vol.364 , Issue.9438 , pp. 937-952
    • Yusuf, P.S.1    Hawken, S.2    Ounpuu, S.3    Dans, T.4    Avezum, A.5    Lanas, F.6    McQueen, M.7    Budaj, A.8    Pais, P.9    Varigos, J.10    Lisheng, L.11
  • 27
    • 2542619763 scopus 로고    scopus 로고
    • Obesity and cardiovascular risk: The new public health problem of worldwide proportions
    • DOI 10.1586/14779072.2.2.203
    • R. Scaglione C. Argano T. Di Chiara G. Licata 2004 Obesity and cardiovascular risk: the new public health problem of worldwide proportions Expert Rev Cardiovasc Ther 2 203 212 15151469 10.1586/14779072.2.2.203 (Pubitemid 38701979)
    • (2004) Expert Review of Cardiovascular Therapy , vol.2 , Issue.2 , pp. 203-212
    • Scaglione, R.1    Argano, C.2    Di Chiara, T.3    Licata, G.4
  • 28
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • DOI 10.1056/NEJM199901143400207
    • R. Ross 1999 Atherosclerosis - an inflammatory disease N Engl J Med 340 115 126 9887164 10.1056/NEJM199901143400207 1:STN:280:DyaK1M%2FptFSqtQ%3D%3D (Pubitemid 29054847)
    • (1999) New England Journal of Medicine , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 30
    • 0035799331 scopus 로고    scopus 로고
    • High-sensitivity C reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
    • 11282915 1:CAS:528:DC%2BD3MXjsFKisbk%3D
    • P.M. Ridker 2001 High-sensitivity C reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease Circulation 103 1813 1818 11282915 1:CAS:528:DC%2BD3MXjsFKisbk%3D
    • (2001) Circulation , vol.103 , pp. 1813-1818
    • Ridker, P.M.1
  • 31
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    • DOI 10.1056/NEJMoa021993
    • P.M. Ridker N. Rifai L. Rose 2002 Comparison of C reactive protein and low density lipoprotein cholesterol levels in the prediction of first cardiovascular events N Engl J Med 347 1557 1565 12432042 10.1056/NEJMoa021993 1:CAS:528:DC%2BD38Xos1KhsL0%3D (Pubitemid 35315836)
    • (2002) New England Journal of Medicine , vol.347 , Issue.20 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3    Buring, J.E.4    Cook, N.R.5
  • 33
    • 33845980607 scopus 로고    scopus 로고
    • C-reactive protein: A nontraditional serum marker of cardiovascular risk
    • DOI 10.1016/j.carpath.2006.04.006, PII S1054880706000718
    • S.D. de Ferranti N. Rifai 2007 C-reactive protein: a nontraditional serum marker of cardiovascular risk Cardiovasc Pathol 16 14 21 17218210 10.1016/j.carpath.2006.04.006 (Pubitemid 46049026)
    • (2007) Cardiovascular Pathology , vol.16 , Issue.1 , pp. 14-21
    • De Ferranti, S.D.1    Rifai, N.2
  • 34
    • 0032568486 scopus 로고    scopus 로고
    • C-reactive protein: Adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction
    • 9610529 1:STN:280:DyaK1c3nt1Slsg%3D%3D
    • P.M. Ridker R.J. Glynn C.H. Hennekens 1998 C-reactive protein: adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction Circulation 97 2007 2011 9610529 1:STN:280: DyaK1c3nt1Slsg%3D%3D
    • (1998) Circulation , vol.97 , pp. 2007-2011
    • Ridker, P.M.1    Glynn, R.J.2    Hennekens, C.H.3
  • 35
    • 34248641015 scopus 로고    scopus 로고
    • C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk. Moving an Inflammatory Hypothesis Toward Consensus
    • DOI 10.1016/j.jacc.2007.02.052, PII S0735109707011187
    • P.M. Ridker 2007 C reactive protein and the prediction of cardiovascular events among those at intermediate risk moving an inflammatory hypothesis toward consensus J Am Coll Cardiol 49 2129 2138 17531663 10.1016/j.jacc.2007.02.052 1:CAS:528:DC%2BD2sXlvVOrsbo%3D (Pubitemid 46783865)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.21 , pp. 2129-2138
    • Ridker, P.M.1
  • 36
  • 37
    • 26044461187 scopus 로고    scopus 로고
    • Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels
    • DOI 10.1592/phco.2005.25.10.1365
    • K.M. Field 2005 Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels Pharmacotherapy 25 1365 1377 16185181 10.1592/phco.2005.25.10.1365 1:CAS:528:DC%2BD2MXhtFGitbzF (Pubitemid 41407634)
    • (2005) Pharmacotherapy , vol.25 , Issue.10 , pp. 1365-1377
    • Field, K.M.1
  • 39
    • 26844564725 scopus 로고    scopus 로고
    • The potential relevance of the multiple lipid-independent (Pleiotropic) effects of statins in the management of acute coronary syndromes
    • DOI 10.1016/j.jacc.2005.05.086, PII S0735109705017730
    • K.K. Ray C.P. Cannon 2005 The potential relevance of the multiple lipid independent (pleiotropic) effects of statins in the management of acute coronary syndromes J Am Coll Cardiol 46 1425 1433 16226165 10.1016/j.jacc.2005.05.086 1:CAS:528:DC%2BD2MXhtFWht7zE (Pubitemid 41446176)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.8 , pp. 1425-1433
    • Ray, K.K.1    Cannon, C.P.2
  • 40
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    • DOI 10.1056/NEJM200106283442601
    • P.M. Ridker N. Rifai M. Clearfield 2001 Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events N Engl J Med 344 1959 1965 11430324 10.1056/NEJM200106283442601 1:CAS:528:DC%2BD3MXltFersrc%3D (Pubitemid 32568149)
    • (2001) New England Journal of Medicine , vol.344 , Issue.26 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3    Downs, J.R.4    Weis, S.E.5    Miles, J.S.6    Gotto Jr., A.M.7
  • 41
    • 33748064338 scopus 로고    scopus 로고
    • Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial
    • DOI 10.1161/CIRCULATIONAHA.106.628909, PII 0000301720060725000007
    • D.A. Morrow J.A. de Lemos M.S. Sabatine 2006 Clinical relevance of C-reactive protein during follow up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial Circulation 114 281 288 16847150 10.1161/CIRCULATIONAHA.106.628909 1:CAS:528:DC%2BD28XntVSms70%3D (Pubitemid 44297094)
    • (2006) Circulation , vol.114 , Issue.4 , pp. 281-288
    • Morrow, D.A.1    De Lemos, J.A.2    Sabatine, M.S.3    Wiviott, S.D.4    Blazing, M.A.5    Shui, A.6    Rifai, N.7    Califf, R.M.8    Braunwald, E.9
  • 42
    • 18944371407 scopus 로고    scopus 로고
    • Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: An analysis of the PROVE-IT TIMI-22 trial
    • DOI 10.1016/j.jacc.2005.02.080, PII S0735109705007424
    • P.M. Ridker D.A. Morrow L.M. Rose 2005 Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/dl: an analysis of the PROVE-IT TIMI-22 trial J Am Coll Cardiol 45 1644 1648 15893181 10.1016/j.jacc.2005.02.080 1:CAS:528:DC%2BD2MXktVOjtrs%3D (Pubitemid 40704500)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.10 , pp. 1644-1648
    • Ridker, P.M.1    Morrow, D.A.2    Rose, L.M.3    Rifai, N.4    Cannon, C.P.5    Braunwald, E.6
  • 43
    • 0024449985 scopus 로고
    • High density lipoprotein - The clinical implications of recent studies
    • 2677733 1:STN:280:DyaK3c%2FhsFSmsA%3D%3D
    • D.J. Gordon B.M. Rifklnd 1989 High density lipoprotein - the clinical implications of recent studies N Engl J Med 321 1311 1316 2677733 1:STN:280:DyaK3c%2FhsFSmsA%3D%3D
    • (1989) N Engl J Med , vol.321 , pp. 1311-1316
    • Gordon, D.J.1    Rifklnd, B.M.2
  • 44
    • 2942750054 scopus 로고    scopus 로고
    • HDL cholesterol and protective factors in atherosclerosis
    • G. Assmann A.M. Gotto Jr 2004 HDL cholesterol and protective factors in atherosclerosis Circulation 109suppl.1 iii8 iii14
    • (2004) Circulation , vol.1091
    • Assmann, G.1    Gotto Jr, A.M.2
  • 45
    • 0023029454 scopus 로고
    • Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study
    • DOI 10.1001/jama.256.20.2835
    • W.P. Castell R.J. Garrison P.W. Wilson 1986 Incidence of coronary heart disease and lipoprotein cholesterol levels: the Framingham study JAMA 256 2835 2838 10.1001/jama.256.20.2835 (Pubitemid 17178361)
    • (1986) Journal of the American Medical Association , vol.256 , Issue.20 , pp. 2835-2838
    • Castelli, W.P.1    Garrison, R.J.2    Wilson, P.W.F.3
  • 46
    • 0035818556 scopus 로고    scopus 로고
    • Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: An idea whose time for testing is coming, part I
    • P.K. Shah S. Kaul J. Nilsson 2001 Exploiting the vascular protective effects of high density lipoprotein and its apolipoproteins: an idea whose time for testing is coming part I Circulation 104 2376 2383 11696481 10.1161/hc4401.098467 1:CAS:528:DC%2BD3MXpt1WltrY%3D (Pubitemid 33049524)
    • (2001) Circulation , vol.104 , Issue.19 , pp. 2376-2383
    • Shah, P.K.1    Kaul, S.2    Nilsson, J.3    Cercek, B.4
  • 47
    • 0025322265 scopus 로고
    • Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
    • 2318976 10.1172/JCI114558 1:CAS:528:DyaK3cXitlehtbw%3D
    • J. Badimon V. Fuster 1990 Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit J Clin Invest 85 1234 1241 2318976 10.1172/JCI114558 1:CAS:528:DyaK3cXitlehtbw%3D
    • (1990) J Clin Invest , vol.85 , pp. 1234-1241
    • Badimon, J.1    Fuster, V.2
  • 49
    • 14944381287 scopus 로고    scopus 로고
    • HDL as a target in the treatment of atherosclerotic cardiovascular disease
    • DOI 10.1038/nrd1658
    • P. Linsel Nitsche A.R. Tall 2005 HDL as a target in the treatment of atherosclerotic cardiovascular disease Nat Rev Drug Discov 4 193 205 10.1038/nrd1658 (Pubitemid 40372554)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.3 , pp. 193-205
    • Linsel-Nitschke, P.1    Tall, A.R.2
  • 50
    • 33746766313 scopus 로고    scopus 로고
    • Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease
    • DOI 10.1016/j.pharmthera.2006.02.003, PII S0163725806000234
    • M.J. Chapman 2006 Therapeutic elevation of HDLcholesterol to prevent atherosclerosis and coronary artery disease Pharmacol Ther 11 893 908 10.1016/j.pharmthera.2006.02.003 (Pubitemid 44164383)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.3 , pp. 893-908
    • Chapman, M.J.1
  • 52
    • 34547858847 scopus 로고    scopus 로고
    • High-density lipoprotein as a therapeutic target: A systematic review
    • DOI 10.1001/jama.298.7.786
    • I.M. Singh M.H. Shishehbor B.J. Ansell 2007 High-density lipoproteins as a therapeutic target: a systematic review JAMA 298 786 798 17699012 10.1001/jama.298.7.786 1:CAS:528:DC%2BD2sXpt1Ghsr4%3D (Pubitemid 47263161)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.7 , pp. 786-798
    • Singh, I.M.1    Shishehbor, M.H.2    Ansell, B.J.3
  • 53
    • 44349114444 scopus 로고    scopus 로고
    • Targeting residual cardiovascular risk: Raising high-density lipoprotein cholesterol levels
    • DOI 10.1136/hrt.2007.125401
    • D.J. Hausenloy D.M. Yellon 2008 Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels Heart 94 706 714 18480348 10.1136/hrt.2007.125401 1:CAS:528:DC%2BD1cXnsFGhtbo%3D (Pubitemid 351744686)
    • (2008) Heart , vol.94 , Issue.6 , pp. 706-714
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 59
    • 33748422658 scopus 로고    scopus 로고
    • High-density lipoprotein: Is it always atheroprotective?
    • DOI 10.1007/s11883-006-0038-4
    • B.J. Ansell G.C. Fonarow A.M. Fogelman 2006 High density lipoprotein: is it always atheroprotective? Curr Atheroscler Rep 8 405 411 16901411 10.1007/s11883-006-0038-4 1:CAS:528:DC%2BD28XpslagsrY%3D (Pubitemid 44340185)
    • (2006) Current Atherosclerosis Reports , vol.8 , Issue.5 , pp. 405-411
    • Ansell, B.J.1    Fonarow, G.C.2    Fogelman, A.M.3
  • 60
    • 50249169416 scopus 로고    scopus 로고
    • HDL: Still a target for new therapies?
    • 18729001 1:CAS:528:DC%2BD1cXhtFKntr7M
    • S.J. Nicholls 2008 HDL: still a target for new therapies? Curr Opin Investig Drugs 9 950 956 18729001 1:CAS:528:DC%2BD1cXhtFKntr7M
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 950-956
    • Nicholls, S.J.1
  • 61
    • 0038645309 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR*trial)
    • DOI 10.1016/S0002-9149(03)00530-7
    • P. Jones M.H. Davidson E.A. Stein 2003 STELLAR study group. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin and pravastatin across doses (STELLAR*Trial) Am J Cardiol 92 152 160 12860216 10.1016/S0002-9149(03)00530-7 1:CAS:528:DC%2BD3sXlt1Wmsb8%3D (Pubitemid 36835963)
    • (2003) American Journal of Cardiology , vol.92 , Issue.2 , pp. 152-160
    • Jones, P.H.1    Davidson, M.H.2    Stein, E.A.3    Bays, H.E.4    McKenney, J.M.5    Miller, E.6    Cain, V.A.7    Blasetto, J.W.8
  • 62
    • 2542582855 scopus 로고    scopus 로고
    • Effects of switching statins on achievement of lipid goals: Measuring Effective Reductions in Cholesterol Using Rosuvastatin Therapy (MERCURY I) study
    • DOI 10.1016/j.ahj.2003.10.004, PII S0002870303007105
    • H. Schuster P.J. Barter S. Stender 2004 Effective Reductions In Cholesterol Using Rosuvastatin Therapy I study group. Effect of switching statins on achievement of lipid goals: Measuring Effective Reductions in Cholesterol Using Rosuvastatin Therapy (MERCURY I) study Am Heart J 147 705 713 15077101 10.1016/j.ahj.2003.10.004 1:CAS:528:DC%2BD2cXivVCrsLY%3D (Pubitemid 38900464)
    • (2004) American Heart Journal , vol.147 , Issue.4 , pp. 705-712
    • Schuster, H.1    Barter, P.J.2    Stender, S.3    Cheung, R.C.4    Bonnet, J.5    Morrell, J.M.6    Watkins, C.7    Kallend, D.8    Raza, A.9
  • 64
    • 3042681157 scopus 로고    scopus 로고
    • Are the effects of statins on HDL-cholesterol clinically relevant?
    • DOI 10.1016/j.ehjsup.2004.04.002, PII S1520765X04000422
    • M.J. Chapman 2004 Are the effect of statins on HDL cholesterol clinically relevant? Eur Heart J Suppl. 6 suppl.C c58 c63 10.1016/j.ehjsup.2004.04.002 1:CAS:528:DC%2BD2cXntVKisrc%3D (Pubitemid 38844954)
    • (2004) European Heart Journal, Supplement , vol.6 , Issue.3
    • Chapman, M.J.1
  • 65
    • 52049089501 scopus 로고    scopus 로고
    • Rosuvastatin and progression of atherosclerosis
    • 18666843 10.1586/14779072.6.7.925 1:CAS:528:DC%2BD1cXpt1ersrw%3D
    • S.J. Nicholls 2008 Rosuvastatin and progression of atherosclerosis Expert Rev Cardiovasc Ther. 6 925 933 18666843 10.1586/14779072.6.7.925 1:CAS:528:DC%2BD1cXpt1ersrw%3D
    • (2008) Expert Rev Cardiovasc Ther. , vol.6 , pp. 925-933
    • Nicholls, S.J.1
  • 66
    • 33751233828 scopus 로고    scopus 로고
    • Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies
    • DOI 10.1185/030079906X148472
    • M.L. Bots 2006 Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies Curr Med Res Opin. 22 2181 2190 17076979 10.1185/030079906X148472 (Pubitemid 44789983)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.11 , pp. 2181-2190
    • Bots, M.L.1
  • 67
    • 58249091563 scopus 로고    scopus 로고
    • Atherosclerosis surrogate imaging trials come of age: For better or for worse?
    • 18950564 10.1007/s11886-008-0081-6
    • M.H. Davidson E. Dembowski 2008 Atherosclerosis surrogate imaging trials come of age: for better or for worse? Curr Cardiol Rep 10 521 525 18950564 10.1007/s11886-008-0081-6
    • (2008) Curr Cardiol Rep , vol.10 , pp. 521-525
    • Davidson, M.H.1    Dembowski, E.2
  • 68
    • 39549112524 scopus 로고    scopus 로고
    • Use of vascular ultrasound in clinical trials to evaluate new cardiovascular therapies
    • 18300539
    • D.T. Nash 2008 Use of vascular ultrasound in clinical trials to evaluate new cardiovascular therapies J Natl Med Assoc 100 222 229 18300539
    • (2008) J Natl Med Assoc , vol.100 , pp. 222-229
    • Nash, D.T.1
  • 69
    • 41849087299 scopus 로고    scopus 로고
    • Ultrasound imaging techniques for the evaluation of cardiovascular therapies
    • 18334471 10.1093/eurheartj/ehn070
    • J.J.P. Kastelein E. de Groot 2008 Ultrasound imaging techniques for the evaluation of cardiovascular therapies Eur Heart J 29 849 858 18334471 10.1093/eurheartj/ehn070
    • (2008) Eur Heart J , vol.29 , pp. 849-858
    • Kastelein, J.J.P.1    De Groot, E.2
  • 70
    • 0032563781 scopus 로고    scopus 로고
    • Clinical trial endpoints: Angiograms, events and plaque instability
    • 9766342 10.1016/S0002-9149(98)00591-8 1:CAS:528:DyaK1cXmslOltbw%3D
    • C.M. Ballantyne 1998 Clinical trial endpoints: angiograms, events and plaque instability Am J Cardiol 82 5M 11M 9766342 10.1016/S0002-9149(98)00591-8 1:CAS:528:DyaK1cXmslOltbw%3D
    • (1998) Am J Cardiol , vol.82
    • Ballantyne, C.M.1
  • 71
    • 33747132177 scopus 로고    scopus 로고
    • Vascular biomarkers and surrogates in cardiovascular disease
    • DOI 10.1161/CIRCULATIONAHA.105.598987, PII 0000301720060627000014
    • J.-C. Tardif T. Heinonen D. Orloff P. Libby 2006 Vascular biomarkers and surrogates in cardiovascular disease Circulation 113 2936 2942 16801474 10.1161/CIRCULATIONAHA.105.598987 (Pubitemid 44297235)
    • (2006) Circulation , vol.113 , Issue.25 , pp. 2936-2942
    • Tardif, J.-C.1    Heinonen, T.2    Orloff, D.3    Libby, P.4
  • 73
    • 33645524176 scopus 로고    scopus 로고
    • ASTEROID Investigators. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: The ASTEROID trial
    • 16533939 10.1001/jama.295.13.jpc60002 1:CAS:528:DC%2BD28Xjt12itrc%3D
    • S.E. Nissen S.J. Nicholls I. Sipahi 2006 ASTEROID Investigators. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial JAMA 295 1556 1565 16533939 10.1001/jama.295.13.jpc60002 1:CAS:528:DC%2BD28Xjt12itrc%3D
    • (2006) JAMA , vol.295 , pp. 1556-1565
    • Nissen, S.E.1    Nicholls, S.J.2    Sipahi, I.3
  • 74
    • 43449113279 scopus 로고    scopus 로고
    • Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: A study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden
    • DOI 10.1161/CIRCULATIONAHA.108.773747, PII 0000301720080513000008
    • C.M. Ballantyne J.S. Raichlen J.S. Nicholls 2008 ASTEROID Investigators. Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden Circulation 117 2458 2466 18378607 10.1161/CIRCULATIONAHA.108.773747 1:CAS:528:DC%2BD1cXltl2hsb8%3D (Pubitemid 351670452)
    • (2008) Circulation , vol.117 , Issue.19 , pp. 2458-2466
    • Ballantyne, C.M.1    Raichlen, J.S.2    Nicholls, S.J.3    Erbel, R.4    Tardif, J.-C.5    Brener, S.J.6    Cain, V.A.7    Nissen, S.E.8
  • 76
    • 9444249842 scopus 로고    scopus 로고
    • Statins in stroke prevention and carotid atherosclerosis: Systematic review and up-to-date meta-analysis
    • DOI 10.1161/01.STR.0000147965.52712.fa
    • P. Amarenco J. Labreuche P. Lavallee P.J. Touboul 2004 Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis Stroke 35 2902 2009 15514180 10.1161/01.STR.0000147965.52712.fa 1:CAS:528:DC%2BD2cXpvVGkt78%3D (Pubitemid 39565192)
    • (2004) Stroke , vol.35 , Issue.12 , pp. 2902-2909
    • Amarenco, P.1    Labreuche, J.2    Lavallee, P.3    Touboul, P.-J.4
  • 77
    • 0035941786 scopus 로고    scopus 로고
    • Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): A prospective, randomised, double-blind trial
    • DOI 10.1016/S0140-6736(00)04053-8
    • T.J. Smilde S. van Wissen H. Wollersheim 2001 Effect of aggressive versus conventional lipid lowering on Atherosclerosis Progression in Familial Hypercholesterolemia (ASAP): a prospective, randomised, double-blind trial Lancet 357 577 581 11558482 10.1016/S0140-6736(00)04053-8 1:CAS:528: DC%2BD3MXhsVKltbo%3D (Pubitemid 32179609)
    • (2001) Lancet , vol.357 , Issue.9256 , pp. 577-581
    • Smilde, T.J.1    Van Wissen, S.2    Wollersheim, H.3    Trip, M.D.4    Kastelein, J.J.P.5    Stalenhoef, A.F.H.6
  • 78
    • 0037109137 scopus 로고    scopus 로고
    • ARBITER: Arterial biology for the investigation of the treatment effects of reducing cholesterol: A randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness
    • DOI 10.1161/01.CIR.0000034508.55617.65
    • A.J. Taylor S.M. Kent P.J. Flaherty 2002 ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness Circulation 106 2055 2060 12379573 10.1161/01.CIR.0000034508. 55617.65 1:CAS:528:DC%2BD38Xns1Sns7c%3D (Pubitemid 35192810)
    • (2002) Circulation , vol.106 , Issue.16 , pp. 2055-2060
    • Taylor, A.J.1    Kent, S.M.2    Flaherty, P.J.3    Coyle, L.C.4    Markwood, T.T.5    Vernalis, M.N.6
  • 80
    • 73449123236 scopus 로고    scopus 로고
    • Intravascular ultrasound evaluation of the effect of rosuvastatin versus atorvastatin on progression of coronary atherosclerosis: Design of the SATURN study
    • 10.1016/S1567-5688(08)70808-0
    • S.J. Nicholls J.S. Raichlen C.M. Ballantyne 2008 Intravascular ultrasound evaluation of the effect of rosuvastatin versus atorvastatin on progression of coronary atherosclerosis: design of the SATURN study Atheroscler Suppl 9 202 10.1016/S1567-5688(08)70808-0
    • (2008) Atheroscler Suppl , vol.9 , pp. 202
    • Nicholls, S.J.1    Raichlen, J.S.2    Ballantyne, C.M.3
  • 81
    • 56749106312 scopus 로고    scopus 로고
    • JUPITER study group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • 18997196 10.1056/NEJMoa0807646 1:CAS:528:DC%2BD1cXhtl2gurnL
    • P.M. Ridker E. Danielson F.A.H. Fonseca 2008 JUPITER study group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N Engl J Med 359 2195 2207 18997196 10.1056/NEJMoa0807646 1:CAS:528:DC%2BD1cXhtl2gurnL
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.H.3
  • 82
    • 63649095045 scopus 로고    scopus 로고
    • Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
    • 19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
    • P.M. Ridker E. Danielson F.A.H. Fonseca 2009 Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial Lancet 373 1175 1182 19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
    • (2009) Lancet , vol.373 , pp. 1175-1182
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.H.3
  • 83
    • 65449138698 scopus 로고    scopus 로고
    • A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    • 1:CAS:528:DC%2BD1MXlsVSlurk%3D
    • R.J. Glynn E. Danielson F.A.H. Fonseca 2009 A randomized trial of rosuvastatin in the prevention of venous thromboembolism N Engl J Med. 2009 Mar 29 360 1851 1861 1:CAS:528:DC%2BD1MXlsVSlurk%3D
    • (2009) N Engl J Med. 2009 Mar 29 , vol.360 , pp. 1851-1861
    • Glynn, R.J.1    Danielson, E.2    Fonseca, F.A.H.3
  • 84
    • 56749106309 scopus 로고    scopus 로고
    • Expanding the orbit of primary prevention: Moving beyond JUPITER
    • 18997195 10.1056/NEJMe0808320 1:CAS:528:DC%2BD1cXhtl2gurbJ
    • M.A. Hlatky 2008 Expanding the orbit of primary prevention: moving beyond JUPITER N Engl J Med 359 2280 2282 18997195 10.1056/NEJMe0808320 1:CAS:528:DC%2BD1cXhtl2gurbJ
    • (2008) N Engl J Med , vol.359 , pp. 2280-2282
    • Hlatky, M.A.1
  • 85
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on the detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on the Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 86
    • 50949134552 scopus 로고    scopus 로고
    • Rosuvastatin: Efficacy,safety and clinical effectiveness
    • 18671469 10.1517/14656566.9.12.2145 1:CAS:528:DC%2BD1cXpt1SmsL8%3D
    • H. Soran P. Durrington 2008 Rosuvastatin: efficacy,safety and clinical effectiveness Expert Opin Pharmacother 9 2145 2160 18671469 10.1517/14656566.9. 12.2145 1:CAS:528:DC%2BD1cXpt1SmsL8%3D
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2145-2160
    • Soran, H.1    Durrington, P.2
  • 87
    • 49749115773 scopus 로고    scopus 로고
    • An overview of the extra-lipid effects of rosuvastatin
    • 18460672 10.1177/1074248408318628 1:CAS:528:DC%2BD1cXhtVOgu7nK
    • M.S. Kostapanos H.J. Milionis M.S. Elisaf 2008 An overview of the extra-lipid effects of rosuvastatin J Cardiovasc Pharmacol Ther 13 157 174 18460672 10.1177/1074248408318628 1:CAS:528:DC%2BD1cXhtVOgu7nK
    • (2008) J Cardiovasc Pharmacol Ther , vol.13 , pp. 157-174
    • Kostapanos, M.S.1    Milionis, H.J.2    Elisaf, M.S.3
  • 88
    • 38349150595 scopus 로고    scopus 로고
    • Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy
    • 10.1016/j.jacc.2007.10.009
    • K. Ramasubbu J. Estep D.L. White 2008 Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy J Am Coll Cardiol 5 415 426 10.1016/j.jacc.2007.10.009
    • (2008) J Am Coll Cardiol , vol.5 , pp. 415-426
    • Ramasubbu, K.1    Estep, J.2    White, D.L.3
  • 89
    • 42149183168 scopus 로고    scopus 로고
    • Observational studies of statins in systolic heart failure
    • DOI 10.1016/j.hfc.2008.01.006, PII S155171360800007X
    • W.C. Levy 2008 Observational studies of statins in systolic heart failure Heart Fail Clin 4 201 208 18433700 10.1016/j.hfc.2008.01.006 (Pubitemid 351539132)
    • (2008) Heart Failure Clinics , vol.4 , Issue.2 , pp. 201-208
    • Levy, W.C.1
  • 92
    • 53249090182 scopus 로고    scopus 로고
    • ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Task Force for DiagnosisTreatment of AcuteChronic Heart Failure 2008 of European Society of Cardiology. 18799522 10.1093/eurheartj/ehn309 1:CAS:528:DC%2BD1cXhtlGisbvO
    • Task Force for DiagnosisTreatment of AcuteChronic Heart Failure 2008 of European Society of Cardiology K. Dickstein A. Cohen-Solal 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) Eur Heart J 29 2388 2442 18799522 10.1093/eurheartj/ehn309 1:CAS:528:DC%2BD1cXhtlGisbvO
    • (2008) Eur Heart J , vol.29 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2
  • 93
    • 53049095795 scopus 로고    scopus 로고
    • Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): A randomized, double-blind, placebo-controlled trial
    • GISSI-HF Investigators. 18757089 10.1016/S0140-6736(08)61240-4
    • GISSI-HF Investigators L. Tavazzi A.P. Maggioni 2008 Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial Lancet 372 1231 1239 18757089 10.1016/S0140-6736(08)61240-4
    • (2008) Lancet , vol.372 , pp. 1231-1239
    • Tavazzi, L.1    Maggioni, A.P.2
  • 94
    • 53049102746 scopus 로고    scopus 로고
    • Statins and n-3 supplementation in heart failure
    • 10.1016/S0140-6736(08)61241-6
    • G. Fornarow 2008 Statins and n-3 supplementation in heart failure Lancet 37 1195 1196 10.1016/S0140-6736(08)61241-6
    • (2008) Lancet , vol.37 , pp. 1195-1196
    • Fornarow, G.1
  • 96
    • 22344458137 scopus 로고    scopus 로고
    • Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    • DOI 10.1056/NEJMoa043545
    • C. Wanner V. Krane W. März 2005 German Diabetes and Dialysis Study Investigators. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis N Engl J Med. 353 238 248 16034009 10.1056/NEJMoa043545 1:CAS:528:DC%2BD2MXmt1Kms7s%3D (Pubitemid 41058323)
    • (2005) New England Journal of Medicine , vol.353 , Issue.3 , pp. 238-248
    • Wanner, C.1    Krane, V.2    Marz, W.3    Olschewski, M.4    Mann, J.F.E.5    Ruf, G.6    Ritz, E.7
  • 98
    • 63849163945 scopus 로고    scopus 로고
    • Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    • 19332456 10.1056/NEJMoa0810177
    • B.C. Fellström A.G. Jardine R.E. Schmieder 2009 Rosuvastatin and cardiovascular events in patients undergoing hemodialysis N Engl J Med 360 1395 1407 19332456 10.1056/NEJMoa0810177
    • (2009) N Engl J Med , vol.360 , pp. 1395-1407
    • Fellström, B.C.1    Jardine, A.G.2    Schmieder, R.E.3
  • 99
    • 63849137073 scopus 로고    scopus 로고
    • Sunset for statins after AURORA
    • 19332454 10.1056/NEJMe0901067 1:CAS:528:DC%2BD1MXjvFGhsbo%3D
    • G.F.M. Strippoli J.C. Craig 2009 Sunset for statins after AURORA N Engl J Med 360 1455 1457 19332454 10.1056/NEJMe0901067 1:CAS:528:DC%2BD1MXjvFGhsbo%3D
    • (2009) N Engl J Med , vol.360 , pp. 1455-1457
    • Strippoli, G.F.M.1    Craig, J.C.2
  • 100
    • 59649099505 scopus 로고    scopus 로고
    • The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelines
    • 19095730 10.1373/clinchem.2008.109728 1:CAS:528:DC%2BD1MXhvVWksrc%3D
    • S. Mora K. Musunuru R.S. Blumenthal 2009 The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelines Clin Chem 55 219 228 19095730 10.1373/clinchem.2008.109728 1:CAS:528:DC%2BD1MXhvVWksrc%3D
    • (2009) Clin Chem , vol.55 , pp. 219-228
    • Mora, S.1    Musunuru, K.2    Blumenthal, R.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.