Decreased serum prohepcidin concentration in patients with polycythemia vera

Journal of Zhejiang University: Science B

Volumn 10, Issue 11, 2009, Pages 791-795

  Kwapisz, Justyna ^a   Zekanowska, Ewa ^a   Jasiniewska, Joanna ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

Hepcidin; Iron metabolism; Polycythemia vera (PV); Prohepcidin

Indexed keywords

FERRITIN; HEPCIDIN; IRON; PROHEPCIDIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REFERENCE VALUE; TRANSFERRIN BLOOD LEVEL; UNSATURATED IRON BINDING CAPACITY;

ADULT; AGED; AGED, 80 AND OVER; ANTIMICROBIAL CATIONIC PEPTIDES; CASE-CONTROL STUDIES; FEMALE; FERRITINS; HOMEOSTASIS; HUMANS; IRON; MALE; MIDDLE AGED; POLYCYTHEMIA VERA; PROTEIN PRECURSORS;

EID: 73449130170     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0920217     Document Type: Article

References (24)

1. M.B. Agarwal 2007 Clinical applications of molecular haematology: JAK2 in myeloproliferative disorders J. Assoc. Physicians India 55 507 510 1:STN:280:DC%2BD2sros12jtg%3D%3D 17907502
2. C. Benedict A.J. Ghio H. Gehring B. Schultes A. Peters K.M. Oltmanns 2007 Transient hypoxia and down-regulation of circulating prohepcidin concentrations in healthy young men Haematologica 92 1 125 126 10.3324/haematol.10637 1:CAS:528:DC%2BD2sXitlOrtbs%3D 17229646 (Pubitemid 46232667)
3. G. Birgegard M. Carlsson B. Sandhagen F. Mannting 1984 Does iron deficiency in treated polycythemia vera affect whole blood viscosity? Acta Med. Scand. 216 2 165 169 1:STN:280:DyaL2M%2FktlWlug%3D%3D 6496176
4. M.J. Brookes N.K. Sharma C. Tselepis T.H. Iqbal 2005 Serum pro-hepcidin: measuring active hepcidin or non-functional precursor? Gut 54 1 169 170 10.1136/gut.2004.047639 1:STN:280:DC%2BD2cnhslWmtw%3D%3D 15591524
5. M.D. Fleming 2008 The regulation of hepcidin and its effects on systemic and cellular iron metabolism Hematology-Am. Soc. Hematol. Educ. Program 2008 151 158
6. D.M. Frazer G.J. Anderson 2009 Hepcidin compared with prohepcidin: an absorbing story Am. J. Clin. Nutr. 89 2 475 476 10.3945/ajcn.2008.27232 1:CAS:528:DC%2BD1MXhtVOitr4%3D 19088153
7. T. Ganz E. Nemeth 2006 Iron imports. IV. Hepcidin and regulation of body iron metabolism Am. J. Physiol. Gastrointest. Liver Physiol. 290 2 199 203 10.1152/ajpgi.00412.2005
8. T. Ganz G. Olbina D. Girelli E. Nemeth M. Westerman 2008 Immunoassay for human serum hepcidin Blood 112 10 4292 4297 10.1182/blood-2008-02-139915 1:CAS:528:DC%2BD1cXhsVSmsrjJ 18689548
9. R.D. Hutton 1979 The effect of iron deficiency on whole blood viscosity in polycythaemic patients Br. J. Haematol. 43 2 191 199 10.1111/j.1365-2141. 1979.tb03741.x 1:STN:280:DyaL3c%2FmsFeqtA%3D%3D 508628
10. E. Kemna P. Pickkers E. Nemeth H. van der Hoeven D. Swinkels 2005 Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS Blood 106 5 1864 1866 10.1182/blood-2005-03-1159 1:CAS:528:DC%2BD2MXps1OgtLw%3D 15886319 (Pubitemid 41208606)
11. E.H. Kemna A.E. Kartikasari L.J. van Tits P. Pickkers H. Tjalsma D.W. Swinkels 2008 Regulation of hepcidin: insights from biochemical analyses on human serum samples Blood Cells Mol. Dis. 40 3 339 346 10.1016/j.bcmd.2007.10. 002 1:CAS:528:DC%2BD1cXkvFahsbo%3D 18023212
12. H. Kulaksiz S.G. Gehrke A. Janetzko D. Rost T. Bruckner B. Kallinowski W. Stremmel 2004 Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia Gut 53 5 735 743 10.1136/gut.2003.022863 1:CAS:528:DC%2BD2cXktlKitL0%3D 15082594 (Pubitemid 38561454)
13. A. Mleczko 2004 Owrzodzenie podudzi jako powikłanie stosowania hydroksymocznika u pacjent'ow leczonych z powodu chor'ob mieloproliferacyjnych PDiA 21 5 255 259
14. E. Nemeth T. Ganz 2006 Hepcidin and iron-loading anemias Haematologica 91 6 727 732 1:CAS:528:DC%2BD28XntF2jtr4%3D 16769573
15. G. Nicolas C. Chauvet L. Viatte J.L. Danan X. Bigard I. Devaux C. Beaumont A. Kahn S. Vaulont 2002 The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J. Clin. Invest. 110 7 1037 1044 1:CAS:528:DC%2BD38XnslSktrs%3D 12370282
16. T.C. Pearson A.J. Grimes N.G. Slater G. Wetherley-Mein 1981 Viscosity and iron deficiency in treated polycythaemia Br. J. Haematol. 49 1 123 127 10.1111/j.1365-2141.1981.tb07205.x 1:STN:280:DyaL38%2FgtVerug%3D%3D 7272225
17. J.P. Pinto S. Ribeiro H. Pontes S. Thowfeegu D. Tosh F. Carvalho G. Porto 2008 Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha Blood 111 12 5727 5733 10.1182/blood-2007-08-106195 1:CAS:528:DC%2BD1cXnsVOkur4%3D 18326822
18. A. Piperno R. Mariani P. Trombini D. Girelli 2009 Hepcidin modulation in human diseases: from research to clinic World J. Gastroenterol. 15 5 538 551 10.3748/wjg.15.538 1:CAS:528:DC%2BD1MXpsFCgtrc%3D 19195055
19. W.G. Rector N.J. Fortuin C.L. Conley 1982 Non-hematologic effects of chronic iron deficiency: a study of patients with polycythemia vera treated solely with venesections Medicine 61 6 382 389 10.1097/00005792-198211000-00004 7144531
20. M.A. Roe C. Spinks A.L. Heath L.J. Harvey R. Foxall J. Wimperis C. Wolf S.J. Fairweather-Tait 2007 Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women Br. J. Nutr. 97 3 544 549 10.1017/S0007114507336829 1:CAS:528:DC%2BD2sXjvVSiu70%3D 17313717 (Pubitemid 46662045)
21. T. Shinzato K. Abe A. Furusu T. Harada K. Shinzato M. Miyazaki S. Kohno 2008 Serum pro-hepcidin level and iron homeostasis in Japanese dialysis patients with erythropoietin (EPO)-resistant anemia Med. Sci. Monit. 14 9 CR431 CR437 1:CAS:528:DC%2BD1cXht1ems7jL 18758412
22. J.L. Spivak 2002 Polycythemia vera: myths, mechanisms, and management Blood 100 13 4272 4290 10.1182/blood-2001-12-0349 1:CAS:528:DC%2BD38XpsFCqsrY%3D 12393615 (Pubitemid 35429665)
23. A. Tefferi 2008 JAK and MPL mutations in myeloid malignancies Leuk. Lymphoma 49 3 388 397 10.1080/10428190801895360 1:CAS:528:DC%2BD1cXit1CmtL8%3D 18297515 (Pubitemid 351298324)
24. A. Tefferi J.W. Vardiman 2008 Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and poin-of-care diagnostic algorithms Leukemia 22 1 14 22 10.1038/sj.leu.2404955 1:CAS:528:DC%2BD1cXmsV2jtA%3D%3D 17882280