Lonazolac analogues: Molecular modeling, synthesis, and in vivo anti-inflammatory activity

Medicinal Chemistry Research

Volumn 18, Issue 9, 2009, Pages 725-744

  Ismail, Mohamed A H ^a   Lehmann, Jochen ^b   Abou El Ella, Dalal A ^a   Albohy, Amgad ^a,b   Abouzid, Khaled A M ^a  

^a Ain Shams University   (Egypt)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Anti inflammatory; Diarylpyrazole; Lonazolac analogues; Molecular modeling study

Indexed keywords

1,3 DIPHENYL 1H PYRAZOLE 4 [N [2 (AMINOCARBONYL) PHENYL]]CARBOXAMIDE; 1,3 DIPHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 2 (AMINOCARBONYL)PHENYL ESTER; 1,3 DIPHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 4 (ACETYLAMIDO)PHENYL ESTER; 3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOLE 4 [N [2 (AMINOCARBONYL) PHENYL]] CARBOX AMIDE; 3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 2 (AMINOCARBONYL) PHENYL ESTER; 3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOLE 4 [N [2 (AMINOCARBONYL) PHENYL]] CARBOX AMIDE; 3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 2 (AMINOCARBONYL) PHENYL ESTER; 3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 4 (ACETYLAMIDO)PHENYL ESTER; 3 (4 METHYLPHENYL) 1 PHENYL 1H PYRAZOLE 4 [N [2 (AMINOCARBONYL) PHENYL]] CARBOX AMIDE; 3 (4 METHYLPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 2 (AMINOCARBONYL) PHENYL ESTER; 3 (4 METHYLPHENYL) 1 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID 4 (ACETYLAMIDO)PHENYL ESTER; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 6 [1,3 DIPHENYL 1H PYRAZOL 4 YL] 4 OXOHEX 5 ENOIC ACID; 6 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4 OXOHEX 5 ENOIC ACID; 6 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4 OXOHEX 5 ENOIC ACID; 6 [3 (4 METHYLPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 4 OXOHEX 5 ENOIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ETORICOXIB; INDOMETACIN; LONAZOLAC; LUMIRACOXIB; ROFECOXIB; UNCLASSIFIED DRUG; VALDECOXIB;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HYDROGEN BOND; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PAW EDEMA; PHARMACOPHORE; RAT;

EID: 73449127563     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9163-2     Document Type: Article

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