The synthesis and activity of spiroindane growth hormone secretagogues

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 6, 1997, Pages 663-668

  Tata, James R ^a   Nargund, Ravi P ^a   Murphy, Marcia M ^a   Johnston, David B R ^a   Patchett, Arthur A ^a   Cheng, Kang ^a   Wei, Liente ^a   Chan, Wanda W S ^a   Butler, Bridget ^a   Jacks, Thomas M ^a   Hickey, Gerard ^a   Smith, Roy ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDAN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH HORMONE RELEASE; HYPOPHYSIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0031576889     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00075-9     Document Type: Article

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21. 20. Compounds were administered orally at the appropriate levels in water to male and female beagles weighing 8-16 kg. Dogs were bled at the jugular vein at -20, 0, 15, 30,45, 60, 90, 120, 180, 240, and 480 minutes after dosing. The sera was analyzed for GH. For more details see ref 12.