Processing in the endoplasmic reticulum generates an epitope on the insulin A chain that stimulates diabetogenic CD8 T cell responses

Journal of Immunology

Volumn 183, Issue 11, 2009, Pages 7187-7195

  Brosi, Helen ^a   Reiser, Michael ^a   Rajasalu, Tarvo ^b   Spyrantis, Andreas ^a   Oswald, Franz ^a   Boehm, Bernhard Otto ^a   Schirmbeck, Reinhold ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INSULIN; PLASMID DNA; POLYPEPTIDE; PREPROINSULIN; SERYLLEUCYLTYROSYLGLUTAMINYLLEUCYLGLUTAMYLASPARAGINYLTYROSYLCYSTEINYLALANINE; UNCLASSIFIED DRUG; B7 ANTIGEN; PROTEIN PRECURSOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DIABETOGENESIS; DISEASE MODEL; ENDOPLASMIC RETICULUM; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOLOGY; METABOLISM; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD80; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM; EPITOPES, T-LYMPHOCYTE; FLUORESCENT ANTIBODY TECHNIQUE; INSULIN; MICE; PROTEIN PRECURSORS;

EID: 73349121329     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901573     Document Type: Article

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