MHC drives TCR repertoire shaping, but not maturation, in recent thymic emigrants

Journal of Immunology

Volumn 183, Issue 11, 2009, Pages 7244-7249

  Houston Jr , Evan G ^a   Fink, Pamela J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELL MATURATION; CELL SELECTION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; HOMEOSTASIS; LYMPHOID TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; RECENT THYMIC EMIGRANT; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; RADIATION CHIMERA; STEM CELL;

HLA ANTIGEN CLASS 2; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMALS; CELL DIFFERENTIATION; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RADIATION CHIMERA; RECEPTORS, ANTIGEN, T-CELL; STEM CELLS; T-LYMPHOCYTES;

EID: 73349114920     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902313     Document Type: Article

References (39)

1. Boursalian, T. E., J. Golub, D. M. Soper, C. J. Cooper, and P. J. Fink. 2004. Continued maturation of thymic emigrants in the periphery. Nat. Immunol. 5: 418-425.
2. + T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J. Exp. Med. 206: 275-285.
3. Hale, J. S., T. E. Boursalian, G. L. Turk, and P. J. Fink. 2006. Thymic output in aged mice. Proc. Natl. Acad. Sci. USA 103: 8447-8452.
4. Houston, E. G., Jr., R. Nechanitzky, and P. J. Fink. 2008. Cutting edge: contact with secondary lymphoid organs drives postthymic T cell maturation. J. Immunol. 181: 5213-5217.
5. Opiela, S. J., T. Koru-Sengul, and B. Adkins. 2009. Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood 113: 5635-5643.
6. Yu, W., H. Nagaoka, M. Jankovic, Z. Misulovin, H. Suh, A. Rolink, F. Melchers, E. Meffre, and M. C. Nussenzweig. 1999. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400: 682-687.
7. McCaughtry, T. M., M. S. Wilken, and K. A. Hogquist. 2007. Thymic emigration revisited. J. Exp. Med. 204: 2513-2520.
8. Surh, C. D., and J. Sprent. 2008. Homeostasis of naive and memory T cells. Immunity 29: 848-862.
9. McNab, F. W., S. P. Berzins, D. G. Pellicci, K. Kyparissoudis, K. Field, M. J. Smyth, and D. I. Godfrey. 2005. The influence of CD1d in postselection NKT cell maturation and homeostasis. J. Immunol. 175: 3762-3768.
10. McNab, F. W., D. G. Pellicci, K. Field, G. Besra, M. J. Smyth, D. I. Godfrey, and S. P. Berzins. 2007. Peripheral NK1.1- NKT cells are mature and functionally distinct from their thymic counterparts. J. Immunol. 179: 6630-6637.
11. Di Rosa, F., S. Ramaswamy, J. P. Ridge, and P. Matzinger. 1999. On the lifespan of virgin T lymphocytes. J. Immunol. 163: 1253-1257.
12. + T cells in major histocompatibility complex class II-deficient mice. Science 253: 1417-1420.
13. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383: 81-85.
14. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
15. Barnden, M. J., J. Allison, W. R. Heath, and F. R. Carbone. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76: 34-40.
16. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342: 559-561.
17. Oxenius, A., M. F. Bachmann, R. M. Zinkernagel, and H. Hengartner. 1998. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28: 390-400.
18. Herzenberg, L. A., J. Tung, W. A. Moore, L. A. Herzenberg, and D. R. Parks. 2006. Interpreting flow cytometry data: a guide for the perplexed. Nat. Immunol. 7: 681-685.
19. Hendricks, D. W., and P. J. Fink. 2009. Uneven colonization of the lymphoid periphery by T cells that undergo early TCR rearrangements. J. Immunol. 182: 4267-4274.
20. Pannetier, C., M. Cochet, S. Carche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90: 4319-4323.
21. + cells. J. Immunol. 152: 4270-4281.
22. + T cells. J. Exp. Med. 176: 1733-1738.
23. Dillon, S. R., and P. J. Fink. 1995. Thymic selection events mediated by the pre-TCR do not depend upon a limiting ligand. Int. Immunol. 7: 1363-1373.
24. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66: 533-540.
25. Merkenschlager, M., C. Benoist, and D. Mathis. 1994. Evidence for a single-niche model of positive selection. Proc. Natl. Acad. Sci. USA 91: 11694-11698.
26. + T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat. Immunol. 1: 329-335.
27. + T cells. Proc. Natl. Acad. Sci. USA 100: 6021-6026.
28. Madsen, L., N. Labrecque, J. Engberg, A. Dierich, A. Svejgaard, C. Benoist, D. Mathis, and L. Fugger. 1999. Mice lacking all conventional MHC class II genes. Proc. Natl. Acad. Sci. USA 96: 10338-10343.
29. + T cell survival controlled by clonal abundance. Science 312: 114-116.
30. Labrecque, N., L. S. Whitfield, R. Obst, C. Waltzinger, C. Benoist, and D. Mathis. 2001. How much TCR does a T cell need? Immunity 15: 71-82.
31. Polic, B., D. Kunkel, A. Scheffold, and K. Rajewsky. 2001. How ab T cells deal with induced TCR α ablation. Proc. Natl. Acad. Sci. USA 98: 8744-8749.
32. Ernst, B., D. S. Lee, J. M. Chang, J. Sprent, and C. D. Surh. 1999. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11: 173-181.
33. + recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat. Immunol. 7: 482-488.
34. Fazilleau, N., J. P. Cabaniols, F. Lemaitre, I. Motta, P. Kourilsky, and J. M. Kanellopoulos. 2005. Vα and Vβ public repertoires are highly conserved in terminal deoxynucleotidyl transferase deficient mice. J. Immunol. 174: 345-355.
35. Gavin, M. A., and M. J. Bevan. 1995. Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire. Immunity 3: 793-800.
36. Gilfillan, S., C. Waltzinger, C. Benoist, and D. Mathis. 1994. More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase. Int. Immunol. 6: 1681-1686.
37. Nishio, J., M. Suzuki, T. Nanki, N. Miyasaka, and H. Kohsaka. 2004. Development of TCRB CDR3 length repertoire of human T lymphocytes. Int. Immunol. 16: 423-431.
38. Matsutani, T., T. Ohmori, M. Ogata, H. Soga, S. Kasahara, T. Yoshioka, R. Suzuki, and T. Itoh. 2007. Comparison of CDR3 length among thymocyte subpopulations: impacts of MHC and BV segment on the CDR3 shortening. Mol. Immunol. 44: 2378-2387.
39. Luther, S. A., and H. Acha-Orbea. 1997. Mouse mammary tumor virus: immunological interplays between virus and host. Adv. Immunol. 65: 139-243.