Uneven colonization of the lymphoid periphery by T cells that undergo early TCRα rearrangements

Journal of Immunology

Volumn 182, Issue 7, 2009, Pages 4267-4274

  Hendricks, Deborah W ^a   Fink, Pamela J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; THY 1 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELE; ANIMAL CELL; ARTICLE; BACTERIAL COLONIZATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; GENE REARRANGEMENT; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE; ANIMAL; C57BL MOUSE; CYTOLOGY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; FLOW CYTOMETRY; GENE REARRANGEMENT, T-LYMPHOCYTE; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 64249100214     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804180     Document Type: Article

References (37)

1. Hawwari, A., and M. S. Krangel. 2005. Regulation of TCR δ and α repertoires by local and long-distance control of variable gene segment chromatin structure. J. Exp. Med. 202: 467-472. (Pubitemid 41186944)
2. α promoters. Nat. Immunol. 6: 481-489.
3. Huang, C.-Y., and O. Kanagawa. 2001. Ordered and coordinated rearrangement of the TCRα locus: role of secondary rearrangement in thymic selection. J. Immunol. 166: 2597-2601.
4. Pasqual, N., M. Gallagher, C. Aude-Garcia, M. Loiodice, F. Thuderoz, J. Demongeot, R. Ceredig, P. N. Marche, and E. Jouvin-Marche. 2002. Quantitative and qualitative changes in V-J α rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor α chain repertoire. J. Exp. Med. 196: 1163-1173. (Pubitemid 35304183)
5. Hernandez-Munain, C., B. P. Sleckman, and M. S. Krangel. 1999. A developmental switch from TCRδ enhancer to TCRα enhancer function during thymocyte maturation. Immunity 10: 723-733. (Pubitemid 29302925)
6. Mancini, S. J., S. M. Candeias, J. P. Di Santo, P. Ferrier, P. N. Marche, and E. Jouvin-Marche. 2001. TCRα gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling. J. Immunol. 167: 4485-4493.
7. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375: 795-798.
8. Egawa, T., T. Kreslavsky, D. R. Littman, and H. von Boehmer. 2008. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS ONE 3: e1512. (Pubitemid 351827381)
9. Rocha, B., H. von Boehmer, and D. Guy-Grand. 1992. Selection of intraepithelial lymphocytes with CD8 α/α co-receptors by self-antigen in the murine gut. Proc. Natl. Acad. Sci. USA 89: 5336-5340.
10. Baldwin, T. A., M. M. Sandau, S. C. Jameson, and K. A. Hogquist. 2005. The timing of TCRα expression critically influences T cell development and selection. J. Exp. Med. 202: 111-121.
11. Cheroutre, H. 2005. IELs: enforcing law and order in the court of the intestinal epithelium. Immunol. Rev. 206: 114-131. (Pubitemid 41105166)
12. Mosley, R. L., and J. R. Klein. 1992. Repopulation kinetics of intestinal intraepithelial lymphocytes in murine bone marrow radiation chimeras. Transplantation 53: 868-874.
13. Hao, Z., and K. Rajewsky. 2001. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J. Exp. Med. 194: 1151-1163. (Pubitemid 32995784)
14. Lee, P. P., D. R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Perez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, et al. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15: 763-774.
15. Wolfer, A., T. Bakker, A. Wilson, M. Nicolas, V. Ioannidis, D. R. Littman, C. B. Wilson, W. Held, H. R. MacDonald, and F. Radtke. 2001. Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development. Nat. Immunol. 2: 235-241. (Pubitemid 33706000)
16. Lefrancois, L. 1996. Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr. Protoc. Immunol. 3.19: 11-16.
17. Pannetier, C., J. Even, and P. Kourilsky. 1995. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today 16: 176-181.
18. DiRienzo, C. G., G. F. Murphy, S. C. Jones, R. Korngold, and T. M. Friedman. 2006. T-cell receptor Vα spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease. Biol. Blood Marrow Transplant. 12: 818-827.
19. Casanova, J. L., P. Romero, C. Widmann, P. Kourilsky, and J. L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174: 1371-1383.
20. Anderson, G., K. J. Hare, and E. J. Jenkinson. 1999. Positive selection of thymocytes: the long and winding road. Immunol. Today 20: 463-468. (Pubitemid 29476076)
21. + intraepithelial lymphocyte precursors in the thymus. Immunity 25: 631-641.
22. Leishman, A. J., O. V. Naidenko, A. Attinger, F. Koning, C. J. Lena, Y. Xiong, H. C. Chang, E. Reinherz, M. Kronenberg, and H. Cheroutre. 2001. T cell responses modulated through interaction between CD8αα and the nonclassical MHC class I molecule, TL. Science 294: 1936-1939.
23. Pannetier, C., M. Cochet, S. Carche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90: 4319-4323. (Pubitemid 23134218)
24. Voehringer, D., H. E. Liang, and R. M. Locksley. 2008. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J. Immunol. 180: 4742-4753.
25. + intraepithelial lymphocytes. Science 243: 1716-1718.
26. Haeryfar, S. M., and D. W. Hoskin. 2004. Thy-1: more than a mouse pan-T cell marker. J. Immunol. 173: 3581-3588.
27. Rocha, B. 2007. The extrathymic T-cell differentiation in the murine gut. Immunol. Rev. 215: 166-177. (Pubitemid 46212238)
28. Schluns, K. S., E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. L. Aguila. 2004. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression. Proc. Natl. Acad. Sci. USA 101: 5616-5621.
29. Kieper, W. C., A. Troy, J. T. Burghardt, C. Ramsey, J. Y. Lee, H.-Q. Jiang, W. Dummer, H. Shen, J. J. Cebra, and C. D. Surh. 2005. Cutting edge: recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol. 174: 3158-3163.
30. King, C., A. Ilic, K. Koelsch, and N. Sarvetnick. 2004. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117: 265-277. (Pubitemid 38496245)
31. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173: 483-486.
32. Latthe, M., L. Terry, and T. T. MacDonald. 1994. High frequency of CD8αα homodimer-bearing T cells in human fetal intestine. Eur. J. Immunol. 24: 1703-1705. (Pubitemid 2094582)
33. Lin, T., G. Matsuzaki, H. Yoshida, H. Kenai, K. Omoto, M. Umesue, C. Singaram, and K. Nomoto. 1996. Thymus ontogeny and the development of TCRαβ intestinal intraepithelial lymphocytes. Cell. Immunol. 171: 132-139. (Pubitemid 26349135)
34. Regnault, A., A. Cumano, P. Vassalli, D. Guy-Grand, and P. Kourilsky. 1994. Oligoclonal repertoire of the CD8αα and the CD8αβ TCR-α/β murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells. J. Exp. Med. 180: 1345-1358. (Pubitemid 24289608)
35. Arstila, T., T. P. Arstila, S. Calbo, F. Selz, M. Malassis-Seris, P. Vassalli, P. Kourilsky, and D. Guy-Grand. 2000. Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph. J. Exp. Med. 191: 823-834.
36. + cells. Science 305: 248-251.
37. Lambolez, F., M. L. Arcangeli, A. M. Joret, V. Pasqualetto, C. Cordier, J. P. Di Santo, B. Rocha, and S. Ezine. 2006. The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat. Immunol. 7: 76-82. (Pubitemid 41823871)