On the lifespan of virgin T lymphocytes

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1253-1257

  Di Rosa, Francesca ^a,c   Ramaswamy, Sridhar ^b   Ridge, John P ^a   Matzinger, Polly ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; HY ANTIGEN;

AGING; ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; ARTICLE; CELL SURVIVAL; FEMALE; IMMUNOLOGICAL MEMORY; IMMUNOREACTIVITY; MEMORY CELL; MOUSE; NEWBORN; NONHUMAN; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY;

AGE FACTORS; AGING; ANIMALS; CELL AGING; FEMALE; H-Y ANTIGEN; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; ISOANTIGENS; MALE; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; MICE, INBRED CBA; T-LYMPHOCYTES; THYMECTOMY; THYMUS GLAND;

EID: 0033179273     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Sprent, J., and D. F. Tough. 1994. Lymphocyte life-span and memory. Science 265:1395.
2. Taylor, R. B. 1965. Decay of immunological responsiveness after thymectomy in adult life. Nature 208:1334.
3. Metcalf, D. 1965. Delayed effect of thymectomy in adult life on immunological competence. Nature 208:1336.
4. Miller, J. F. 1965. Effect of thymectomy in adult mice on immunological responsiveness. Nature 208:1337.
5. Kappler, J. W., P. C. Hunter, D. Jacobs, and E. Lord. 1974. Functional heterogeneity among the T-derived lymphocytes of the mouse: analysis by adult thymectomy. J. Immunol. 113:27.
6. Bell, E. B., S. M. Sparshott, M. T. Drayson, and W. L. Ford. 1987. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J. Immunol. 139:1379.
7. Sprent, J., M. Schaefer, M. Hurd, C. D. Surh, and Y. Ron. 1991. Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype. J. Exp. Med. 174:717.
8. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
9. Tanchot, C., and B. Rocha. 1997. Peripheral selection of T cell repertoires: the role of continuous thymus output. J. Exp. Med. 186:1099.
10. Tanchot, C., M. M. Rosado, F. Agenes, A. A. Freitas, and B. Rocha. 1997. Lymphocyte homeostasis. Semin. Immunol. 9:331.
11. Bevan, M. J. 1977. Killer cells reactive to altered-self-antigens can also be alloreactive. Proc. Natl. Acad. Sci. USA 74:2094.
12. Ashwell, J. D., C. Chen, and R. H. Schwartz. 1986. High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigens in association with self class II molecules. J. Immunol. 136:389.
13. Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179: 1933.
14. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:109.
15. von Boehmer, H. 1990. Developmental biology of T cells in T-cell receptor transgenic mice. Annu. Rev. Immunol. 8:531.
16. von Boehmer, H., and K. Hafen. 1993. The life span of naive α/β T cells in secondary lymphoid organs. J. Exp. Med. 177:891.
17. Gordon, R. D., E. Simpson, and L. E. Samelson. 1975. In vitro cell-mediated immune responses to the male-specific (H-Y) antigen in mice. J. Exp. Med. 142: 1108.
18. Gray, D., and P. Matzinger. 1991. T cell memory is short-lived in the absence of antigen. J. Exp. Med. 174:969.
19. Fuchs, E. J., and P. Matzinger. 1992. B cells turn off virgin but not memory T cells. Science 258:1156.
20. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
21. Bruno, L., H. von Boehmer, and J. Kirberg. 1996. Cell division in the compartment of naive and memory T lymphocytes. Eur. J. Immunol. 26:3179.
22. + T cells. Eur. J. Immunol. 26:2640.
23. Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
24. Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
25. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
26. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T-cell subsets: phenotype, function, and the role of lymphokines in regulating their development. Immunol. Rev. 123:115.
27. Linton, P. J., L. Haynes, N. R. Klinman, and S. L. Swain. 1996. Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184:1891.
28. Matzinger, P., and M. J. Bevan. 1977. Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell. Immunol. 29:1.
29. Kourilsky, P., and J. M. Claverie. 1986. The peptidic self model: a hypothesis on the molecular nature of the immunological self. Ann. Inst. Pasteur Immunol. 137:3.
30. De Boer, R. J., and A. S. Perelson. 1997. Competitive control of the self-renewing T cell repertoire. Int. Immunol. 9:779.
31. + T cell pools. Eur. J. Immunol. 25:2127.
32. Scollay, R. G., E. C. Butcher, and I. L. Weissman. 1980. Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10:210.
33. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
34. Wucherpfennig, K. W., and J. Strominger. 1995. Molecular mimicry in T-cell mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
35. Lefkovitz, I., and H. Waldmann. 1979. Limiting Dilution Analysis of Cells in the Immune System. Cambridge University Press, Cambridge, p. 262.
36. + T-helper and a T-killer cell. Nature 393: 474.
37. Bennett, S. R. M., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. A. P. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393:478.
38. Schoenberger, S. P., R. E. M. Toes, E. I. H. van der Voort, R. Offringa, and C. J. M. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.