Human and monkey lenses cultured with calcium ionophore form αB-crystallin lacking the c-terminal lysine, a prominent feature of some human cataracts

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 12, 2009, Pages 5828-5836

  Nakajima, Emi ^a,b   David, Larry L ^b   Riviere, Michael A ^b   Azuma, Mitsuyoshi ^a,b   Shearer, Thomas R ^b  

^a Senju Pharmaceutical Corporation Limited   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ALPHA CRYSTALLIN[1-174]; CALCIUM ION; CALCIUM IONOPHORE; LYSINE; UNCLASSIFIED DRUG; ZINC; CALCIMYCIN; CALCIUM; CARBOXYPEPTIDASE H; IONOPHORE;

AGED; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CARBOXYPEPTIDASE E GENE; CATARACT; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HAPLORHINI; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PURIFICATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LENS; MACACA; METABOLISM; ORGAN CULTURE TECHNIQUE; POLYACRYLAMIDE GEL ELECTROPHORESIS;

AGED; AGED, 80 AND OVER; ALPHA-CRYSTALLIN B CHAIN; ANIMALS; BLOTTING, WESTERN; CALCIMYCIN; CALCIUM; CARBOXYPEPTIDASE H; CATARACT; CHILD, PRESCHOOL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IONOPHORES; LENS, CRYSTALLINE; LYSINE; MACACA MULATTA; MASS SPECTROMETRY; ORGAN CULTURE TECHNIQUES; ZINC;

EID: 73349087193     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4015     Document Type: Article

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