Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways

Molecular Biology and Evolution

Volumn 26, Issue 11, 2009, Pages 2455-2462

  Brown, Kyle M ^a   Depristo, Mark A ^a,b   Weinreich, Daniel M ^a,c   Hartl, Daniel L ^a  

^a HARVARD UNIVERSITY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Adaptive evolution; Antibiotic resistance; Beta lactamase; Enzyme evolution; Evolutionary pathways; Regulatory evolution

Indexed keywords

ARABINOSE; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFOTAXIME; TEM BETA LACTAMASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE EXPRESSION; GENE MAPPING; GENE SEQUENCE; LANDSCAPE; MISSENSE MUTATION; MOLECULAR EVOLUTION; MUTANT; NONHUMAN; PROMOTER REGION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CLASSIFICATION; DIRECTED MOLECULAR EVOLUTION; GENETICS; KINETICS; MICROBIOLOGICAL EXAMINATION; MUTATION;

ENTEROBACTERIACEAE;

BETA-LACTAMASES; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; KINETICS; MICROBIAL SENSITIVITY TESTS; MUTATION;

EID: 73349085245     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msp151     Document Type: Article

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