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Volumn 51, Issue 6, 2010, Pages 977-979

Design and synthesis of indole derivatives of adenophostin A. A entry into subtype-selective IP3 receptor ligands

Author keywords

[No Author keywords available]

Indexed keywords

ADENOPHOSTIN A; INDOLE DERIVATIVE; INOSITOL TRISPHOSPHATE;

EID: 73249152059     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.12.045     Document Type: Article
Times cited : (9)

References (31)
  • 23
    • 73249144558 scopus 로고    scopus 로고
    • note
    • The preoptimized geometries by HF/3-21G* were taken to be the input geometries for final optimization by B3LYP/6-31G*. Single point energies and all electronic properties were calculated by B3LYP/6-31G*.
  • 24
    • 73249144764 scopus 로고    scopus 로고
    • note
    • Preliminary experiments suggested that in the glycosidation of α-disaccharide donors at the 1β-position of the ribose moiety with indoline as an acceptor, a bulky protecting group, such as TBS group, at the 5-primary hydroxyl of the donor might prevent the glycosidation to proceed.
  • 26
    • 73249142809 scopus 로고    scopus 로고
    • note
    • The anomeric β-configuration was confirmed from an NOE correlation between H-2 of the indole moiety and H-2′ of the ribose moiety.
  • 27
    • 73249119901 scopus 로고    scopus 로고
    • note
    • When deprotection of the 5′-O-allyl group was examined after the introduction of the o-xylene phosphate units at the 2′, 3″, and 4″-hydroxyls, it was unsuccessful.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.