Synthesis of adenophostin A analogues conjugating an aromatic group at the 5′-position as potent IP3 receptor ligands

Journal of Medicinal Chemistry

Volumn 49, Issue 19, 2006, Pages 5750-5758

  Mochizuki, Tetsuya ^a   Kondo, Yoshihiko ^a   Abe, Hiroshi ^a   Tovey, Stephen C ^b   Dedos, Skarlatos G ^b   Taylor, Colin W ^b   Paul, Michael ^c   Potter, Barry V L ^c   Matsuda, Akira ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 BENZYL 5 DEOXY 3 O (2,6 DI O BENZYL 3,4 DI O ISOBUTYRYL ALPHA DEXTRO GLUCOPYRANOSYL) 1,2 DI O ISOBUTYRYL DEXTRO RIBOFURANOSE; 5 DEOXY 3 O (2,6 DI O BENZYL 3,4 DI O ISOBUTYRYL ALPHA DEXTRO GLUCOPYRANOSYL) 1,2 DI O ISOBUTYRYL 5 PHENETHYL DEXTRO RIBOFURANOSE; 5' DEOXY 5' BENZYLADENOPHOSTIN A 2', 2'', 4'' TRIPHOSPHATE; 5' DEOXY 5' PHENETHYLADENOPHOSTIN A 2',3'',4'' TRIPHOSPHATE; 5' DEOXY 5' PHENYLADENOPHOSTIN A; 6 N BENZOYL 9 [5 BENZYL 5 DEOXY 3 O (2,6 DI O BENZYL 3,4 DI O ISOBUTYRYL ALPHA DEXTRO GLUCOPYRANOSYL) 2 O ISOBUTYRYL BETA DEXTRO RIBOFURANOSYL]ADENINE; 6 N BENZOYL 9 [5 DEOXY 3 O (2,6 DI O BENZYL 3,4 DI O ISOBUTYRYL ALPHA DEXTRO GLUCOPYRANOSYL) 2 O ISOBUTYRYL 5 PHENETHYL BETA DEXTRO RIBOFURANOSYL]ADENINE; ADENINE DERIVATIVE; ADENOPHOSTIN A; GLUCOSIDE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; ISOBUTYRIC ACID DERIVATIVE; LIGAND; SULFINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CONJUGATION; DRUG SYNTHESIS; GLYCOSIDATION; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PHOSPHORYLATION; PROTEIN DOMAIN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL LINE; CHICKENS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748853312     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060310d     Document Type: Article

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