메뉴 건너뛰기




Volumn 94, Issue 12, 2009, Pages 4938-4945

Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: Prospective randomized trial

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FOLLITROPIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; METFORMAX; METFORMIN; PRASTERONE SULFATE; SIMVACHOL; SIMVASTATIN; TESTOSTERONE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 73249141771     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1674     Document Type: Article
Times cited : (82)

References (47)
  • 6
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A 1989 Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38:1165-1174
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 10
    • 23844453653 scopus 로고    scopus 로고
    • Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span
    • Azziz R, Marin C, Hoq L, Badamgarav E, Song P 2005 Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab 90:4650-4658
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4650-4658
    • Azziz, R.1    Marin, C.2    Hoq, L.3    Badamgarav, E.4    Song, P.5
  • 11
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation
    • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M 2000 Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85:139-146
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Perrone, F.5    Caputo, M.6    Zanolin, E.7    Muggeo, M.8
  • 12
    • 33646076447 scopus 로고    scopus 로고
    • Lipids in polycystic ovary syndrome: Role of hyperinsulinemia and effects of metformin
    • Banaszewska B, Duleba AJ, Spaczynski RZ, Pawelczyk L 2006 Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin. Am J Obstet Gynecol 194:1266-1272
    • (2006) Am J Obstet Gynecol , vol.194 , pp. 1266-1272
    • Banaszewska, B.1    Duleba, A.J.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 13
    • 33745512819 scopus 로고    scopus 로고
    • The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome - a randomised, doubleblind, placebo-controlled trial
    • Lord J, Thomas R, Fox B, Acharya U, Wilkin T 2006 The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome - a randomised, doubleblind, placebo-controlled trial. BJOG 113:817-824
    • (2006) BJOG , vol.113 , pp. 817-824
    • Lord, J.1    Thomas, R.2    Fox, B.3    Acharya, U.4    Wilkin, T.5
  • 15
    • 0031968394 scopus 로고    scopus 로고
    • Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome
    • Morin-Papunen LC, Koivunen RM, Ruokonen A, Martikainen HK 1998 Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertil Steril 69:691-696
    • (1998) Fertil Steril , vol.69 , pp. 691-696
    • Morin-Papunen, L.C.1    Koivunen, R.M.2    Ruokonen, A.3    Martikainen, H.K.4
  • 17
    • 33645403158 scopus 로고    scopus 로고
    • Simvastatin improves biochemical parameters inwomenwith polycystic ovary syndrome: Results of a prospective, randomized trial
    • Duleba AJ, Banaszewska B, Spaczynski RZ, Pawelczyk L 2006 Simvastatin improves biochemical parameters inwomenwith polycystic ovary syndrome: results of a prospective, randomized trial. Fertil Steril 85:996-1001
    • (2006) Fertil Steril , vol.85 , pp. 996-1001
    • Duleba, A.J.1    Banaszewska, B.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 18
    • 33847004030 scopus 로고    scopus 로고
    • Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: Prospective, randomized, crossover trial
    • Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ 2007 Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: prospective, randomized, crossover trial. J Clin Endocrinol Metab 92:456-461
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 456-461
    • Banaszewska, B.1    Pawelczyk, L.2    Spaczynski, R.Z.3    Dziura, J.4    Duleba, A.J.5
  • 19
    • 58149394432 scopus 로고    scopus 로고
    • The effect of atorvastatin in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled study
    • Sathyapalan T, Kilpatrick ES, Coady AM, Atkin SL 2009 The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. J Clin Endocrinol Metab 94:103-108
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 103-108
    • Sathyapalan, T.1    Kilpatrick, E.S.2    Coady, A.M.3    Atkin, S.L.4
  • 21
    • 59349098805 scopus 로고    scopus 로고
    • Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF, Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen E, Society P 2009 The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91:456-488
    • Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF, Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen E, Society P 2009 The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91:456-488
  • 22
    • 0347447267 scopus 로고    scopus 로고
    • Ultrasound assessment of the polycystic ovary: International consensus definitions
    • Balen AH, Laven JS, Tan SL, Dewailly D 2003 Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update 9:505-514
    • (2003) Hum Reprod Update , vol.9 , pp. 505-514
    • Balen, A.H.1    Laven, J.S.2    Tan, S.L.3    Dewailly, D.4
  • 23
    • 12644305063 scopus 로고
    • Clinical assessment of body hair growth in women
    • Ferriman D, Gallway JD 1961 Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21:1440-1447
    • (1961) J Clin Endocrinol Metab , vol.21 , pp. 1440-1447
    • Ferriman, D.1    Gallway, J.D.2
  • 24
    • 0034111902 scopus 로고    scopus 로고
    • Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
    • Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L 2000 Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 73:1149-1154
    • (2000) Fertil Steril , vol.73 , pp. 1149-1154
    • Kolodziejczyk, B.1    Duleba, A.J.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 25
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 26
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 27
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS 1990 Regulation of the mevalonate pathway. Nature 343:425-430
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 28
    • 0033868493 scopus 로고    scopus 로고
    • Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells
    • Bouterfa HL, Sattelmeyer V, Czub S, Vordermark D, Roosen K, Tonn JC 2000 Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells. Anticancer Res 20:2761-2771
    • (2000) Anticancer Res , vol.20 , pp. 2761-2771
    • Bouterfa, H.L.1    Sattelmeyer, V.2    Czub, S.3    Vordermark, D.4    Roosen, K.5    Tonn, J.C.6
  • 29
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • Wassmann S, Laufs U, Bäumer AT, Müller K, Konkol C, Sauer H, Böhm M, Nickenig G 2001 Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol 59:646-654
    • (2001) Mol Pharmacol , vol.59 , pp. 646-654
    • Wassmann, S.1    Laufs, U.2    Bäumer, A.T.3    Müller, K.4    Konkol, C.5    Sauer, H.6    Böhm, M.7    Nickenig, G.8
  • 30
    • 0024523730 scopus 로고
    • Mevinolin (lovastatin) inhibits androstenedione production by porcine ovarian theca cells at the level of the 17 α-hydroxylase:C-17,20-lyase complex
    • Engelhardt H, Gore-Langton RE, Armstrong DT 1989 Mevinolin (lovastatin) inhibits androstenedione production by porcine ovarian theca cells at the level of the 17 α-hydroxylase:C-17,20-lyase complex. Endocrinology 124:2297-2304
    • (1989) Endocrinology , vol.124 , pp. 2297-2304
    • Engelhardt, H.1    Gore-Langton, R.E.2    Armstrong, D.T.3
  • 31
    • 5044235633 scopus 로고    scopus 로고
    • Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis
    • Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ 2004 Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. Fertil Steril 82(Suppl 3):1193-1197
    • (2004) Fertil Steril , vol.82 , Issue.SUPPL. 3 , pp. 1193-1197
    • Izquierdo, D.1    Foyouzi, N.2    Kwintkiewicz, J.3    Duleba, A.J.4
  • 32
    • 0020035932 scopus 로고
    • Morphology and morphogenesis of the Stein-Leventhal ovary and of so called hyperthecosis
    • Hughesdon PE 1982 Morphology and morphogenesis of the Stein-Leventhal ovary and of so called "hyperthecosis." Obstet Gynecol Surv 37:59-77
    • (1982) Obstet Gynecol Surv , vol.37 , pp. 59-77
    • Hughesdon, P.E.1
  • 33
    • 0030832255 scopus 로고    scopus 로고
    • Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
    • Gilling-Smith C, Story H, Rogers V, Franks S 1997 Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol (Oxf) 47:93-99
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 93-99
    • Gilling-Smith, C.1    Story, H.2    Rogers, V.3    Franks, S.4
  • 34
  • 35
    • 0028141408 scopus 로고
    • Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: Relation to anthropometric, endocrine and metabolic variables
    • Holte J, Bergh T, Berne C, Lithell H 1994 Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin Endocrinol (Oxf) 41:463-471
    • (1994) Clin Endocrinol (Oxf) , vol.41 , pp. 463-471
    • Holte, J.1    Bergh, T.2    Berne, C.3    Lithell, H.4
  • 36
    • 0029987755 scopus 로고    scopus 로고
    • Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study
    • discussion 1229-1232
    • Guzick DS, Talbott EO, Sutton-Tyrrell K, Herzog HC, Kuller LH, Wolfson Jr SK 1996 Carotid atherosclerosis in women with polycystic ovary syndrome: initial results from a case-control study. Am J Obstet Gynecol 174:1224-1229; discussion 1229-1232
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1224-1229
    • Guzick, D.S.1    Talbott, E.O.2    Sutton-Tyrrell, K.3    Herzog, H.C.4    Kuller, L.H.5    Wolfson Jr, S.K.6
  • 38
    • 0027525673 scopus 로고
    • Renal function and insulin sensitivity during simvastatin treatment in type 2 (non-insulin-dependent) diabetic patients with microalbuminuria
    • Nielsen S, Schmitz O, Møller N, Pørksen N, Klausen IC, Alberti KG, Mogensen CE 1993 Renal function and insulin sensitivity during simvastatin treatment in type 2 (non-insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 36:1079-1086
    • (1993) Diabetologia , vol.36 , pp. 1079-1086
    • Nielsen, S.1    Schmitz, O.2    Møller, N.3    Pørksen, N.4    Klausen, I.C.5    Alberti, K.G.6    Mogensen, C.E.7
  • 39
    • 67349224722 scopus 로고    scopus 로고
    • Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients
    • Koh KK, Quon MJ, Han SH, Lee Y, Kim SJ, Park JB, Shin EK 2009 Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients. Atherosclerosis 204:483-490
    • (2009) Atherosclerosis , vol.204 , pp. 483-490
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Lee, Y.4    Kim, S.J.5    Park, J.B.6    Shin, E.K.7
  • 40
    • 0034119173 scopus 로고    scopus 로고
    • Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome
    • Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Tapanainen JS 2000 Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome. Hum Reprod 15:1266-1274
    • (2000) Hum Reprod , vol.15 , pp. 1266-1274
    • Morin-Papunen, L.C.1    Vauhkonen, I.2    Koivunen, R.M.3    Ruokonen, A.4    Tapanainen, J.S.5
  • 41
    • 57349113274 scopus 로고    scopus 로고
    • The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials
    • Hoeger K, Davidson K, Kochman L, Cherry T, Kopin L, Guzick DS 2008 The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. J Clin Endocrinol Metab 93:4299-4306
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4299-4306
    • Hoeger, K.1    Davidson, K.2    Kochman, L.3    Cherry, T.4    Kopin, L.5    Guzick, D.S.6
  • 43
    • 29144477303 scopus 로고    scopus 로고
    • Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study
    • Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH 2006 Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study. Hum Reprod 21:80-89
    • (2006) Hum Reprod , vol.21 , pp. 80-89
    • Tang, T.1    Glanville, J.2    Hayden, C.J.3    White, D.4    Barth, J.H.5    Balen, A.H.6
  • 45
    • 33846839230 scopus 로고    scopus 로고
    • Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1
    • Fisslthaler B, Fleming I, Keserü B, Walsh K, Busse R 2007 Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1. Circ Res 100:e12-e21
    • (2007) Circ Res , vol.100
    • Fisslthaler, B.1    Fleming, I.2    Keserü, B.3    Walsh, K.4    Busse, R.5
  • 46
    • 33947276374 scopus 로고    scopus 로고
    • Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: Implications for the management of polycystic ovary syndrome
    • Barber TM, Wass JA, McCarthy MI, Franks S 2007 Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome. Clin Endocrinol (Oxf) 66:513-517
    • (2007) Clin Endocrinol (Oxf) , vol.66 , pp. 513-517
    • Barber, T.M.1    Wass, J.A.2    McCarthy, M.I.3    Franks, S.4
  • 47
    • 17144429420 scopus 로고    scopus 로고
    • Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins
    • Edison RJ, Muenke M 2004 Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins. Am J Med Genet A 131: 287-298
    • (2004) Am J Med Genet A , vol.131 , pp. 287-298
    • Edison, R.J.1    Muenke, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.