메뉴 건너뛰기




Volumn 194, Issue 5, 2006, Pages 1266-1272

Lipids in polycystic ovary syndrome: Role of hyperinsulinemia and effects of metformin

Author keywords

Lipids; Metformin; PCOS

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; METFORMIN; TRIACYLGLYCEROL;

EID: 33646076447     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2005.11.009     Document Type: Article
Times cited : (44)

References (43)
  • 1
    • 0031773509 scopus 로고    scopus 로고
    • Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study
    • Knochenhauer E.S., Key T.J., Kahsar-Miller M., Waggoner W., Boots L.R., and Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 83 (1998) 3078-3082
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3078-3082
    • Knochenhauer, E.S.1    Key, T.J.2    Kahsar-Miller, M.3    Waggoner, W.4    Boots, L.R.5    Azziz, R.6
  • 4
    • 0014767566 scopus 로고
    • Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease
    • Yen S.S., Vela P., and Rankin J. Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 30 (1970) 435-442
    • (1970) J Clin Endocrinol Metab , vol.30 , pp. 435-442
    • Yen, S.S.1    Vela, P.2    Rankin, J.3
  • 5
    • 0020635004 scopus 로고
    • Insulin resistance in nonobese patients with polycystic ovarian disease
    • Chang R.J., Nakamura R.M., Judd H.L., and Kaplan S.A. Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57 (1983) 356-359
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 356-359
    • Chang, R.J.1    Nakamura, R.M.2    Judd, H.L.3    Kaplan, S.A.4
  • 6
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease
    • Burghen G.A., Givens J.R., and Kitabchi A.E. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 50 (1980) 113-116
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113-116
    • Burghen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 7
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia
    • Dunaif A., Graf M., Mandeli J., Laumas V., and Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J Clin Endocrinol Metab 65 (1987) 499-507
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3    Laumas, V.4    Dobrjansky, A.5
  • 8
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A., Segal K.R., Futterweit W., and Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38 (1989) 1165-1174
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 9
    • 0022354308 scopus 로고
    • Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome
    • Wild R.A., Painter P.C., Coulson P.B., Carruth K.B., and Ranney G.B. Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome. J Clin Endocrinol Metab 61 (1985) 946-951
    • (1985) J Clin Endocrinol Metab , vol.61 , pp. 946-951
    • Wild, R.A.1    Painter, P.C.2    Coulson, P.B.3    Carruth, K.B.4    Ranney, G.B.5
  • 10
    • 0025250529 scopus 로고
    • Metabolic profiles and lipoprotein lipid concentrations in non-obese and obese patients with polycystic ovarian disease
    • Mahabeer S., Naidoo C., Norman R.J., Jialal I., Reddi K., and Joubert S.M. Metabolic profiles and lipoprotein lipid concentrations in non-obese and obese patients with polycystic ovarian disease. Horm Metab Res 22 (1990) 537-540
    • (1990) Horm Metab Res , vol.22 , pp. 537-540
    • Mahabeer, S.1    Naidoo, C.2    Norman, R.J.3    Jialal, I.4    Reddi, K.5    Joubert, S.M.6
  • 11
    • 0028141408 scopus 로고
    • Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables
    • Holte J., Bergh T., Berne C., and Lithell H. Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin Endocrinol 41 (1994) 463-471
    • (1994) Clin Endocrinol , vol.41 , pp. 463-471
    • Holte, J.1    Bergh, T.2    Berne, C.3    Lithell, H.4
  • 13
    • 0026689423 scopus 로고
    • Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome
    • Conway G.S., Agrawal R., Betteridge D.J., and Jacobs H.S. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol 37 (1992) 119-125
    • (1992) Clin Endocrinol , vol.37 , pp. 119-125
    • Conway, G.S.1    Agrawal, R.2    Betteridge, D.J.3    Jacobs, H.S.4
  • 15
    • 0026574154 scopus 로고
    • Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones
    • Dahlgren E., Johansson S., Lindsted G., Knutsson F., Oden A., Janson P., et al. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 57 (1992) 505-513
    • (1992) Fertil Steril , vol.57 , pp. 505-513
    • Dahlgren, E.1    Johansson, S.2    Lindsted, G.3    Knutsson, F.4    Oden, A.5    Janson, P.6
  • 17
    • 0031964322 scopus 로고    scopus 로고
    • UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. UK Prospective Diabetes Study Group
    • Anonymous. UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. UK Prospective Diabetes Study Group. Diabetes Care 21 (1998) 87-92
    • (1998) Diabetes Care , vol.21 , pp. 87-92
  • 18
    • 0028963260 scopus 로고
    • United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years
    • Anonymous. United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 310 (1995) 83-88
    • (1995) BMJ , vol.310 , pp. 83-88
  • 19
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
    • Anonymous. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352 (1998) 854-865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 20
    • 0025837055 scopus 로고
    • Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects
    • DeFronzo R.A., Barzilai N., and Simonson D.C. Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab 73 (1991) 1294-1301
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1294-1301
    • DeFronzo, R.A.1    Barzilai, N.2    Simonson, D.C.3
  • 21
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez E.M., Mendoza S., Hamer T., Sosa F., and Glueck C.J. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metab Clin Experim 43 (1994) 647-654
    • (1994) Metab Clin Experim , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 22
    • 0030745921 scopus 로고    scopus 로고
    • Menstrual cyclicity after metformin therapy in polycystic ovary syndrome
    • Velazquez E., Acosta A., and Mendoza S.G. Menstrual cyclicity after metformin therapy in polycystic ovary syndrome. Obstet Gynecol 90 (1997) 392-395
    • (1997) Obstet Gynecol , vol.90 , pp. 392-395
    • Velazquez, E.1    Acosta, A.2    Mendoza, S.G.3
  • 23
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • Nestler J.E., Jakubowicz D.J., Evans W.S., and Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 338 (1998) 1876-1880
    • (1998) N Engl J Med , vol.338 , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3    Pasquali, R.4
  • 24
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation
    • Moghetti P., Castello R., Negri C., Tosi F., Perrone F., Caputo M., et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85 (2000) 139-146
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Perrone, F.5    Caputo, M.6
  • 26
    • 14644406278 scopus 로고    scopus 로고
    • Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome
    • Rautio K., Tapanainen J.S., Ruokonen A., and Morin-Papunen L.C. Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome. Eur J Endocrinol 152 (2005) 269-275
    • (2005) Eur J Endocrinol , vol.152 , pp. 269-275
    • Rautio, K.1    Tapanainen, J.S.2    Ruokonen, A.3    Morin-Papunen, L.C.4
  • 27
    • 12444286845 scopus 로고    scopus 로고
    • The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients
    • Cibula D., Fanta M., Vrbikova J., Stanicka S., Dvorakova K., Hill M., et al. The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients. Hum Reprod 20 (2005) 180-184
    • (2005) Hum Reprod , vol.20 , pp. 180-184
    • Cibula, D.1    Fanta, M.2    Vrbikova, J.3    Stanicka, S.4    Dvorakova, K.5    Hill, M.6
  • 28
    • 0034886493 scopus 로고    scopus 로고
    • Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial
    • Ng E.H., Wat N.M., and Ho P.C. Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial. Hum Reprod 16 (2001) 1625-1631
    • (2001) Hum Reprod , vol.16 , pp. 1625-1631
    • Ng, E.H.1    Wat, N.M.2    Ho, P.C.3
  • 29
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group
    • DeFronzo R.A., and Goodman A.M. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 333 (1995) 541-549
    • (1995) N Engl J Med , vol.333 , pp. 541-549
    • DeFronzo, R.A.1    Goodman, A.M.2
  • 30
    • 0029905092 scopus 로고    scopus 로고
    • Metformin's effects on glucose and lipid metabolism in patients with secondary failure to sulfonylureas
    • Fanghanel G., Sanchez-Reyes L., Trujillo C., Sotres D., and Espinosa-Campos J. Metformin's effects on glucose and lipid metabolism in patients with secondary failure to sulfonylureas. Diabetes Care 19 (1996) 1185-1189
    • (1996) Diabetes Care , vol.19 , pp. 1185-1189
    • Fanghanel, G.1    Sanchez-Reyes, L.2    Trujillo, C.3    Sotres, D.4    Espinosa-Campos, J.5
  • 31
    • 0030022720 scopus 로고    scopus 로고
    • The effects of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes
    • Grant P.J. The effects of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes. Diabetes Care 19 (1996) 64-66
    • (1996) Diabetes Care , vol.19 , pp. 64-66
    • Grant, P.J.1
  • 32
    • 0030052398 scopus 로고    scopus 로고
    • Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease
    • Carlsen S.M., Rossvoll O., Bjerve K.S., and Folling I. Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease. J Int Med 239 (1996) 227-233
    • (1996) J Int Med , vol.239 , pp. 227-233
    • Carlsen, S.M.1    Rossvoll, O.2    Bjerve, K.S.3    Folling, I.4
  • 33
    • 0343750649 scopus 로고    scopus 로고
    • Treatment with metformin of non-diabetic men with hypertension, hypertriglyceridaemia and central fat distribution: the BIGPRO 1.2 trial
    • Charles M.A., Eschwege E., Grandmottet P., Isnard F., Cohen J.M., Bensoussan J.L., et al. Treatment with metformin of non-diabetic men with hypertension, hypertriglyceridaemia and central fat distribution: the BIGPRO 1.2 trial. Diabetes Metab Res Rev 16 (2000) 2-7
    • (2000) Diabetes Metab Res Rev , vol.16 , pp. 2-7
    • Charles, M.A.1    Eschwege, E.2    Grandmottet, P.3    Isnard, F.4    Cohen, J.M.5    Bensoussan, J.L.6
  • 34
    • 9544247850 scopus 로고    scopus 로고
    • The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. BIGPRO Study Group
    • Fontbonne A., Charles M.A., Juhan-Vague I., Bard J.A., Andre P., Isnard F., et al. The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. BIGPRO Study Group. Diabetes Care 19 (1996) 920-926
    • (1996) Diabetes Care , vol.19 , pp. 920-926
    • Fontbonne, A.1    Charles, M.A.2    Juhan-Vague, I.3    Bard, J.A.4    Andre, P.5    Isnard, F.6
  • 35
    • 0031767174 scopus 로고    scopus 로고
    • The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control
    • Robinson A.C., Burke J., Robinson S., Johnston D.G., and Elkeles R.S. The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control. Diabetes Care 21 (1998) 701-705
    • (1998) Diabetes Care , vol.21 , pp. 701-705
    • Robinson, A.C.1    Burke, J.2    Robinson, S.3    Johnston, D.G.4    Elkeles, R.S.5
  • 36
    • 0036170744 scopus 로고    scopus 로고
    • Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial
    • Fleming R., Hopkinson Z.E., Wallace A.M., Greer I.A., and Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endorinol Metab 87 (2002) 569-574
    • (2002) J Clin Endorinol Metab , vol.87 , pp. 569-574
    • Fleming, R.1    Hopkinson, Z.E.2    Wallace, A.M.3    Greer, I.A.4    Sattar, N.5
  • 37
    • 0023145240 scopus 로고
    • Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects
    • Laakso M., Pyorala K., Voutilainen E., and Marniemi J. Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects. Am J Epidemiol 125 (1987) 611-621
    • (1987) Am J Epidemiol , vol.125 , pp. 611-621
    • Laakso, M.1    Pyorala, K.2    Voutilainen, E.3    Marniemi, J.4
  • 38
    • 0033338775 scopus 로고    scopus 로고
    • Fasting remnant lipoprotein cholesterol and triglyceride concentrations are elevated in nondiabetic, insulin-resistant, female volunteers
    • Abbasi F., McLaughlin T., Lamendola C., Yeni-Komshian H., Tanaka A., Wang T., et al. Fasting remnant lipoprotein cholesterol and triglyceride concentrations are elevated in nondiabetic, insulin-resistant, female volunteers. J Clin Endorinol Metab 84 (1999) 3903-3906
    • (1999) J Clin Endorinol Metab , vol.84 , pp. 3903-3906
    • Abbasi, F.1    McLaughlin, T.2    Lamendola, C.3    Yeni-Komshian, H.4    Tanaka, A.5    Wang, T.6
  • 39
    • 0024593457 scopus 로고
    • Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance
    • Zavaroni I., Bonora E., Pagliara M., Dall'Aglio E., Luchetti L., Buonanno G., et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320 (1989) 702-706
    • (1989) N Engl J Med , vol.320 , pp. 702-706
    • Zavaroni, I.1    Bonora, E.2    Pagliara, M.3    Dall'Aglio, E.4    Luchetti, L.5    Buonanno, G.6
  • 40
    • 0034111902 scopus 로고    scopus 로고
    • Metformin therapy improves hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
    • Kolodziejczyk B., Duleba A.J., Spaczynski R.Z., and Pawelczyk L. Metformin therapy improves hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 73 (2000) 11149-11154
    • (2000) Fertil Steril , vol.73 , pp. 11149-11154
    • Kolodziejczyk, B.1    Duleba, A.J.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 41
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Rev 18 (1997) 774-800
    • (1997) Endocrine Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 43
    • 0031828158 scopus 로고    scopus 로고
    • Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in patients with coronary artery disease independent of obesity
    • Psyrogiannis A.J., Alexopoulos D.K., Kyriazopoulou V.E., and Vagenakis A.G. Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in patients with coronary artery disease independent of obesity. Angiology 49 (1998) 607-612
    • (1998) Angiology , vol.49 , pp. 607-612
    • Psyrogiannis, A.J.1    Alexopoulos, D.K.2    Kyriazopoulou, V.E.3    Vagenakis, A.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.