Patients with Leber hereditary optic neuropathy fail to compensate impaired oxidative phosphorylation

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1797, Issue 2, 2010, Pages 197-203

  Korsten, Alex ^a   de Coo, Irenaeus F M ^a   Spruijt, Liesbeth ^b   de Wit, L Elly A ^a   Smeets, Hubert J M ^b   Sluiter, Wim ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Biochemical phenotype; Leber hereditary optic neuropathy; Mitochondrial density; Oxidative phosphorylation; Peripheral blood mononuclear cell

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; DIGITONIN; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE);

ADULT; AGED; ARTICLE; CELL MEMBRANE PERMEABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; LEBER HEREDITARY OPTIC NEUROPATHY; MALE; OXIDATIVE PHOSPHORYLATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; VISUAL IMPAIRMENT;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CITRATE (SI)-SYNTHASE; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; FEMALE; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; MUTATION; OPTIC ATROPHY, HEREDITARY, LEBER; OXIDATIVE PHOSPHORYLATION; PROTONS; YOUNG ADULT;

EID: 73249138396     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2009.10.003     Document Type: Article

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