Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations

Toxicology

Volumn 201, Issue 1-3, 2004, Pages 67-75

  Johnson, Victor J ^a   He, Quanren ^a   Osuchowski, Marcin F ^a   Sharma, Raghubir P ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Immunosuppression; Mycotoxin; Myriocin; Serine palmitoyltransferase; Sphinganine; T lymphocytes

Indexed keywords

CD4 ANTIGEN; MYCOTOXIN; SPHINGANINE; SPHINGOLIPID; THERMOZYMOCIDIN;

ANIMAL CELL; ARTICLE; CELL POPULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLOGY; CYTOTOXICITY; HOMEOSTASIS; INJECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION KINETICS; SPLEEN CELL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; THYMOCYTE; TOXICITY TESTING;

ACYLTRANSFERASES; ANIMALS; FATTY ACIDS, MONOUNSATURATED; FLOW CYTOMETRY; HOMEOSTASIS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED BALB C; SERINE C-PALMITOYLTRANSFERASE; SPHINGOLIPIDS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 3543132398     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.04.019     Document Type: Article

References (22)

1. Baumruker T., Prieschl E.E. Sphingolipids and the regulation of the immune response. Semin. Immunol. 14:2002;57-63
2. Chiba K., Yanagawa Y., Masubuchi Y., Kataoka H., Kawaguchi T., Ohtsuki M., Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. 1. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. 160:1998;5037-5044
3. Cho Y.J., Park J.P., Hwang H.J., Kim S.W., Choi J.W., Yun J.W. Production of red pigment by submerged culture of Paecilomyces sinclairii. Lett. Appl. Microbiol. 35:2002;195-202
4. Fujita T., Inoue K., Yamamoto S., Ikumoto T., Sasaki S., Toyama R., Chiba K., Hoshino Y., Okumoto T. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J. Antibiot. (Tokyo). 47:1994;208-215
5. Fujita T., Yoneta M., Hirose R. Simple compounds, 2-alkyl-2-amino-1,3- propanediols have potent immunosuppressive activity. Biol. Med. Chem. Lett. 5:1995;847-852
6. He Q., Riley R.T., Sharma R.P. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. Toxicol. Appl. Pharmacol. 174:2001;69-77
7. He Q., Johnson V.J., Osuchowski M.F., Sharma R.P. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. Mycopathologia. 157:2004;339-347
8. Im D.S. Linking Chinese medicine and G-protein-coupled receptors. Trends Pharmacol. Sci. 24:2003;2-4
9. 1. Int. Immunopharmacol. 1:2001;2023-2034
10. Kiuchi M., Adachi K., Kohara T., Minoguchi M., Hanano T., Aoki Y., Mishina T., Arita M., Nakao N., Ohtsuki M., Hoshino Y., Teshima K., Chiba K., Sasaki S., Fujita T. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J. Med. Chem. 43:2000;2946-2961
11. Matloubin M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 22:2004;355-360
12. Merrill A.H. Jr., Schmelz E.M., Dillehay D.L., Spiegel S., Shayman J.A., Schroeder J.J., Riley R.T., Voss K.A., Wang E. Sphingolipids - the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142:1997;208-225
13. Merrill A.H. Jr., Sullards M.C., Wang E., Voss K.A., Riley R.T. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ. Health Perspect. 109(Suppl. 2):2001;283-289
14. Merrill A.H. Jr., Wang E., Mullins R.E., Jamison W.C., Nimkar S., Liotta D.C. Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal. Biochem. 171:1988;373-381
15. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T., Kawasaki T. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211:1995;396-403
16. Nakamura S., Kozutsumi Y., Sun Y., Miyake Y., Fujita T., Kawasaki T. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. J. Biol. Chem. 271:1996;1255-1257
17. Napoli K.L. The FTY720 story. Ther. Drug Monit. 22:2000;47-51
18. Osuchowski M.F., Johnson V.J., He Q., Sharma R.P. Myriocin, a serine palmitoyltransferase inhibitor, alters regional brain neurotransmitter levels without concurrent inhibition of the brain sphingolipid biosynthesis in mice. Toxicol. Lett. 147:2004;87-94
19. Pinschewer D.D., Ochsenbein A.F., Odermatt B., Brinkmann V., Hengartner H., Zinkernagel R.M. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J. Immunol. 164:2000;5761-5770
20. Riley R.T., Voss K.A., Norred W.P., Bacon C.W., Meredith F.I., Sharma R.P. Serine palmitoyltransferase inhibition reverses anti-proliferative effects of ceramide synthase inhibition in cultured renal cells and suppresses free sphingoid base accumulation in kidney of BALB/c mice. Environ. Toxicol. Pharmacol. 7:1999;109-118
21. Yang Z., Chen M., Fialkow L.B., Ellett J.D., Wu R., Brinkman V., Nadler J.L., Lunch K.R. The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice. Clin. Immunol. 107:2003;30-35
22. Ye P., Kirschner D.E. Measuring emigration of human thymocytes by T-cell receptor excision circles. Crit. Rev. Immunol. 22:2002;483-497