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Volumn 51, Issue 6, 2010, Pages 912-916

Highly enantioselective aldol reactions using N-arylprolinamides with enhanced acidity and double H-bonding potential

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; PROLINE DERIVATIVE;

EID: 73249124460     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.12.014     Document Type: Article
Times cited : (39)

References (53)
  • 41
    • 73249120973 scopus 로고    scopus 로고
    • note
    • See 'Supplementary data' for the preparation and characterization of organocatalysts 7-10.
  • 42
    • 73249128337 scopus 로고    scopus 로고
    • note
    • Representative procedure for the enantioselective aldol reaction with catalyst 10: A mixture of catalyst 10 (31 mg, 0.13 mmol), cyclohexanone (646 mg, 6.6 mmol), and TFA (7.5 mg, 0.066 mmol) contained in 1.0 mL of DMF (1.0 mL) was stirred at room temperature for 45 min. Subsequently, the temperature was brought down to 3 °C and the aldehyde (100 mg, 0.66 mmol) was introduced. The reaction mixture was stirred at 3 °C until the reaction was judged to be complete, based on TLC analysis. The reaction mixture was directly passed through a short silica gel column to isolate the pure aldol product.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.