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Volumn 58, Issue 41, 2002, Pages 8167-8177

Diversity-based strategy for discovery of environmentally benign organocatalyst: Diamine-protonic acid catalysts for asymmetric direct aldol reaction

Author keywords

Aldol reactions; Asymmetric reactions; Diamines; Enamines

Indexed keywords

ACETOACETIC ACID; ACETONE; ACID; ALDEHYDE DERIVATIVE; DIAMINE;

EID: 0037037912     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)00965-1     Document Type: Article
Times cited : (211)

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    • In the meanwhile, diamine 4-(1S)-camphorsulfonic acid catalayst was reported to promote the direct aldol reaction and the asymmetric three-component Mannich-type reaction by Barbas, III, see Refs. 7d,8d. Diamine 4 alone tested for the Mannich-type reaction by List, see Ref. 8j and: supporting information of Ref. 8c. Diamine 4 alone tested for the direct asymmetric Michael reaction and the asymmetric Robinson annulation reaction by Barbas, III, see Ref. 8b and: (a) Betancort J.M., Barbas C.F. III. Org. Lett. 3:2001;3737 (b) Betancort J.M., Sakthivel K., Thayumanavan R., Barbas C.F. III. Tetrahedron Lett. 42:2001;4441.
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    • Crystallographic data (excluding structure factors) for the X-ray crystal structure analysis reported in this paper have been deposited with Cambridge Crystallographic Data Center (CCDC) as supplementary publication no. CCDC-184706. Copies of the data can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: +44-1223-336-033, e-mail: deposit@ccdc.cam.ac.uk)
    • Crystallographic data (excluding structure factors) for the X-ray crystal structure analysis reported in this paper have been deposited with Cambridge Crystallographic Data Center (CCDC) as supplementary publication no. CCDC-184706. Copies of the data can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: +44-1223-336-033, e-mail: deposit@ccdc.cam.ac.uk).
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