Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts

Brain Research Bulletin

Volumn 81, Issue 2-3, 2010, Pages 273-278

  Sharma, Ajay ^a,d   Ghosh, Arkasubhra ^c   Hansen, Eric T ^a,d   Newman, Jason M ^a,d   Mohan, Rajiv R ^a,b,d  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

AAAV2 6; AAV2 8; AAV2 9; Cornea; Gene transfer; Human corneal fibroblasts

Indexed keywords

ALKALINE PHOSPHATASE; PARVOVIRUS VECTOR;

ARTICLE; CELL CULTURE; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; CORNEA; CYTOCHEMISTRY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SEROTYPE; VIRAL GENE DELIVERY SYSTEM; VIRUS HYBRID;

ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CORNEA; DEPENDOVIRUS; FIBROBLASTS; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; INDOLES; SPECTROPHOTOMETRY; TRANSDUCTION, GENETIC;

EID: 73149120964     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.07.005     Document Type: Article

References (30)

1. Akache B., Grimm D., Pandey K., Yant S.R., Xu H., and Kay M.A. The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8,2,3, and 9. J. Virol. 80 (2006) 9831-9836
2. Alexander J.J., and Hauswirth W.W. Adeno-associated viral vectors and the retina. Adv. Exp. Med. Biol. 613 (2008) 121-128
3. Bainbridge J.W., Smith A.J., Barker S.S., Robbie S., Henderson R., Balaggan K., Viswanathan A., Holder G.E., Stockman A., Tyler N., Petersen-Jones S., Bhattacharya S.S., Thrasher A.J., Fitzke F.W., Carter B.J., Rubin G.S., Moore A.T., and Ali R.R. Effect of gene therapy on visual function in Leber's congenital amaurosis. N. Engl. J. Med. 358 (2008) 2231-2239
4. Bish L.T., Morine K., Sleeper M.M., Sanmiguel J., Wu D., Gao G., Wilson J.M., and Sweeney L. AAV9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Hum. Gene Ther. 19 (2008) 1359-1368
5. Broekman M.L., Comer L.A., Hyman B.T., and Sena-Esteves M. Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience 138 (2006) 501-510
6. Cheng H.C., Yeh S.I., Tsao Y.P., and Kuo P.C. Subconjunctival injection of recombinant AAV-angiostatin ameliorates alkali burn induced corneal angiogenesis. Mol. Vis. 13 (2007) 2344-2352
7. Gao G., Lu Y., Calcedo R., Grant R.L., Bell P., Wang L., Figueredo J., Lock M., and Wilson J.M. Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates. Mol. Ther. 13 (2006) 77-87
8. Gao G.P., Alvira M.R., Wang L., Calcedo R., Johnston J., and Wilson J.M. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 11854-11859
9. Ghosh A., Yue Y., and Duan D. Viral serotype and the transgene sequence influence overlapping adeno-associated viral (AAV) vector-mediated gene transfer in skeletal muscle. J. Gene Med. 8 (2006) 298-305
10. Klein R.L., Dayton R.D., Leidenheimer N.J., Jansen K., Golde T.E., and Zweig R.M. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol. Ther. 13 (2006) 517-527
11. Lai L.J., Xiao X., and Wu J.H. Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model. J. Biomed. Sci. 14 (2007) 313-322
12. Lebherz C., Maguire A., Tang W., Bennett J., and Wilson J.M. Novel AAV serotypes for improved ocular gene transfer. J. Gene Med. 10 (2008) 375-382
13. Limberis M.P., and Wilson J.M. Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 12993-12998
14. Limberis M.P., Vandenberghe L.H., Zhang L., Pickles R.J., and Wilson J.M. Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro. Mol. Ther. 17 (2009) 294-301
15. Liu J., Saghizadeh M., Tuli S.S., Kramerov A.A., Lewin A.S., Bloom D.C., Hauswirth W.W., Castro M.G., Schultz G.S., and Ljubimov A.V. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Mol. Vis. 14 (2008) 22087-22096
16. Maguire A.M., Simonelli F., Pierce E.A., Pugh Jr. E.N., Mingozzi F., Bennicelli J., Banfi S., Marshall K.A., Testa F., Surace E.M., Rossi S., Lyubarsky A., Arruda V.R., Konkle B., Stone E., Sun J., Jacobs J., Dell'Osso L., Hertle R., Ma J.X., Redmond T.M., Zhu X., Hauck B., Zelenaia O., Shindler K.S., Maguire M.G., Wright J.F., Volpe N.J., McDonnell J.W., Auricchio A., High K.A., and Bennett J. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N. Engl. J. Med. 358 (2008) 2240-2248
17. Masur S.K., Cheung J.K., and Antohi S. Identification of integrins in cultured corneal fibroblasts and in isolated keratocytes. Invest. Ophthalmol. Vis. Sci. 34 (1993) 2690-2698
18. Mohan R.R., Sharma A., Netto M.V., Sinha S., and Wilson S.E. Gene therapy in the cornea. Prog. Retin. Eye Res. 24 (2005) 537-559
19. Mohan R.R., Schultz G.S., Hong J.W., Mohan R.R., and Wilson S.E. Gene transfer into rabbit keratocytes using AAV and lipid-mediated plasmid DNA vectors with a lamellar flap for stromal access. Exp. Eye Res. 76 (2003) 373-383
20. Mohan R.R., Schultz G.S., Sharma A., Sinha S., Netto M.V., and Wilson S.E. Controlled and site-selective gene delivery into mouse keratocytes by adeno-associated viral, lentiviral and plasmid vectors. Invest. Ophthalmol. Vis. Sci. 46 (2005) E-2163
21. Polyak S., Mah C., Porvasnik S., Herlihy J.D., Campbell-Thompson M., Byrne B.J., and Valentine J.F. Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5. Dig. Dis. Sci. 53 (2008) 1261-1270
22. Saika S., Yamanaka O., Sumioka T., Miyamoto T., Miyazaki K., Okada Y., Kitano A., Shirai K., Tanaka S., and Ikeda K. Fibrotic disorders in the eye: targets of gene therapy. Prog. Retin. Eye Res. 27 (2008) 177-196
23. A. Sharma, A. Ghosh, C. Siddappa, R.R. Mohan, Ocular surface: gene therapy. Encyclopedia Eye, in press.
24. Stepp M.A. Corneal integrins and their functions. Exp. Eye Res. 83 (2006) 3-15
25. Surace E.M., and Auricchio A. Versatility of AAV vectors for retinal gene transfer. Vision Res. 48 (2008) 353-359
26. Van Vliet K.M., Blouin V., Brument N., Agbandje-McKenna M., and Snyder R.O. The role of the adeno-associated virus capsid in gene transfer. Methods Mol. Biol. 437 (2008) 51-91
27. Verma I., and Weitzman M.D. Gene therapy: twenty-first century medicine. Annu. Rev. Biochem. 74 (2005) 711-738
28. Vij N., Sharma A., Thakkar M., Sinha S., and Mohan R.R. PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway. Mol. Vis. 14 (2008) 1020-1027
29. Wang Z., Zhu T., Qiao C., Zhou L., Wang B., Zhang J., Chen C., Li J., and Xiao X. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23 (2005) 321-328
30. Wu Z., Miller E., Agbandje-McKenna M., and Samulski R.J. Alpha2,3 and alpha2, 6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6. J. Virol. 80 (2006) 9093-9103