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Volumn 81, Issue 2-3, 2010, Pages 219-228

Innate immunity of the ocular surface

Author keywords

Epithelium; Inflammation; Innate immunity; Ocular surface; Toll like receptors (TLRs)

Indexed keywords

DOUBLE STRANDED RNA; FLAGELLIN; I KAPPA B; I KAPPA B ZETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 73149107224     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.10.001     Document Type: Review
Times cited : (97)

References (27)
  • 1
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S. Toll-like receptor signaling. J. Biol. Chem. 278 (2003) 38105-38108
    • (2003) J. Biol. Chem. , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 2
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • Cho J.H. The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8 (2008) 458-466
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 3
  • 4
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: the control of NF-κB activity
    • Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18 (2000) 621-663
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 6
    • 40549125645 scopus 로고    scopus 로고
    • Human conjunctival epithelial cells express functional Toll-like receptor 5
    • Kojima K., Ueta M., Hamuro J., Hozono Y., Kawasaki S., Yokoi N., et al. Human conjunctival epithelial cells express functional Toll-like receptor 5. Br. J. Ophthalmol. 92 (2008) 411-416
    • (2008) Br. J. Ophthalmol. , vol.92 , pp. 411-416
    • Kojima, K.1    Ueta, M.2    Hamuro, J.3    Hozono, Y.4    Kawasaki, S.5    Yokoi, N.6
  • 7
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto M., Kikkawa S., Kohase M., Miyake K., and Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293 (2002) 1364-1369
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 8
    • 73149089942 scopus 로고    scopus 로고
    • Methods 1. Immunohistochemistry of TLR2,3,4,5 in Human Cornea Sections and Conjunctival Sections. Human corneal tissues were obtained from corneal buttons of a patient undergoing corneal transplantation for early-stage bullous keratopathy and human conjunctival tissues were obtained at conjunctivochalasis surgery. Serial sections (6 μm) were prepared and slides were fixed with methanol for 30 min. And then, slides were incubated with purified mouse anti-human TLR2 (TL2.1) or 3 (TLR3.7) or 4 (HTA125) monoclonal antibody (mAb; eBioscience, San Diego, CA) or TLR5 monoclonal antibody (mAb; Abcam, Cambridge, UK, or isotype control mouse IgG2a for TLR2,4,5, or mouse IgG1 for TLR3 (DakoCytomation, Kyoto, Japan) at 4 °C in a moist chamber overnight. After the slides were washed in PBS, Alexa Fluor 488 donkey anti-mouse IgG (H+L, Molecular Probes, Eugene, OR) was applied for 1 h at room temperature. After the slides were washed, they were mounted with antifade mounting medium with PI
    • Methods 1. Immunohistochemistry of TLR2,3,4,5 in Human Cornea Sections and Conjunctival Sections. Human corneal tissues were obtained from corneal buttons of a patient undergoing corneal transplantation for early-stage bullous keratopathy and human conjunctival tissues were obtained at conjunctivochalasis surgery. Serial sections (6 μm) were prepared and slides were fixed with methanol for 30 min. And then, slides were incubated with purified mouse anti-human TLR2 (TL2.1) or 3 (TLR3.7) or 4 (HTA125) monoclonal antibody (mAb; eBioscience, San Diego, CA) or TLR5 monoclonal antibody (mAb; Abcam, Cambridge, UK), or isotype control mouse IgG2a for TLR2,4,5, or mouse IgG1 for TLR3 (DakoCytomation, Kyoto, Japan) at 4 °C in a moist chamber overnight. After the slides were washed in PBS-, Alexa Fluor 488 donkey anti-mouse IgG (H+L) (Molecular Probes, Eugene, OR) was applied for 1 h at room temperature. After the slides were washed, they were mounted with antifade mounting medium with PI (Vectashield; Vector Laboratories, Burlingame, CA).
  • 9
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., and Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 10
    • 0036786764 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea
    • Sotozono C., Inagaki K., Fujita A., Koizumi N., Sano Y., Inatomi T., et al. Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea. Cornea 21 (2002) S94-101
    • (2002) Cornea , vol.21
    • Sotozono, C.1    Inagaki, K.2    Fujita, A.3    Koizumi, N.4    Sano, Y.5    Inatomi, T.6
  • 11
    • 34347248417 scopus 로고    scopus 로고
    • New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome
    • Sotozono C., Ang L.P., Koizumi N., Higashihara H., Ueta M., Inatomi T., et al. New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology 114 (2007) 1294-1302
    • (2007) Ophthalmology , vol.114 , pp. 1294-1302
    • Sotozono, C.1    Ang, L.P.2    Koizumi, N.3    Higashihara, H.4    Ueta, M.5    Inatomi, T.6
  • 12
    • 63149154841 scopus 로고    scopus 로고
    • Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications
    • Sotozono C., Ueta M., Koizumi N., Inatomi T., Shirakata Y., Ikezawa Z., et al. Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. Ophthalmology 116 (2009) 685-690
    • (2009) Ophthalmology , vol.116 , pp. 685-690
    • Sotozono, C.1    Ueta, M.2    Koizumi, N.3    Inatomi, T.4    Shirakata, Y.5    Ikezawa, Z.6
  • 13
    • 34447505084 scopus 로고    scopus 로고
    • Toll-like receptors and Type I interferons
    • Uematsu S., and Akira S. Toll-like receptors and Type I interferons. J. Biol. Chem. 282 (2007) 15319-15323
    • (2007) J. Biol. Chem. , vol.282 , pp. 15319-15323
    • Uematsu, S.1    Akira, S.2
  • 14
    • 58149216785 scopus 로고    scopus 로고
    • Innate immunity of the ocular surface and ocular surface inflammatory disorders
    • Ueta M. Innate immunity of the ocular surface and ocular surface inflammatory disorders. Cornea 27 Suppl. 1 (2008) S31-40
    • (2008) Cornea , vol.27 , Issue.SUPPL. 1
    • Ueta, M.1
  • 15
    • 4344705045 scopus 로고    scopus 로고
    • Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
    • Ueta M., Nochi T., Jang M.H., Park E.J., Igarashi O., Hino A., et al. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 173 (2004) 3337-3347
    • (2004) J. Immunol. , vol.173 , pp. 3337-3347
    • Ueta, M.1    Nochi, T.2    Jang, M.H.3    Park, E.J.4    Igarashi, O.5    Hino, A.6
  • 16
    • 17444368008 scopus 로고    scopus 로고
    • Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines
    • Ueta M., Hamuro J., Kiyono H., and Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem. Biophys. Res. Commun. 331 (2005) 285-294
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 285-294
    • Ueta, M.1    Hamuro, J.2    Kiyono, H.3    Kinoshita, S.4
  • 17
    • 13944268238 scopus 로고    scopus 로고
    • Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice
    • Ueta M., Hamuro J., Yamamoto M., Kaseda K., Akira S., and Kinoshita S. Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice. Invest. Ophthalmol. Vis. Sci. 46 (2005) 579-588
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 579-588
    • Ueta, M.1    Hamuro, J.2    Yamamoto, M.3    Kaseda, K.4    Akira, S.5    Kinoshita, S.6
  • 18
  • 19
    • 34347342813 scopus 로고    scopus 로고
    • Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome
    • Ueta M., Sotozono C., Inatomi T., Kojima K., Tashiro K., Hamuro J., et al. Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br. J. Ophthalmol. 91 (2007) 962-965
    • (2007) Br. J. Ophthalmol. , vol.91 , pp. 962-965
    • Ueta, M.1    Sotozono, C.2    Inatomi, T.3    Kojima, K.4    Tashiro, K.5    Hamuro, J.6
  • 21
    • 49049084082 scopus 로고    scopus 로고
    • Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice
    • Ueta M., Hamuro J., Ueda E., Katoh N., Yamamoto M., Takeda K., et al. Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. Invest. Ophthalmol. Vis. Sci. 49 (2008) 3387-3394
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49 , pp. 3387-3394
    • Ueta, M.1    Hamuro, J.2    Ueda, E.3    Katoh, N.4    Yamamoto, M.5    Takeda, K.6
  • 23
    • 44649130287 scopus 로고    scopus 로고
    • Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications
    • Ueta M., Sotozono C., Inatomi T., Kojima K., Hamuro J., and Kinoshita S. Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1809-1813
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49 , pp. 1809-1813
    • Ueta, M.1    Sotozono, C.2    Inatomi, T.3    Kojima, K.4    Hamuro, J.5    Kinoshita, S.6
  • 24
    • 3142581432 scopus 로고    scopus 로고
    • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    • Yamamoto M., Yamazaki S., Uematsu S., Sato S., Hemmi H., Hoshino K., et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430 (2004) 218-222
    • (2004) Nature , vol.430 , pp. 218-222
    • Yamamoto, M.1    Yamazaki, S.2    Uematsu, S.3    Sato, S.4    Hemmi, H.5    Hoshino, K.6
  • 25
    • 37349123939 scopus 로고    scopus 로고
    • Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006
    • Yamane Y., Aihara M., and Ikezawa Z. Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006. Allergol. Int. 56 (2007) 419-425
    • (2007) Allergol. Int. , vol.56 , pp. 419-425
    • Yamane, Y.1    Aihara, M.2    Ikezawa, Z.3
  • 26
    • 0035920176 scopus 로고    scopus 로고
    • A novel IkappaB protein. IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei
    • Yamazaki S., Muta T., and Takeshige K. A novel IkappaB protein. IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J. Biol. Chem. 276 (2001) 27657-27662
    • (2001) J. Biol. Chem. , vol.276 , pp. 27657-27662
    • Yamazaki, S.1    Muta, T.2    Takeshige, K.3
  • 27
    • 0019268993 scopus 로고
    • Etiologic factors of the Stevens-Johnson syndrome
    • Yetiv J.Z., Bianchine J.R., and Owen Jr. J.A. Etiologic factors of the Stevens-Johnson syndrome. South Med. J. 73 (1980) 599-602
    • (1980) South Med. J. , vol.73 , pp. 599-602
    • Yetiv, J.Z.1    Bianchine, J.R.2    Owen Jr., J.A.3


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